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Aliases for CYP3A4 Gene

Aliases for CYP3A4 Gene

  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 2 3
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4 2 3
  • Taurochenodeoxycholate 6-Alpha-Hydroxylase 3 4
  • 1,8-Cineole 2-Exo-Monooxygenase 3 4
  • Albendazole Monooxygenase 3 4
  • Albendazole Sulfoxidase 3 4
  • Quinine 3-Monooxygenase 3 4
  • Cytochrome P450 NF-25 3 4
  • Cytochrome P450-PCN1 3 4
  • Cytochrome P450 3A3 3 4
  • Cytochrome P450 HLp 3 4
  • Nifedipine Oxidase 3 4
  • CYPIIIA3 3 4
  • CYPIIIA4 3 4
  • CYP3A3 3 4
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3 3
  • Glucocorticoid-Inducible P450 3
  • P450-III, Steroid Inducible 3
  • Cytochrome P450 3A4 3
  • EC 4
  • EC 4
  • EC 4
  • EC 4
  • EC 63
  • EC 1.14.13.- 4
  • P450PCN1 3
  • P450C3 3
  • CYP3A 3
  • NF-25 3
  • CP33 3
  • CP34 3
  • HLP 3

External Ids for CYP3A4 Gene

Previous HGNC Symbols for CYP3A4 Gene

  • CYP3A3

Previous GeneCards Identifiers for CYP3A4 Gene

  • GC07M097889
  • GC07M098952
  • GC07M098967
  • GC07M098968
  • GC07M098892
  • GC07M098999
  • GC07M099192
  • GC07M099355
  • GC07M093991

Summaries for CYP3A4 Gene

Entrez Gene Summary for CYP3A4 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

GeneCards Summary for CYP3A4 Gene

CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4) is a Protein Coding gene. Diseases associated with CYP3A4 include xanthomatosis and methemoglobinemia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP3A4 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.

Tocris Summary for CYP3A4 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They are found at high levels in the liver, where they have an important role in metabolism of drugs and endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis, cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP3A4 Gene

PharmGKB "VIP" Summary for CYP3A4 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for CYP3A4 Gene

Genomics for CYP3A4 Gene

Regulatory Elements for CYP3A4 Gene

Genomic Location for CYP3A4 Gene

99,756,960 bp from pter
99,784,265 bp from pter
27,306 bases
Minus strand

Genomic View for CYP3A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP3A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A4 Gene

Proteins for CYP3A4 Gene

  • Protein details for CYP3A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 3A4
    Protein Accession:
    Secondary Accessions:
    • P05184
    • Q16757
    • Q9UK50

    Protein attributes for CYP3A4 Gene

    503 amino acids
    Molecular mass:
    57343 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Three dimensional structures from OCA and Proteopedia for CYP3A4 Gene

neXtProt entry for CYP3A4 Gene

Proteomics data for CYP3A4 Gene at MOPED

Post-translational modifications for CYP3A4 Gene

  • Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CYP3A4 (CYP3A4)

Domains for CYP3A4 Gene

Gene Families for CYP3A4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A4: view

Function for CYP3A4 Gene

Molecular function for CYP3A4 Gene

GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 4 (niphedipine oxidase);highly expressed in the liver,see CYP3A@,with a significant association of the wild type enzyme with epipodophyllotoxin-induced leukemogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
1,8-cineole + NADPH + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
UniProtKB/Swiss-Prot Induction:
By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Gene Ontology (GO) - Molecular Function for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0005496 steroid binding IDA 15256616
GO:0005506 iron ion binding IDA 15256616
GO:0008395 steroid hydroxylase activity IMP 18356043
GO:0016491 oxidoreductase activity IDA 15039299
genes like me logo Genes that share ontologies with CYP3A4: view

Animal Model Products

CRISPR Products

miRNA for CYP3A4 Gene

miRTarBase miRNAs that target CYP3A4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP3A4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP3A4 Gene

Localization for CYP3A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A4 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CYP3A4 Gene COMPARTMENTS Subcellular localization image for CYP3A4 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 2
extracellular 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18446064
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle TAS 3460094
genes like me logo Genes that share ontologies with CYP3A4: view

