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CYP1A2 Gene

protein-coding   GIFtS: 71
GCID: GC15P075041

Cytochrome P450, Family 1, Subfamily A, Polypeptide 2

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)
  See CYP1A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 21 2     P450(PA)2
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 21 2     Aryl Hydrocarbon Hydroxylase2
Cytochrome P(3)4502 3     Cytochrome P450 1A22
Cytochrome P450 42 3     Dioxin-Inducible P3-4502
Cytochrome P450-P32 3     Flavoprotein-Linked Monooxygenase2
CYPIA22 3     Microsomal Monooxygenase2
EC 1.14.14.13 8     P450 Form 42
CP122     Xenobiotic Monooxygenase2
P3-4502     

External Ids:    HGNC: 25961   Entrez Gene: 15442   Ensembl: ENSG000001405057   OMIM: 1240605   UniProtKB: P051773   

Export aliases for CYP1A2 gene to outside databases

Previous GC identifers: GC15M070968 GC15M068160 GC15P072617 GC15P072757 GC15P072828 GC15P051838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP1A2 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is
induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's
endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other
xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this
gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CYP1A2 Gene:
CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2) is a protein-coding gene. Diseases associated with CYP1A2 include hypoadrenalism, and porphyria cutanea tarda. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP1B1.

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine
is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the
metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and
heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin

Gene Wiki entry for CYP1A2 Gene

PharmGKB "VIP" summary for CYP1A2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP1A2 gene promoter:
         GR   p53   Pax-2   Nkx5-1   Arnt   C/EBPalpha   HNF-4alpha1   MZF-1   Ik-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP1A2 promoter sequence
   Search Chromatin IP Primers for CYP1A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP1A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CYP1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075041:  view genomic region     (about GC identifiers)

Start:
75,041,184 bp from pter      End:
75,048,941 bp from pter
Size:
7,758 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177 (See protein sequence)
Recommended Name: Cytochrome P450 1A2  
Size: 515 amino acids; 58294 Da
Cofactor: Heme group
1 PDB 3D structure from and Proteopedia for CYP1A2:
2HI4 (3D)    
Secondary accessions: Q16754 Q6NWU5 Q9BXX7 Q9UK49
Alternative splicing: 2 isoforms:  P05177-1   P05177-2   

Explore the universe of human proteins at neXtProt for CYP1A2: NX_P05177

Explore proteomics data for CYP1A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP1A2 (P05177) (see all 25)
     LEAFILE  FSIASDP  PILRYLP  YLPNPAL 


    See CYP1A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000752.2  
    ENSEMBL proteins: 
     ENSP00000342007  
    Reactome Protein details: P05177

    CYP1A2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP1A2
    CYP1 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008066 Cyt_P450_E_grp-I_CYP1

    Graphical View of Domain Structure for InterPro Entry P05177

    ProtoNet protein and cluster: P05177

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008066 CYP1A P450 family signature


    UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP1A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP1A2_HUMAN, P05177
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine
    is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the
    metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and
    heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole;
    KM=21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline;
    KM=27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; KM=71 uM for
    2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; KM=25 uM for phenacetin;
    Induction: By nicotine, omeprazole, phenobarbital, primidone and rifampicin

         Genatlas biochemistry entry for CYP1A2:
    cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IDA15327587
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity TAS2813353
    GO:0016491oxidoreductase activity IDA16401082
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
         
    Find genes that share ontologies with CYP1A2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CYP1A2:
     Decreased nuclei size in G2M 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cyp1a2):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  no phenotypic analysis  respiratory system 
     tumorigenesis 

    Find genes that share phenotypes with CYP1A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CYP1A2: Cyp1a2tm1Dwn Cyp1a2tm1Gonz Cyp1a2/Cyp1a1Cyp1a2/tm2Dwn Cyp1a2/Cyp1a1Cyp1a2/tm1.1Bra

       genOway: Develop your customized and physiologically relevant rodent model for CYP1A2

    miRNA
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    miRTarBase miRNAs that target CYP1A2:
    hsa-let-7b-5p (MIRT052168)

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    SwitchGear 3'UTR luciferase reporter plasmidCYP1A2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP1A2_HUMAN, P05177: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    chloroplast2
    cytosol2
    golgi apparatus2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle IDA2813353

