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CHRNA4 Gene

protein-coding GIFtS: 69

GC20M061446

cholinergic receptor, nicotinic, alpha 4
(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: EBN, EBN1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BFNC ^¹, ²
EBN ^²
EBN1 ^²
ENFL1 ^⁵
FLJ95812 ^²
NACHR ^²
NACHRA4 ^²
NACRA4 ^², ³

Descriptions
cholinergic receptor, nicotinic, alpha 4 ^²
cholinergic receptor, nicotinic, alpha 4 subunit ^²
cholinergic receptor, nicotinic, alpha polypeptide 4 ^¹, ²
neuronal nicotinic acetylcholine receptor alpha-4 subunit ^²

External Ids
HGNC: 1958¹
Entrez Gene: 1137²
UniProtKB: P43681³
Ensembl: ENSG00000101204⁷

Search outside databases for aliases for CHRNA4 gene

Previous GC identifers: GC20U990005 GC20M061813 GC20M062655 GC20M062702

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CHRNA4:

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of

ligand-gated ion channels that play a role in fast signal transmission at synapses. These

pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that

leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an

integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to

form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.

Polymorphisms in this gene that provide protection against nicotine addiction have been described.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ACHA4_HUMAN, P43681

Function: After binding acetylcholine, the AChR responds by an extensive change in conformation

that affects all subunits and leads to opening of an ion-conducting channel across the plasma

membrane

Gene Wiki entry for CHRNA4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CHRNA4 gene

Entrez Gene cytogenetic band: 20q13.2-q13.3 Ensembl cytogenetic band: 20q13.33 HGNC chromosome: 20

CHRNA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M061446: (about GC identifiers)

Start:	61,445,109 bp from pter
End:	61,463,192 bp from pter
Size:	18,084 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011333.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACHA4_HUMAN, P43681 (See protein sequence)

Recommended Name: Neuronal acetylcholine receptor subunit alpha-4 precursor

Size: 627 amino acids; 69957 Da

Subunit: Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4

subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with

RIC3; which is required for proper folding and assembly

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2GVT (3D)

Secondary accessions: Q4JGR7 Q4VAQ6

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000735.1

ENSEMBL proteins:

ENSP00000359285 ENSP00000359280

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Nicotinic Acetylcholine Receptor alpha 4)
	Human Recombinant Proteins from Abnova (CHRNA4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	ISS	--
GO:0005886	plasma membrane	ISS	--
GO:0005892	nicotinic acetylcholine-gated receptor-channel complex	IDA	8906617
GO:0009897	external side of plasma membrane	ISS	--
GO:0016021	integral to membrane	NAS	8906617

About this table

Antibodies for CHRNA4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CHRNA4
	Sigma-Aldrich Antibodies for CHRNA4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Nicotinic Acetylcholine Receptor alpha 4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CHRNA4)
	Novus Biologicals Antibodies for CHRNA4

Assays for CHRNA4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P43681

ProtoNet protein and cluster: P43681

2 Blocks protein families:

IPB002394 Nicotinic acetylcholine receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: ACHA4_HUMAN, P43681

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRNA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRNA4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000744

Applied Biosystems Silencer® siRNAs for CHRNA4

Sigma-Aldrich siRNA and siRNA Panels for CHRNA4

Sigma-Aldrich shRNA Panels and shRNA for CHRNA4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CHRNA4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000744
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000744
untagged cDNA clone in CMV expression vector: NM_000744

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000744

UniProtKB/Swiss-Prot: ACHA4_HUMAN, P43681

Function: After binding acetylcholine, the AChR responds by an extensive change in conformation

that affects all subunits and leads to opening of an ion-conducting channel across the plasma

membrane

Genatlas biochemistry entry for CHRNA4:

cholinergic receptor,nicotinic,alpha 4 polypeptide,neuronal

5 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Chrna4):

behavior/neurological

homeostasis/metabolism

nervous system

no phenotypic analysis

touch/vibrissae

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	IDA	8906617
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0015464	acetylcholine receptor activity	IDA	8906617

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for CHRNA4 (Your Favorite Gene powered by Ingenuity)

Calcium Signaling

GeneDecks CHRNA4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CHRNA4

5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001508	regulation of action potential	ISS	--
GO:0001666	response to hypoxia	IDA	12189247
GO:0006281	DNA repair	IMP	16332175
GO:0006811	ion transport	NAS	8906617
GO:0006816	calcium ion transport	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CHRNA4