Pathways for CYP3A4 Gene

SuperPathways for CYP3A4 Gene

Superpath Contained pathways
1 Biological oxidations
2 Chemical carcinogenesis
3 Cytochrome P450 - arranged by substrate type
4 Venlafaxine Pathway, Pharmacokinetics
5 Gefitinib Pathway, Pharmacokinetics
genes like me logo Genes that share pathways with CYP3A4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 2492107
GO:0006706 steroid catabolic process IMP 18356043
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 3259858
GO:0008209 androgen metabolic process TAS 19651758
genes like me logo Genes that share ontologies with CYP3A4: view

Drugs for CYP3A4 Gene

(558) Drugbank Compounds for CYP3A4 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • DHC
125-28-0 5284543 Enzyme substrate approved, experimental, illicit
  • Butramin
106650-56-0 5210 Enzyme substrate approved, illicit, investigational, withdrawn
  • 8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine
28981-97-7 2118 Enzyme substrate approved, illicit, investigational
  • (-)-Buprenorphine
52485-79-7 40400 Enzyme inhibitor, substrate approved, illicit, investigational
  • 1-Phenethyl-4-(N-phenylpropionamido)piperidine
437-38-7 3345 Enzyme inhibitor, substrate approved, illicit, investigational

(5) Tocris Compounds for CYP3A4 Gene

Compound Action Cas Number
Exemestane Steroidal aromatase (CYP19) inhibitor [107868-30-4]
Ketoconazole Cytochrome P450c17 inhibitor [65277-42-1]
Letrozole Potent, reversible non-steroidal aromatase inhibitor [112809-51-5]
Methoxyresorufin Fluorometric CYP450 substrate [5725-89-3]
Pentoxyresorufin Fluorometric cytochrome P450 substrate [87687-03-4]

(4) ApexBio Compounds for CYP3A4 Gene

Compound Action Cas Number
8-Methoxypsoralen CYP inhibitor [298-81-7]
Alizarin Biological stain [72-48-0]
Cobicistat (GS-9350) Selective CYP3A inhibitor [1004316-88-4]
PF-4981517 CYP3A4 inhibitor,potent and selective [1390637-82-7]

(483) HMDB Compounds for CYP3A4 Gene

Compound Synonyms Cas Number PubMed IDs
  • 11,12,15-TriHETRE
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoate

(146) Novoseek inferred chemical compound relationships for CYP3A4 Gene

Compound -log(P) Hits PubMed IDs
troleandomycin 91.4 57
1-hydroxymidazolam 88.3 16
ketoconazole 87.7 127
midazolam 87.2 194
androstane 86.2 25

