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CYP1A2 Gene

protein-coding GIFtS: 71
GCID: GC15P075041

Cytochrome P450, Family 1, Subfamily A, Polypeptide 2

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 2¹ ²		P450(PA)²
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2¹ ²		Aryl Hydrocarbon Hydroxylase²
Cytochrome P(3)450² ³		Cytochrome P450 1A2²
Cytochrome P450 4² ³		Dioxin-Inducible P3-450²
Cytochrome P450-P3² ³		Flavoprotein-Linked Monooxygenase²
CYPIA2² ³		Microsomal Monooxygenase²
EC 1.14.14.1³ ⁸		P450 Form 4²
CP12²		Xenobiotic Monooxygenase²
P3-450²

External Ids:	HGNC: 2596¹	Entrez Gene: 1544²	Ensembl: ENSG00000140505⁷	OMIM: 124060⁵	UniProtKB: P05177³

Export aliases for CYP1A2 gene to outside databases

Previous GC identifers: GC15M070968 GC15M068160 GC15P072617 GC15P072757 GC15P072828 GC15P051838

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP1A2 Gene:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids

and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is

induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's

endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other

xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this

gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. (provided by RefSeq,

Jul 2008)

GeneCards Summary for CYP1A2 Gene:

CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2) is a protein-coding gene. Diseases associated with CYP1A2 include hemoglobin e - beta-thalassemia, and cytochrome p450 oxidoreductase deficiency. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP1B1.

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is

involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated

compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine

is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the

metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and

heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin

Gene Wiki entry for CYP1A2 Gene

PharmGKB "VIP" summary for CYP1A2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000015.10 NC_018926.2 NT_010194.18

Regulatory elements:

Regulatory transcription factor binding sites in the CYP1A2 gene promoter:
GR p53 Pax-2 Nkx5-1 Arnt C/EBPalpha HNF-4alpha1 MZF-1 Ik-2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP1A2 promoter sequence

Search Chromatin IP Primers for CYP1A2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP1A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

CYP1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P075041: view genomic region (about GC identifiers)

Start:	75,041,184 bp from pter	End:	75,048,941 bp from pter
Size:	7,758 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177 (See protein sequence)

Recommended Name: Cytochrome P450 1A2

Size: 515 amino acids; 58294 Da

Cofactor: Heme group

1 PDB 3D structure from and Proteopedia for CYP1A2:

2HI4 (3D)

Secondary accessions: Q16754 Q6NWU5 Q9BXX7 Q9UK49

Alternative splicing: 2 isoforms: P05177-1 P05177-2

Explore the universe of human proteins at neXtProt for CYP1A2: NX_P05177

Explore proteomics data for CYP1A2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for CYP1A2 (P05177) (see all 25)

LEAFILE

FSIASDP

PILRYLP

YLPNPAL

See CYP1A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000752.2

ENSEMBL proteins:

ENSP00000342007

Reactome Protein details: P05177

CYP1A2 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP1A2

CYP1 family

4 InterPro protein domains:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

IPR008066 Cyt_P450_E_grp-I_CYP1

Graphical View of Domain Structure for InterPro Entry P05177

ProtoNet protein and cluster: P05177

2 Blocks protein domains:

IPB002401 E-class P450 group I signature

IPB008066 CYP1A P450 family signature

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Similarity: Belongs to the cytochrome P450 family

CYP1A2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CP1A2_HUMAN, P05177

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is

involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated

compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine

is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the

metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and

heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Biophysicochemical properties: Kinetic parameters: KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole;

KM=21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline;

KM=27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; KM=71 uM for

2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; KM=25 uM for phenacetin;

Induction: By nicotine, omeprazole, phenobarbital, primidone and rifampicin

Genatlas biochemistry entry for CYP1A2:

cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

Gene Ontology (GO): Selected molecular function terms (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IDA	15327587
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	TAS	2813353
GO:0016491	oxidoreductase activity	IDA	16401082
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--

CYP1A2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CYP1A2:

Decreased nuclei size in G2M

11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cyp1a2):

behavior/neurological	cardiovascular system	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	no phenotypic analysis	respiratory system
tumorigenesis

