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Aliases for CHRNB4 Gene

Aliases for CHRNB4 Gene

  • Cholinergic Receptor, Nicotinic, Beta 4 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Beta Polypeptide 4 2
  • Acetylcholine Receptor 2
  • Beta 4 (Neuronal) 2
  • Nicotinic 2

External Ids for CHRNB4 Gene

Previous GeneCards Identifiers for CHRNB4 Gene

  • GC15P074970
  • GC15M072006
  • GC15M076492
  • GC15M076632
  • GC15M076703
  • GC15M078916
  • GC15M055674

Summaries for CHRNB4 Gene

GeneCards Summary for CHRNB4 Gene

CHRNB4 (Cholinergic Receptor, Nicotinic, Beta 4 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNB4 include lung cancer. Among its related pathways are Nanog in Mammalian ESC Pluripotency and SIDS Susceptibility Pathways. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and ligand-gated ion channel activity. An important paralog of this gene is CHRNA3.

UniProtKB/Swiss-Prot for CHRNB4 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Wiki entry for CHRNB4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNB4 Gene

Genomics for CHRNB4 Gene

Regulatory Elements for CHRNB4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRNB4 Gene

78,624,119 bp from pter
78,727,754 bp from pter
103,636 bases
Minus strand

Genomic View for CHRNB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNB4 Gene

Proteins for CHRNB4 Gene

  • Protein details for CHRNB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal acetylcholine receptor subunit beta-4
    Protein Accession:
    Secondary Accessions:
    • A4FTX5
    • E9PHE8
    • Q16607
    • Q4VBA5
    • Q8WXC8
    • Q9BQR4

    Protein attributes for CHRNB4 Gene

    498 amino acids
    Molecular mass:
    56380 Da
    Quaternary structure:
    • Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.

    Three dimensional structures from OCA and Proteopedia for CHRNB4 Gene

    Alternative splice isoforms for CHRNB4 Gene


neXtProt entry for CHRNB4 Gene

Proteomics data for CHRNB4 Gene at MOPED

Post-translational modifications for CHRNB4 Gene

  • Glycosylation at Asn36, Asn93, Asn138, and Asn166
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNB4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRNB4 Gene

Domains for CHRNB4 Gene

Gene Families for CHRNB4 Gene

  • CHR :Cholinergic receptors
  • CHRN :Ligand-gated ion channels / Acetylcholine receptors, nicotinic

Suggested Antigen Peptide Sequences for CHRNB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • P30926
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily.
genes like me logo Genes that share domains with CHRNB4: view

Function for CHRNB4 Gene

Molecular function for CHRNB4 Gene

GENATLAS Biochemistry:
cholinergic receptor,nicotinic,beta 4 polypeptide,neuronal
UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Ontology (GO) - Molecular Function for CHRNB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 acetylcholine-activated cation-selective channel activity TAS 11742001
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0015276 ligand-gated ion channel activity TAS 20438829
GO:0015464 acetylcholine receptor activity IDA 8906617
genes like me logo Genes that share ontologies with CHRNB4: view
genes like me logo Genes that share phenotypes with CHRNB4: view

Animal Models for CHRNB4 Gene

MGI Knock Outs for CHRNB4:

Animal Model Products

miRNA for CHRNB4 Gene

miRTarBase miRNAs that target CHRNB4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNB4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CHRNB4 Gene

Localization for CHRNB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNB4 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CHRNB4 Gene COMPARTMENTS Subcellular localization image for CHRNB4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CHRNB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 11742001
GO:0005892 acetylcholine-gated channel complex TAS 11742001
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 8906617
genes like me logo Genes that share ontologies with CHRNB4: view

Pathways for CHRNB4 Gene

genes like me logo Genes that share pathways with CHRNB4: view

Gene Ontology (GO) - Biological Process for CHRNB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IEA --
GO:0006810 transport --
GO:0006811 ion transport TAS 8906617
GO:0006812 cation transport TAS 11742001
GO:0006939 smooth muscle contraction IEA --
genes like me logo Genes that share ontologies with CHRNB4: view

