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Aliases for CYP1A2 Gene

Aliases for CYP1A2 Gene

  • Cytochrome P450 Family 1 Subfamily A Member 2 2 3 5
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2 2 3
  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 2 3
  • Cholesterol 25-Hydroxylase 3 4
  • Cytochrome P(3)450 3 4
  • Cytochrome P450-P3 3 4
  • Cytochrome P450 4 3 4
  • EC 1.14.14.1 4 63
  • CYPIA2 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Dioxin-Inducible P3-450 3
  • P450 Form 4 3
  • P450(PA) 3
  • P3-450 3
  • CP12 3

External Ids for CYP1A2 Gene

Previous GeneCards Identifiers for CYP1A2 Gene

  • GC15M070968
  • GC15M068160
  • GC15P072617
  • GC15P072757
  • GC15P072828
  • GC15P075041
  • GC15P051838

Summaries for CYP1A2 Gene

Entrez Gene Summary for CYP1A2 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP1A2 Gene

CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include cyp1a2-related altered drug metabolism and toxicity or absent response to clozapine. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP17A1.

UniProtKB/Swiss-Prot for CYP1A2 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.

Gene Wiki entry for CYP1A2 Gene

PharmGKB "VIP" Summary for CYP1A2 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A2 Gene

Genomics for CYP1A2 Gene

Regulatory Elements for CYP1A2 Gene

Genomic Location for CYP1A2 Gene

Chromosome:
15
Start:
74,748,843 bp from pter
End:
74,756,600 bp from pter
Size:
7,758 bases
Orientation:
Plus strand

Genomic View for CYP1A2 Gene

Genes around CYP1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1A2 Gene

Proteins for CYP1A2 Gene

  • Protein details for CYP1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05177-CP1A2_HUMAN
    Recommended name:
    Cytochrome P450 1A2
    Protein Accession:
    P05177
    Secondary Accessions:
    • Q16754
    • Q6NWU5
    • Q9BXX7
    • Q9UK49

    Protein attributes for CYP1A2 Gene

    Size:
    515 amino acids
    Molecular mass:
    58294 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP1A2 Gene

    Alternative splice isoforms for CYP1A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP1A2 Gene

Proteomics data for CYP1A2 Gene at MOPED

Post-translational modifications for CYP1A2 Gene

  • Glycosylation at Ser 69
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP1A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CYP1A2 (CYP1A2)

Domains & Families for CYP1A2 Gene

Gene Families for CYP1A2 Gene

Suggested Antigen Peptide Sequences for CYP1A2 Gene

Graphical View of Domain Structure for InterPro Entry

P05177

UniProtKB/Swiss-Prot:

CP1A2_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A2: view

Function for CYP1A2 Gene

Molecular function for CYP1A2 Gene

GENATLAS Biochemistry:
cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3,2-d]imidazole {ECO:0000269 PubMed:14725854}; KM=21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline {ECO:0000269 PubMed:14725854}; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline {ECO:0000269 PubMed:14725854}; KM=27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline {ECO:0000269 PubMed:14725854}; KM=71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine {ECO:0000269 PubMed:14725854}; KM=25 uM for phenacetin {ECO:0000269 PubMed:14725854};
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
UniProtKB/Swiss-Prot Induction:
By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

Enzyme Numbers (IUBMB) for CYP1A2 Gene

Gene Ontology (GO) - Molecular Function for CYP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS --
GO:0032451 demethylase activity IDA 2813353
genes like me logo Genes that share ontologies with CYP1A2: view
genes like me logo Genes that share phenotypes with CYP1A2: view

Human Phenotype Ontology for CYP1A2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYP1A2 Gene

MGI Knock Outs for CYP1A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP1A2

No data available for Transcription Factor Targets and HOMER Transcription for CYP1A2 Gene

Localization for CYP1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A2 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP1A2 Gene COMPARTMENTS Subcellular localization image for CYP1A2 gene
Compartment Confidence
endoplasmic reticulum 5
chloroplast 2
cytosol 2
extracellular 2
golgi apparatus 2
mitochondrion 2
nucleus 2
plasma membrane 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CYP1A2 Gene

Pathways & Interactions for CYP1A2 Gene

genes like me logo Genes that share pathways with CYP1A2: view

Interacting Proteins for CYP1A2 Gene

Gene Ontology (GO) - Biological Process for CYP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006725 cellular aromatic compound metabolic process IEA --
GO:0006778 porphyrin-containing compound metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0009403 toxin biosynthetic process IDA 11511187
GO:0009404 toxin metabolic process IEA --
genes like me logo Genes that share ontologies with CYP1A2: view

No data available for SIGNOR curated interactions for CYP1A2 Gene

Drugs & Compounds for CYP1A2 Gene

(392) Drugs for CYP1A2 Gene - From: DrugBank, HMDB, Novoseek, ClinicalTrials, PharmGKB, FDA Approved Drugs, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Nutra Antagonist, Enzyme, substrate, inhibitor 339
Acetaminophen Approved Pharma Enzyme, substrate 864
Carbamazepine Approved, Investigational Pharma Enzyme, substrate, inhibitor, inducer 118
Fluvoxamine Approved, Investigational Pharma Enzyme, substrate, inhibitor 46
Ketoconazole Approved, Investigational Pharma Pore Blocker, Enzyme, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 173

