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Aliases for CPT1A Gene

Aliases for CPT1A Gene

  • Carnitine Palmitoyltransferase 1A 2 3 4
  • Carnitine Palmitoyltransferase 1A (Liver) 2 3 5
  • Carnitine O-Palmitoyltransferase I, Liver Isoform 3 4
  • EC 2.3.1.21 4 63
  • CPT1-L 3 4
  • CPTI-L 3 4
  • CPT I 3 4
  • CPT1 3 4
  • Carnitine Palmitoyltransferase I, Liver 3
  • EC 2.3.1 63
  • L-CPT1 3

External Ids for CPT1A Gene

Previous HGNC Symbols for CPT1A Gene

  • CPT1

Previous GeneCards Identifiers for CPT1A Gene

  • GC11M071048
  • GC11M070218
  • GC11M068300
  • GC11M068279
  • GC11M068524
  • GC11M064859

Summaries for CPT1A Gene

Entrez Gene Summary for CPT1A Gene

  • The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPT1A Gene

CPT1A (Carnitine Palmitoyltransferase 1A) is a Protein Coding gene. Diseases associated with CPT1A include cpt deficiency, hepatic, type ia and mitochondrial complex i deficiency due to acad9 deficiency. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include identical protein binding and carnitine O-palmitoyltransferase activity. An important paralog of this gene is CRAT.

UniProtKB/Swiss-Prot for CPT1A Gene

  • Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPT1A Gene

Genomics for CPT1A Gene

Regulatory Elements for CPT1A Gene

Genomic Location for CPT1A Gene

Chromosome:
11
Start:
68,754,620 bp from pter
End:
68,844,410 bp from pter
Size:
89,791 bases
Orientation:
Minus strand

Genomic View for CPT1A Gene

Genes around CPT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPT1A Gene

Proteins for CPT1A Gene

  • Protein details for CPT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50416-CPT1A_HUMAN
    Recommended name:
    Carnitine O-palmitoyltransferase 1, liver isoform
    Protein Accession:
    P50416
    Secondary Accessions:
    • Q8TCU0
    • Q9BWK0

    Protein attributes for CPT1A Gene

    Size:
    773 amino acids
    Molecular mass:
    88368 Da
    Quaternary structure:
    • Homohexamer and homotrimer. Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1. Also identified in complexes with ACSL1 and VDAC2 and VDAC3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CPT1A Gene

    Alternative splice isoforms for CPT1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPT1A Gene

Proteomics data for CPT1A Gene at MOPED

Post-translational modifications for CPT1A Gene

  • Ubiquitination at Lys 86, Lys 161, Lys 180, and Lys 195
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CPT1A (CPT1A)

Domains & Families for CPT1A Gene

Protein Domains for CPT1A Gene

Suggested Antigen Peptide Sequences for CPT1A Gene

Graphical View of Domain Structure for InterPro Entry

P50416

UniProtKB/Swiss-Prot:

CPT1A_HUMAN :
  • A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA.
  • Belongs to the carnitine/choline acetyltransferase family.
Domain:
  • A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA.
Family:
  • Belongs to the carnitine/choline acetyltransferase family.
genes like me logo Genes that share domains with CPT1A: view

No data available for Gene Families for CPT1A Gene

Function for CPT1A Gene

Molecular function for CPT1A Gene

GENATLAS Biochemistry:
carnitine palmitoyltransferase of the outer mitochondrial membrane 1A,88kDa,malonyl CoA sensitive,liver isoform,generating palmitoylcarnitine and CoAsH (palmitoyl-CoA shuttle system)
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by malonyl-CoA.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.
UniProtKB/Swiss-Prot Induction:
Up-regulated by fatty acids.

Enzyme Numbers (IUBMB) for CPT1A Gene

genes like me logo Genes that share phenotypes with CPT1A: view

Human Phenotype Ontology for CPT1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CPT1A Gene

MGI Knock Outs for CPT1A:

Animal Model Products

CRISPR Products

miRNA for CPT1A Gene

miRTarBase miRNAs that target CPT1A

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CPT1A Gene

Localization for CPT1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPT1A Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPT1A Gene COMPARTMENTS Subcellular localization image for CPT1A gene
Compartment Confidence
mitochondrion 5
peroxisome 4
cytosol 2
endoplasmic reticulum 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CPT1A Gene

Pathways & Interactions for CPT1A Gene

genes like me logo Genes that share pathways with CPT1A: view

UniProtKB/Swiss-Prot P50416-CPT1A_HUMAN

  • Pathway: Lipid metabolism; fatty acid beta-oxidation.

Gene Ontology (GO) - Biological Process for CPT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IEA --
GO:0006641 triglyceride metabolic process IEA --
GO:0006853 carnitine shuttle TAS --
GO:0007623 circadian rhythm TAS --
GO:0014070 response to organic cyclic compound IEA --
genes like me logo Genes that share ontologies with CPT1A: view

No data available for SIGNOR curated interactions for CPT1A Gene

Drugs & Compounds for CPT1A Gene

(24) Drugs for CPT1A Gene - From: Novoseek, HMDB, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Perhexiline Approved Pharma inhibitor, Target 7
L-Carnitine Approved Pharma Target, activator 0
Glyburide Approved Pharma Channel blocker, Target 107
Glycerol Experimental Pharma 191
PROPIONYL-L-CARNITINE Pharma 0

(25) Additional Compounds for CPT1A Gene - From: HMDB and Novoseek