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Aliases for CYP2A6 Gene

Aliases for CYP2A6 Gene

  • Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 2 3
  • CYP2A3 3 4 6
  • Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 6 2 3
  • 1,4-Cineole 2-Exo-Monooxygenase 3 4
  • Coumarin 7-Hydroxylase 3 4
  • Cytochrome P450 IIA3 3 4
  • Cytochrome P450(I) 3 4
  • P450C2A 3 6
  • CYPIIA6 3 4
  • CYP2A 3 6
  • Flavoprotein-Linked Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 2A6 3
  • EC 1.14.14.1 64
  • EC 1.14.13.- 4
  • P450PB 3
  • CPA6 3

External Ids for CYP2A6 Gene

Previous Symbols for CYP2A6 Gene

  • CYP2A3

Summaries for CYP2A6 Gene

Entrez Gene Summary for CYP2A6 Gene

  • This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2A6 Gene

CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6) is a Protein Coding gene. Diseases associated with CYP2A6 include lung cancer and coumarin resistance. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2A6 Gene

  • Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.

Gene Wiki entry for CYP2A6 Gene

PharmGKB "VIP" Summary for CYP2A6 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2A6 Gene

Genomics for CYP2A6 Gene

Genomic Location for CYP2A6 Gene

Start:
40,843,538 bp from pter
End:
40,882,210 bp from pter
Size:
38,673 bases
Orientation:
Minus strand

Genomic View for CYP2A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2A6 Gene

Regulatory Elements for CYP2A6 Gene

Proteins for CYP2A6 Gene

  • Protein details for CYP2A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11509-CP2A6_HUMAN
    Recommended name:
    Cytochrome P450 2A6
    Protein Accession:
    P11509
    Secondary Accessions:
    • A7YAE5
    • B2R7F6
    • P00190
    • P10890
    • Q16803
    • Q4VAT9
    • Q4VAU0
    • Q4VAU1
    • Q9H1Z7
    • Q9UCU0
    • Q9UK48

    Protein attributes for CYP2A6 Gene

    Size:
    494 amino acids
    Molecular mass:
    56501 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA52147.1; Type=Miscellaneous discrepancy; Note=Numerous conflicts and frameshifts.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CYP2A6 Gene

neXtProt entry for CYP2A6 Gene

Proteomics data for CYP2A6 Gene at MOPED

Post-translational modifications for CYP2A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2A6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CYP2A6 Gene

Gene Families for CYP2A6 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

UniProtKB/Swiss-Prot:

CP2A6_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • P11509
genes like me logo Genes that share domains with CYP2A6: view

Function for CYP2A6 Gene

Molecular function for CYP2A6 Gene

GENATLAS Biochemistry: cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 6,major nicotine c oxidase,involved in nicotine elimination,susceptibility factor for nicotine addiction and lung cancer,reduced by gene deletion,deleted in the poor metabolizer phenotype
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.23 uM for coumarin {ECO:0000269 PubMed:11695850, ECO:0000269 PubMed:16086027}; KM=530 uM for 1,4-cineole {ECO:0000269 PubMed:11695850, ECO:0000269 PubMed:16086027}; Vmax=3.5 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole {ECO:0000269 PubMed:11695850, ECO:0000269 PubMed:16086027};
UniProtKB/Swiss-Prot CatalyticActivity: 1,4-cineole + NADPH + O(2) = 2-exo-hydroxy-1,4-cineole + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
UniProtKB/Swiss-Prot Induction: By phenobarbital and dexamethasone.

Enzyme Numbers (IUBMB) for CYP2A6 Gene

Gene Ontology (GO) - Molecular Function for CYP2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008389 coumarin 7-hydroxylase activity IDA 16086027
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
genes like me logo Genes that share ontologies with CYP2A6: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP2A6 Gene

Localization for CYP2A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2A6 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2A6 Gene COMPARTMENTS Subcellular localization image for CYP2A6 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
cytosol 2
golgi apparatus 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CYP2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with CYP2A6: view

Pathways for CYP2A6 Gene

genes like me logo Genes that share pathways with CYP2A6: view

Interacting Proteins for CYP2A6 Gene

Gene Ontology (GO) - Biological Process for CYP2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0009804 coumarin metabolic process IDA 19651758
GO:0017144 drug metabolic process IMP 18356043
GO:0019373 epoxygenase P450 pathway IBA --
genes like me logo Genes that share ontologies with CYP2A6: view

