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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPA3 Gene

protein-coding   GIFtS: 57
GCID: GC03P148583

Carboxypeptidase A3 (Mast Cell)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase A3 (Mast Cell)1 2     EC 3.4.17.13
Mast Cell Carboxypeptidase A1 2     Carboxypeptidase A33
Tissue Carboxypeptidase A1 2     EC 3.4.178
MC-CPA2 3     

External Ids:    HGNC: 22981   Entrez Gene: 13592   Ensembl: ENSG000001637517   OMIM: 1148515   UniProtKB: P150883   

Export aliases for CPA3 gene to outside databases

Previous GC identifers: GC03P145532 GC03P149468 GC03P149864 GC03P149903 GC03P150065 GC03P145955


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPA3 Gene:
Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which
is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory
granule metalloexopeptidase. (provided by RefSeq, Jan 2009)

GeneCards Summary for CPA3 Gene: 
CPA3 (carboxypeptidase A3 (mast cell)) is a protein-coding gene. Diseases associated with CPA3 include mastocytosis, and pancreatitis, and among its related super-pathways are Metabolism of Angiotensinogen to Angiotensins and Insulin Processing. GO annotations related to this gene include metallocarboxypeptidase activity and zinc ion binding. An important paralog of this gene is CPO.

Gene Wiki entry for CPA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPA3 gene promoter:
         TBP   USF1   STAT1   HSF1 (long)   STAT1beta   STAT1alpha   FOXJ2 (long isoform)   HSF1short   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

CPA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P148583:  view genomic region     (about GC identifiers)

Start:
148,583,043 bp from pter      End:
148,614,983 bp from pter
Size:
31,941 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPA3_HUMAN, P15088 (See protein sequence)
Recommended Name: Mast cell carboxypeptidase A precursor  
Size: 417 amino acids; 48670 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules
Secondary accessions: Q96E94

Explore the universe of human proteins at neXtProt for CPA3: NX_P15088

Explore proteomics data for CPA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15088

  • 4 DME Specific Peptides for CPA3 (P15088)
     AFCQWFV  GIHAREW  ESEKETKA  GTDLNRNF 

    CPA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPA3 Protein Expression
    REFSEQ proteins: NP_001861.2  
    ENSEMBL proteins: 
     ENSP00000296046  
    Reactome Protein details: P15088
    Human Recombinant Protein Products for CPA3: 
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    OriGene Protein Over-expression Lysate for CPA3
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    Novus Biologicals CPA3 Proteins
    Novus Biologicals CPA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPA3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0030133transport vesicle IEA--
    GO:0030141secretory granule NAS2594780

    CPA3 for ontologies           About GeneDecksing



    CPA3 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CPA3 

    Assay Products for CPA3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CPA3 
    Cloud-Clone Corp. CLIAs for CPA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A3 (mast cell) 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry P15088

    ProtoNet protein and cluster: P15088

    2 Blocks protein domains:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPA3_HUMAN, P15088
    Similarity: Belongs to the peptidase M14 family


    CPA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPA3_HUMAN, P15088
    Catalytic activity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or
    -Pro

         Genatlas biochemistry entry for CPA3:
    carboxypeptidase A3,mast cell,highly induced by histone deacetylase inhibitor during differentiation of prostate
    epithelial cancer cells

         Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.11

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity TAS1629626
    GO:0008270zinc ion binding IEA--
         
    CPA3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cpa3):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    CPA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cpa3tm1Hrr for CPA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPA3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPA3:
    hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidCPA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPA3
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CPA3 (NM_001870)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA3
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                         Customized lentivirus expression plasmids for stable overexpression of CPA3 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Renin-angiotensin system
    Renin-angiotensin system0.43
    Metabolism of Angiotensinogen to Angiotensins0.43
    2Insulin Processing
    Peptide hormone metabolism0.39
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Protein digestion and absorption
    Protein digestion and absorption
    5Pancreatic secretion
    Pancreatic secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for CPA3
        Metabolism of Angiotensinogen to Angiotensins
    Metabolism of proteins
    Peptide hormone metabolism


    3         Kegg Pathways  (Kegg details for CPA3):
        Renin-angiotensin system
    Pancreatic secretion
    Protein digestion and absorption


    CPA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPA3

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002002regulation of angiotensin levels in blood ----
    GO:0002003angiotensin maturation TAS--
    GO:0006508proteolysis TAS2708524
    GO:0044267cellular protein metabolic process TAS--

    CPA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPA3 (CBPA3)

    5 HMDB Compounds for CPA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    KinetensinIle-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu 103131-69-7--
    Kinetensin 1-8Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe;KT(1-8) 51833-69-3--
    Neuromedin NIle-Pro-Tyr-Ile-Leu;NN 102577-25-3--
    Neuromedin N (1-4)Ile-Pro-Tyr-Ile ----
    ZincZinc (see all 2)7440-66-6--

    1 Novoseek inferred chemical compound relationship for CPA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 27.8 1 1639103 (1)

    Search CenterWatch for drugs/clinical trials and news about CPA3 / CBPA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPA3 gene: 
    NM_001870.2  

    Unigene Cluster for CPA3:

    Carboxypeptidase A3 (mast cell)
    Hs.646  [show with all ESTs]
    Unigene Representative Sequence: NM_001870
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296046(uc003ewm.3) ENST00000477926
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPA3:
    hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidCPA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPA3
    Clone
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    OriGene clones in human, mouse for CPA3 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: CPA3 (NM_001870)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA3
    Sirion Biotech Customized lentivirus for stable overexpression of CPA3 
                         Customized lentivirus expression plasmids for stable overexpression of CPA3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPA3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA3