(107) PharmGKB related drug/compound annotations for CYP3A4 Gene

Drug/compound Annotation
abiraterone DrugLabel,Clinical Annotation
acetaminophen DrugLabel,Clinical Annotation
afatinib DrugLabel,Clinical Annotation
amlodipine DrugLabel,Clinical Annotation
anastrozole DrugLabel,Clinical Annotation
aripiprazole DrugLabel,Clinical Annotation
atazanavir DrugLabel,Clinical Annotation
atorvastatin DrugLabel,Clinical Annotation
axitinib DrugLabel,Clinical Annotation
boceprevir DrugLabel,Clinical Annotation
bosutinib DrugLabel,Clinical Annotation
brentuximab vedotin DrugLabel,Clinical Annotation
cabazitaxel DrugLabel,Clinical Annotation
carbamazepine DrugLabel,Clinical Annotation
ceritinib DrugLabel,Clinical Annotation
cevimeline DrugLabel,Clinical Annotation
citalopram DrugLabel,Clinical Annotation
clobazam DrugLabel,Clinical Annotation
clopidogrel DrugLabel,Clinical Annotation
clozapine DrugLabel,Clinical Annotation
codeine DrugLabel,Clinical Annotation
crizotinib DrugLabel,Clinical Annotation
cyclophosphamide DrugLabel,Clinical Annotation
cyclosporine DrugLabel,Clinical Annotation
dabrafenib DrugLabel,Clinical Annotation
darifenacin DrugLabel,Clinical Annotation
darunavir DrugLabel,Clinical Annotation
dasatinib DrugLabel,Clinical Annotation
dexlansoprazole DrugLabel,Clinical Annotation
dextromethorphan DrugLabel,Clinical Annotation
diazepam DrugLabel,Clinical Annotation
docetaxel DrugLabel,Clinical Annotation
dronedarone DrugLabel,Clinical Annotation
drospirenone DrugLabel,Clinical Annotation
efavirenz DrugLabel,Clinical Annotation
eliglustat DrugLabel,Clinical Annotation
eltrombopag DrugLabel,Clinical Annotation
emtricitabine DrugLabel,Clinical Annotation
erlotinib DrugLabel,Clinical Annotation
erythromycin DrugLabel,Clinical Annotation
esomeprazole DrugLabel,Clinical Annotation
ethinyl estradiol DrugLabel,Clinical Annotation
everolimus DrugLabel,Clinical Annotation
exemestane DrugLabel,Clinical Annotation
fentanyl DrugLabel,Clinical Annotation
fesoterodine DrugLabel,Clinical Annotation
fluvoxamine DrugLabel,Clinical Annotation
fosamprenavir DrugLabel,Clinical Annotation
fulvestrant DrugLabel,Clinical Annotation
gefitinib DrugLabel,Clinical Annotation
iloperidone DrugLabel,Clinical Annotation
imatinib DrugLabel,Clinical Annotation
indacaterol DrugLabel,Clinical Annotation
indinavir DrugLabel,Clinical Annotation
irinotecan DrugLabel,Clinical Annotation
ivabradine DrugLabel,Clinical Annotation
ivacaftor DrugLabel,Clinical Annotation
lapatinib DrugLabel,Clinical Annotation
letrozole DrugLabel,Clinical Annotation
lomitapide DrugLabel,Clinical Annotation
maraviroc DrugLabel,Clinical Annotation
methadone DrugLabel,Clinical Annotation
midazolam DrugLabel,Clinical Annotation
modafinil DrugLabel,Clinical Annotation
nefazodone DrugLabel,Clinical Annotation
nelfinavir DrugLabel,Clinical Annotation
nifedipine DrugLabel,Clinical Annotation
nilotinib DrugLabel,Clinical Annotation
omeprazole DrugLabel,Clinical Annotation
paclitaxel DrugLabel,Clinical Annotation
pantoprazole DrugLabel,Clinical Annotation
pazopanib DrugLabel,Clinical Annotation
pimozide DrugLabel,Clinical Annotation
ponatinib DrugLabel,Clinical Annotation
posaconazole DrugLabel,Clinical Annotation
prasugrel DrugLabel,Clinical Annotation
propafenone DrugLabel,Clinical Annotation
quinidine DrugLabel,Clinical Annotation
quinine DrugLabel,Clinical Annotation
ranolazine DrugLabel,Clinical Annotation
regorafenib DrugLabel,Clinical Annotation
ritonavir DrugLabel,Clinical Annotation
rosuvastatin DrugLabel,Clinical Annotation
ruxolitinib DrugLabel,Clinical Annotation
sildenafil DrugLabel,Clinical Annotation
simeprevir DrugLabel,Clinical Annotation
simvastatin DrugLabel,Clinical Annotation
sirolimus DrugLabel,Clinical Annotation
sunitinib DrugLabel,Clinical Annotation
tacrolimus DrugLabel,Clinical Annotation
telaprevir DrugLabel,Clinical Annotation
telithromycin DrugLabel,Clinical Annotation
tenofovir DrugLabel,Clinical Annotation
ticagrelor DrugLabel,Clinical Annotation
tiotropium DrugLabel,Clinical Annotation
tipranavir DrugLabel,Clinical Annotation
tolterodine DrugLabel,Clinical Annotation
tramadol DrugLabel,Clinical Annotation
trametinib DrugLabel,Clinical Annotation
trastuzumab emtansine DrugLabel,Clinical Annotation
vandetanib DrugLabel,Clinical Annotation
vardenafil DrugLabel,Clinical Annotation
vemurafenib DrugLabel,Clinical Annotation
venlafaxine DrugLabel,Clinical Annotation
voriconazole DrugLabel,Clinical Annotation
vortioxetine DrugLabel,Clinical Annotation
zonisamide DrugLabel,Clinical Annotation
genes like me logo Genes that share compounds with CYP3A4: view