Compounds for CHRNB4 Gene

(32) ApexBio Compounds for CHRNB4 Gene

Compound Action Cas Number
Acetylcholine Chloride Major transmitter at many nervous sites [60-31-1]
Acetylcysteine Antioxidant;mucolytic agent [616-91-1]
Atropine MAChRs antagonist [5908-99-6]
Bethanechol chloride Muscarinic receptor agonist [590-63-6]
Decamethonium Bromide [541-22-0]
Diphemanil Methylsulfate [62-97-5]
Flavoxate hydrochloride [3717-88-2]
Galanthamine HBr Acetylcholinesterase inhibitor [1953-4-4]
Gallamine Triethiodide [65-29-2]
Hexamethonium Bromide [55-97-0]
Homatropine Bromide Muscarinic AChR antagonist [51-56-9]
Homatropine Methylbromide Muscarinic AChR antagonist [80-49-9]
Hyoscyamine [101-31-5]
Ipratropium Bromide [22254-24-6]
LY2119620 [886047-22-9]
Methscopolamine Muscarinic acetylcholine receptor blocker [155-41-9]
Neostigmine Bromide Cholinesterase inhibitor [114-80-7]
Nitenpyram [150824-47-8]
Orphenadrine Citrate Antiparkinsonian and analgesic drug [4682-36-4]
Otilonium Bromide [26095-59-0]
Oxybutynin [5633-20-5]
Oxybutynin chloride [1508-65-2]
Pancuronium dibromide AChR antagonist [15500-66-0]
Paroxetine HCl Antidepressant agents [78246-49-8]
PNU-120596 "α7 nAChR modulator,positive allosteric" [501925-31-1]
Pregnenolone [145-13-1]
Rivastigmine Tartrate [129101-54-8]
Rocuronium Bromide TGF-βR I kinase inhibitor [119302-91-9]
Succinylcholine Chloride Dihydrate [6101-15-1]
Tiotropium Bromide hydrate Muscarinic antagonist [139404-48-1]
Tropicamide Antimuscarinic drug [1508-75-4]
Varenicline Tartrate "Subtype-selective agonist of α4β2 nicotinic receptors,orally active" [375815-87-5]

(4) Drugbank Compounds for CHRNB4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (-)-Galanthamine
357-70-0 target allosteric modulator
Levomethadyl Acetate
  • 1-alpha-acetylmethadol
1477-40-3 target other/unknown
  • L-Nicotine
54-11-5 target agonist
  • Pentolinium tartrate
52-62-0 target antagonist
genes like me logo Genes that share compounds with CHRNB4: view

Transcripts for CHRNB4 Gene

Unigene Clusters for CHRNB4 Gene

Cholinergic receptor, nicotinic, beta 4 (neuronal):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNB4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNB4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - -
SP3: -

Relevant External Links for CHRNB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRNB4 Gene

mRNA expression in normal human tissues for CHRNB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHRNB4 Gene

This gene is overexpressed in Testis (26.4) and Colon - Sigmoid (4.0).

Protein differential expression in normal tissues for CHRNB4 Gene

This gene is overexpressed in Fetal heart (57.8) and Heart (11.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHRNB4 Gene

SOURCE GeneReport for Unigene cluster for CHRNB4 Gene Hs.624178

genes like me logo Genes that share expressions with CHRNB4: view

Expression partners for CHRNB4 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHRNB4 Gene

