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CHRM3 Gene

protein-coding GIFtS: 66

GC01P237858

cholinergic receptor, muscarinic 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HM3 ^²

Descriptions
cholinergic receptor, muscarinic 3 ^²
m3 muscarinic receptor ^²
muscarinic acetylcholine receptor M3 ^²

External Ids
HGNC: 1952¹
Entrez Gene: 1131²
UniProtKB: P20309³
Ensembl: ENSG00000133019⁷

Search outside databases for aliases for CHRM3 gene

Previous GC identifers: GC01P238144 GC01P235523 GC01P235846 GC01P237111 GC01P236396

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CHRM3:

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The

functional diversity of these receptors is defined by the binding of acetylcholine and includes

cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and

potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the

central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth

muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACM3_HUMAN, P20309

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including

inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium

channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Wiki entry for CHRM3 (Muscarinic_acetylcholine_receptor_M3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CHRM3 gene

Entrez Gene cytogenetic band: 1q43 Ensembl cytogenetic band: 1q43 HGNC cytogenetic band: 1q41-q44

CHRM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P237858: (about GC identifiers)

Start:	237,858,996 bp from pter
End:	238,139,343 bp from pter
Size:	280,348 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004836.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ACM3_HUMAN, P20309 (See protein sequence)

Recommended Name: Muscarinic acetylcholine receptor M3

Size: 590 amino acids; 66128 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse,

postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass

membrane protein

PDB structures from and Proteopedia :

2CSA (3D)

Secondary accessions: Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60

REFSEQ proteins: NP_000731.1

ENSEMBL proteins:

ENSP00000255380

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CHRM3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Muscarinic Acetylcholine Receptor M3)
	Human Recombinant Proteins from Abnova (CHRM3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9547368
GO:0005887	integral to plasma membrane	TAS	3443095
GO:0016323	basolateral plasma membrane	IEA	--
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--

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Antibodies for CHRM3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CHRM3
	Sigma-Aldrich Antibodies for CHRM3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Muscarinic Acetylcholine Receptor M3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CHRM3)
	Novus Biologicals Antibodies for CHRM3

Assays for CHRM3:

	Invitrogen Assays for CHRM3
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20309

ProtoNet protein and cluster: P20309

2 Blocks protein families:

IPB000995 Muscarinic acetylcholine receptor signature

IPB001183 Muscarinic M3 receptor signature

UniProtKB/Swiss-Prot: ACM3_HUMAN, P20309

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRM3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRM3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000740

Applied Biosystems Silencer® siRNAs for CHRM3

Sigma-Aldrich siRNA and siRNA Panels for CHRM3

Sigma-Aldrich shRNA Panels and shRNA for CHRM3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of CHRM3

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000740
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000740
untagged cDNA clone in CMV expression vector: NM_000740

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000740

UniProtKB/Swiss-Prot: ACM3_HUMAN, P20309

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including

inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium

channels through the action of G proteins. Primary transducing effect is Pi turnover

Genatlas biochemistry entry for CHRM3:

cholinergic receptor,muscarinic 3,G protein coupled receptor superfamily

11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Chrm3):

	adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	muscle	nervous system	renal/urinary system
vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphoinositide phospholipase C activity	TAS	1905013
GO:0004872	receptor activity	TAS	10940357
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004981	muscarinic acetylcholine receptor activity	TAS	9547368

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CHRM3 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling

GeneDecks CHRM3 for the pathways selected above

About GeneDecksing

1 Interacting protein for CHRM3 (P20309²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
PPP1R9B Q96SB3² MINT-4953558
About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 protein modification process TAS 10051746
GO:0007165 signal transduction TAS 10940357
GO:0007186 G-protein coupled receptor protein signaling pathway TAS 9603968
GO:0007399 nervous system development TAS 2739737
GO:0007586 digestion IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CHRM3

Sigma-Aldrich Small Molecules for CHRM3:

Antagonist Agonist Inhibitor Ligand

Compounds for CHRM3 available from Tocris Bioscience

Compound	Action	CAS number
Oxotremorine sesquifumarate	Muscarinic agonist	[17360-35-9]
J 104129 fumarate	Potent, selective M3 antagonist	[244277-89-2]
Zamifenacin fumarate	Selective M3 antagonist	[127308-98-9]
DAU 5884 hydrochloride	M3 receptor antagonist	[131780-47-7]
4-DAMP	Muscarinic M3 antagonist	[1952-15-4]

About this table

10/19 Novoseek chemical compound relationships for CHRM3 gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zamifenacin	84.77	2	10188786 (1), 10580922 (1)
5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one	82.27	1	9214706 (1)
phosphoinositide	71.16	10	1343598 (1), 8832588 (1), 2154728 (1), 15383626 (1) (see all 10)
inositol 1,4,5 trisphosphate	55.55	8	8383801 (1), 1731321 (1), 7575458 (1), 8401943 (1) (see all 6)
calcium	51.51	54	1731321 (3), 1319463 (3), 15068397 (2), 8383801 (2) (see all 37)
phosphatidylinositol	39.16	2	8752132 (1)
gtp	38.75	2	9309207 (1), 14630933 (1)
cyclic amp	36.68	2	11877431 (1), 1657623 (1)
tyrosine	21.43	11	9636140 (3), 7713942 (2), 7957182 (1), 10816433 (1) (see all 7)
phorbol 12,13-dibutyrate	15.77	1	8977143 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRM3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRM3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000740

