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CHRNA7 Gene

protein-coding GIFtS: 66

GC15P030110

cholinergic receptor, nicotinic, alpha 7
(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHRNA7-2 ^²
NACHRA7 ^², ³

Descriptions
a7 nicotinic acetylcholine receptor ^²
alpha 7 neuronal nicotinic acetylcholine receptor ^²
alpha-7 nicotinic cholinergic receptor subunit ^²
cholinergic receptor, nicotinic, alpha 7 ^²
cholinergic receptor, nicotinic, alpha polypeptide 7 ^¹, ²
neuronal acetylcholine receptor protein, alpha-7 chain ^²

External Ids
HGNC: 1960¹
Entrez Gene: 1139²
UniProtKB: P36544³
Ensembl: ENSG00000175344⁷

Search outside databases for aliases for CHRNA7 gene

Previous GC identifers: GC15M026503 GC15P025077 GC15P029901 GC15P030038

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CHRNA7:

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion

channels that mediate fast signal transmission at synapses. The nAChRs are thought to be

hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a

conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a

variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal

extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays

marked permeability to calcium ions and is a major component of brain nicotinic receptors that are

blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine,

it undergoes an extensive change in conformation that affects all subunits and leads to opening of

an ion-conducting channel across the plasma membrane. This gene is located in a region identified

as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location

involved in the genetic transmission of schizophrenia. An evolutionarily recent partial

duplication event in this region results in a hybrid containing sequence from this gene and a

novel FAM7A gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544

Function: After binding acetylcholine, the AChR responds by an extensive change in conformation

that affects all subunits and leads to opening of an ion-conducting channel across the plasma

membrane. The channel is blocked by alpha-bungarotoxin

Gene Wiki entry for CHRNA7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CHRNA7 gene

Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q13.3 HGNC cytogenetic band: 15q13.3

CHRNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P030110: (about GC identifiers)

Start:	30,110,018 bp from pter
End:	30,249,002 bp from pter
Size:	138,985 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544 (See protein sequence)

Recommended Name: Neuronal acetylcholine receptor subunit alpha-7 precursor

Size: 502 amino acids; 56449 Da

Subunit: Homopentamer. Interacts with RIC3; which is required for proper folding and assembly

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Mass spectrometry: Mass=54157.68; Method=MALDI; Range=23-502; Source=PubMed:11840567;

Secondary accessions: A8K7Q4 Q15826 Q96RH2 Q99555 Q9BXH0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000737.1

ENSEMBL proteins:

ENSP00000385389 ENSP00000303727

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Nicotinic Acetylcholine Receptor alpha 7)
	Human Recombinant Proteins from Abnova (CHRNA7)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/18 Gene Ontology (GO) cellular component terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IDA	16280133
GO:0005892	nicotinic acetylcholine-gated receptor-channel complex	IDA	8906617
GO:0009897	external side of plasma membrane	IEA	--

About this table

Antibodies for CHRNA7:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CHRNA7
	Sigma-Aldrich Antibodies for CHRNA7
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Nicotinic Acetylcholine Receptor alpha 7), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for CHRNA7

Assays for CHRNA7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P36544

ProtoNet protein and cluster: P36544

2 Blocks protein families:

IPB002394 Nicotinic acetylcholine receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRNA7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRNA7)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000746

Applied Biosystems Silencer® siRNAs for CHRNA7

Sigma-Aldrich siRNA and siRNA Panels for CHRNA7

Sigma-Aldrich shRNA Panels and shRNA for CHRNA7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000746
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000746
untagged cDNA clone in CMV expression vector: NM_000746

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000746

UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544

Function: After binding acetylcholine, the AChR responds by an extensive change in conformation

that affects all subunits and leads to opening of an ion-conducting channel across the plasma

membrane. The channel is blocked by alpha-bungarotoxin

Genatlas biochemistry entry for CHRNA7:

cholinergic receptor,nicotinic,alpha 7 polypeptide (alpha-bungarotoxin binding),brain,partially

duplicated

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Chrna7):

behavior/neurological	homeostasis/metabolism	immune system	lethality-prenatal/perinatal	nervous system
reproductive system

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001540	beta-amyloid binding	IPI	10681545
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	IDA	8145738 8906617
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0008144	drug binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for CHRNA7 (Your Favorite Gene powered by Ingenuity)