CYP1A2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for CYP1A2: Cyp1a2^tm1Dwn Cyp1a2^tm1Gonz Cyp1a2/Cyp1a1^{Cyp1a2/tm2Dwn} Cyp1a2/Cyp1a1^{Cyp1a2/tm1.1Bra}

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genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP1A2

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CP1A2_HUMAN, P05177: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
chloroplast	2
cytosol	2
golgi apparatus	2
nucleus	2
extracellular	1
mitochondrion	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0043231	intracellular membrane-bounded organelle	IDA	2813353

CYP1A2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CYP1A2 About (see all 21)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Biological oxidations

Biological oxidations	0.56	Tamoxifen Pathway, Pharmacokinetics
Phase II conjugation	0.56	Phenytoin Pathway, Pharmacokinetics
metapathway biotransformation	0.42	Tamoxifen metabolism
Benzodiazepine Pathway, Pharmacokinetics	0.00	Estradiol metabolism

Chemical carcinogenesis

Chemical carcinogenesis	0.71	Aflatoxin B1 metabolism	0.00
Metabolism of xenobiotics by cytochrome P450	0.71	Arylamine metabolism	0.00
Drug metabolism - cytochrome P450	0.69	Benzo a pyrene metabolism	0.00
Retinol metabolism	0.35

Cytochrome P450 - arranged by substrate type

Cytochrome P450 - arranged by substrate type	0.75	Xenobiotics	0.00
Phase 1 - Functionalization of compounds	0.75	Fatty Acid Omega Oxidation	0.00
cytochrome P450	0.74

Arachidonic acid metabolism

	Linoleic acid metabolism	0.64			Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.00
	Arachidonic acid metabolism	0.40			Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	0.00

Venlafaxine Pathway, Pharmacokinetics

	Imipramine/Desipramine Pathway, Pharmacokinetics	0.50			Clomipramine Pathway, Pharmacokinetics	0.00
	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	0.00

Pathways by source See SuperPaths
Show all pathways

Selected GeneGo (Thomson Reuters) Pathways for CYP1A2 (see all 8)

	Estradiol metabolism
	Retinol metabolism
	Naphthalene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Estrone metabolism

Selected BioSystems Pathways for CYP1A2 (see all 13)

	Aflatoxin B1 metabolism
	cytochrome P450
	Tamoxifen metabolism
	Arylamine metabolism
	Nuclear receptors in lipid metabolism and toxicity

4 Reactome Pathways for CYP1A2

	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
	Methylation

Selected PharmGKB Pathways for CYP1A2 (see all 15)

	Acetaminophen Pathway, Pharmacokinetics
	Benzodiazepine Pathway, Pharmacokinetics
	Caffeine Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Clomipramine Pathway, Pharmacokinetics

Selected Kegg Pathways (Kegg details for CYP1A2) (see all 9):

	Steroid hormone biosynthesis
	Caffeine metabolism
	Tryptophan metabolism
	Linoleic acid metabolism
	Retinol metabolism

CYP1A2 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including CYP1A2 (see all 6):

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for CYP1A2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CYP1A2 (P05177³ ENSP00000342007⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 96)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POR	P16435³	I2D: score=2
ADAMTSL4	Q6UY14³	I2D: score=1
AP2B1	P63010³	I2D: score=1
BEGAIN	Q9BUH8³	I2D: score=1
CHIC2	Q9UKJ5³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 34): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006706	steroid catabolic process	IMP	18356043
GO:0006725	cellular aromatic compound metabolic process	--	--
GO:0006778	porphyrin-containing compound metabolic process	IEA	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0006950	response to stress	--	--

CYP1A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CYP1A2 (CP1A2)

Selected HMDB Compounds for CYP1A2 (see all 69) About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	19919601
1,7-Dimethyluric acid		--	--
1-Methylxanthine		--	--
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--

