Aliases for CYP1A2 Gene
Aliases for CYP1A2 Gene
- Cytochrome P450 Family 1 Subfamily A Member 2 2 3 5
- Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2 2 3
- Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 2 3
- Cholesterol 25-Hydroxylase 3 4
- Cytochrome P(3)450 3 4
- Cytochrome P450-P3 3 4
- Cytochrome P450 4 3 4
- EC 1.14.14.1 4 56
- CYPIA2 3 4
- Flavoprotein-Linked Monooxygenase 3
External Ids for CYP1A2 Gene
- HGNC: 2596
- Entrez Gene: 1544
- Ensembl: ENSG00000140505
- OMIM: 124060
- UniProtKB: P05177
Previous GeneCards Identifiers for CYP1A2 Gene
- GC15M070968
- GC15M068160
- GC15P072617
- GC15P072757
- GC15P072828
- GC15P075041
- GC15P051838
Summaries for CYP1A2 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP1A2 Gene
CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include Toxicity Or Absent Response To Clozapine and Acetaminophen Metabolism. Among its related pathways are Gefitinib Pathway, Pharmacokinetics and Estrogen Receptor Pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A1.
UniProtKB/Swiss-Prot for CYP1A2 Gene
-
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Additional gene information for CYP1A2 Gene
- Monarch Initiative
- Search for CYP1A2 at DataMed
- Search for CYP1A2 at HumanCyc
No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A2 Gene
Genomics for CYP1A2 Gene
GeneHancer (GH) Regulatory Elements for CYP1A2 Gene
- Top Transcription factor binding sites by QIAGEN in the CYP1A2 gene promoter:
Regulatory Element Products
Genomic Locations for CYP1A2 Gene
- chr15:74,748,843-74,756,600
- (GRCh38/hg38)
- Size:
- 7,758 bases
- Orientation:
- Plus strand
- chr15:75,041,184-75,048,941
- (GRCh37/hg19)
Genomic View for CYP1A2 Gene
- Cytogenetic band:
-
- 15q24.1 by Ensembl
- 15q24.1 by Entrez Gene
- 15q24.1 by HGNC


RefSeq DNA sequence for CYP1A2 Gene
Proteins for CYP1A2 Gene
-
Protein details for CYP1A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05177-CP1A2_HUMAN
- Recommended name:
- Cytochrome P450 1A2
- Protein Accession:
- P05177
- Q16754
- Q6NWU5
- Q9BXX7
- Q9UK49
Protein attributes for CYP1A2 Gene
- Size:
- 515 amino acids
- Molecular mass:
- 58294 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP1A2 Gene
Selected DME Specific Peptides for CYP1A2 Gene
- P05177:
-
- LLQQLEFS
- LEAFILE
- TTAISWSL
- QGDDFKGRP
- CVFVNQWQ
- YLPNPAL
- ELDTVIG
- RRPRLSDR
- PHSTTRDT
- YGDVLQI
- WAARRRLAQ
- FGAGFDT
- FSIASDP
- PILRYLP
- LQRFKAFNQ
- PEIQRKIQ
- GKRRCIGE
- SATELLL
- PFTIPHST
- VIGAMCFG
- LTLGKNPH
- TPIYGLT
- FRPERFLT
- LNGFYIP
- DRPQLPY
Post-translational modifications for CYP1A2 Gene
- Glycosylation at posLast=6969
Other Protein References for CYP1A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for CYP1A2 (CYP1A2)
-
Custom Antibody ServicesOriGene Antibodies for CYP1A2
- Novus Biologicals Antibodies for CYP1A2
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Abcam antibodies for CYP1A2
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Cloud-Clone Corp. Antibodies for CYP1A2
- Invitrogen Antibodies for CYP1A2
- GeneTex CYP1A2 antibody for CYP1A2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A2
Protein Products
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OriGene Purified Proteins for CYP1A2
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A2
- Origene Custom Protein Services for CYP1A2
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Cloud-Clone Corp. Proteins for CYP1A2
- Search GeneTex for Proteins for CYP1A2
-
Abcam proteins for CYP1A2
Assay Products
-
Cloud-Clone Corp. Assay Kits for CYP1A2
-
Abcam assays for CYP1A2
Domains & Families for CYP1A2 Gene
Gene Families for CYP1A2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted membrane proteins
Protein Domains for CYP1A2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP1A2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05177- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP1A2 Gene
Molecular function for CYP1A2 Gene
- GENATLAS Biochemistry:
- cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3,2-d]imidazole {ECO:0000269 PubMed:14725854}; KM=21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline {ECO:0000269 PubMed:14725854}; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline {ECO:0000269 PubMed:14725854}; KM=27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline {ECO:0000269 PubMed:14725854}; KM=71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine {ECO:0000269 PubMed:14725854}; KM=25 uM for phenacetin {ECO:0000269 PubMed:14725854};
- UniProtKB/Swiss-Prot CatalyticActivity:
- RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
- UniProtKB/Swiss-Prot Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
- UniProtKB/Swiss-Prot Induction:
- By nicotine, omeprazole, phenobarbital, primidone and rifampicin.