Sigma-Aldrich Small Molecules for CHRNA4:

Antagonist Blocker Agonist

Compounds for CHRNA4 available from Tocris Bioscience

Compound	Action	CAS number
RJR 2403 oxalate	alpha4beta2 selective nicotinic agonist	[183288-99-5]
5-Iodo-A-85380 dihydrochloride	High affinity alpha4beta2 and alpha6beta2 subtype-selective agonist	[213764-92-2]
TC 2559 difumarate	Selective partial agonist at alpha4beta2 receptors	[212332-35-9]
Sazetidine A dihydrochloride	alpha4beta2 receptor ligand; may act as an agonist or a desensitizer	[820231-95-6]

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3 Novoseek chemical compound relationships for CHRNA4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	21.97	4	7620586 (1), 11888238 (1), 11579435 (1)
sodium	7.78	1	11579435 (1)
phenylalanine	4.01	1	7550350 (1)

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2 PharmGKB drug compound relationships for CHRNA4 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
nicotine	FA	12511591
xenobiotics	FA	12511591

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRNA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRNA4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000744

Sigma-Aldrich siRNA and siRNA Panels for CHRNA4

Sigma-Aldrich shRNA Panels and shRNA for CHRNA4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000744

REFSEQ mRNAs for CHRNA4 gene:

NM_000744.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000744

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000744
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000744
                                 untagged cDNA clone in CMV expression vector: NM_000744

Additional cDNA sequence:

AK296430.1 AK314907.1 BC096290.1 BC096291.1 BC096292.1 BC096293.3 L35901.1 X87629.1

Y08421.1

6 DOTS entries:

DT.120804469 DT.455403 DT.92416817 DT.120804474 DT.120804492 DT.120804482

24/30 AceView cDNA sequences (see all 30 ):

BM929812 R56604 BM929424 BM710937 Z40094 NM_000744 L35901 U62433

H28110 BF594703 H27913 Y08421 AI937242 BI917752 X89745 Z44054

BM666038 CB156220 X87629 H30878 X89741 R56603 AV708847 X89742

highest scoring ESTs for CHRNA4:

L35901 R88602 AA985359 AV708847 BC096290 BC096291 BC096292 BC096293 BF511254 BI917752

Unigene Cluster for CHRNA4:

Cholinergic receptor, nicotinic, alpha 4

Hs.10734 [show with all ESTs]

Unigene Representative Sequence: NM_000744

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA4

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b
SP1:					-										-
SP2:													-		-
SP3:													-
SP4:															-

About this scheme

ECgene alternative splicing isoforms for CHRNA4

2 Ensembl transcripts including schematic representations:

ENST00000370263 ENST00000370258

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CHRNA4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CHRNA4

¹ / ² / ³

11 probe-sets matching CHRNA4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
85309_at²^{, 3}	U95-E	1	1.00	1.00	0.98	0.98	R88602	0.80	1.00	0.91	1
83355_at²^{, 3}	U95-D	1	1.00	1.00	0.60	1.20	AI937242	0.40	1.00	0.76	1
34447_at²^{, 3}	U95-A	1	1.00	1.00	0.48	0.71	U62433	0.60	1.00	0.82	1
206736_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L35901	0.80	1.00	0.91	1
216900_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X89745	0.20	1.00	0.72	1
206735_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000744	0.40	1.00	0.76	1
216886_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	X89745	0.20	1.00	0.72	1
206736_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216900_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206735_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216886_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks CHRNA4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACCAAGCCC

SOURCE GeneReport for Unigene cluster: Hs.10734
Expression variation in blood from EXPOLDB for CHRNA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CHRNA4 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CHRNA4¹	--	cholinergic receptor, nicotinic, alpha 4	88.17(n) 88.17(a)	485972 XM_543097.2 XP_543097.2
chimpanzee (Pan troglodytes)	CHRNA4¹	--	cholinergic receptor, nicotinic, alpha 4	98.51(n) 98.41(a)	469999 NM_001034114.1 NP_001029286.1
cow (Bos taurus)	CHRNA4¹	--	cholinergic receptor, nicotinic, alpha 4	85.92(n) 86.71(a)	537251 XM_617408.3 XP_617408.3
rat (Rattus norvegicus)	Chrna4¹	--	cholinergic receptor, nicotinic, alpha 4	83.73(n) 84.8(a)	25590 NM_024354.1 NP_077330.1
mouse (Mus musculus)	Chrna4^{1, 5}	2 (108.00 cM)⁵	cholinergic receptor, nicotinic, alpha polypeptide more^{1, 5}	83.57(n)¹ 85.28(a)¹	11438¹ NM_015730.4¹ NP_056545.3¹ AB010002⁵ AF225912⁵ (see all 16)