Compounds for CYP2A6 Gene

(50) HMDB Compounds for CYP2A6 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(73) Drugbank Compounds for CYP2A6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE
target
2H-1-BENZOPYRAN-2-ONE
target
4,4'-DIPYRIDYL DISULFIDE
target
Acetaminophen
  • Acetaminofen
103-90-2 enzyme substrate
Amlodipine
  • Amlodipine Benzenesulfonate
88150-42-9 enzyme inhibitor

(157) Novoseek inferred chemical compound relationships for CYP2A6 Gene

Compound -log(P) Hits PubMed IDs
coumarin 93.5 157
chlorzoxazone 86.9 17
troleandomycin 84.2 8
sulfaphenazole 83.9 6
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 82.8 9

(12) PharmGKB related drug/compound annotations for CYP2A6 Gene

genes like me logo Genes that share compounds with CYP2A6: view

Transcripts for CYP2A6 Gene

Unigene Clusters for CYP2A6 Gene

Cytochrome P450, family 2, subfamily A, polypeptide 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2A6 Gene

No ASD Table

Relevant External Links for CYP2A6 Gene

GeneLoc Exon Structure for
CYP2A6
ECgene alternative splicing isoforms for
CYP2A6

Expression for CYP2A6 Gene

mRNA expression in normal human tissues for CYP2A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2A6 Gene

This gene is overexpressed in Liver (52.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2A6 Gene

SOURCE GeneReport for Unigene cluster for CYP2A6 Gene Hs.250615

mRNA Expression by UniProt/SwissProt for CYP2A6 Gene

P11509-CP2A6_HUMAN
Tissue specificity: Liver.
genes like me logo Genes that share expressions with CYP2A6: view

Orthologs for CYP2A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 62 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYP2A13 37
  • 87 (a)
ManyToMany
CYP2A13 37
  • 89 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp2a12 37
  • 71 (a)
ManyToMany
Cyp2a22 37
  • 71 (a)
ManyToMany
Cyp2a4 37
  • 84 (a)
ManyToMany
Cyp2a5 36
  • 84.62 (n)
  • 85.22 (a)
Cyp2a5 37
  • 85 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2a3 36
  • 84.35 (n)
  • 85.43 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp2a6 36
  • 58.25 (n)
  • 55.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp304a1 38
  • 26 (a)
Cyp303a1 38
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-36A1 36
  • 43.08 (n)
  • 32.53 (a)
F14H3.10 38
  • 29 (a)
B0213.12 38
  • 30 (a)
C41G6.1 38
  • 26 (a)
F41B5.2 38
  • 29 (a)
T10H4.11 38
  • 31 (a)
F42A9.5 38
  • 31 (a)
B0213.16 38
  • 30 (a)
F41B5.7 38
  • 29 (a)
K09A11.3 38
  • 33 (a)
C49C8.4 38
  • 32 (a)
C34B7.3 38
  • 32 (a)
B0213.10 38
  • 28 (a)
C50H11.15 38
  • 33 (a)
K09A11.4 38
  • 32 (a)
C03G6.14 38
  • 27 (a)
B0213.14 38
  • 29 (a)
C25E10.2 38
  • 27 (a)
F41B5.3 38
  • 32 (a)
K07C6.2 38
  • 30 (a)
K09D9.2 38
  • 28 (a)
K07C6.5 38
  • 29 (a)
F44C8.1 38
  • 30 (a)
K05D4.4 38
  • 32 (a)
C49G7.8 38
  • 29 (a)
B0304.3 38
  • 29 (a)
B0213.15 38
  • 30 (a)
C03G6.15 38
  • 29 (a)
F41B5.4 38
  • 30 (a)
K09A11.2 38
  • 32 (a)
R08F11.3 38
  • 31 (a)
B0213.11 38
  • 30 (a)
T09H2.1 38
  • 26 (a)
C45H4.17 38
  • 30 (a)
K07C6.3 38
  • 30 (a)
T10H4.10 38
  • 31 (a)
Species with no ortholog for CYP2A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2A6 Gene

ENSEMBL:
Gene Tree for CYP2A6 (if available)
TreeFam:
Gene Tree for CYP2A6 (if available)

Paralogs for CYP2A6 Gene

genes like me logo Genes that share paralogs with CYP2A6: view

Variants for CYP2A6 Gene

Sequence variations from dbSNP and Humsavar for CYP2A6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1137115 -- 40,850,376(-) ACTGT(A/G)ATGGT reference, synonymous-codon
rs1801272 Pathogenic, - 40,848,628(-) CGCCC(A/T)CCGGG missense, reference
rs1809810 - 40,844,759(-) AGTGT(A/T)CCCTA reference, missense
rs1809811 -- 40,846,935(+) AGCGT(A/G)CGCTG reference, synonymous-codon
rs2002975 -- 40,844,584(+) GAGGC(C/G)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2A6 Gene

Variant ID Type Subtype PubMed ID
dgv1084e1 CNV Complex 17122850
dgv3872n71 CNV Gain 21882294
nsv817836 CNV Gain+Loss 17921354
esv21610 CNV Gain+Loss 19812545
nsv9729 CNV Loss 18304495
dgv3873n71 CNV Loss 21882294
dgv3874n71 CNV Gain 21882294
dgv3875n71 CNV Gain 21882294
esv2718568 CNV Deletion 23290073
nsv2490 CNV Insertion 18451855
esv33053 CNV Gain 17666407
nsv516972 CNV Loss 19592680
nsv911739 CNV Gain+Loss 21882294
dgv642e199 CNV Deletion 23128226
nsv482219 CNV Gain 20164927
nsv911741 CNV Loss 21882294
dgv3876n71 CNV Loss 21882294
nsv442765 CNV CNV 18776908
nsv433318 CNV Loss 18776910
nsv911744 CNV Gain 21882294
dgv3877n71 CNV Gain+Loss 21882294
nsv911747 CNV Loss 21882294
dgv3878n71 CNV Loss 21882294
nsv436743 CNV Insertion 17901297
nsv435697 CNV Deletion 17901297
nsv438302 CNV Loss 16468122
dgv588n67 CNV Loss 20364138
dgv563e201 CNV Deletion 23290073
dgv643e199 CNV Deletion 23128226

Relevant External Links for CYP2A6 Gene

HapMap Linkage Disequilibrium report
CYP2A6
Human Gene Mutation Database (HGMD)
CYP2A6
Locus Specific Mutation Databases (LSDB)
CYP2A6
The Human Cytochrome P450 Allele Nomenclature Database
CYP2A6

Disorders for CYP2A6 Gene

(3) OMIM Diseases for CYP2A6 Gene (122720)

(2) University of Copenhagen DISEASES for CYP2A6 Gene

(39) Novoseek inferred disease relationships for CYP2A6 Gene

Disease -log(P) Hits PubMed IDs
cancer lung 34.2 36
tobacco dependence 33.8 2
smoking habit 27.9 5
cancer 16.8 25
liver damage 15.3 1

Relevant External Links for CYP2A6

Genetic Association Database (GAD)
CYP2A6
Human Genome Epidemiology (HuGE) Navigator
CYP2A6
genes like me logo Genes that share disorders with CYP2A6: view

No data available for UniProtKB/Swiss-Prot for CYP2A6 Gene

Publications for CYP2A6 Gene

  1. Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. (PMID: 18360915) Mwenifumbo J.C. … Tyndale R.F. (Hum. Mutat. 2008) 3 4 23 49
  2. Genetic and environmental influences on therapeutic and toxicity outcomes: studies with CYP2A6. (PMID: 18666753) Satarug S. … Moore M.R. (Curr Clin Pharmacol 2006) 3 23 49
  3. Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism. (PMID: 17522595) Mwenifumbo J.C. … Tyndale R.F. (Clin. Pharmacol. Ther. 2008) 3 23 49
  4. Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children. (PMID: 17927692) SinuAcs B. … Ferrandez-LongA!s A. (Basic Clin. Pharmacol. Toxicol. 2008) 3 23 49
  5. CYP2A6 gene polymorphism and personality traits for NEO-FFI on the smoking behavior of youths. (PMID: 17934923) Waga C. … Iwahashi K. (Drug Chem Toxicol 2007) 3 23 49

Products for CYP2A6 Gene

Sources for CYP2A6 Gene

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