Transcripts for CYP3A4 Gene

Unigene Clusters for CYP3A4 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP3A4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A4 Gene

No ASD Table

Relevant External Links for CYP3A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP3A4 Gene

mRNA expression in normal human tissues for CYP3A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP3A4 Gene

This gene is overexpressed in Liver (43.8) and Small Intestine - Terminal Ileum (6.9).

Protein differential expression in normal tissues for CYP3A4 Gene

This gene is overexpressed in Gallbladder (35.3), Liver (24.7), and Fetal Liver (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP3A4 Gene

SOURCE GeneReport for Unigene cluster for CYP3A4 Gene Hs.728751

mRNA Expression by UniProt/SwissProt for CYP3A4 Gene

Tissue specificity: Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
genes like me logo Genes that share expressions with CYP3A4: view

Expression partners for CYP3A4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYP3A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYP3A5 35
  • 82.64 (n)
  • 77.14 (a)
-- 36
  • 77 (a)
CYP3A5 36
  • 71 (a)
CYP3A5 36
  • 77 (a)
(Canis familiaris)
Mammalia CYP3A4 35
  • 84.56 (n)
  • 80.52 (a)
-- 36
  • 77 (a)
-- 36
  • 76 (a)
CYP3A12 36
  • 81 (a)
CYP3A26 36
  • 78 (a)
(Pan troglodytes)
Mammalia CYP3A4 35
  • 99.4 (n)
  • 98.41 (a)
CYP3A4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Cyp3a2 35
  • 77.2 (n)
  • 71.77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
-- 36
  • 67 (a)
-- 36
  • 66 (a)
-- 36
  • 65 (a)
(Mus musculus)
Mammalia Cyp3a11 36
  • 73 (a)
Cyp3a13 36
  • 75 (a)
Cyp3a16 36
  • 70 (a)
Cyp3a25 36
  • 71 (a)
Cyp3a41a 36
  • 71 (a)
Cyp3a41b 36
  • 71 (a)
Cyp3a44 36
  • 69 (a)
Cyp3a57 36
  • 68 (a)
Cyp3a59 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
-- 36
  • 56 (a)
-- 36
  • 55 (a)
(Gallus gallus)
Aves CYP3A4 35
  • 63.04 (n)
  • 61.09 (a)
CYP3A37 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
-- 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487054 35
  • 60.78 (n)
  • 55.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68821 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6641 35
(Danio rerio)
Actinopterygii cyp3a65 36
  • 54 (a)
cyp3c1 36
  • 48 (a)
cyp3c1l2 36
  • 51 (a)
cyp3c4 36
  • 48 (a)
si:dkey-21n8.3 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp28a5 37
  • 24 (a)
Cyp28c1 37
  • 25 (a)
Cyp28d1 37
  • 27 (a)
Cyp28d2 37
  • 30 (a)
Cyp309a1 37
  • 24 (a)
Cyp309a2 37
  • 25 (a)
Cyp313a1 37
  • 27 (a)
Cyp313a2 37
  • 25 (a)
Cyp317a1 37
  • 24 (a)
Cyp6a13 37
  • 32 (a)
Cyp6a14 37
  • 33 (a)
Cyp6a17 37
  • 34 (a)
Cyp6a18 37
  • 31 (a)
Cyp6a19 37
  • 31 (a)
Cyp6a2 37
  • 32 (a)
Cyp6a20 37
  • 31 (a)
Cyp6a21 37
  • 30 (a)
Cyp6a22 37
  • 32 (a)
Cyp6a23 37
  • 35 (a)
Cyp6a8 37
  • 30 (a)
Cyp6a9 37
  • 31 (a)
Cyp6d2 37
  • 29 (a)
Cyp6d4 37
  • 33 (a)
Cyp6d5 37
  • 31 (a)
Cyp6g1 37
  • 33 (a)
Cyp6g2 37
  • 30 (a)
Cyp6t1 37
  • 26 (a)
Cyp6t3 37
  • 27 (a)
Cyp6u1 37
  • 26 (a)
Cyp6v1 37
  • 32 (a)
Cyp6w1 37
  • 30 (a)
Cyp9b1 37
  • 27 (a)
Cyp9b2 37
  • 32 (a)
Cyp9c1 37
  • 31 (a)
Cyp9f2 37
  • 33 (a)
Cyp9h1 37
  • 30 (a)
Cyp9f2 35
  • 47.35 (n)
  • 35.84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012293 35
  • 48.95 (n)
  • 41.35 (a)
(Caenorhabditis elegans)
Secernentea C36A4.1 37
  • 31 (a)
C36A4.2 37
  • 30 (a)
C36A4.6 37
  • 28 (a)
F14F7.2 37
  • 31 (a)
F14F7.3 37
  • 32 (a)
F42A6.4 37
  • 28 (a)
K06G5.2 37
  • 25 (a)
T10B9.1 37
  • 30 (a)
T10B9.2 37
  • 30 (a)
T10B9.3 37
  • 29 (a)
T10B9.5 37
  • 30 (a)
T10B9.7 37
  • 30 (a)
T10B9.8 37
  • 29 (a)
ZK1320.4 37
  • 26 (a)
cyp-25A1 35
  • 46.71 (n)
  • 32.68 (a)
Species with no ortholog for CYP3A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A4 Gene

