V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CHRM1 Gene

protein-coding GIFtS: 63

GC11M062432

cholinergic receptor, muscarinic 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HM1 ^²
M1 ^²
MGC30125 ^²

Descriptions
cholinergic receptor, muscarinic 1 ^²
muscarinic acetylcholine receptor M1 ^²

External Ids
HGNC: 1950¹
Entrez Gene: 1128²
UniProtKB: P11229³
Ensembl: ENSG00000168539⁷

Search outside databases for aliases for CHRM1 gene

Previous GC identifers: GC11M065188 GC11M064251 GC11M062927 GC11M062452 GC11M062453

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CHRM1:

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The

functional diversity of these receptors is defined by the binding of acetylcholine and includes

cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and

potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the

central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in

mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal

tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including

inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium

channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Wiki entry for CHRM1 (Muscarinic_acetylcholine_receptor_M1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CHRM1 gene

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12-q13

CHRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M062432: (about GC identifiers)

Start:	62,432,727 bp from pter
End:	62,445,588 bp from pter
Size:	12,862 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229 (See protein sequence)

Recommended Name: Muscarinic acetylcholine receptor M1

Size: 460 amino acids; 51421 Da

Subunit: Interacts with GPRASP2

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse,

postsynaptic cell membrane; Multi-pass membrane protein

REFSEQ proteins: NP_000729.2

ENSEMBL proteins:

ENSP00000306490

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CHRM1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Muscarinic Acetylcholine Receptor 1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	7925360
GO:0005886	plasma membrane	TAS	7925360
GO:0005887	integral to plasma membrane	TAS	8508928
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--

About this table

Antibodies for CHRM1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CHRM1
	Sigma-Aldrich Antibodies for CHRM1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Muscarinic Acetylcholine Receptor 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CHRM1)
	Novus Biologicals Antibody for CHRM1

Assays for CHRM1:

	Invitrogen Assays for CHRM1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11229

ProtoNet protein and cluster: P11229

2 Blocks protein families:

IPB000995 Muscarinic acetylcholine receptor signature

IPB002228 Muscarinic M1 receptor signature

UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000738

Applied Biosystems Silencer® siRNAs for CHRM1

Sigma-Aldrich siRNA and siRNA Panels for CHRM1

Sigma-Aldrich shRNA Panels and shRNA for CHRM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CHRM1
		Millipore Clones for the Expression of CHRM1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000738
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000738
untagged cDNA clones in CMV expression vector (see all 2): BC007740

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC007740

UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including

inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium

channels through the action of G proteins. Primary transducing effect is Pi turnover

Genatlas biochemistry entry for CHRM1:

cholinergic receptor,muscarinic 1,G protein coupled receptor superfamily

5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Chrm1):

behavior/neurological

digestive/alimentary

endocrine/exocrine gland

hearing/vestibular/ear

nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphoinositide phospholipase C activity	TAS	9614217
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004981	muscarinic acetylcholine receptor activity	TAS	9614217

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for CHRM1 (Your Favorite Gene powered by Ingenuity)

Nitric Oxide Signaling in the Cardiovascular System
G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling

GeneDecks CHRM1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CHRM1

5/72 Interacting proteins for CHRM1 (ENSP00000306490³) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAQ	ENSP00000286548³	STRING (score=.97)
PRKCA	ENSP00000284384³	STRING (score=.953)
PRKCB	ENSP00000305355³	STRING (score=.953)
ADCY2	ENSP00000371971³	STRING (score=.952)
NMS	ENSP00000366061³	STRING (score=.951)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	TAS	1411529
GO:0007165	signal transduction	TAS	3443095 9614217
GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	TAS	9603968
GO:0007207	activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway	TAS	8139539
GO:0007274	neuromuscular synaptic transmission	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CHRM1

Sigma-Aldrich Small Molecules for CHRM1:

Antagonist Agonist Inhibitor Ligand

Compounds for CHRM1 available from Tocris Bioscience

Compound	Action	CAS number
McN-A 343	Selective M1 muscarinic agonist	[55-45-8]
Xanomeline oxalate	Functionally selective M1 agonist	[141064-23-5]
Oxotremorine sesquifumarate	Muscarinic agonist	[17360-35-9]
Telenzepine dihydrochloride	Potent selective M1 antagonist	[147416-96-4]
Pirenzepine dihydrochloride	Selective M1 muscarinic antagonist	[28797-61-7]

About this table

10/17 Novoseek chemical compound relationships for CHRM1 gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iqnp	82.98	3	7562924 (2)
brucine	67.09	2	9224827 (2)
phosphoinositide	56.18	7	8666061 (3), 9566019 (1), 1720757 (1), 7713942 (1)
tyrosine	33.44	12	9878055 (2), 12200418 (2), 8606776 (2), 9636140 (1) (see all 9)
phosphatidylinositol	28.47	7	1980618 (3), 8196770 (1), 8226735 (1), 11504829 (1) (see all 5)
pip2	27.66	1	8380916 (1)
inositol 1,4,5 trisphosphate	25.22	2	8906560 (1), 10413035 (1)
calcium	21.28	9	8978936 (2), 7761266 (1), 1980618 (1), 8097328 (1) (see all 6)
bacteriorhodopsin	18.60	1	1663559 (1)
potassium	7.55	2	10188799 (1), 11060307 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHRM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHRM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000738