Sigma-Aldrich siRNA and siRNA Panels for CHRM3

Sigma-Aldrich shRNA Panels and shRNA for CHRM3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000740

REFSEQ mRNAs for CHRM3 gene:

NM_000740.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000740

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000740
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000740
                                 untagged cDNA clone in CMV expression vector: NM_000740

Additional cDNA sequence:

AF279779.1 AF385589.1 AF498917.1 AK056349.1 AK074575.1 BC096844.1 BC121026.2 BC121027.2

7 DOTS entries:

DT.309020 DT.70102224 DT.121429975 DT.100019144 DT.100672701 DT.95339810 DT.99982637

24/32 AceView cDNA sequences (see all 32 ):

CA390548 AW611918 NM_000740 AF498917 BM128615 AK074575 CA395561 BM462969

BM128379 T28795 BF311874 BF966880 AF279779 CA394725 AF385589 T23501

BP360731 BI196876 CB565880 CD654050 AK056349 CB528690 BP370844 AA349743

highest scoring ESTs for CHRM3:

AA349743 AF279779 AF385589 AF498917 AK074575 AW950854 BE933387 BF311874 BG190770 BG978953

Unigene Cluster for CHRM3:

Cholinergic receptor, muscarinic 3

Hs.7138 [show with all ESTs]

Unigene Representative Sequence: NM_000740

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000255380

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CHRM3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CHRM3

¹ / ² / ³

5 probe-sets matching CHRM3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36759_at*²^{, 3}	U95-A	1	--	--	1.00	1.00	U29589	0.20	1.00	0.72	1
1559634_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1564339_a_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
1559633_a_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
1553705_a_at²	U133Plus2	2	0.64	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTCTGGTGA

SOURCE GeneReport for Unigene cluster: Hs.7138
Expression variation in blood from EXPOLDB for CHRM3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CHRM3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CHRM3¹	--	cholinergic receptor, muscarinic 3	88.34(n) 92.7(a)	403827 XM_546069.2 XP_546069.2
chimpanzee (Pan troglodytes)	CHRM3¹	--	cholinergic receptor, muscarinic 3	99.49(n) 99.66(a)	469725 XM_001159461.1 XP_001159461.1
cow (Bos taurus)	CHRM3¹	--	cholinergic receptor, muscarinic 3	90.51(n) 94.92(a)	281685 NM_174270.2 NP_776695.1
rat (Rattus norvegicus)	Chrm3¹	--	cholinergic receptor, muscarinic 3	87.55(n) 91.68(a)	24260 NM_012527.1 NP_036659.1
mouse (Mus musculus)	Chrm3^{1, 5}	13 (7.00 cM)⁵	cholinergic receptor, muscarinic 3, cardiac^{1, 5}	87.04(n)¹ 91.85(a)¹	12671¹ NM_033269.3¹ NP_150372.1¹ AF264050⁵ AI851832⁵ (see all 9)

About this table Species with no ortholog for CHRM3

ENSEMBL Gene Tree for CHRM3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CHRM3 gene

CHRM5² CHRM2² CHRM1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1678 NCBI SNPs in CHRM3 are shown (see all 1678 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 542)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2067481^1,2	C,F,H	238137567(+)	`ATACCG/ATCTGG`	1	I/V	mis¹ ese³		8		EU EA WA	840
--	rs10802782^1,2	A,C	237859298(+)	`tgcgcA/Gcacac`	1	--	ut5¹		0	--	--	--	--
	rs16839102^1,2	C,H	238138666(+)	`CCAGCT/CAGAGT`	1	P/L	mis¹		7		NA EU EA WA	554
	rs6699221^1,2	F,H	237908182(+)	`ACATTG/ATATTG`	1	--	ut5¹		4		EU EA WA	414
--	rs10925932^1,2	A	237859325(+)	`tgtctA/Ggcact`	1	--	ut5¹ ese³		0	--	--	--	--
	rs1431719^1,2	A,C,F,H,O	237947826(+)	`TTTATA/GGAGAG`	1	--	int¹		11		NA EU EA WA	980
	rs717227^1,2	A,C,F,H,O	237949222(+)	`TATACC/TTGTCC`	1	--	int¹		16		NA EA NS EU WA	1030
	rs2120241^1,2	A,C,F,H,O	237875114(+)	`GGCACA/TGCACC`	1	--	int¹		7		EU EA WA NA	560
	rs726168^1,2	A,C,F,H,O	237860987(-)	`TATCCC/TTTCTT`	1	--	int¹ trp³		5		MN EU EA WA	602
--	rs479933^1,2	A,C,F,H,O	237996528(-)	`CTGTGG/AACTTC`	1	--	int¹		11		EU EA WA NA	980

