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Aliases for CPA3 Gene

Aliases for CPA3 Gene

  • Carboxypeptidase A3 (Mast Cell) 2 3
  • Mast Cell Carboxypeptidase A 2 3
  • Tissue Carboxypeptidase A 2 3
  • MC-CPA 3 4
  • Carboxypeptidase A3 4
  • EC 3.4.17.1 4
  • EC 3.4.17 63

External Ids for CPA3 Gene

Previous GeneCards Identifiers for CPA3 Gene

  • GC03P145532
  • GC03P149468
  • GC03P149864
  • GC03P149903
  • GC03P150065
  • GC03P148583
  • GC03P145955

Summaries for CPA3 Gene

Entrez Gene Summary for CPA3 Gene

  • Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory granule metalloexopeptidase. [provided by RefSeq, Jan 2009]

GeneCards Summary for CPA3 Gene

CPA3 (Carboxypeptidase A3 (Mast Cell)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Pancreatic secretion. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPA2.

Gene Wiki entry for CPA3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA3 Gene

Genomics for CPA3 Gene

Genomic Location for CPA3 Gene

Start:
148,865,256 bp from pter
End:
148,897,196 bp from pter
Size:
31,941 bases
Orientation:
Plus strand

Genomic View for CPA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA3 Gene

Proteins for CPA3 Gene

  • Protein details for CPA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15088-CBPA3_HUMAN
    Recommended name:
    Mast cell carboxypeptidase A
    Protein Accession:
    P15088
    Secondary Accessions:
    • Q96E94

    Protein attributes for CPA3 Gene

    Size:
    417 amino acids
    Molecular mass:
    48670 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for CPA3 Gene

Proteomics data for CPA3 Gene at MOPED

Selected DME Specific Peptides for CPA3 Gene

Post-translational modifications for CPA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CPA3 Gene

Gene Families for CPA3 Gene

Suggested Antigen Peptide Sequences for CPA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15088

UniProtKB/Swiss-Prot:

CBPA3_HUMAN :
  • P15088
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA3: view

Function for CPA3 Gene

Molecular function for CPA3 Gene

GENATLAS Biochemistry: carboxypeptidase A3,mast cell,highly induced by histone deacetylase inhibitor during differentiation of prostate epithelial cancer cells
UniProtKB/Swiss-Prot CatalyticActivity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro

Enzyme Numbers (IUBMB) for CPA3 Gene

Gene Ontology (GO) - Molecular Function for CPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity --
GO:0004181 metallocarboxypeptidase activity TAS 1629626
GO:0008233 peptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPA3: view
genes like me logo Genes that share phenotypes with CPA3: view

Animal Models for CPA3 Gene

MGI Knock Outs for CPA3:

miRNA for CPA3 Gene

miRTarBase miRNAs that target CPA3

No data available for Transcription Factor Targeting and HOMER Transcription for CPA3 Gene

Localization for CPA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA3 Gene

Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA3 Gene COMPARTMENTS Subcellular localization image for CPA3 gene
Compartment Confidence
extracellular 4
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0030133 transport vesicle IEA --
GO:0030141 secretory granule NAS 2594780
genes like me logo Genes that share ontologies with CPA3: view

Pathways for CPA3 Gene

genes like me logo Genes that share pathways with CPA3: view

Interacting Proteins for CPA3 Gene

Gene Ontology (GO) - Biological Process for CPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002002 regulation of angiotensin levels in blood --
GO:0002003 angiotensin maturation TAS --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006508 proteolysis TAS 2708524
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with CPA3: view

Compounds for CPA3 Gene

(5) HMDB Compounds for CPA3 Gene

Compound Synonyms Cas Number PubMed IDs
Kinetensin
  • Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu
103131-69-7
Kinetensin 1-8
  • Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe
51833-69-3
Neuromedin N
  • Ile-Pro-Tyr-Ile-Leu
102577-25-3
Neuromedin N (1-4)
  • Ile-Pro-Tyr-Ile
Not Available
Zinc
  • Zinc
7440-66-6

(1) Novoseek inferred chemical compound relationships for CPA3 Gene

Compound -log(P) Hits PubMed IDs
heparin 27.8 1
genes like me logo Genes that share compounds with CPA3: view

Transcripts for CPA3 Gene

mRNA/cDNA for CPA3 Gene

(39) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPA3 Gene

Carboxypeptidase A3 (mast cell):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPA3 Gene

No ASD Table

Relevant External Links for CPA3 Gene

GeneLoc Exon Structure for
CPA3
ECgene alternative splicing isoforms for
CPA3

Expression for CPA3 Gene

mRNA expression in normal human tissues for CPA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPA3 Gene

This gene is overexpressed in Lung (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPA3 Gene