Sigma-Aldrich siRNA and siRNA Panels for CHRM1

Sigma-Aldrich shRNA Panels and shRNA for CHRM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000738

REFSEQ mRNAs for CHRM1 gene:

NM_000738.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000738

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000738
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000738
                                 untagged cDNA clones in CMV expression vector (see all 2): BC007740

Additional cDNA sequence:

AF385587.1 AF498915.1 AJ006520.1 AK312374.1 BC007740.2 BC022984.1 BT007166.1 XM_001715920.1

4 DOTS entries:

DT.40120991 DT.99947477 DT.97774125 DT.95265990

24/47 AceView cDNA sequences (see all 47 ):

BX424634 AF498915 BI757352 BI755888 BX280318 CB154035 CB154895 NM_000738

AL536991 CD671895 BC022984 BC007740 BM674438 AL537084 BX643235 BI913662

BI197683 AJ006520 CB153700 BM548382 AI202576 BM717057 BF312407 AI685922

highest scoring ESTs for CHRM1:

AJ006520 AL537084 BC007740 BC022984 BF315022 BG820557 BI755888 BI757352 BI913560 BI913662

Unigene Cluster for CHRM1:

Cholinergic receptor, muscarinic 1

Hs.632119 [show with all ESTs]

Unigene Representative Sequence: NM_000738

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000306960

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CHRM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CHRM1

¹ / ² / ³

3 probe-sets matching CHRM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
80873_at²^{, 3}	U95-E	1	0.94	1.00	1.00	1.00	H19732	0.80	1.00	0.91	1
231783_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI500293	0.60	1.00	0.82	1
231783_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CHRM1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCTCCCAGC

SOURCE GeneReport for Unigene cluster: Hs.632119

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CHRM1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CHRM1¹	--	cholinergic receptor, muscarinic 1	92.39(n) 98.04(a)	483776 XM_540897.2 XP_540897.2
chimpanzee (Pan troglodytes)	CHRM1¹	--	cholinergic receptor, muscarinic 1	99.86(n) 100(a)	451272 XM_001159938.1 XP_001159938.1
cow (Bos taurus)	CHRM1¹	--	cholinergic receptor, muscarinic 1	93.3(n) 98.85(a)	281684 XM_001255657.1 XP_001255658.1
rat (Rattus norvegicus)	Chrm1¹	--	cholinergic receptor, muscarinic 1	91.59(n) 98.7(a)	25229 NM_080773.1 NP_542951.1
mouse (Mus musculus)	Chrm1^{1, 5}	19⁵	cholinergic receptor, muscarinic 1, CNS^{1, 5}	91.38(n)¹ 98.91(a)¹	12669¹ NM_007698.2¹ NP_031724.2¹ AJ006521⁵ AK081248⁵ (see all 11)

About this table Species with no ortholog for CHRM1

ENSEMBL Gene Tree for CHRM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CHRM1 gene

CHRM5² CHRM2² CHRM3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/46 NCBI SNPs in CHRM1 are shown (see all 46 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 40)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11823728^1,2	C,F,H	62433378(+)	`CACACC/TGCAAT`	1	--	ut3¹ ese³		4		EU EA WA	406
	rs17157628^1,2	C,F,H	62432263(+)	`TTTTGA/GCCTAA`	1	--	ng5¹		12		NA EU EA WA	1024
	rs5026237^1,2	A	62433764(+)	`GGGACC/TATCAG`	1	--	ut3¹		0	--	--	--	--
--	rs2067477^1,2	C,F,H	62434882(-)	`ATGGGC/ACACTG`	1	G/G	syn¹ ese³		6		EU EA WA MN	1926
	rs2067478^1,2	C,F,H	62434105(-)	`GAGCAG/ACTGGC`	1	Q/Q	syn¹ ese³		4		MN EU EA	346
	rs2067479^1,2	C,F,H	62433928(-)	`CTGTGC/TTACGT`	1	C/C	syn¹		4		EU EA WA	420
	rs544978^1,2	C,F,H,O	62441806(+)	`TAATAA/CTATCA`	1	--	int¹		13		MN EU EA WA NA	1238
--	rs1942499^1,2	A,C,H	62440101(-)	`gcaggC/Tggatc`	1	--	int¹		4		EU EA WA	418
	rs12272560^1,2	F,H	62441353(+)	`GGAGGG/AACTTA`	1	--	int¹ trp³		4		EU EA WA	420
	rs12362741^1,2	A,H	62437848(+)	`ATAATC/TTTATT`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for CHRM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118510