    Additional mRNA sequence: 

    AK313628.1 BC012613.1 M27717.1 S40234.1 

    4 DOTS entries:

    DT.410863  DT.120929344  DT.99992718  DT.120929300 

    24/39 AceView cDNA sequences (see all 39):

    BX105358 N79582 AV711717 AV713325 AA233718 CA393298 AI925693 BC012613 
    NM_001870 AU100115 S40234 AV760428 M27717 CD245136 BF508919 BE326998 
    BF002788 W16617 BF242520 BI769240 CD687232 BF478157 BM769163 BU160770 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPA3 expression in normal human tissues (normalized intensities)      CPA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTTCATC
    CPA3 Expression
    About this image


    CPA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived hematopoietic stem cells
             Fetal Liver CD36+ Cells   
             BONE MARROW   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Human Calvarial Osteoblasts (HCO)   
             BONE MARROW   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
             Human Umbilical Artery Endothelial Cells (HUAEC)   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Fetal Liver CD36+ Cells   
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   

    See CPA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPA3

    SOURCE GeneReport for Unigene cluster: Hs.646
        SABiosciences Expression via Pathway-Focused PCR Array including CPA3: 
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPA3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpa31 , 5 carboxypeptidase A3, mast cell1, 5 83.37(n)1
    81.29(a)1
      3 (6.25 cM)5
    128731  NM_007753.21  NP_031779.11 
     202156175 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    55(a)
    51(a)
    1 ↔ many
    1 ↔ many
    3(19214283-19230765)
    3(19197662-19210774)
    zebrafish
    (Danio rerio)
    Actinopterygii cpb16
    carboxypeptidase B1 (tissue)
    47(a)
    1 → many
    24(4835111-4845460)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG185853   -- 33(a)
    (best of 16)
      28C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.93   -- 32(a)
    (best of 4)
      I(748486-756927)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM146
    Putative metalloprotease with similarity to the zi...
    26(a)
    1 → many
    VIII(368502-369794)


    ENSEMBL Gene Tree for CPA3 (if available)
    TreeFam Gene Tree for CPA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPA3 gene
    CPO2  CPA22  CPA12  CPA62  CPB12  CPA52  CPB22  CPA42  
    9 SIMAP similar genes for CPA3 using alignment to 1 protein entry:     CBPA3_HUMAN:
    DKFZp779K1333    CPO    CPB1    CPA6    CPA1    CPA4
    CPB2    CPA2    CPA5

    CPA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/814 SNPs in CPA3 are shown (see all 814)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355466211,2
    C--145966103(+) ATATA-/TAAATAG 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1492609691,2
    C--148581107(+) TTTTTA/GGAATC 1 -- us2k10--------
    rs130961261,2
    C,F,A,H--148581112(+) AGAATC/GAGAAA 1 -- us2k1 tfbs311Minor allele frequency- G:0.04NS EA NA 958
    rs1918993631,2
    --148581142(+) AGCTAC/TAACAT 1 -- us2k10--------
    rs15466321,2
    C,F,A,H--148581159(+) AAATTC/ATTGAA 1 -- us2k126Minor allele frequency- A:0.45NS EA NA WA CSA 2759
    rs1830436351,2
    --148581188(+) AATACA/GGAGAC 1 -- us2k10--------
    rs1881280871,2
    --148581263(+) TTCTGC/TAGGCT 1 -- us2k10--------
    rs784406511,2
    C,F--148581266(+) TGCAGG/CCTGGC 1 -- us2k11Minor allele frequency- C:0.16EA 120
    rs798796911,2
    F--148581359(+) TACCAC/TGAAGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs755314711,2
    --148581371(+) CCTAAC/TATATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPA3 (148583043 - 148614983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CPA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829751CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPA3
    DNA2.0 Custom Variant and Variant Library Synthesis for CPA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114851    OMIM disorders: --

    5 diseases for CPA3:    About MalaCards
    mastocytosis    pancreatitis    asthma    prostatitis
    leukemia


    CPA3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CPA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia basophilic 73.9 1 1744088 (1)


    Export disorders for CPA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPA3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CPA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the novel gene for mast cell carboxypeptidase A. (PubMed id 1729276)1, 2, 9 Reynolds D.S.... Austen K.F. (1992)
    2. Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy. (PubMed id 1629626)1, 2, 9 Natsuaki M.... Goldstein S.M. (1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. (PubMed id 2594780)1, 2 Reynolds D.S.... Serafin W.E. (1989)
    5. Human mast cell carboxypeptidase. Purification and characterization. (PubMed id 2708524)1, 2 Goldstein S.M.... Wintroub B.U. (1989)
    6. Novel insights into the biological function of mast c ell carboxypeptidase A. (PubMed id 19643669)1 Pejler G....Wernersson S. (2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    9. Cloning and expression of human colon mast cell carboxypeptidase. (PubMed id 14760754)1 Chen Z.Q. and He S.H. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1359 HGNC: 2298 AceView: CPA3 Ensembl:ENSG00000163751 euGenes: HUgn1359
    ECgene: CPA3 Kegg: 1359 H-InvDB: CPA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPA3 gene:
    Search GeneIP for patents involving CPA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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