(113) Additional Compounds for CYP1A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,7-Dimethyluric acid
1-Methylxanthine
Aflatoxin B1
  • AFB1
  • AFBI
1162-65-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Paraxanthine
  • 1,7-Dimethyl-Xanthine
  • 1,7-Dimethylxanthine
611-59-6
genes like me logo Genes that share compounds with CYP1A2: view

Transcripts for CYP1A2 Gene

mRNA/cDNA for CYP1A2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP1A2 Gene

Cytochrome P450, family 1, subfamily A, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A2 Gene

No ASD Table

Relevant External Links for CYP1A2 Gene

GeneLoc Exon Structure for
CYP1A2
ECgene alternative splicing isoforms for
CYP1A2

Expression for CYP1A2 Gene

mRNA expression in normal human tissues for CYP1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A2 Gene

This gene is overexpressed in Liver (x51.8).

Protein differential expression in normal tissues from HIPED for CYP1A2 Gene

This gene is overexpressed in Gallbladder (51.2) and Liver (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP1A2 Gene



SOURCE GeneReport for Unigene cluster for CYP1A2 Gene Hs.1361

mRNA Expression by UniProt/SwissProt for CYP1A2 Gene

P05177-CP1A2_HUMAN
Tissue specificity: Liver.
genes like me logo Genes that share expression patterns with CYP1A2: view

Protein tissue co-expression partners for CYP1A2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYP1A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP1A2 35
  • 85.14 (n)
  • 81.98 (a)
CYP1A2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP1A2 35
  • 84.31 (n)
  • 82.42 (a)
CYP1A2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp1a2 35
  • 80.01 (n)
  • 73.05 (a)
Cyp1a2 16
Cyp1a2 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC735881 35
  • 92.81 (n)
  • 90.35 (a)
CYP1A2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp1a2 35
  • 80.6 (n)
  • 75.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves CYP1A1 36
  • 60 (a)
ManyToMany
CYP1A4 36
  • 55 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11738 35
zebrafish
(Danio rerio)
Actinopterygii cyp1a 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp307a1 37
  • 26 (a)
spo 36
  • 22 (a)
ManyToMany
spok 36
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP703A2 35
  • 41.45 (n)
  • 30.47 (a)
rice
(Oryza sativa)
Liliopsida Os08g0131100 35
  • 44.3 (n)
  • 30.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
Species with no ortholog for CYP1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1A2 Gene

ENSEMBL:
Gene Tree for CYP1A2 (if available)
TreeFam:
Gene Tree for CYP1A2 (if available)

Paralogs for CYP1A2 Gene

Paralogs for CYP1A2 Gene

genes like me logo Genes that share paralogs with CYP1A2: view

Variants for CYP1A2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A2 Gene

P05177-CP1A2_HUMAN
The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are slow caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).

Sequence variations from dbSNP and Humsavar for CYP1A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs56160784 - 74,749,801(+) ATCTT(C/G)TGCCT reference, missense
rs56276455 - 74,751,854(+) AGCTG(A/G)GTACA reference, missense
VAR_020794 -
rs55889066 - 74,753,234(+) ATGCT(A/G)TGTCT reference, missense
rs28399424 - 74,754,828(+) CTGAG(C/T)GGTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP1A2 Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897

Variation tolerance for CYP1A2 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 44.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP1A2 Gene

HapMap Linkage Disequilibrium report
CYP1A2
Human Gene Mutation Database (HGMD)
CYP1A2
The Human Cytochrome P450 Allele Nomenclature Database
CYP1A2

Disorders for CYP1A2 Gene

MalaCards: The human disease database

(23) MalaCards diseases for CYP1A2 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cyp1a2-related altered drug metabolism
  • phenacetin metabolism, defect in
toxicity or absent response to clozapine
headache
porphyria cutanea tarda
  • porphyria, hepatoerythropoietic
sporadic porphyria cutanea tarda
  • porphyria cutanea tarda type i
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP1A2

Genetic Association Database (GAD)
CYP1A2
Human Genome Epidemiology (HuGE) Navigator
CYP1A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP1A2
genes like me logo Genes that share disorders with CYP1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A2 Gene

Publications for CYP1A2 Gene

  1. Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. (PMID: 15770072) Soyama A. … Sawada J. (Drug Metab. Pharmacokinet. 2005) 3 4 48 67
  2. Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. (PMID: 19919601) Chang T.K. … Yeung E.Y. (J. Pineal Res. 2010) 23 25 26
  3. A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. (PMID: 19204080) Turpeinen M. … Zanger U.M. (Drug Metab. Dispos. 2009) 23 25 26
  4. Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. (PMID: 19754423) Wang B. … Zhou S.F. (Curr. Med. Chem. 2009) 23 25 26
  5. [Use of antidepressant drugs in schizophrenic patients with depression]. (PMID: 16910628) Micallef J. … Blin O. (Encephale 2006) 23 25 26

Products for CYP1A2 Gene

Sources for CYP1A2 Gene

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