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CPA3 Gene

protein-coding   GIFtS: 57
GCID: GC03P148583

Carboxypeptidase A3 (Mast Cell)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase A3 (Mast Cell)1 2     EC 3.4.17.13
Mast Cell Carboxypeptidase A1 2     Carboxypeptidase A33
Tissue Carboxypeptidase A1 2     EC 3.4.178
MC-CPA2 3     

External Ids:    HGNC: 22981   Entrez Gene: 13592   Ensembl: ENSG000001637517   OMIM: 1148515   UniProtKB: P150883   

Export aliases for CPA3 gene to outside databases

Previous GC identifers: GC03P145532 GC03P149468 GC03P149864 GC03P149903 GC03P150065 GC03P145955


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPA3 Gene:
Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which
is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory
granule metalloexopeptidase. (provided by RefSeq, Jan 2009)

GeneCards Summary for CPA3 Gene:
CPA3 (carboxypeptidase A3 (mast cell)) is a protein-coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPO.

Gene Wiki entry for CPA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPA3 gene promoter:
         TBP   USF1   STAT1   HSF1 (long)   STAT1beta   STAT1alpha   FOXJ2 (long isoform)   HSF1short   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPA3 promoter sequence
   Search Chromatin IP Primers for CPA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

CPA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P148583:  view genomic region     (about GC identifiers)

Start:
148,583,043 bp from pter      End:
148,614,983 bp from pter
Size:
31,941 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBPA3_HUMAN, P15088 (See protein sequence)
Recommended Name: Mast cell carboxypeptidase A precursor  
Size: 417 amino acids; 48670 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q96E94

Explore the universe of human proteins at neXtProt for CPA3: NX_P15088

Explore proteomics data for CPA3 at MOPED

4 DME Specific Peptides for CPA3 (P15088)
 AFCQWFV  GIHAREW  ESEKETKA  GTDLNRNF 


See CPA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001861.2  
ENSEMBL proteins: 
 ENSP00000296046  
Reactome Protein details: P15088

CPA3 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for CPA3

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Search eBioscience for ELISAs for CPA3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A3 (mast cell)
Metallocarboxypeptidases

3 InterPro protein domains:
 IPR003146 Prot_inh_M14A
 IPR000834 Peptidase_M14
 IPR009020 Prot_inh_propept

Graphical View of Domain Structure for InterPro Entry P15088

ProtoNet protein and cluster: P15088

2 Blocks protein domains:
IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
IPB003146 Carboxypeptidase activation peptide


UniProtKB/Swiss-Prot: CBPA3_HUMAN, P15088
Similarity: Belongs to the peptidase M14 family


Find genes that share domains with CPA3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CBPA3_HUMAN, P15088
Catalytic activity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or
-Pro

     Genatlas biochemistry entry for CPA3:
carboxypeptidase A3,mast cell,highly induced by histone deacetylase inhibitor during differentiation of prostate
epithelial cancer cells

     Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.11

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004180carboxypeptidase activity ----
GO:0004181metallocarboxypeptidase activity TAS1629626
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with CPA3           About GenesLikeMe


Phenotypes:
     5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cpa3):
 cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

Find genes that share phenotypes with CPA3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cpa3tm1Hrr for CPA3

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPA3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPA3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPA3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPA3

miRNA
Products:
    
miRTarBase miRNAs that target CPA3:
hsa-mir-148b-3p (MIRT019464), hsa-mir-122-5p (MIRT023344)

Block miRNA regulation of human, mouse, rat CPA3 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate CPA3:
hsa-miR-9*
SwitchGear 3'UTR luciferase reporter plasmidCPA3 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for CPA3
Predesigned siRNA for gene silencing in human, mouse, rat CPA3

Gene Editing
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GenScript: all cDNA clones in your preferred vector: CPA3 (NM_001870)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CBPA3_HUMAN, P15088: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular4
cytosol1
endoplasmic reticulum1
lysosome1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0030133transport vesicle IEA--
GO:0030141secretory granule NAS2594780

Find genes that share ontologies with CPA3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CPA3 About    
See pathways by source