10/14 Novoseek disease relationships for CHRM1 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	48.43	8	7816331 (3), 9109749 (1), 9869334 (1), 11718746 (1) (see all 5)
cognitive disorder	42.14	2	16879488 (1)
congenital heart block	41.69	4	11247640 (2), 10402042 (2)
schizophrenia	22.33	8	10822350 (2), 11384900 (2), 11153542 (1), 18033152 (1)
lung diseases obstructive	21.97	1	9121347 (1)
overactive bladder	20.85	2	16879488 (1)
dementia	18.25	3	15059034 (2), 11718746 (1)
neurodegenerative diseases	9.34	2	15059034 (1)
glioma	3.14	1	8084514 (1)
pulmonary disease chronic obstructive	0.00	2	16879488 (1)

About this table

Genetic Association Database: CHRM1
Human Genome Epidemiology Navigator: CHRM1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/192 PubMed articles for CHRM1 gene (see all 192 ):

Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. (PubMed id 15383745)^{3, 6} Liu H.C....Tsai S.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PubMed id 15086532)^{3, 4} Simonin F....Kieffer B.L. (2004)
Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients. (PubMed id 14504414)^{3, 6} Liao D.L....Tsai S.J. (2003)
Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor. (PubMed id 1445347)^{3, 4} Arden J.R.... Sadee W. (1992)
Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification. (PubMed id 2336407)^{3, 4} Chapman C.G. and Browne M.J. (1990)
Distinct primary structures, ligand-binding properties and tissue- specific expression of four human muscarinic acetylcholine receptors. (PubMed id 3443095)^{3, 4} Peralta E.G....Capon D.J. (1987)
Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor. (PubMed id 3697105)^{3, 4} Allard W.J.... Dixon R.A.F. (1987)
The presence of m1 to m5 receptors in human sclera: evidence of the sclera as a potential site of action for muscarinic receptor antagonists. (PubMed id 16877267)^{1, 3} Qu J....Lu F. (2006)
Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (PubMed id 16874522)^{1, 3} Lou X.Y....Li M.D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1128	HGNC: 1950	AceView: CHRM1	Ensembl:ENSG00000168539	euGenes: HUgn1128
ECgene: CHRM1	H-InvDB: CHRM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CHRM1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CHRM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CHRM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CHRM1		Antibodies for CHRM1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CHRM1		Small molecules for CHRM1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (CHRM1)
	Chimera RNAi (CHRM1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Muscarinic Acetylcholine Receptor 1)
	Antibodies (Muscarinic Acetylcholine Receptor 1)

Search OriGene for CHRM1

Tocris compounds for CHRM1

	Drugs for CHRM1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CHRM1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CHRM1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CHRM1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for CHRM1

Summaries
for CHRM1

Genomic Location
for CHRM1

Proteins
for CHRM1

Protein Domains/
Families
for CHRM1

Gene Function
for CHRM1

Pathways & Interactions
for CHRM1

Drugs & Compounds
for CHRM1

Transcripts
for CHRM1

Expression
for CHRM1

Orthologs
for CHRM1

Paralogs
for CHRM1

SNPs/Variants
for CHRM1

Disorders & Mutations
for CHRM1

Medical News
for CHRM1

Publications
for CHRM1

Search for CHRM1

Genome Databases showing CHRM1

Other Databases showing CHRM1

Specialized Databases showing CHRM1

Licensable Technologies
for CHRM1

Services
for CHRM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CHRM1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor CHRM1

Summariesfor CHRM1

Genomic Locationfor CHRM1

Proteinsfor CHRM1

Protein Domains/Familiesfor CHRM1

Gene Functionfor CHRM1

Pathways & Interactionsfor CHRM1

Drugs & Compoundsfor CHRM1

Transcriptsfor CHRM1

Expression for CHRM1

Orthologsfor CHRM1

Paralogsfor CHRM1

SNPs/Variantsfor CHRM1

Disorders & Mutationsfor CHRM1

Medical Newsfor CHRM1

Publicationsfor CHRM1

Search for CHRM1

Genome Databases showing CHRM1

Other Databases showing CHRM1

Specialized Databases showing CHRM1

Licensable Technologiesfor CHRM1

Servicesfor CHRM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CHRM1

Summaries
for CHRM1

Genomic Location
for CHRM1

Proteins
for CHRM1

Protein Domains/
Families
for CHRM1

Gene Function
for CHRM1

Pathways & Interactions
for CHRM1

Drugs & Compounds
for CHRM1

Transcripts
for CHRM1

Expression
for CHRM1

Orthologs
for CHRM1

Paralogs
for CHRM1

SNPs/Variants
for CHRM1

Disorders & Mutations
for CHRM1

Medical News
for CHRM1

Publications
for CHRM1

Licensable Technologies
for CHRM1

Services
for CHRM1