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Aliases for CINP Gene

Aliases for CINP Gene

  • Cyclin-Dependent Kinase 2 Interacting Protein 2 3
  • CDK2-Interacting Protein 4

External Ids for CINP Gene

Previous GeneCards Identifiers for CINP Gene

  • GC14M100200
  • GC14M096630
  • GC14M100798
  • GC14M101878
  • GC14M102814
  • GC14M082991
  • GC14M102808

Summaries for CINP Gene

Entrez Gene Summary for CINP Gene

  • The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. [provided by RefSeq, Jul 2013]

GeneCards Summary for CINP Gene

CINP (Cyclin-Dependent Kinase 2 Interacting Protein) is a Protein Coding gene. Diseases associated with CINP include dysthymic disorder.

UniProtKB/Swiss-Prot for CINP Gene

  • Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CINP Gene

Genomics for CINP Gene

Regulatory Elements for CINP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CINP Gene

Start:
102,341,102 bp from pter
End:
102,362,916 bp from pter
Size:
21,815 bases
Orientation:
Minus strand

Genomic View for CINP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CINP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CINP Gene

Proteins for CINP Gene

  • Protein details for CINP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW66-CINP_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2-interacting protein
    Protein Accession:
    Q9BW66
    Secondary Accessions:
    • F5H7P3
    • F5H8A7
    • Q9NPF9

    Protein attributes for CINP Gene

    Size:
    212 amino acids
    Molecular mass:
    24324 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.
    SequenceCaution:
    • Sequence=BU174070; Type=Frameshift; Positions=183, 197; Evidence={ECO:0000305};

    Alternative splice isoforms for CINP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CINP Gene

Proteomics data for CINP Gene at MOPED

Post-translational modifications for CINP Gene

Other Protein References for CINP Gene

Antibody Products

No data available for DME Specific Peptides for CINP Gene

Domains for CINP Gene

Protein Domains for CINP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CINP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW66

UniProtKB/Swiss-Prot:

CINP_HUMAN :
  • Q9BW66
Family:
  • Belongs to the CINP family.
genes like me logo Genes that share domains with CINP: view

No data available for Gene Families for CINP Gene

Function for CINP Gene

Molecular function for CINP Gene

UniProtKB/Swiss-Prot Function:
Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

Gene Ontology (GO) - Molecular Function for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21131973
genes like me logo Genes that share ontologies with CINP: view

Phenotypes for CINP Gene

GenomeRNAi human phenotypes for CINP:
genes like me logo Genes that share phenotypes with CINP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CINP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CINP Gene

Localization for CINP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CINP Gene

Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CINP Gene COMPARTMENTS Subcellular localization image for CINP gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CINP: view

Pathways for CINP Gene

SuperPathways for CINP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CINP: view

No data available for Pathways by source for CINP Gene

Compounds for CINP Gene

(2) HMDB Compounds for CINP Gene

Compound Synonyms Cas Number PubMed IDs
3-hydroxyoctadecanoyl-CoA
  • 3-Hydroxyoctadecanoyl-coenzyme A
42578-91-6
Docosanoyl-CoA
  • behenoyl-CoA
Not Available
genes like me logo Genes that share compounds with CINP: view

Transcripts for CINP Gene

Unigene Clusters for CINP Gene

Cyclin-dependent kinase 2 interacting protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CINP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CINP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8:

Relevant External Links for CINP Gene

GeneLoc Exon Structure for
CINP
ECgene alternative splicing isoforms for
CINP

Expression for CINP Gene

mRNA expression in normal human tissues for CINP Gene

Protein differential expression in normal tissues for CINP Gene

This gene is overexpressed in Retina (47.9), CD8 Tcells (14.5), and Placenta (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CINP Gene

SOURCE GeneReport for Unigene cluster for CINP Gene Hs.129634

genes like me logo Genes that share expressions with CINP: view

Expression partners for CINP Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CINP Gene

Orthologs for CINP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CINP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CINP 35
  • 82.86 (n)
  • 79.25 (a)
CINP 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CINP 35
  • 82.39 (n)
  • 76.42 (a)
CINP 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cinp 35
  • 79.09 (n)
  • 77.83 (a)
Cinp 16
Cinp 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CINP 35
  • 99.21 (n)
  • 99.06 (a)
CINP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cinp 35
  • 78.62 (n)
  • 78.3 (a)
oppossum
(Monodelphis domestica)
Mammalia CINP 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CINP 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CINP 35
  • 67.31 (n)
  • 62.5 (a)
CINP 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cinp 35
  • 59.97 (n)
  • 55.39 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15051 35
zebrafish
(Danio rerio)
Actinopterygii LOC100003640 35
  • 57.43 (n)
  • 51.49 (a)
cinp 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6870 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for CINP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CINP Gene

ENSEMBL:
Gene Tree for CINP (if available)
TreeFam:
Gene Tree for CINP (if available)

Paralogs for CINP Gene

No data available for Paralogs for CINP Gene

Variants for CINP Gene

Sequence variations from dbSNP and Humsavar for CINP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7011 - 102,348,705(+) CCGTG(C/T)GCTTC missense, reference, utr-variant-3-prime
rs7012 -- 102,348,608(-) GACAG(C/T)AGGCT reference, synonymous-codon, utr-variant-3-prime
rs1047409 -- 102,348,402(-) CCAGG(C/G)GTGCT utr-variant-3-prime, downstream-variant-500B
rs1063180 -- 102,348,441(-) GTCTT(C/T)TGGCC utr-variant-3-prime, downstream-variant-500B
rs1063204 -- 102,348,350(-) GCCTT(C/T)TCTGC utr-variant-3-prime, downstream-variant-500B

Relevant External Links for CINP Gene

HapMap Linkage Disequilibrium report
CINP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CINP Gene

Disorders for CINP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CINP Gene in MalaCards »

(1) Diseases for CINP Gene including...

(1) University of Copenhagen DISEASES for CINP Gene

Relevant External Links for CINP

Genetic Association Database (GAD)
CINP
Human Genome Epidemiology (HuGE) Navigator
CINP
genes like me logo Genes that share disorders with CINP: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CINP Gene

Publications for CINP Gene

  1. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes. (PMID: 16082200) Grishina I. … Lattes B. (Cell Cycle 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Functional genomic screens identify CINP as a genome maintenance protein. (PMID: 19889979) Lovejoy C.A. … Cortez D. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  4. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. (PMID: 21131973) Kalay E. … Wollnik B. (Nat. Genet. 2011) 3 4
  5. Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP). (PMID: 21628470) Wang Y. … Yuan Z. (J. Biol. Chem. 2011) 3

Products for CINP Gene

Sources for CINP Gene

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