Calcium Signaling

GeneDecks CHRNA7 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CHRNA7

5/35 Interacting proteins for CHRNA7 (ENSP00000303727³ P36544¹) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	P05067¹	EBI-79333, EBI-77613
CHRNA5	ENSP00000299565³	STRING (score=.91)
CHRNB2	ENSP00000357461³	STRING (score=.91)
CHRNB3	ENSP00000289957³	STRING (score=.91)
CHRNA1	ENSP00000261007³	STRING (score=.909)

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5/31 Gene Ontology (GO) biological process terms (links to tree view) (see all 31 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IDA	10771023
GO:0001666	response to hypoxia	IDA	12189247
GO:0001988	positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure	IEA	--
GO:0006811	ion transport	NAS	8906617
GO:0006816	calcium ion transport	IMP	10771023

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CHRNA7

Sigma-Aldrich Small Molecules for CHRNA7:

Antagonist Blocker Agonist

Compounds for CHRNA7 available from Tocris Bioscience

Compound	Action	CAS number
PNU 282987	Selective alpha7 nAChR agonist	[123464-89-1]
PNU 120596	Positive allosteric modulator of alpha7 nAChR; active in vivo	[501925-31-1]
alpha-Conotoxin ImI	alpha7 and alpha9 selective nAChR antagonist	[156467-85-5]
PHA 543613 hydrochloride	Potent and selective alpha7 nAChR agonist	[478149-53-0]
Methyllycaconitine citrate	alpha7 neuronal nicotinic receptor antagonist	[21019-30-7]

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10/19 Novoseek chemical compound relationships for CHRNA7 gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha-bungarotoxin	92.93	20	12614199 (2), 11207427 (2), 10987839 (1), 17254563 (1) (see all 17)
3 (2,4 dimethoxybenzylidene)anabaseine	89.09	2	16754836 (1)
dihydro-beta-erythroidine	83.59	7	15469877 (1), 10082212 (1), 11906789 (1), 15044058 (1) (see all 5)
5-hydroxyindole	81.39	2	12243767 (1)
quinuclidine	67.08	1	11212100 (1)
1,1 dimethyl 4 phenylpiperazinium	60.48	2	9808669 (1)
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone	39.64	2	15807899 (1), 15161935 (1)
calcium	36.42	22	15969741 (2), 8996225 (2), 16257255 (2), 16344526 (1) (see all 13)
proline	9.78	1	10230802 (1)
tyrosine	7.19	5	15469877 (1), 17709503 (1), 14722323 (1), 11032889 (1)

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2 PharmGKB drug compound relationships for CHRNA7 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
nicotine	FA	10082212 12511591
xenobiotics	FA	12511591

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRNA7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRNA7)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000746

Sigma-Aldrich siRNA and siRNA Panels for CHRNA7

Sigma-Aldrich shRNA Panels and shRNA for CHRNA7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000746

REFSEQ mRNAs for CHRNA7 gene:

NM_000746.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000746

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000746
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000746
                                 untagged cDNA clone in CMV expression vector: NM_000746

Additional cDNA sequence:

AF385585.1 AJ586911.1 AK292069.1 AK294229.1 AK309709.1 AY909581.1 BC037571.1 CR594008.1

CR620753.1 EF405802.1 EF405803.1 EF405804.1 EF405805.1 EF405806.1 EF405807.1 EF405808.1

EF405809.1 EF405810.1 EF405811.1 EF405812.1 EF405813.1 EF405814.1 EF405815.1 EF405816.1

EF405817.1 EF405818.1 EF405819.1 EF405820.1 L25827.1 U40583.1 U62436.1 X70297.1

Y08420.1 Z23141.1

5 DOTS entries:

DT.100778392 DT.100025592 DT.100778393 DT.97837952 DT.100778391

24/71 AceView cDNA sequences (see all 71 ):

NM_000746 BF507825 AA301331 AI208142 BU149265 CR620753 BX090309 BI963064

BU680930 AI791902 AA897701 BX282644 CR605947 BM451308 BX422848 CR608436

CR594008 AA639641 BC037571 CK903362 U62436 AL519942 BG925223 AA706348

highest scoring ESTs for CHRNA7:

X70297 AA426529 AF385585 BC037571 BG395536 BM451308 U40583 U62436 Y08420 Z23141

Unigene Cluster for CHRNA7:

Cholinergic receptor, nicotinic, alpha 7

Hs.511772 [show with all ESTs]

Unigene Representative Sequence: NM_000746

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000401522 ENST00000306901

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CHRNA7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CHRNA7