Enzyme Numbers (IUBMB) for CYP1A2 Gene
Phenotypes From GWAS Catalog for CYP1A2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004497 | monooxygenase activity | TAS | -- |
GO:0005506 | iron ion binding | IEA | -- |
GO:0009055 | electron transfer activity | TAS | 2813353 |
GO:0016491 | oxidoreductase activity | IDA | 16401082 |
GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
Phenotypes for CYP1A2 Gene
- MGI mutant phenotypes for CYP1A2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CYP1A2:
Animal Models for CYP1A2 Gene
- MGI Knock Outs for CYP1A2:
-
- Cyp1a2 tm1Gonz
- Cyp1a2 tm1Dwn
- Cyp1a2/Cyp1a1 tm1.1Bra
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CYP1A2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP1A2 gene
- Search ViGene Biosciences for CYP1A2
CRISPR Products
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OriGene CRISPR knockouts for CYP1A2
- genomics-online: gRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- Applied Biological Materials CRISPR for CYP1A2
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2
- GenScript: Design CRISPR guide RNA sequences for CYP1A2
miRNA for CYP1A2 Gene
- miRTarBase miRNAs that target CYP1A2
-
- hsa-let-7b-5p (MIRT052168)
- hsa-mir-7703 (MIRT619665)
- hsa-mir-6720-5p (MIRT619666)
- hsa-mir-6512-3p (MIRT619667)
- hsa-mir-196a-3p (MIRT619668)
- hsa-mir-4252 (MIRT619669)
- hsa-mir-3128 (MIRT619670)
- hsa-mir-4793-3p (MIRT619671)
- hsa-mir-766-3p (MIRT619672)
- hsa-mir-1292-3p (MIRT619673)
- hsa-mir-8073 (MIRT619674)
- hsa-mir-221-5p (MIRT619675)
- hsa-mir-6849-3p (MIRT619676)
- hsa-mir-1273g-3p (MIRT619677)
- hsa-mir-508-5p (MIRT619678)
miRNA Products
- Search ViGene Biosciences for CYP1A2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CYP1A2
- Browse OriGene Inhibitory RNA Products For CYP1A2
- genomics-online: shRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for CYP1A2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYP1A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CYP1A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for CYP1A2
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ViGene Biosciences adenoviral particle packaged cDNA for CYP1A2 gene
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ViGene Biosciences ready-to-package AAV shRNAs for CYP1A2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A2 Gene
Localization for CYP1A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP1A2 Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031090 | organelle membrane | IEA | -- |
GO:0043231 | intracellular membrane-bounded organelle | IDA,IEA | 2813353 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A2 Gene
Pathways & Interactions for CYP1A2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Clomipramine Pathway, Pharmacokinetics | ||
3 | Cytochrome P450 - arranged by substrate type |
.39
.01
|
|
4 | superpathway of tryptophan utilization | ||
5 | Caffeine Pathway, Pharmacokinetics |
Pathways by source for CYP1A2 Gene
1 Cell Signaling Technology pathway for CYP1A2 Gene
19 BioSystems pathways for CYP1A2 Gene
28 PharmGKB pathways for CYP1A2 Gene
9 KEGG pathways for CYP1A2 Gene
8 GeneGo (Thomson Reuters) pathways for CYP1A2 Gene
Interacting Proteins for CYP1A2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006706 | steroid catabolic process | IMP | 18356043 |
GO:0006725 | cellular aromatic compound metabolic process | IEA | -- |
GO:0006778 | porphyrin-containing compound metabolic process | IEA | -- |
GO:0006805 | xenobiotic metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for CYP1A2 Gene
Drugs & Compounds for CYP1A2 Gene
(453) Drugs for CYP1A2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Caffeine | Approved | Nutra | Antagonist, Enzyme, substrate, inhibitor | 434 | ||
Carbamazepine | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor, inducer | 134 | ||