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP1A2 About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen Pathway, Pharmacokinetics0.00
    Phase II conjugation0.56
    Phenytoin Pathway, Pharmacokinetics0.00
    metapathway biotransformation0.42
    Tamoxifen metabolism0.00
    Benzodiazepine Pathway, Pharmacokinetics0.00
    Estradiol metabolism0.00
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Aflatoxin B1 metabolism0.00
    Metabolism of xenobiotics by cytochrome P4500.71
    Arylamine metabolism0.00
    Drug metabolism - cytochrome P4500.69
    Benzo a pyrene metabolism0.00
    Retinol metabolism0.35
    3Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    cytochrome P4500.74
    4Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.00
    Arachidonic acid metabolism0.40
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.00
    5Venlafaxine Pathway, Pharmacokinetics
    Imipramine/Desipramine Pathway, Pharmacokinetics0.50
    Clomipramine Pathway, Pharmacokinetics0.00
    Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A20.00


    Find genes that share SuperPaths with CYP1A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for CYP1A2 (see all 8)
        Estradiol metabolism
    Retinol metabolism
    Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Estrone metabolism

    Selected BioSystems Pathways for CYP1A2 (see all 13)
        Aflatoxin B1 metabolism
    cytochrome P450
    Tamoxifen metabolism
    Arylamine metabolism
    Nuclear receptors in lipid metabolism and toxicity

    4 Reactome Pathways for CYP1A2
        Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    Methylation

    Selected PharmGKB Pathways for CYP1A2 (see all 15)
        Acetaminophen Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Caffeine Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics
    Clomipramine Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP1A2) (see all 9):
        Steroid hormone biosynthesis
    Caffeine metabolism
    Tryptophan metabolism
    Linoleic acid metabolism
    Retinol metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP1A2 (see all 6): 
              Cancer Drug Resistance in human mouse rat
              Hepatotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP1A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP1A2 (P051773 ENSP000003420074) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PORP164353I2D: score=2 
    ADAMTSL4Q6UY143I2D: score=1 
    AP2B1P630103I2D: score=1 
    BEGAINQ9BUH83I2D: score=1 
    CHIC2Q9UKJ53I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006706steroid catabolic process IMP18356043
    GO:0006725cellular aromatic compound metabolic process ----
    GO:0006778porphyrin-containing compound metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0006950response to stress ----

    Find genes that share ontologies with CYP1A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for CYP1A2 (CP1A2)

    Selected HMDB Compounds for CYP1A2 (see all 69)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-419919601
    1,7-Dimethyluric acid ----
    1-Methylxanthine ----
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----

    Selected DrugBank Compounds for CYP1A2 (see all 248)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FluvoxamineFluvoxamina [INN-Spanish] (see all 4)54739-18-3enzymesubstrate inhibitor8846619 10774624 16910628 15664751 8968657 9868741 19934256
    Clozapine-- 5786-21-0enzymesubstrate inhibitor8846619 9840430 19934256 10976659 19515014 19754423
    PropranololDl-Propranolol Hydrochloride (see all 7)525-66-6enzymesubstrate inhibitor7895609 7640150 8846619 19934256 10976659 19754423
    ErlotinibCP358774 (see all 2)183321-74-6enzymesubstrate17575239 16890575 16609030 16166415 19733976
    AmitriptylineAmitriprolidine (see all 5)50-48-6enzymesubstrate11259560 18359012 19934256 19515014
    CaffeineCafeina (see all 7)58-08-2enzymesubstrate inhibitor8846619 19934256 9492382 19515014
    DuloxetineDuloxetine HCl (see all 2)136434-34-9enzymesubstrate18307373 21366359 17121211 19480470
    Frovatriptan-- 158747-02-5enzymesubstrate11735616 12028322 19934256 12028321
    MelatoninMEL (see all 4)73-31-4enzymesubstrate inhibitor19919601 15616152 19934256 15626586
    Nortriptyline-- 72-69-5enzymesubstrate18359012 19934256 9193876 19515014

    Selected Novoseek inferred chemical compound relationships for CYP1A2 gene (see all 154)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    furafylline 92.6 50 9585555 (3), 8261428 (2), 2378786 (2), 8093105 (2) (see all 29)
    phenacetin 90.5 79 10189256 (5), 8474022 (3), 15766918 (3), 9195021 (2) (see all 44)
    ethoxyresorufin 90.2 84 15766918 (4), 8093105 (3), 10460801 (2), 10224324 (1) (see all 52)
    alpha-naphthoflavone 89.9 44 15766918 (2), 8723730 (1), 12758162 (1), 7895609 (1) (see all 32)
    paraxanthine 88.6 40 1302044 (3), 16261361 (2), 8919637 (2), 15980104 (2) (see all 23)
    1,7-dimethyluric acid 87.6 19 10197295 (2), 10027663 (1), 12189363 (1), 11393735 (1) (see all 13)
    afmu 86.7 36 10027663 (1), 10197295 (1), 15025748 (1), 11596199 (1) (see all 15)
    sulfaphenazole 85.4 12 8214760 (1), 11792676 (1), 17702393 (1), 9431831 (1) (see all 11)
    chlorzoxazone 83.7 17 8968357 (1), 9744576 (1), 10421611 (1), 12818727 (1) (see all 17)
    1-methylxanthine 83 30 10197295 (2), 10027663 (1), 12189363 (1), 11393735 (1) (see all 14)