Selected DrugBank Compounds for CYP1A2 (see all 248) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Fluvoxamine	Fluvoxamina [INN-Spanish] (see all 4)	54739-18-3	enzyme	substrate inhibitor	8846619 10774624 16910628 15664751 8968657 9868741 19934256
Clozapine	--	5786-21-0	enzyme	substrate inhibitor	8846619 9840430 19934256 10976659 19515014 19754423
Propranolol	Dl-Propranolol Hydrochloride (see all 7)	525-66-6	enzyme	substrate inhibitor	7895609 7640150 8846619 19934256 10976659 19754423
Erlotinib	CP358774 (see all 2)	183321-74-6	enzyme	substrate	17575239 16890575 16609030 16166415 19733976
Amitriptyline	Amitriprolidine (see all 5)	50-48-6	enzyme	substrate	11259560 18359012 19934256 19515014
Caffeine	Cafeina (see all 7)	58-08-2	enzyme	substrate inhibitor	8846619 19934256 9492382 19515014
Duloxetine	Duloxetine HCl (see all 2)	136434-34-9	enzyme	substrate	18307373 21366359 17121211 19480470
Frovatriptan	--	158747-02-5	enzyme	substrate	11735616 12028322 19934256 12028321
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate inhibitor	19919601 15616152 19934256 15626586
Nortriptyline	--	72-69-5	enzyme	substrate	18359012 19934256 9193876 19515014

Selected Novoseek inferred chemical compound relationships for CYP1A2 gene (see all 154) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
furafylline	92.6	50	9585555 (3), 8261428 (2), 2378786 (2), 8093105 (2) (see all 29)
phenacetin	90.5	79	10189256 (5), 8474022 (3), 15766918 (3), 9195021 (2) (see all 44)
ethoxyresorufin	90.2	84	15766918 (4), 8093105 (3), 10460801 (2), 10224324 (1) (see all 52)
alpha-naphthoflavone	89.9	44	15766918 (2), 8723730 (1), 12758162 (1), 7895609 (1) (see all 32)
paraxanthine	88.6	40	1302044 (3), 16261361 (2), 8919637 (2), 15980104 (2) (see all 23)
1,7-dimethyluric acid	87.6	19	10197295 (2), 10027663 (1), 12189363 (1), 11393735 (1) (see all 13)
afmu	86.7	36	10027663 (1), 10197295 (1), 15025748 (1), 11596199 (1) (see all 15)
sulfaphenazole	85.4	12	8214760 (1), 11792676 (1), 17702393 (1), 9431831 (1) (see all 11)
chlorzoxazone	83.7	17	8968357 (1), 9744576 (1), 10421611 (1), 12818727 (1) (see all 17)
1-methylxanthine	83	30	10197295 (2), 10027663 (1), 12189363 (1), 11393735 (1) (see all 14)

7 PharmGKB related drug/compound annotations for CYP1A2 gene About this table

Drug/compound	PharmGKB Annotation
antipsychotics	CA
caffeine	CA
clopidogrel	CA
fluvoxamine
leflunomide	CA
olanzapine	CA
paroxetine	CA

CYP1A2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CYP1A2 gene:

NM_000761.4

Unigene Cluster for CYP1A2:

Cytochrome P450, family 1, subfamily A, polypeptide 2

Hs.1361 [show with all ESTs]

Unigene Representative Sequence: M55053

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000343932(uc002ayr.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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Additional mRNA sequence:

AF182274.1 BC067424.1 BC067425.1 BC067426.1 BC067427.1 BC067428.1 BC067429.1 M12078.1

M55053.1 Z00036.1

1 DOTS entry:

DT.101963399

Selected AceView cDNA sequences (see all 27):

CF271973 CB115370 BC067426 BC067428 BC067424 CF271968 BC067425 CF271972

NM_000761 BC067427 CK130237 BC067429 CF271974 CF271975 Z00036 T62882

T62116 CK130236 AF182274 M12078 CF271976 CF271978 BU658511 M55053

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CYP1A2 expression in normal human tissues (normalized intensities) CYP1A2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

CYP1A2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Liver (Hepatobiliary System) fully expand to see all 3 entries
Mature Hepatocytes Liver Lobule

CYP1A2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CYP1A2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1361

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Tissue specificity: Liver

Pathway & Disease-focused RT² Profiler PCR Arrays including CYP1A2 (see all 6):