¹ / ² / ³

3 probe-sets matching CHRNA7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39566_at²^{, 3}	U95-A	2	1.00	0.50	1.00	1.00	X70297	1.00	0.80	0.91	1
210123_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	U62436	0.80	0.88	0.84	1
210123_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.511772

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CHRNA7 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CHRNA7¹	--	cholinergic receptor, nicotinic, alpha 7	91.18(n) 97.17(a)	488696 XM_545813.2 XP_545813.2
chimpanzee (Pan troglodytes)	CHRNA7¹	--	cholinergic receptor, nicotinic, alpha 7	99.27(n) 100(a)	467639 XM_001164138.1 XP_001164138.1
cow (Bos taurus)	CHRNA7¹	--	cholinergic receptor, nicotinic, alpha 7	87.93(n) 94.57(a)	282178 NM_174515.2 NP_776940.1
rat (Rattus norvegicus)	Chrna7¹	--	cholinergic receptor, nicotinic, alpha 7	87.32(n) 93.56(a)	25302 NM_012832.2 NP_036964.2
mouse (Mus musculus)	Chrna7^{1, 5}	7 (30.00 cM)⁵	cholinergic receptor, nicotinic, alpha polypeptide more^{1, 5}	88.06(n)¹ 93.96(a)¹	11441¹ NM_007390.2¹ NP_031416.2¹ AF225980⁵ AF325348⁵ (see all 12)

About this table Species with no ortholog for CHRNA7

ENSEMBL Gene Tree for CHRNA7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CHRNA7 gene

CHRFAM7A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/734 NCBI SNPs in CHRNA7 are shown (see all 734 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 191)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3826029^1,2	A,C,F,H	30108777(-)	`CTTAAG/ATGTAT`	1	--	ng5¹		4	EU EA WA	412
	rs6494165^1,2	A,C,F,H	30108578(+)	`ACGCCT/GGTCTG`	1	--	ng5¹		8	EU EA WA	822
--	rs3087454^1,2	A,C,F	30108259(-)	`TTATTA/C/G/T ATTTT`	1	--	ng5¹ tfbs³		2	NA	182
--	rs12899798^1,2	H	30180831(+)	`ACATTT/GGGCTG`	1	G/W	mis¹		4	EU EA WA	404
	rs904951^1,2	A,C,F,H,O	30205330(+)	`TGGGCG/ATGAAT`	1	--	int¹		8	NA EA MN EU WA	798
	rs904952^1,2	A,C,F,H,O	30206037(+)	`CCTCGT/CTCCCT`	1	--	int¹		20	NA EA EU WA	1826
	rs883473^1,2	A,C,F,H,O	30112968(-)	`GCAGAT/CGAAAG`	1	--	int¹		14	NA EA EU WA	1224
	rs1039394^1,2	A,C,F,H,O	30195021(-)	`AAGCAG/CTAGGG`	1	--	int¹		9	MN EU EA WA	1024
	rs982574^1,2	A,C,F,H,O	30161315(+)	`tccctC/Gctttc`	1	--	int¹		5	EU EA WA MN	602
	rs11071530^1,2	A,C,F,H	30147264(+)	`aagcaG/Aagtta`	1	--	int¹		4	EU EA WA	406

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HapMap Linkage Disequilibrium images for CHRNA7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118511

10/25 Novoseek disease relationships for CHRNA7 gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	73.76	121	19181484 (6), 16889592 (5), 16134405 (4), 17113175 (4) (see all 54)
alzheimers disease	65.01	36	11958863 (2), 17493709 (2), 15591800 (2), 19442215 (2) (see all 31)
cognitive deficit	53.70	7	17094961 (2), 17898229 (1), 17504249 (1), 15695160 (1) (see all 6)
senile plaques	50.14	3	11958863 (1), 15698636 (1), 10681545 (1)
cognitive dysfunction	47.65	2	17349863 (1), 17470817 (1)
neurodegeneration	37.08	4	18180036 (2), 16842101 (1), 15228589 (1)
neurodegenerative diseases	23.18	2	19287501 (1)
psychotic	22.74	1	16889592 (1)
brain diseases	19.78	3	11958863 (1), 10681545 (1), 15858066 (1)
bipolar disorder	16.83	8	16889592 (3), 14729237 (2), 18545269 (1), 16823804 (1)

About this table

1 PharmGKB disease relationship for CHRNA7 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Lung Neoplasms	FA	12511591

About this table

Human Gene Mutation Database: CHRNA7
Genetic Association Database: CHRNA7
Human Genome Epidemiology Navigator: CHRNA7 (36 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/274 PubMed articles for CHRNA7 gene (see all 274 ):