SuperPathContained pathways About
1Peptide hormone metabolism
Peptide hormone metabolism0.30
Metabolism of Angiotensinogen to Angiotensins0.00
2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
Renin-angiotensin system0.37
3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30
4Protein digestion and absorption
Protein digestion and absorption
5Pancreatic secretion
Pancreatic secretion


Find genes that share SuperPaths with CPA3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for CPA3
    Metabolism of Angiotensinogen to Angiotensins


3 Kegg Pathways  (Kegg details for CPA3):
    Renin-angiotensin system
Pancreatic secretion
Protein digestion and absorption

    Pathway & Disease-focused RT2 Profiler PCR Array including CPA3: 
          Allergy & Asthma in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CPA3

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for CPA3 (ENSP000002960464) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MASP1ENSP000002962804STRING: ENSP00000296280
MASP2ENSP000003836904STRING: ENSP00000383690
--ENSP000003821134STRING: ENSP00000382113
--ENSP000003459804STRING: ENSP00000345980
--ENSP000003307324STRING: ENSP00000330732
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002002regulation of angiotensin levels in blood ----
GO:0002003angiotensin maturation TAS--
GO:0006508proteolysis TAS2708524
GO:0044267cellular protein metabolic process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CPA3 (CBPA3)

5 HMDB Compounds for CPA3    About this table
CompoundSynonyms CAS #PubMed Ids
KinetensinIle-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu 103131-69-7--
Kinetensin 1-8Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe;KT(1-8) 51833-69-3--
Neuromedin NIle-Pro-Tyr-Ile-Leu;NN 102577-25-3--
Neuromedin N (1-4)Ile-Pro-Tyr-Ile ----
ZincZinc (see all 2)7440-66-6--

1 Novoseek inferred chemical compound relationship for CPA3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
heparin 27.8 1 1639103 (1)



Find genes that share compounds with CPA3           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CPA3 gene: 
NM_001870.2  

Unigene Cluster for CPA3:

Carboxypeptidase A3 (mast cell)
Hs.646  [show with all ESTs]
Unigene Representative Sequence: NM_001870
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296046(uc003ewm.3) ENST00000477926
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CPA3 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate CPA3:
hsa-miR-9*
SwitchGear 3'UTR luciferase reporter plasmidCPA3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CPA3
Predesigned siRNA for gene silencing in human, mouse, rat CPA3
Clone
Products:
     
OriGene clones in human, mouse for CPA3 (see all 6)
OriGene ORF clones in mouse, rat for CPA3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CPA3 (NM_001870)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CPA3
OriGene qSTAR qPCR primer pairs in human, mouse for CPA3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPA3
  QuantiTect SYBR Green Assays in human, mouse, rat CPA3
  QuantiFast Probe-based Assays in human, mouse, rat CPA3

Additional mRNA sequence: 

AK313628.1 BC012613.1 M27717.1 S40234.1 

4 DOTS entries:

DT.410863  DT.120929344  DT.99992718  DT.120929300 

Selected AceView cDNA sequences (see all 39):

N79582 AA233718 BX105358 AV711717 AV713325 W16617 CD245136 S40234 
BF508919 AI925693 BF002788 AV760428 AU100115 M27717 CA393298 BC012613 
NM_001870 BE326998 BI769240 CD687232 BM769163 BF242520 BF478157 AI669644 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CPA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGCTTCATC
CPA3 Expression
About this image


CPA3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 3 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem E15, Meso-prx/latp Progenitor
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)
         PureStem E15, Meso-prx/latp Progenitor
 
 Yolk Sac (Extraembryonic Tissues)
         Definitive Hematopoietic Stem Cells Definitive Yolk Sac
CPA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CPA3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.646
    Pathway & Disease-focused RT2 Profiler PCR Array including CPA3: 
          Allergy & Asthma in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CPA3
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QuantiFast Probe-based Assays in human, mouse, rat CPA3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA3 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cpa31 , 5 carboxypeptidase A3, mast cell1, 5 83.37(n)1
81.29(a)1
  3 (6.25 cM)5
128731  NM_007753.21  NP_031779.11 
 202156175 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
55(a)
51(a)
1 ↔ many
1 ↔ many
3(19214283-19230765)
3(19197662-19210774)
tropical clawed frog
(Xenopus tropicalis)
Amphibia cpb11 carboxypeptidase B1 (tissue) 61.31(n)
50.36(a)
  496994  XM_002937338.2  XP_002937384.2 
zebrafish
(Danio rerio)
Actinopterygii cpb16
carboxypeptidase B1 (tissue)
47(a)
1 → many
24(4835111-4845460) ENSDARG00000045442
fruit fly
(Drosophila melanogaster)
Insecta CG185853   -- 33(a)
(best of 16)
  28C1   --
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.93   -- 32(a)
(best of 4)
  I(748486-756927)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM141 ECM14 43.56(n)
30.41(a)
  856533   NP_012000.1 