SOURCE GeneReport for Unigene cluster for CPA3 Gene Hs.646

genes like me logo Genes that share expressions with CPA3: view

No data available for mRNA Expression by UniProt/SwissProt for CPA3 Gene

Orthologs for CPA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA3 35
  • 99.2 (n)
  • 98.56 (a)
CPA3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPA3 35
  • 89.21 (n)
  • 85.13 (a)
CPA3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPA3 35
  • 90.73 (n)
  • 87.77 (a)
CPA3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpa3 35
  • 83.37 (n)
  • 81.29 (a)
Cpa3 16
Cpa3 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPA3 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpa3 35
  • 83.53 (n)
  • 82.49 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cpb1 35
  • 61.31 (n)
  • 50.36 (a)
zebrafish
(Danio rerio)
Actinopterygii cpb1 36
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013181 35
  • 44.27 (n)
  • 34.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12374 36
  • 26 (a)
ManyToMany
CG14820 36
  • 30 (a)
ManyToMany
CG17633 36
  • 28 (a)
ManyToMany
CG18417 36
  • 28 (a)
ManyToMany
CG18585 36
  • 31 (a)
ManyToMany
CG2915 36
  • 28 (a)
ManyToMany
CG32379 36
  • 29 (a)
ManyToMany
CG4017 36
  • 31 (a)
ManyToMany
CG4408 36
  • 25 (a)
ManyToMany
CG7025 36
  • 29 (a)
ManyToMany
CG8539 36
  • 21 (a)
ManyToMany
CG8560 36
  • 26 (a)
ManyToMany
CG8562 36
  • 29 (a)
ManyToMany
CG8563 36
  • 24 (a)
ManyToMany
CG8564 36
  • 17 (a)
ManyToMany
CG8564 37
  • 32 (a)
CG3097 37
  • 31 (a)
CG3108 37
  • 31 (a)
CG18585 37
  • 33 (a)
CG15769 37
  • 28 (a)
CG14820 37
  • 31 (a)
CG18415 37
  • 29 (a)
CG17633 37
  • 31 (a)
CG8945 37
  • 27 (a)
CG8562 37
  • 30 (a)
CG2915 37
  • 32 (a)
CG12374 37
  • 27 (a)
CG4408 37
  • 28 (a)
CG4017 37
  • 33 (a)
CG7025 37
  • 31 (a)
CG18417 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 36
  • 26 (a)
ManyToMany
suro-1 36
  • 19 (a)
ManyToMany
T06A4.1 36
  • 24 (a)
ManyToMany
T06A4.3 36
  • 27 (a)
ManyToMany
W01A8.6 36
  • 24 (a)
ManyToMany
Y18H1A.9 36
  • 29 (a)
ManyToMany
Y47G6A.19 36
  • 25 (a)
ManyToMany
ZC434.9 36
  • 17 (a)
ManyToMany
R11A5.7 37
  • 30 (a)
Y18H1A.9 37
  • 32 (a)
T06A4.3 37
  • 31 (a)
Y59C2A.1 37
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR045W 35
  • 43.96 (n)
  • 32.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 35
  • 43.56 (n)
  • 30.41 (a)
ECM14 36
  • 26 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F27929g 35
  • 46.72 (n)
  • 34.04 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01464 35
  • 44.87 (n)
  • 30.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC337.07c 35
  • 46.21 (n)
  • 33.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
CSA.11311 36
  • 34 (a)
ManyToMany
CSA.4005 36
  • 17 (a)
ManyToMany
Species with no ortholog for CPA3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPA3 Gene

ENSEMBL:
Gene Tree for CPA3 (if available)
TreeFam:
Gene Tree for CPA3 (if available)

Paralogs for CPA3 Gene

Paralogs for CPA3 Gene

Selected SIMAP similar genes for CPA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPA3: view

Variants for CPA3 Gene

Sequence variations from dbSNP and Humsavar for CPA3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12962 -- 148,897,003(+) AAACC(C/T)TCAGT utr-variant-3-prime, downstream-variant-500B
rs753946 -- 148,897,211(-) GATAG(A/G)CAAAT downstream-variant-500B
rs957790 -- 148,895,599(+) TCCCC(A/G)GTGCC intron-variant
rs1032465 -- 148,879,695(+) GGAAA(G/T)AATTG intron-variant
rs1154910 -- 148,890,679(+) GTTAT(C/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPA3 Gene

Variant ID Type Subtype PubMed ID
nsv829751 CNV Loss 17160897

Relevant External Links for CPA3 Gene

HapMap Linkage Disequilibrium report
CPA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA3 Gene

Disorders for CPA3 Gene

(1) Novoseek inferred disease relationships for CPA3 Gene

Disease -log(P) Hits PubMed IDs
leukemia basophilic 73.9 1
genes like me logo Genes that share disorders with CPA3: view

No data available for UniProtKB/Swiss-Prot for CPA3 Gene

Publications for CPA3 Gene

  1. Cloning and characterization of the novel gene for mast cell carboxypeptidase A. (PMID: 1729276) Reynolds D.S. … Austen K.F. (J. Clin. Invest. 1992) 3 4 23
  2. Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy. (PMID: 1629626) Natsuaki M. … Goldstein S.M. (J. Invest. Dermatol. 1992) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. (PMID: 2594780) Reynolds D.S. … Serafin W.E. (Proc. Natl. Acad. Sci. U.S.A. 1989) 3 4
  5. Human mast cell carboxypeptidase. Purification and characterization. (PMID: 2708524) Goldstein S.M. … Wintroub B.U. (J. Clin. Invest. 1989) 3 4

Products for CPA3 Gene

Sources for CPA3 Gene

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