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A2 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cyp1a2^{1 , 5}	cytochrome P450, family 1, subfamily a, polypeptide more^{1, 5}	80.01(n)¹ 73.05(a)¹		9 (31.30 cM)⁵ 13077¹ NM_009993.3¹ NP_034123.1¹ 57676937⁵
chicken (Gallus gallus)	Aves	CYP1A1⁶ CYP1A4⁶	Gallus gallus cytochrome P450 1A4 (CYP1A4), mRNA.	60(a) 55(a)	many ↔ many many ↔ many	10(1938235-1941050) 10(1943039-1946669)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	Uncharacterized protein (see all 3)	59(a) 56(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343721.1(50982-63103) GL343721.1(108802-116982)
zebrafish (Danio rerio)	Actinopterygii	cyp1a⁶	cytochrome P450, family 1, subfamily A	53(a)	1 → many	18(4974676-4985566) ENSDARG00000026039
fruit fly (Drosophila melanogaster)	Insecta	Cyp307a1³	cytochrome P450	26(a)		64D5 --
thale cress (Arabidopsis thaliana)	eudicotyledons	CYP703A2¹	CYP703A2	41.45(n) 30.47(a)		839470 NM_100010.3 NP_171635.1
rice (Oryza sativa)	Liliopsida	Os08g0131100¹	Os08g0131100	44.3(n) 30.59(a)		4344594 NM_001067462.1 NP_001060927.1

ENSEMBL Gene Tree for CYP1A2 (if available)
TreeFam Gene Tree for CYP1A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CYP1A2 gene

CYP1B1² CYP1A1² CYP17A1² CYP21A2²

Selected SIMAP similar genes for CYP1A2 using alignment to 2 protein entries: CP1A2_HUMAN (see all proteins) (see all similar genes):

CYP1A1 CYP1B1 CYP17A1 CYP2U1 CYP2A6 CYP2G1P

CYP2D6 CYP2A13 CYP2A7 CYP2B6 CYP2J2 DKFZp686I24235

CYP2F1 CYP2A6V2 CYP2B7 CYP2R1 CYP2C18 CYP2C19

CYP1A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot

CP1A2_HUMAN, P05177: The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the

non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who

are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased

intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial

infraction (MI)

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2069522^1,2	C,F,H	--	55090275(+)	`CTGTTC/TCTCTA`	1	--	us2k¹		34		NA NS EA MN WA CSA	3560
rs181692221^1,2		--	55090284(+)	`TATTGA/GATTCC`	1	--	us2k¹		0	--	--	--	--
rs34633714^1,2	F	--	55090288(+)	`GGATTC/TCCCAT`	1	--	us2k¹		5		MN	400
rs12592480^1,2	C,F,H	--	55090314(+)	`TCTTCA/CCAGGT`	1	--	us2k¹		17		NS EA NA MN	1456
rs35590132^1,2	F	--	55090345(+)	`TTTCAG/AGAATA`	1	--	us2k¹		5		MN	400
rs72556503^1,2	F	--	55090389(+)	`CTCACA/TTCCAT`	1	--	us2k¹		5		MN	396
rs35694136^1,2	C,F	--	55090655(+)	`GCACAT/-GAACC`	1	--	us2k¹		8		MN NA CSA	402
rs185379004^1,2		--	55090700(+)	`AAAAAA/GAAAAA`	1	--	us2k¹		0	--	--	--	--
rs191321504^1,2		--	55090768(+)	`TAGATA/CTGACT`	1	--	us2k¹		0	--	--	--	--
rs56661147^1,2	C	--	55090810(+)	`GTACAA/GCAAAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYP1A2 (75041184 - 75048941 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for CYP1A2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv904380	CNV	Loss	21882294
nsv833055	CNV	Loss	17160897

The Human Cytochrome P450 Allele Nomenclature Database: CYP1A2

Human Gene Mutation Database (HGMD): CYP1A2
Locus Specific Mutation Databases (LSDB): CYP1A2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CYP1A2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 124060 OMIM disorders: --