Orthologs for CHRNB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRNB4 35
  • 87.69 (n)
  • 88.16 (a)
  • 87 (a)
(Canis familiaris)
Mammalia CHRNB4 35
  • 85.77 (n)
  • 85.57 (a)
  • 76 (a)
(Mus musculus)
Mammalia Chrnb4 35
  • 84.69 (n)
  • 84.29 (a)
Chrnb4 16
Chrnb4 36
  • 83 (a)
(Pan troglodytes)
Mammalia CHRNB4 35
  • 98.84 (n)
  • 98.14 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Chrnb4 35
  • 84.12 (n)
  • 83.44 (a)
(Monodelphis domestica)
Mammalia CHRNB4 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CHRNB4 36
  • 77 (a)
(Gallus gallus)
Aves CHRNB4 35
  • 68.67 (n)
  • 75.98 (a)
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chrnb4 35
  • 64.84 (n)
  • 72.09 (a)
(Danio rerio)
Actinopterygii LOC568566 35
  • 68.71 (n)
  • 67.23 (a)
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-30D 37
  • 30 (a)
nAcRalpha-7E 37
  • 50 (a)
nAcRalpha-80B 37
  • 40 (a)
nAcRalpha-96Aa 37
  • 53 (a)
nAcRalpha-96Ab 37
  • 49 (a)
nAcRbgr-64B 37
  • 42 (a)
nAcRbgr-96A 37
  • 42 (a)
(Caenorhabditis elegans)
Secernentea acr-12 37
  • 34 (a)
acr-13 37
  • 30 (a)
acr-14 37
  • 28 (a)
acr-2 37
  • 45 (a)
acr-3 37
  • 37 (a)
acr-5 37
  • 26 (a)
acr-8 37
  • 34 (a)
acr-9 37
  • 32 (a)
deg-3 37
  • 26 (a)
F18G5.4 37
  • 34 (a)
lev-1 37
  • 37 (a)
unc-29 37
  • 39 (a)
unc-38 37
  • 41 (a)
Y44A6E.1 37
  • 27 (a)
Y73F8A.30 37
  • 30 (a)
ZK973.5 37
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1655 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for CHRNB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNB4 Gene

Gene Tree for CHRNB4 (if available)
Gene Tree for CHRNB4 (if available)

Paralogs for CHRNB4 Gene

Selected SIMAP similar genes for CHRNB4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHRNB4: view

Variants for CHRNB4 Gene

Sequence variations from dbSNP and Humsavar for CHRNB4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1948 -- 78,625,057(-) GTGGC(C/T)GATGA utr-variant-3-prime, synonymous-codon, reference
rs950776 -- 78,633,676(+) GGGTC(C/T)TTATG intron-variant
rs1316971 -- 78,638,168(+) CTGAC(A/G)GGGCT intron-variant
rs2869548 -- 78,630,296(+) ACCAC(A/G)CCCGG intron-variant
rs2904130 -- 78,624,280(+) GTACA(C/G)AGGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CHRNB4 Gene

Variant ID Type Subtype PubMed ID
nsv457208 CNV Gain 19166990
nsv1628 CNV Insertion 18451855
esv2749912 CNV Deletion 23290073
esv2059419 CNV Deletion 18987734
esv2749913 CNV Deletion 23290073
esv1211887 CNV Deletion 17803354
dgv8e24 CNV Loss 17666407
esv2750601 CNV Gain 17666407

Relevant External Links for CHRNB4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNB4 Gene

Disorders for CHRNB4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CHRNB4 Gene in MalaCards »

(1) Diseases for CHRNB4 Gene including...

(4) University of Copenhagen DISEASES for CHRNB4 Gene

Relevant External Links for CHRNB4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CHRNB4: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CHRNB4 Gene

Publications for CHRNB4 Gene

  1. Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes. (PMID: 11742001) Valor L.M. … Criado M. (J. Biol. Chem. 2002) 3 4 23
  2. Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis. (PMID: 19628475) Sabatelli M. … Zollino M. (Hum. Mol. Genet. 2009) 3 23 48
  3. Neuronal-type nicotinic receptors in human neuroblastoma and small- cell lung carcinoma cell lines. (PMID: 1330682) Tarroni P. … Clementi F. (FEBS Lett. 1992) 3 4
  4. Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits. (PMID: 1572664) Raimondi E. … Clementi F. (Genomics 1992) 3 23
  5. Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. (PMID: 2004777) Eng C.M. … Zoghbi H.Y. (Genomics 1991) 2 3

Products for CHRNB4 Gene

Sources for CHRNB4 Gene

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