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CRYM Gene

protein-coding   GIFtS: 59

GC16M021177
crystallin, mu
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DFNA40 1, 2, 5
OTTHUMP00000115878 2
THBP 2, 3
Descriptions
NADP-regulated thyroid-hormone binding protein 2
NADP-regulated thyroid-hormone-binding protein 3
crystallin, mu 2
External Ids
HGNC: 24181
Entrez Gene: 14282
UniProtKB: Q148943
Ensembl: ENSG000001033167
Search outside databases for aliases for CRYM gene

Previous GC identifers: GC16M020678 GC16M021278 GC16M021236

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CRYM:
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also
called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of
vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene
encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to
bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in
lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles.
Multiple alternatively spliced transcript variants have been found for this gene. [provided by
RefSeq]

UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894
Function: Binds thyroid hormone. Presumably involved in the regulation of the free intracellular
concentration of triiodothyronine and access to its nuclear receptors

Gene Wiki entry for CRYM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CRYM gene  

Entrez Gene cytogenetic band: 16p13.11-p12.3   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p

CRYM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M021177:     (about GC identifiers)

Start:
21,177,343 bp from pter
End:
21,221,918 bp from pter
Size:
44,576 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894 (See protein sequence)
Recommended Name: Mu-crystallin homolog  
Size: 314 amino acids; 33776 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
2I99 (3D)    

REFSEQ proteins (2 alternative transcripts): 
NP_001014444.1  NP_001879.1  


ENSEMBL proteins: 
ENSP00000379341 ENSP00000219599 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (mu Crystallin)
Human Recombinant Proteins from Abnova (CRYM)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IDA12471561 12590647
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Antibodies for CRYM: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for CRYM
Browse R&D Systems for Antibodies
Antibodies from Abcam (mu Crystallin), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (CRYM)
Novus Biologicals Antibodies for CRYM

Assays for CRYM: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR003462 ODC_Mu_crystall
 IPR016040 NAD(P)-bd_dom


   GeneDecks  CRYM for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q14894

ProtoNet protein and cluster: Q14894

1 Blocks protein family: IPB003462 Ornithine cyclodeaminase/mu-crystallin

UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894
Similarity: Belongs to the ornithine cyclodeaminase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CRYM)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CRYM)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001888

              Applied Biosystems Silencer® siRNAs for CRYM

              Sigma-Aldrich siRNA and siRNA Panels for CRYM  
                     Sigma-Aldrich shRNA for CRYM  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for CRYM
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001014444
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001014444
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001014444 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001888

UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894
Function: Binds thyroid hormone. Presumably involved in the regulation of the free intracellular
concentration of triiodothyronine and access to its nuclear receptors

Genatlas biochemistry entry for CRYM:
crystallin,mu polypeptide

5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crym):

endocrine/exocrine glandgrowth/sizehearing/vestibular/earhomeostasis/metabolism

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003714 transcription corepressor activity IMP11897713
GO:0003824 catalytic activity IEA--
GO:0005488 binding IEA--
GO:0050661 NADP or NADPH binding IDA17242435
GO:0070324 thyroid hormone binding IMP16740909
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  CRYM  (Your Favorite Gene powered by Ingenuity) 
 Arginine and Proline Metabolism

   GeneDecks  CRYM for the pathways selected above  
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3 Interacting proteins for CRYM (ENSP000002195993) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
DECR1ENSP000002207643STRING (score=.916)
CRYBA1ENSP000002253873STRING (score=.797)
CRYBB1ENSP000002159393STRING (score=.796)
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4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP11897713
GO:0007605 sensory perception of sound IMP12471561
GO:0008152 metabolic process IEA--
GO:0070327 thyroid hormone transport IMP11897713
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CRYM
5 Novoseek chemical compound relationships for CRYM gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine 69.44 8 15516582 (2), 15518536 (1), 17242435 (1), 17692531 (1) (see all 7)
nadph 48.01 2 17242435 (1), 9285773 (1)
triiodothyronine 36.30 1 17289043 (1)
potassium 7.39 2 16740909 (1)
atp 0.00 1 17233837 (1)
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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CRYM)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CRYM)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001888

              Sigma-Aldrich siRNA and siRNA Panels for CRYM  
                     Sigma-Aldrich shRNA for CRYM  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001014444  NM_001888  

REFSEQ mRNAs for CRYM gene (2 alternative transcripts): 

NM_001014444.1   NM_001888.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001014444  NM_001888  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001014444
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001014444
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001014444 

Additional cDNA sequence: 

AK290852.1 AK310424.1 BC008398.1 BC018061.1 BX648477.1 L02950.1 U85772.1 

8 DOTS entries:

DT.113280  DT.95164008  DT.120657645  DT.87046931  DT.100781760  DT.120657639  DT.40126790  DT.95196460 

24/90 AceView cDNA sequences (see all 90 ):