    Selected PharmGKB related drug/compound annotations for CYP1A2 gene (see all 43)    About this table
    Drug/compound PharmGKB Annotation
    acetaminophen
    anastrozole
    antipsychoticsCA  
    caffeineCA  
    chlorpromazineCA  
    citalopram
    clobazam
    clomipramine
    clopidogrel  CA  
    clozapine  CA  



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP1A2 gene: 
    NM_000761.4  

    Unigene Cluster for CYP1A2:

    Cytochrome P450, family 1, subfamily A, polypeptide 2
    Hs.1361  [show with all ESTs]
    Unigene Representative Sequence: M55053
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343932(uc002ayr.1)
    miRNA
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    Additional mRNA sequence: 

    AF182274.1 BC067424.1 BC067425.1 BC067426.1 BC067427.1 BC067428.1 BC067429.1 M12078.1 
    M55053.1 Z00036.1 

    1 DOTS entry:

    DT.101963399 

    Selected AceView cDNA sequences (see all 27):

    CF271973 CB115370 BC067426 BC067428 BC067424 CF271968 BC067425 CF271972 
    NM_000761 BC067427 CK130237 BC067429 CF271974 CF271975 Z00036 T62882 
    T62116 CK130236 AF182274 M12078 CF271976 CF271978 BU658511 M55053 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP1A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP1A2 Expression
    About this image


    CYP1A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Mature Hepatocytes Liver Lobule
    CYP1A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP1A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1361

    UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177
    Tissue specificity: Liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP1A2 (see all 6): 
              Cancer Drug Resistance in human mouse rat
              Hepatotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP1A2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp1a21 , 5 cytochrome P450, family 1, subfamily a, polypeptide more1, 5 80.01(n)1
    73.05(a)1
      9 (31.30 cM)5
    130771  NM_009993.31  NP_034123.11 
     576769375 
    chicken
    (Gallus gallus)
    Aves CYP1A16
    CYP1A46
    Gallus gallus cytochrome P450 1A4 (CYP1A4), mRNA.
    60(a)
    55(a)
    many ↔ many
    many ↔ many
    10(1938235-1941050)
    10(1943039-1946669)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    59(a)
    56(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343721.1(50982-63103)
    GL343721.1(108802-116982)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp1a6
    cytochrome P450, family 1, subfamily A
    53(a)
    1 → many
    18(4974676-4985566) ENSDARG00000026039
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp307a13 cytochrome P450 26(a)   64D5   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP703A21 CYP703A2 41.45(n)
    30.47(a)
      839470  NM_100010.3  NP_171635.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01311001 Os08g0131100 44.3(n)
    30.59(a)
      4344594  NM_001067462.1  NP_001060927.1 


    ENSEMBL Gene Tree for CYP1A2 (if available)
    TreeFam Gene Tree for CYP1A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP1A2 gene
    CYP1B12  CYP1A12  CYP17A12  CYP21A22  
    Selected SIMAP similar genes for CYP1A2 using alignment to 2 protein entries:     CP1A2_HUMAN (see all proteins) (see all similar genes):
    CYP1A1    CYP1B1    CYP17A1    CYP2U1    CYP2A6    CYP2G1P
    CYP2D6    CYP2A13    CYP2A7    CYP2B6    CYP2J2    DKFZp686I24235
    CYP2F1    CYP2A6V2    CYP2B7    CYP2R1    CYP2C18    CYP2C19

    Find genes that share paralogs with CYP1A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CP1A2_HUMAN, P05177: The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the
    non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who
    are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased
    intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial
    infraction (MI)


    Selected SNPs for CYP1A2 (see all 340)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20695221,2
    C,F,H--55090275(+) CTGTTC/TCTCTA 1 -- us2k134Minor allele frequency- N:0.00NA NS EA MN WA CSA 3560
    rs1816922211,2
    --55090284(+) TATTGA/GATTCC 1 -- us2k10--------
    rs346337141,2
    F--55090288(+) GGATTC/TCCCAT 1 -- us2k15Minor allele frequency- T:0.01MN 400
    rs125924801,2
    C,F,H--55090314(+) TCTTCA/CCAGGT 1 -- us2k117Minor allele frequency- C:0.01NS EA NA MN 1456
    rs355901321,2
    F--55090345(+) TTTCAG/AGAATA 1 -- us2k15Minor allele frequency- A:0.01MN 400
    rs725565031,2
    F--55090389(+) CTCACA/TTCCAT 1 -- us2k15Minor allele frequency- T:0.01MN 396
    rs356941361,2
    C,F--55090655(+) GCACAT/-GAACC 1 -- us2k18Minor allele frequency- -:0.41MN NA CSA 402
    rs1853790041,2
    --55090700(+) AAAAAA/GAAAAA 1 -- us2k10--------
    rs1913215041,2
    --55090768(+) TAGATA/CTGACT 1 -- us2k10--------
    rs566611471,2
    C--55090810(+) GTACAA/GCAAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYP1A2 (75041184 - 75048941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP1A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904380CNV Loss21882294
    nsv833055CNV Loss17160897