Selected diseases for CYP1A2 (see all 88): About MalaCards

hemoglobin e - beta-thalassemia cytochrome p450 oxidoreductase deficiency porphyria cutanea tarda hypoadrenalism

warfarin sensitivity tardive dyskinesia paranoid schizophrenia porphyria

hepatocellular adenoma antley-bixler syndrome omenn syndrome autoimmune polyendocrine syndrome

germ cell cancer gilbert syndrome beta thalassemia thalassemia

attention deficit hyperactivity disorder liver disease growth hormone deficiency pandas

4 diseases from the University of Copenhagen DISEASES database for CYP1A2:

Porphyria cutanea tarda Cancer Schizophrenia Liver disease

CYP1A2 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for CYP1A2 gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chemical carcinogenesis	54.6	4	1486867 (1), 12520071 (1), 11370663 (1), 11943609 (1)
porphyria cutanea tarda	40.9	4	12566081 (1), 11153915 (1), 15202857 (1)
hepatitis autoimmune	23	2	8905121 (1), 9241657 (1)
cancer	22.7	19	10493258 (2), 10473105 (1), 16402077 (1), 7881341 (1) (see all 17)
apeced	19.1	1	14764761 (1)
liver diseases	18.4	3	12569554 (1), 9453493 (1)
breast cancer	15.9	31	17507615 (4), 15217502 (3), 16538170 (3), 19415745 (2) (see all 13)
schizophrenia	13.2	28	15564895 (3), 16775389 (3), 10889552 (3), 16490169 (2) (see all 13)
chronic liver disease	11.1	3	16841221 (1), 8672739 (1), 19643819 (1)
colorectal cancer	10.2	16	12534642 (3), 16800822 (2), 11751443 (2), 17603900 (1) (see all 10)

Genetic Association Database (GAD): CYP1A2
Human Genome Epidemiology (HuGE) Navigator: CYP1A2 (273 documents)

Export disorders for CYP1A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYP1A2 gene, integrated from 10 sources (see all 1366):
(articles sorted by number of sources associating them with CYP1A2)

Utopia: connect your pdf to the dynamic
world of online information

Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. (PubMed id 15770072)^{1, 2, 4} Soyama A.... Sawada J. (Drug Metab. Pharmacokinet. 2005)
The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population. (PubMed id 16153396)^{1, 4, 9} Chen X....He F. (Clin. Pharmacol. Ther. 2005)
CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. (PubMed id 19843669)^{1, 4, 9} Peterson S....Lampe J.W. (amp 2009)
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. (PubMed id 16609368)^{1, 4, 9} Jiang Z....Nebert D.W. (Pharmacogenet. Genomics 2006)
Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS. (PubMed id 17852022)^{1, 4, 9} Ajroud-Driss S....Lukas T.J. (Amyotroph Lateral Scler 2007)
Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. (PubMed id 19450128)^{1, 4, 9} Gunes A....Dahl M.L. (Pharmacogenomics 2009)
Genetic association analysis of functional polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene with tardive dyskinesia in Japanese patients with schizophrenia. (PubMed id 15564895)^{1, 4, 9} Matsumoto C....Nakamura J. (Psychiatr. Genet. 2004)
Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2. (PubMed id 12445035)^{1, 4, 9} Han X.M....Zhou H.H. (Br J Clin Pharmacol 2002)
[Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan]. (PubMed id 18389617)^{1, 4, 9} Korytina G.F....Viktorova T.V. (Mol. Biol. (Mosk.) 2008)
The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers. (PubMed id 17507615)^{1, 4, 9} Kotsopoulos J....Narod S.A. (amp 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1544	HGNC: 2596	AceView: CYP1A2	Ensembl:ENSG00000140505	euGenes: HUgn1544
ECgene: CYP1A2	Kegg: 1544	H-InvDB: CYP1A2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYP1A2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP1A2	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp1a2.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp1a2/

Intellectual Property for CYP1A2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP1A2 gene:
Search GeneIP for patents involving CYP1A2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CYP1A2 Gene

Cytochrome P450, Family 1, Subfamily A, Polypeptide 2

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CYP1A2 Gene

Cytochrome P450, Family 1, Subfamily A, Polypeptide 2

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