About this table Species with no ortholog for CHRNA4

ENSEMBL Gene Tree for CHRNA4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CHRNA4 gene

CHRNA3² CHRNA2² CHRNA1² CHRNA6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/280 NCBI SNPs in CHRNA4 are shown (see all 280 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 91)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6090378^1,2	A,C,F,H	61445822(+)	`cctccA/Gttcct`	1	--	ut3¹		15	EU EA WA NA	1400
	rs4522666^1,2	A,C,F,H	61444924(+)	`CAACCG/ATGGGT`	1	--	ng5¹		19	EU EA WA NA NS	1404
	rs2236196^1,2	A,C,F	61448000(+)	`GGAGCA/GCTGCT`	1	--	ut3¹ ese³		10	EA NA NS	1884
	rs6011770^1,2	C,F,H	61447875(+)	`GGAACC/TAGCTC`	1	--	ut3¹		9	EU EA WA NS	572
--	rs41283010^1,2	C,F	61447493(+)	`GTGGAG/CGTCCT`	1	--	ut3¹		5	NS	190
--	rs45494793^1,2	C,F	61446068(-)	`AGCACC/GGTGGA`	1	--	ut3¹		5	NS	178
--	rs41283008^1,2	C,F	61447459(+)	`GACTTC/TCTGCC`	1	--	ut3¹		5	NS	190
	rs12625573^1,2	C,H	61445126(+)	`CTCGGC/TGGGCC`	1	--	ut3¹		4	EU EA WA	384
	rs4809294^1,2	C,F	61448167(+)	`GGGGCG/AGTCGG`	1	--	ut3¹ ese³		5	NS	180
--	rs41283006^1,2	C,F	61447364(+)	`GAGGCT/CGTGCT`	1	--	ut3¹		5	NS	190

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HapMap Linkage Disequilibrium images for CHRNA4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118504 disorders: 600513 188890

UniProtKB/Swiss-Prot: ACHA4_HUMAN, P43681

Defects in CHRNA4 are the cause of nocturnal frontal lobe epilepsy type 1 (ENFL1)

[MIM:600513]; also symbolized ADNFLE. ENFL1 is an autosomal dominant epilepsy characterized by

nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements

10/19 Novoseek disease relationships for CHRNA4 gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
epilepsy frontal lobe	96.02	43	10939581 (2), 12887446 (2), 19058950 (2), 10448807 (2) (see all 29)
familial benign neonatal convulsions	92.70	10	12204289 (1), 11888238 (1), 7647781 (1), 8833159 (1) (see all 9)
myoclonic epilepsy juvenile	81.22	2	17008177 (1), 9259383 (1)
childhood absence epilepsy	76.31	2	17008177 (1), 9259383 (1)
seizures febrile	74.36	6	12887442 (2), 10896263 (1), 17008177 (1), 11579435 (1) (see all 5)
epilepsy generalized	72.61	4	16049035 (1), 16278970 (1), 17008177 (1), 11579435 (1)
epilepsies partial	69.38	6	10446744 (1), 9758605 (1), 11121188 (1), 9259383 (1) (see all 5)
epilepsy	68.88	17	9921897 (2), 9216991 (2), 9259280 (1), 16049035 (1) (see all 14)
epilepsy, idiopathic generalized	62.43	2	9259383 (2)
epilepsies myoclonic	60.85	1	17008177 (1)

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1 PharmGKB disease relationship for CHRNA4 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Lung Neoplasms	FA	12511591

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GeneTests: CHRNA4

Nocturnal Frontal Lobe Epilepsy

Human Gene Mutation Database: CHRNA4
Genetic Association Database: CHRNA4
Human Genome Epidemiology Navigator: CHRNA4 (40 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/155 PubMed articles for CHRNA4 gene (see all 155 ):