Gene Tree for CYP3A4 (if available)
Gene Tree for CYP3A4 (if available)

Paralogs for CYP3A4 Gene Pseudogenes for CYP3A4 Gene

genes like me logo Genes that share paralogs with CYP3A4: view

Variants for CYP3A4 Gene

Sequence variations from dbSNP and Humsavar for CYP3A4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs28988568 -- 99,784,925(-) AGAAG(-/ATGGAGTAG)TCACC upstream-variant-2KB
rs34533196 -- 99,779,665(+) AACTA(-/AGTA)TGACT intron-variant
rs34554553 -- 99,757,470(+) TGATC(-/A)AAAAA utr-variant-3-prime
rs34642455 -- 99,777,087(-) GAGAT(A/G)ATAGA intron-variant
rs34703484 -- 99,785,106(-) GAAGG(A/G)TTCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYP3A4 Gene

Variant ID Type Subtype PubMed ID
nsv888771 CNV Loss 21882294
nsv482109 CNV Gain 20164927

Relevant External Links for CYP3A4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)
The Human Cytochrome P450 Allele Nomenclature Database

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A4 Gene

Disorders for CYP3A4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CYP3A4 Gene in MalaCards »

(3) Diseases for CYP3A4 Gene

(2) University of Copenhagen DISEASES for CYP3A4 Gene

(89) Novoseek inferred disease relationships for CYP3A4 Gene

Disease -log(P) Hits PubMed IDs
acetaminophen metabolism 52.5 1
rhabdomyolysis 46.3 4
colon carcinoma 32.8 16
immunodeficiency 30.4 11
torsades de pointes 23.6 3

Relevant External Links for CYP3A4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CYP3A4: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CYP3A4 Gene

Publications for CYP3A4 Gene

  1. Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. (PMID: 15634941) Lee S.J. … Goldstein J.A. (J. Pharmacol. Exp. Ther. 2005) 3 25 26 48
  2. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. (PMID: 18332045) Cooper B.W. … Wallace A.D. (Toxicol. Sci. 2008) 3 23 25 26
  3. Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine. (PMID: 9088578) Zhang H. … Wanwimolruk S. (Br. J. Clin. Pharmacol. 1997) 3 4 23
  4. Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. (PMID: 11051261) Naoe T. … Ohno R. (Clin. Cancer Res. 2000) 3 23 48
  5. Pharmacogenetic polymorphisms of the AR and metabolism and susceptibility to hormone-induced azoospermia. (PMID: 11549683) Yu B. … Handelsman D.J. (J. Clin. Endocrinol. Metab. 2001) 3 23 48

Products for CYP3A4 Gene

Sources for CYP3A4 Gene

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