About this table

HapMap Linkage Disequilibrium images for CHRM3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118494

10/14 Novoseek disease relationships for CHRM3 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
overactive bladder	68.60	8	15839920 (2), 16100298 (2), 15493952 (1), 16096831 (1) (see all 6)
xerostomia	60.54	3	17899308 (1), 12974516 (1), 17914991 (1)
sjogrens syndrome	58.09	4	15866705 (1), 16014696 (1), 11850533 (1), 15030576 (1)
sjogrens syndrome primary	56.28	5	9099930 (1), 9430556 (1), 15353609 (1), 11850533 (1) (see all 5)
astrocytoma	47.34	2	7935319 (1), 16280122 (1)
pulmonary disease chronic obstructive	33.34	1	10069502 (1)
leukemia basophilic	26.97	2	7557261 (1), 15467192 (1)
lung diseases obstructive	15.79	1	16870658 (1)
colon cancer	13.70	9	12379313 (2), 14583469 (2), 18653726 (1), 19221016 (1) (see all 5)
asthma	12.82	2	12642833 (2)

About this table

Human Gene Mutation Database: CHRM3
Genetic Association Database: CHRM3
Human Genome Epidemiology Navigator: CHRM3 (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/251 PubMed articles for CHRM3 gene (see all 251 ):

Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy. (PubMed id 12642833)^{1, 3, 6} Donfack J....Ober C. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal. (PubMed id 15870063)^{3, 4} Iverson H.A.... Nathanson N.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Mutation screening of the muscarinic m2 and m3 receptor genes in asthmatics, outgrow subjects, and normal controls. (PubMed id 12381439)^{3, 6} Yamamoto T....Ohta K. (2002)
Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. (PubMed id 11238933)^{3, 4} Speek M. (2001)
Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. (PubMed id 3272174)^{3, 4} Bonner T.I.... Buckley N.J. (1988)
Distinct primary structures, ligand-binding properties and tissue- specific expression of four human muscarinic acetylcholine receptors. (PubMed id 3443095)^{3, 4} Peralta E.G....Capon D.J. (1987)
Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor. (PubMed id 7629074)^{1, 3} Blin N....Wess J. (1995)
Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. (PubMed id 18272392)^{1, 3} Gomez-Ramos A....Avila J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1131	HGNC: 1952	AceView: CHRM3	Ensembl:ENSG00000133019	euGenes: HUgn1131
ECgene: CHRM3	H-InvDB: CHRM3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CHRM3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CHRM3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CHRM3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CHRM3		Antibodies for CHRM3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CHRM3		Small molecules for CHRM3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CHRM3)
	Antibodies (CHRM3)
	Chimera RNAi (CHRM3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Muscarinic Acetylcholine Receptor M3)
	Antibodies (Muscarinic Acetylcholine Receptor M3)

Search OriGene for CHRM3

Tocris compounds for CHRM3

	Drugs for CHRM3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CHRM3

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CHRM3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CHRM3

Summaries
for CHRM3

Genomic Location
for CHRM3

Proteins
for CHRM3

Protein Domains/
Families
for CHRM3

Gene Function
for CHRM3

Pathways & Interactions
for CHRM3

Drugs & Compounds
for CHRM3

Transcripts
for CHRM3

Expression
for CHRM3

Orthologs
for CHRM3

Paralogs
for CHRM3

SNPs/Variants
for CHRM3

Disorders & Mutations
for CHRM3

Medical News
for CHRM3

Publications
for CHRM3

Search for CHRM3

Genome Databases showing CHRM3

Other Databases showing CHRM3

Specialized Databases showing CHRM3

Licensable Technologies
for CHRM3

Services
for CHRM3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CHRM3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CHRM3

Summariesfor CHRM3

Genomic Locationfor CHRM3

Proteinsfor CHRM3

Protein Domains/Familiesfor CHRM3

Gene Functionfor CHRM3

Pathways & Interactionsfor CHRM3

Drugs & Compoundsfor CHRM3

Transcriptsfor CHRM3

Expression for CHRM3

Orthologsfor CHRM3

Paralogsfor CHRM3

SNPs/Variantsfor CHRM3

Disorders & Mutationsfor CHRM3

Medical Newsfor CHRM3

Publicationsfor CHRM3

Search for CHRM3

Genome Databases showing CHRM3

Other Databases showing CHRM3

Specialized Databases showing CHRM3

Licensable Technologiesfor CHRM3

Servicesfor CHRM3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CHRM3

Summaries
for CHRM3

Genomic Location
for CHRM3

Proteins
for CHRM3

Protein Domains/
Families
for CHRM3

Gene Function
for CHRM3

Pathways & Interactions
for CHRM3

Drugs & Compounds
for CHRM3

Transcripts
for CHRM3

Expression
for CHRM3

Orthologs
for CHRM3

Paralogs
for CHRM3

SNPs/Variants
for CHRM3

Disorders & Mutations
for CHRM3

Medical News
for CHRM3

Publications
for CHRM3

Licensable Technologies
for CHRM3

Services
for CHRM3