Molecular cloning and chromosomal localization of the human alpha 7- nicotinic receptor subunit gene (CHRNA7). (PubMed id 8188270)^{2, 3, 4} Chini B....Heinemann S.F. (1994)
Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. (PubMed id 12470124)^{1, 3, 6} Leonard S....Freedman R. (2002)
A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PubMed id 11829490)^{1, 3, 4} Riley B.... Makoff A. (2002)
Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families. (PubMed id 11803513)^{1, 3, 6} Xu J....Pato C.N. (2001)
Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder. (PubMed id 14729237)^{1, 3, 6} Hong C.J....Tsai S.J. (2004)
Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. (PubMed id 14582144)^{1, 3, 6} Gault J....Leonard S. (2003)
Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells. (PubMed id 15504725)^{1, 3, 4} Williams M.E.... Aiyar J. (2005)
Identification of molecular variants at the promoter region of the human alpha 7 neuronal nicotinic acetylcholine receptor subunit gene but lack of association with schizophrenia. (PubMed id 15531077)^{1, 3, 6} Li C.H....Chen C.H. (2004)
Association analysis of the partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant and Alzheimer's disease. (PubMed id 11455129)^{1, 3, 6} Liou Y.J....Tsai S.J. (2001)
Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (PubMed id 16314871)^{3, 6} Greenbaum L....Lerer B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1139	HGNC: 1960	AceView: CHRNA7	Ensembl:ENSG00000175344	euGenes: HUgn1139
ECgene: CHRNA7	H-InvDB: CHRNA7

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CHRNA7
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for CHRNA7 gene:

Weizmann Institute:

Diagnosis and Follow-up of Schizophrenia

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CHRNA7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CHRNA7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CHRNA7		Antibodies for CHRNA7
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CHRNA7		Small molecules for CHRNA7
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CHRNA7)
	Search for Antibodies
	Chimera RNAi (CHRNA7)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Nicotinic Acetylcholine Receptor alpha 7)
	Antibodies (Nicotinic Acetylcholine Receptor alpha 7)

Search OriGene for CHRNA7

Tocris compounds for CHRNA7

	Drugs for CHRNA7
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for CHRNA7

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CHRNA7 Gene at Home site.
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CHRNA7 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CHRNA7

Summaries
for CHRNA7

Genomic Location
for CHRNA7

Proteins
for CHRNA7

Protein Domains/
Families
for CHRNA7

Gene Function
for CHRNA7

Pathways & Interactions
for CHRNA7

Drugs & Compounds
for CHRNA7

Transcripts
for CHRNA7

Expression
for CHRNA7

Orthologs
for CHRNA7

Paralogs
for CHRNA7

SNPs/Variants
for CHRNA7

Disorders & Mutations
for CHRNA7

Medical News
for CHRNA7

Publications
for CHRNA7

Search for CHRNA7

Genome Databases showing CHRNA7

Other Databases showing CHRNA7

Specialized Databases showing CHRNA7

Licensable Technologies
for CHRNA7

Services
for CHRNA7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CHRNA7 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CHRNA7

Summariesfor CHRNA7

Genomic Locationfor CHRNA7

Proteinsfor CHRNA7

Protein Domains/Familiesfor CHRNA7

Gene Functionfor CHRNA7

Pathways & Interactionsfor CHRNA7

Drugs & Compoundsfor CHRNA7

Transcriptsfor CHRNA7

Expression for CHRNA7

Orthologsfor CHRNA7

Paralogsfor CHRNA7

SNPs/Variantsfor CHRNA7

Disorders & Mutationsfor CHRNA7

Medical Newsfor CHRNA7

Publicationsfor CHRNA7

Search for CHRNA7

Genome Databases showing CHRNA7

Other Databases showing CHRNA7

Specialized Databases showing CHRNA7

Licensable Technologiesfor CHRNA7

Servicesfor CHRNA7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CHRNA7

Summaries
for CHRNA7

Genomic Location
for CHRNA7

Proteins
for CHRNA7

Protein Domains/
Families
for CHRNA7

Gene Function
for CHRNA7

Pathways & Interactions
for CHRNA7

Drugs & Compounds
for CHRNA7

Transcripts
for CHRNA7

Expression
for CHRNA7

Orthologs
for CHRNA7

Paralogs
for CHRNA7

SNPs/Variants
for CHRNA7

Disorders & Mutations
for CHRNA7

Medical News
for CHRNA7

Publications
for CHRNA7

Licensable Technologies
for CHRNA7

Services
for CHRNA7