ENSEMBL Gene Tree for CPA3 (if available)
TreeFam Gene Tree for CPA3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CPA3 gene
CPO2  CPA22  CPA12  CPB12  CPA62  CPA52  CPB22  CPA42  
9 SIMAP similar genes for CPA3 using alignment to 1 protein entry:     CBPA3_HUMAN:
DKFZp779K1333    CPO    CPB1    CPA6    CPA1    CPA4
CPB2    CPA2    CPA5

Find genes that share paralogs with CPA3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CPA3 (see all 814)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs355466211,2
C--145966103(+) ATATA-/TAAATAG 1 -- int11Minor allele frequency- TA:0.00NA 2
rs1492609691,2
C--148581107(+) TTTTTA/GGAATC 1 -- us2k10--------
rs130961261,2
C,F,A,H--148581112(+) AGAATC/GAGAAA 1 -- us2k1 tfbs311Minor allele frequency- G:0.04NS EA NA 958
rs1918993631,2
--148581142(+) AGCTAC/TAACAT 1 -- us2k10--------
rs15466321,2
C,F,A,H--148581159(+) AAATTC/ATTGAA 1 -- us2k126Minor allele frequency- A:0.45NS EA NA WA CSA 2759
rs1830436351,2
--148581188(+) AATACA/GGAGAC 1 -- us2k10--------
rs1881280871,2
--148581263(+) TTCTGC/TAGGCT 1 -- us2k10--------
rs784406511,2
C,F--148581266(+) TGCAGG/CCTGGC 1 -- us2k11Minor allele frequency- C:0.16EA 120
rs798796911,2
F--148581359(+) TACCAC/TGAAGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs755314711,2
--148581371(+) CCTAAC/TATATC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CPA3 (148583043 - 148614983 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CPA3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv829751CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CPA3
DNA2.0 Custom Variant and Variant Library Synthesis for CPA3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 114851    OMIM disorders: --


Find genes that share disorders with CPA3           About GenesLikeMe

1 Novoseek inferred disease relationship for CPA3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia basophilic 73.9 1 1744088 (1)


Export disorders for CPA3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CPA3 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with CPA3)
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  1. Cloning and characterization of the novel gene for mast cell carboxypeptidase A. (PubMed id 1729276)1, 2, 9 Reynolds D.S.... Austen K.F. (J. Clin. Invest. 1992)
  2. Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy. (PubMed id 1629626)1, 2, 9 Natsuaki M.... Goldstein S.M. (J. Invest. Dermatol. 1992)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. (PubMed id 2594780)1, 2 Reynolds D.S.... Serafin W.E. (Proc. Natl. Acad. Sci. U.S.A. 1989)
  5. Human mast cell carboxypeptidase. Purification and characterization. (PubMed id 2708524)1, 2 Goldstein S.M.... Wintroub B.U. (J. Clin. Invest. 1989)
  6. Novel insights into the biological function of mast cell carboxypeptidase A. (PubMed id 19643669)1 Pejler G....Wernersson S. (Trends Immunol. 2009)
  7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
  9. Cloning and expression of human colon mast cell carboxypeptidase. (PubMed id 14760754)1 Chen Z.Q. and He S.H. (World J. Gastroenterol. 2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1359 HGNC: 2298 AceView: CPA3 Ensembl:ENSG00000163751 euGenes: HUgn1359
ECgene: CPA3 Kegg: 1359 H-InvDB: CPA3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CPA3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CPA3 gene:
Search GeneIP for patents involving CPA3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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