Fluvoxamine | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor | 53 | ||
Ketoconazole | Approved, Investigational | Pharma | Pore Blocker, Enzyme, inhibitor | Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor | 179 | |
Miconazole | Approved, Investigational, Vet_approved | Pharma | Antagonist, Pore Blocker, Enzyme, inhibitor | 3838 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
1,7-Dimethyluric acid |
|
|||||
1-Methylxanthine |
|
|||||
Aflatoxin B1 |
|
1162-65-8 | ||||
nadph |
|
53-57-6 | ||||
Paraxanthine |
|
611-59-6 |
(7) ApexBio Compounds for CYP1A2 Gene
Compound | Action | Cas Number |
---|---|---|
Abiraterone acetate | Cytochrome p450 17a1 inhibitor | 154229-18-2 |
Avasimibe | ACAT inhibitor,orally bioavailable | 166518-60-1 |
Gemfibrozil | 25812-30-0 | |
Ifosfamide | Cytostatic agent | 3778-73-2 |
Ketoconazole | Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase | 65277-42-1 |
Methoxyresorufin | 5725-89-3 | |
Oltipraz | An antischistosomal agent | 64224-21-1 |
Transcripts for CYP1A2 Gene
mRNA/cDNA for CYP1A2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (27) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYP1A2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYP1A2
- genomics-online: gRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- Applied Biological Materials CRISPR for CYP1A2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2
- GenScript: Design CRISPR guide RNA sequences for CYP1A2
miRNA Products
- Search ViGene Biosciences for CYP1A2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CYP1A2
- Browse OriGene Inhibitory RNA Products For CYP1A2
- genomics-online: shRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP1A2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYP1A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CYP1A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CYP1A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Perivenous Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CYP1A2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYP1A2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CYP1A2 Gene:
CYP1A2SOURCE GeneReport for Unigene cluster for CYP1A2 Gene:
Hs.1361mRNA Expression by UniProt/SwissProt for CYP1A2 Gene:
P05177-CP1A2_HUMANEvidence on tissue expression from TISSUES for CYP1A2 Gene
- Liver(4.8)
- Urine(2.6)
- Blood(2.5)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs for CYP1A2
-
OriGene qPCR primer pairs and template standards for CYP1A2
- genomics-online: primer clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A2 Gene
Orthologs for CYP1A2 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CYP1A2 34 |
|
OneToOne | |
LOC735881 33 |
|
||||
cow (Bos Taurus) |
Mammalia | CYP1A2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | CYP1A2 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cyp1a2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Cyp1a2 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | CYP1A1 34 |
|
ManyToMany | |
CYP1A4 34 |
|
ManyToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
zebrafish (Danio rerio) |
Actinopterygii | cyp1a 34 |
|
OneToMany | |
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11738 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Cyp307a1 35 |
|
|
|
spok 34 |
|
ManyToMany | |||
spo 34 |
|
ManyToMany | |||
thale cress (Arabidopsis thaliana) |
eudicotyledons | CYP703A2 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os08g0131100 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany |
- Species where no ortholog for CYP1A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CYP1A2 Gene
(25) SIMAP similar genes for CYP1A2 Gene using alignment to 2 proteins:
Variants for CYP1A2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A2 Gene
- CP1A2_HUMAN-P05177
- The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are slow caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).
SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000539344 | -- | 74,751,037(+) | G/A/T | intron_variant | |
rs1001162410 | -- | 74,753,008(+) | G/C/T | intron_variant | |
rs1001244975 | -- | 74,756,353(+) | G/A | 3_prime_UTR_variant | |
rs1001753001 | -- | 74,749,364(+) | G/A | intron_variant | |
rs1001805272 | -- | 74,749,647(+) | G/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3581763 | CNV | loss | 25503493 |
nsv1121512 | CNV | deletion | 24896259 |
nsv833055 | CNV | loss | 17160897 |
Additional Variant Information for CYP1A2 Gene
Disorders for CYP1A2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
toxicity or absent response to clozapine |
|
|
acetaminophen metabolism |
|
|
porphyria cutanea tarda |
|
|
hepatocellular adenoma |
|
|
cytochrome p450 oxidoreductase deficiency |
|
|
Additional Disease Information for CYP1A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A2 Gene
Publications for CYP1A2 Gene
- Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 22 44 58
- CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. (PMID: 19843669) Peterson S … Lampe JW (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 44 58
- Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. (PMID: 19450128) Gunes A … Dahl ML (Pharmacogenomics 2009) 3 22 44 58
- [Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan]. (PMID: 18389617) Korytina GF … Viktorova TV (Molekuliarnaia biologiia 2008) 3 22 44 58
- Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. (PMID: 17507624) Cunningham JM … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 22 44 58
Products for CYP1A2 Gene
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- Custom Antibody ServicesOriGene Antibodies for CYP1A2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CYP1A2
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A2
- Origene Custom Protein Services for CYP1A2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A2
- Browse OriGene Inhibitory RNA Products For CYP1A2
- OriGene qPCR primer pairs and template standards for CYP1A2
- OriGene qPCR primer pairs for CYP1A2
- OriGene CRISPR knockouts for CYP1A2
- OriGene ORF clones in human for CYP1A2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYP1A2
- GenScript: Next-day shipping of latest version cDNA ORF clones for CYP1A2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CYP1A2
- GenScript Custom Assay Services for CYP1A2
- GenScript Custom overexpressing Cell Line Services for CYP1A2
- GenScript: Design CRISPR guide RNA sequences for CYP1A2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CYP1A2
- Cell Signaling Technology (CST) Antibodies for CYP1A2 (CYP1A2)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
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- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CYP1A2
- Novus Biologicals proteins and lysates for CYP1A2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CYP1A2
- Abcam proteins for CYP1A2
- Abcam assays for CYP1A2
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Cloud-Clone Corp. Antibodies for CYP1A2
- Cloud-Clone Corp. Proteins for CYP1A2
- Cloud-Clone Corp. Assay Kits for CYP1A2
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CYP1A2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CYP1A2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP1A2
- VectorBuilder custom plasmid, inducible vectors for CYP1A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 189 available CYP1A2 Antibodies ranked by validation data
- Compare Top CYP1A2 Antibodies
- antibodies-online: Search results for 34 available CYP1A2 Elisa Kits ranked by validation data
- Compare Top CYP1A2 Elisa Kits
- antibodies-online: Search results for 10 available CYP1A2 Proteins ranked by validation data
- Compare Top CYP1A2 Proteins
- Quality Products:
- GeneTex CYP1A2 antibody for CYP1A2
- Search GeneTex for Proteins for CYP1A2
- ViGene Biosciences adenoviral particle packaged cDNA for CYP1A2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CYP1A2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYP1A2 gene
- Search ViGene Biosciences for CYP1A2
- Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A2
- Search Santa Cruz Biotechnology (SCBT) for CYP1A2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2
- Horizon Cell Lines for CYP1A2
- genomics-online: cdna clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- orf clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- genomics-online: gRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- genomics-online: primer clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- genomics-online: shRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
Sources for CYP1A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew