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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CINP Gene

protein-coding   GIFtS: 49
GCID: GC14M102814

cyclin-dependent kinase 2 interacting protein

 Explore 2 diseases affiliated with
CINP via our new
 Human Malady Compendium 
Biological research products
for CINP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 2 Interacting Protein1 2
CDK2-Interacting Protein2 3
MGC8491
Cyclin-Dependent Kinase 2-Interacting Protein2

External Ids:    HGNC: 237891   Entrez Gene: 515502   Ensembl: ENSG000001008657   OMIM: 6133625   UniProtKB: Q9BW663   

Export aliases for CINP gene to outside databases

Previous GC identifers: GC14M100200 GC14M096630 GC14M100798 GC14M101878 GC14M082991


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CINP:
The protein encoded by this gene interacts with CDK2, MCM5, and CDC7, and is associated with the origin recognition
complex protein ORC2. It acts as a homodimer and is involved in replication and ATR-mediated checkpoint signaling.
Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: CINP_HUMAN, Q9BW66
Function: Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a
functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated
checkpoint signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CINP gene promoter:
         AhR   Olf-1   CUTL1   LCR-F1   GATA-1   HEN1   POU2F1   POU2F1a   HSF2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCINP promoter sequence
   Search SABiosciences Chromatin IP Primers for CINP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CINP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

CINP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CINP gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102814:  view genomic region     (about GC identifiers)

Start:
102,808,956 bp from pter      End:
102,829,253 bp from pter
Size:
20,298 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CINP_HUMAN, Q9BW66 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 2-interacting protein  
Size: 212 amino acids; 24324 Da
Subunit: Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3,
MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152
Subcellular location: Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start
of DNA replication
Secondary accessions: F5H7P3 Q9NPF9
Alternative splicing: 2 isoforms:  Q9BW66-1   Q9BW66-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CINP: NX_Q9BW66

Post-translational modifications:

  • Phosphorylated by CDC7 but not by CDK21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BW66

  • CINP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_116019.1  NP_001171082.1  NP_001171083.1  

    ENSEMBL proteins: 
     ENSP00000453846   ENSP00000453839   ENSP00000216756   ENSP00000442057   ENSP00000442377  
     ENSP00000452982  

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    Novus Biologicals CINP Proteins
    Novus Biologicals CINP Lysates
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    ProSpec Recombinant Protein for CINP
    Uscn Proteins for CINP

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    CINP for ontologies           About GeneDecksing



    CINP Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CINP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR023250 Cyclin-dep_Kinase_2_interact

    Graphical View of Domain Structure for InterPro Entry Q9BW66

    ProtoNet protein and cluster: Q9BW66

    UniProtKB/Swiss-Prot: CINP_HUMAN, Q9BW66
    Similarity: Belongs to the CINP family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CINP_HUMAN, Q9BW66
    Function: Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a
    functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated
    checkpoint signaling

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CINP (see all 3)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CINP

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    CINP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CINP:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CINP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CINP (Q9BW663 ENSP000002167564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLUAP1Q96AJ13, ENSP000003443924I2D: score=4 STRING: ENSP00000344392
    TRIM2Q9C0403I2D: score=1 
    ATRENSP000003437414STRING: ENSP00000343741
    ATRIPENSP000003230994STRING: ENSP00000323099
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0007049cell cycle IEA--
    GO:0051301cell division IEA--


    CINP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CINP

    2 HMDB Compounds for CINP    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-hydroxyoctadecanoyl-CoA3-Hydroxyoctadecanoyl-coenzyme A (see all 5)42578-91-6--
    Docosanoyl-CoAbehenoyl-CoA (see all 2)----
    Search CenterWatch for drugs/clinical trials and news about CINP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CINP gene (3 alternative transcripts): 
    NM_032630.2  NM_001177611.1  NM_001177612.1  

    Unigene Cluster for CINP:

    Cyclin-dependent kinase 2 interacting protein
    Hs.129634  [show with all ESTs]
    Unigene Representative Sequence: BX248279
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559504(uc001ylu.1 uc021sea.1) ENST00000559514(uc001ylv.1 uc021seb.1)
    ENST00000560326 ENST00000216756 ENST00000536961 ENST00000541568 ENST00000561468
    ENST00000558764 ENST00000558523

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CINP
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CINP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CINP

    Additional cDNA sequence: 

    BC000600.2 BX248279.1 CR457178.1 

    10 DOTS entries:

    DT.100801628  DT.102843640  DT.91720179  DT.40309464  DT.315051  DT.100801625  DT.100801626  DT.100036633 
    DT.120750251  DT.40209278 

    24/291 AceView cDNA sequences (see all 291):

    AI870472 W68247 CR600690 BE551358 BU848706 BM474041 AK090833 NM_032630 
    BU155770 BE348347 CR593168 BM826541 BM855454 BM714105 CB158066 AA442039 
    CB124440 CR623828 W32613 AA357682 BE731364 BU902312 AA236698 H63463 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CINP (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
    SP1:        -                 -     -                                                   
    SP2:        -                 -                                                         
    SP3:                          -     -                                                   
    SP4:        -                 -     -                                                   
    SP5:                          -     -                                                   


    ECgene alternative splicing isoforms for CINP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CINP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCACAACCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CINP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CINP

    SOURCE GeneReport for Unigene cluster: Hs.129634
        SABiosciences Custom PCR Arrays for CINP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CINP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CINP gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cinp1 , 5 cyclin-dependent kinase 2 interacting protein1, 5 78.73(n)1
    77.14(a)1
      12 (60.85 cM)5
    672361  NM_026048.41  NP_080324.11 
     1108726105 
    chicken
    (Gallus gallus)
    Aves CINP1 cyclin-dependent kinase 2 interacting protein 67.84(n)
    63.82(a)
      423467  XM_421375.3  XP_421375.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.150512 Xenopus laevis transcribed sequence with weak similarity more 73.34(n)    CD325380.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000036401 cyclin-dependent kinase 2-interacting protein-like 57.43(n)
    51.49(a)
      100003640  NM_001202484.1  NP_001189413.1 


    ENSEMBL Gene Tree for CINP (if available)
    TreeFam Gene Tree for CINP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 NCBI SNPs in CINP are shown (see all 205    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399716991,2
    --102814122(+) TGCCAC/TGTCCC 3 -- ds50010--------
    rs1154167901,2
    F,--102814218(+) ATTTAA/TGACGA 3 -- ds50011Minor allele frequency- T:0.06WA 118
    rs1883496541,2
    --102814334(+) GGCACA/GCGCCA 3 -- ds50010--------
    rs1811639001,2
    --102814475(+) GCCACC/TGCACC 3 -- ds50010--------
    rs1154912921,2
    C,F,--102814644(+) ATTTTA/CCTCTG 3 -- ut311Minor allele frequency- C:0.03WA 118
    rs115444251,2
    --102814691(+) AGAAGA/GCTGAG 3 -- ut310--------
    rs71411411,2
    C,F,H,--102814698(+) TGAGCG/AGCACC 3 -- ut31 ese321Minor allele frequency- A:0.07NA NS EA WA CSA 925
    rs1457875961,2
    --102814738(+) GAGCAC/TGCCTG 3 -- ut310--------
    rs1489826791,2
    --102814752(+) AGGCCA/GTGGGG 3 -- ut310--------
    rs32104701,2
    F--102814781(-) GGGGTC/TTTCTG 3 -- ut31 ese31Minor allele frequency- T:0.02MN 184

    HapMap Linkage Disequilibrium report for CINP (102808956 - 102829253 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CINP: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CINP for disorders           About GeneDecksing

    OMIM gene information: 613362    OMIM disorders: --

    2 diseases for CINP:    About MalaCards
    hepatitis c    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CINP:
    Dysthymic disorder
    Human Genome Epidemiology (HuGE) Navigator: CINP (61 documents)

    Export disorders for CINP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CINP gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CINP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes. (PubMed id 16082200)1, 2, 3 Grishina I. and Lattes B. (2005)
    2. Functional genomic screens identify CINP as a genome maintenance protein. (PubMed id 19889979)1, 2 Lovejoy C.A.... Cortez D. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Hepatitis C virus NS5B protein delays s phase progres sion in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP). (PubMed id 21628470)1 Wang Y....Yuan Z. (2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. CEP152 is a genome maintenance protein disrupted in S eckel syndrome. (PubMed id 21131973)2 Kalay E....Wollnik B. (2010)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51550 HGNC: 23789 AceView: CINP Ensembl:ENSG00000100865 euGenes: HUgn51550
    ECgene: CINP H-InvDB: CINP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CINP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CINP gene:
    Search GeneIP for patents involving CINP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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