Association of the neuronal nicotinic acetylcholine receptor subunit alpha4 polymorphisms with febrile convulsions. (PubMed id 12887442)^{1, 3, 6} Chou I.C....Tsai F.J. (2003)
Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4). (PubMed id 8833159)^{1, 3, 4} Steinlein O.K.... Propping P. (1996)
Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. (PubMed id 15902904)^{1, 3, 6} Kim S.A....Chung J.H. (2004)
A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy. (PubMed id 10563623)^{1, 3, 4} Hirose S.... Mitsudome A. (1999)
A missense mutation in the neuronal nicotinic acetylcholine receptor alpha-4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. (PubMed id 7550350)^{1, 3, 4} Steinlein O.K.... Berkovic S.F. (1995)
Lack of an association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. (PubMed id 16205844)^{1, 3, 6} Haider M.Z....Al-Bloushi M. (2005)
Nicotinic acetylcholine receptor alpha4 subunit gene polymorphism and attention deficit hyperactivity disorder. (PubMed id 11409698)^{1, 3, 6} Kent L....Craddock N. (2001)
A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation. (PubMed id 14623738)^{1, 3, 4} Cho Y.-W.... Steinlein O.K. (2003)
Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. (PubMed id 12214130)^{1, 3, 6} Kawamata J. and Shimohama S. (2002)
Support for association between ADHD and two candidate genes: NET1 and DRD1. (PubMed id 15717291)^{3, 6} Bobb A.J....Rapoport J.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1137	HGNC: 1958	AceView: CHRNA4	Ensembl:ENSG00000101204	euGenes: HUgn1137
ECgene: CHRNA4	H-InvDB: CHRNA4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=CHRNA4
NIEHS-SNPs	http://egp.gs.washington.edu/data/chrna4/

Licensable Technologies for CHRNA4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CHRNA4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CHRNA4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CHRNA4		Antibodies for CHRNA4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CHRNA4		Small molecules for CHRNA4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CHRNA4)
	Antibodies (CHRNA4)
	Chimera RNAi (CHRNA4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Nicotinic Acetylcholine Receptor alpha 4)
	Antibodies (Nicotinic Acetylcholine Receptor alpha 4)

Search OriGene for CHRNA4

Tocris compounds for CHRNA4

	Drugs for CHRNA4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CHRNA4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CHRNA4 Gene at Home site.
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CHRNA4 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for CHRNA4

Summaries
for CHRNA4

Genomic Location
for CHRNA4

Proteins
for CHRNA4

Protein Domains/
Families
for CHRNA4

Gene Function
for CHRNA4

Pathways & Interactions
for CHRNA4

Drugs & Compounds
for CHRNA4

Transcripts
for CHRNA4

Expression
for CHRNA4

Orthologs
for CHRNA4

Paralogs
for CHRNA4

SNPs/Variants
for CHRNA4

Disorders & Mutations
for CHRNA4

Medical News
for CHRNA4

Publications
for CHRNA4

Search for CHRNA4

Genome Databases showing CHRNA4

Other Databases showing CHRNA4

Specialized Databases showing CHRNA4

Licensable Technologies
for CHRNA4

Services
for CHRNA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CHRNA4 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor CHRNA4

Summariesfor CHRNA4

Genomic Locationfor CHRNA4

Proteinsfor CHRNA4

Protein Domains/Familiesfor CHRNA4

Gene Functionfor CHRNA4

Pathways & Interactionsfor CHRNA4

Drugs & Compoundsfor CHRNA4

Transcriptsfor CHRNA4

Expression for CHRNA4

Orthologsfor CHRNA4

Paralogsfor CHRNA4

SNPs/Variantsfor CHRNA4

Disorders & Mutationsfor CHRNA4

Medical Newsfor CHRNA4

Publicationsfor CHRNA4

Search for CHRNA4

Genome Databases showing CHRNA4

Other Databases showing CHRNA4

Specialized Databases showing CHRNA4

Licensable Technologiesfor CHRNA4

Servicesfor CHRNA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CHRNA4

Summaries
for CHRNA4

Genomic Location
for CHRNA4

Proteins
for CHRNA4

Protein Domains/
Families
for CHRNA4

Gene Function
for CHRNA4

Pathways & Interactions
for CHRNA4

Drugs & Compounds
for CHRNA4

Transcripts
for CHRNA4

Expression
for CHRNA4

Orthologs
for CHRNA4

Paralogs
for CHRNA4

SNPs/Variants
for CHRNA4

Disorders & Mutations
for CHRNA4

Medical News
for CHRNA4

Publications
for CHRNA4

Licensable Technologies
for CHRNA4

Services
for CHRNA4