CD107892 AV703147 BI914956 T28859 AA662278 BI860684 AI659267 BQ639566 
AA936267 BM709216 BV179762 AI859176 L02950 NM_001888 CD513160 BQ639878 
CA944935 U85772 AA843560 BM782465 BM543469 BV168075 BI757722 BX097510 

highest scoring ESTs for CRYM:

BX648477 AA176144 AA176145 AA323038 AA467777 AA469006 AA843560 AA936267 AI126476 AI214541 

Unigene Cluster for CRYM:

Crystallin, mu
Hs.924  [show with all ESTs]
Unigene Representative Sequence: BX648477


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CRYM

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1:                                            -           -                 -         
SP2:                    -                       -           -                           
SP3:                                                                                    
SP4:                                                                                    

About this scheme

ECgene alternative splicing isoforms for CRYM

2 Ensembl transcripts including schematic representations:
ENST00000396023  ENST00000219599  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CRYM expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CRYM

1 / 2 / 3

3 probe-sets matching CRYM gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
38285_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF039397 0.20 1.00 0.72 1

205489_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001888 0.60 1.00 0.82 1

205489_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  CRYM for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTTTACCTTA

SOURCE GeneReport for Unigene cluster: Hs.924

Expression variation in blood from EXPOLDB for CRYM

UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894
Tissue specificity: Expressed in neural tissue, muscle and kidney

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for CRYM gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CRYM1   -- crystallin, mu 91.3(n)
92.36(a)
479818  XM_845361.1  XP_850454.1 
chimpanzee
(Pan troglodytes)
CRYM1   -- crystallin, mu 99.47(n)
99.68(a)
742586  XM_001159747.1  XP_001159747.1 
cow
(Bos taurus)
CRYM1   -- crystallin, mu 89.38(n)
90.13(a)
505167  NM_001045914.1  NP_001039379.1 
mouse
(Mus musculus)
Crym1, 5 7 (55.00 cM)5
crystallin, mu1, 5 87.01(n)1
88.82(a)1
129711  NM_016669.11  NP_057878.11 
 AF0393915  AK1384225  (see all 9)
chicken
(Gallus gallus)
CRYM1   -- crystallin, mu 70.1(n)
73.95(a)
427008  XM_424610.2  XP_424610.2 
About this table        Species with no ortholog for CRYM

ENSEMBL Gene Tree for CRYM
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/234 NCBI SNPs in CRYM are shown (see all 234 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 73)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 16 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs38482591,2
C,F,H21197127(-) CAGCCG/CAGGGT 2 -- ut51 int1 ese310Minor allele frequency- C:0.23EA NA MN WA 624
rs129190631,2
H21198088(+) tgttgT/Ctatta 2 -- ng31 int1 tfbs34Minor allele frequency- C:0.00EU EA WA 358
--
rs107261,2
C21177512(-) TCCCCA/GGTGAA 2 -- ut31 ese31Minor allele frequency- G:0.00MN 184
rs2260351,2
A,C,F,H,O21202238(+) CAATAC/TAGCTC 1 -- int1 tfbs38Minor allele frequency- T:0.27MN NA EU EA WA 742
rs2260421,2
A,C,F,H21195086(-) GACTTC/GGTGAT 2 -- int121Minor allele frequency- G:0.45EA NS EU WA NA 2594
rs2260411,2
A,C,F,H21195195(-) ACTTAC/TACTCA 2 -- int16Minor allele frequency- T:0.11EU EA NA 422
rs27339111,2
A,C,F,H21194200(+) AATTTC/TGTGAA 2 -- int14Minor allele frequency- T:0.20EU EA WA 364
rs2260391,2
A,C,F,H21195602(-) CATGGT/CTGGAC 2 -- int17Minor allele frequency- C:0.22EU EA WA NA 496
rs2260461,2
A,C,F,H21211648(+) aacTTG/TATTAT 1 -- int117Minor allele frequency- T:0.20EU EA WA NS NA 1150
rs26290891,2
A,C,F,H21192058(-) GTATAC/TGGAGC 2 -- int17Minor allele frequency- T:0.19EU EA WA NA 526
About this table

HapMap Linkage Disequilibrium images for CRYM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123740

1 Novoseek disease relationship for CRYM gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0.00 5 12160330 (1), 11888886 (1)
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Human Gene Mutation Database: CRYM

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/32 PubMed articles for CRYM gene (see all 32 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1428 HGNC: 2418 AceView: CRYM Ensembl:ENSG00000103316 euGenes: HUgn1428
ECgene: CRYM H-InvDB: CRYM
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for CRYM:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CRYM-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for CRYM Antibodies for CRYM
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for CRYM Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (CRYM)
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 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(mu Crystallin)
 Antibodies (mu Crystallin)
 Search OriGene for CRYM
 Search Tocris compounds for CRYM




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for CRYM

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