    The Human Cytochrome P450 Allele Nomenclature Database: CYP1A2 
    Human Gene Mutation Database (HGMD): CYP1A2
    Locus Specific Mutation Databases (LSDB): CYP1A2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP1A2
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP1A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124060    OMIM disorders: --

    9 diseases for CYP1A2:    
    About MalaCards
    hypoadrenalism    porphyria cutanea tarda    cytochrome p450 oxidoreductase deficiency    tardive dyskinesia
    warfarin sensitivity    beta thalassemia    antley-bixler syndrome    omenn syndrome
    schizophrenia

    4 diseases from the University of Copenhagen DISEASES database for CYP1A2:
    Porphyria cutanea tarda     Cancer     Schizophrenia     Liver disease

    Find genes that share disorders with CYP1A2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP1A2 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chemical carcinogenesis 54.6 4 1486867 (1), 12520071 (1), 11370663 (1), 11943609 (1)
    porphyria cutanea tarda 40.9 4 12566081 (1), 11153915 (1), 15202857 (1)
    hepatitis autoimmune 23 2 8905121 (1), 9241657 (1)
    cancer 22.7 19 10493258 (2), 10473105 (1), 16402077 (1), 7881341 (1) (see all 17)
    apeced 19.1 1 14764761 (1)
    liver diseases 18.4 3 12569554 (1), 9453493 (1)
    breast cancer 15.9 31 17507615 (4), 15217502 (3), 16538170 (3), 19415745 (2) (see all 13)
    schizophrenia 13.2 28 15564895 (3), 16775389 (3), 10889552 (3), 16490169 (2) (see all 13)
    chronic liver disease 11.1 3 16841221 (1), 8672739 (1), 19643819 (1)
    colorectal cancer 10.2 16 12534642 (3), 16800822 (2), 11751443 (2), 17603900 (1) (see all 10)

    Genetic Association Database (GAD): CYP1A2
    Human Genome Epidemiology (HuGE) Navigator: CYP1A2 (273 documents)

    Export disorders for CYP1A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP1A2 gene, integrated from 10 sources (see all 1366):
    (articles sorted by number of sources associating them with CYP1A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. (PubMed id 15770072)1, 2, 4 Soyama A.... Sawada J. (Drug Metab. Pharmacokinet. 2005)
    2. The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population. (PubMed id 16153396)1, 4, 9 Chen X....He F. (Clin. Pharmacol. Ther. 2005)
    3. CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. (PubMed id 19843669)1, 4, 9 Peterson S....Lampe J.W. (amp 2009)
    4. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. (PubMed id 16609368)1, 4, 9 Jiang Z....Nebert D.W. (Pharmacogenet. Genomics 2006)
    5. Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS. (PubMed id 17852022)1, 4, 9 Ajroud-Driss S....Lukas T.J. (Amyotroph Lateral Scler 2007)
    6. Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. (PubMed id 19450128)1, 4, 9 Gunes A....Dahl M.L. (Pharmacogenomics 2009)
    7. Genetic association analysis of functional polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene with tardive dyskinesia in Japanese patients with schizophrenia. (PubMed id 15564895)1, 4, 9 Matsumoto C....Nakamura J. (Psychiatr. Genet. 2004)
    8. Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2. (PubMed id 12445035)1, 4, 9 Han X.M....Zhou H.H. (Br J Clin Pharmacol 2002)
    9. [Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan]. (PubMed id 18389617)1, 4, 9 Korytina G.F....Viktorova T.V. (Mol. Biol. (Mosk.) 2008)
    10. The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers. (PubMed id 17507615)1, 4, 9 Kotsopoulos J....Narod S.A. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1544 HGNC: 2596 AceView: CYP1A2 Ensembl:ENSG00000140505 euGenes: HUgn1544
    ECgene: CYP1A2 Kegg: 1544 H-InvDB: CYP1A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYP1A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP1A2 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp1a2.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp1a2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP1A2 gene:
    Search GeneIP for patents involving CYP1A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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