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Aliases for CHIA Gene

Aliases for CHIA Gene

  • Chitinase, Acidic 2 3
  • Lung-Specific Protein TSA1902 3 4
  • EC 3.2.1.14 4 64
  • TSA1902 3 6
  • AMCASE 3 4
  • CHIT2 3 6
  • Acidic Mammalian Chitinase 3

External Ids for CHIA Gene

Summaries for CHIA Gene

Entrez Gene Summary for CHIA Gene

  • The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for CHIA Gene

CHIA (Chitinase, Acidic) is a Protein Coding gene. Diseases associated with CHIA include asthma and neuromyelitis optica. Among its related pathways are Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include carbohydrate binding and lysozyme activity. An important paralog of this gene is CHI3L2.

UniProtKB/Swiss-Prot for CHIA Gene

  • Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHIA Gene

Genomics for CHIA Gene

Genomic Location for CHIA Gene

Start:
111,290,852 bp from pter
End:
111,320,566 bp from pter
Size:
29,715 bases
Orientation:
Plus strand

Genomic View for CHIA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHIA Gene

Regulatory Elements for CHIA Gene

Proteins for CHIA Gene

  • Protein details for CHIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZP6-CHIA_HUMAN
    Recommended name:
    Acidic mammalian chitinase
    Protein Accession:
    Q9BZP6
    Secondary Accessions:
    • Q32W79
    • Q32W80
    • Q3B866
    • Q5U5Z5
    • Q5VUV4
    • Q86UD8
    • Q9ULY3
    • Q9ULY4

    Protein attributes for CHIA Gene

    Size:
    476 amino acids
    Molecular mass:
    52271 Da
    Quaternary structure:
    • Interacts with EGFR.

    Three dimensional structures from OCA and Proteopedia for CHIA Gene

    Alternative splice isoforms for CHIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHIA Gene

Proteomics data for CHIA Gene at MOPED

Selected DME Specific Peptides for CHIA Gene

Post-translational modifications for CHIA Gene

No Post-translational modifications

Domains for CHIA Gene

UniProtKB/Swiss-Prot:

CHIA_HUMAN
Domain:
  • Contains 1 chitin-binding type-2 domain.:
    • Q9BZP6
Family:
  • Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.:
    • Q9BZP6
genes like me logo Genes that share domains with CHIA: view

No data available for Gene Families for CHIA Gene

Function for CHIA Gene

Molecular function for CHIA Gene

UniProtKB/Swiss-Prot CatalyticActivity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
UniProtKB/Swiss-Prot Function: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
UniProtKB/Swiss-Prot Induction: Up-regulated in lung epithelial cells from asthma patients.

Enzyme Numbers (IUBMB) for CHIA Gene

Gene Ontology (GO) - Molecular Function for CHIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity NAS 11085997
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004568 chitinase activity NAS 10548734
GO:0008061 chitin binding TAS 11085997
GO:0019900 kinase binding IPI 18824549
genes like me logo Genes that share ontologies with CHIA: view
genes like me logo Genes that share phenotypes with CHIA: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHIA Gene

Localization for CHIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHIA Gene

Isoform 1: Secreted. Note=Secretion depends on EGFR activity.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHIA Gene COMPARTMENTS Subcellular localization image for CHIA gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 18824549
GO:0005737 cytoplasm NAS 10548734
genes like me logo Genes that share ontologies with CHIA: view

Pathways for CHIA Gene

genes like me logo Genes that share pathways with CHIA: view

Pathways by source for CHIA Gene

1 KEGG pathway for CHIA Gene

Interacting Proteins for CHIA Gene

Gene Ontology (GO) - Biological Process for CHIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000272 polysaccharide catabolic process IEA --
GO:0002532 production of molecular mediator involved in inflammatory response IDA 18824549
GO:0005975 carbohydrate metabolic process --
GO:0006030 chitin metabolic process NAS 10548734
GO:0006032 chitin catabolic process NAS 11085997
genes like me logo Genes that share ontologies with CHIA: view

Compounds for CHIA Gene

(3) HMDB Compounds for CHIA Gene

Compound Synonyms Cas Number PubMed IDs
Chitin
  • Poly 2-Acetamido-2-deoxy-D-glucose
1398-61-4
N-Acetyl-D-glucosamine
  • 2-(acetylamino)-2-deoxyhexose
7512-17-6
Water
  • Dihydrogen oxide
7732-18-5

(3) Novoseek inferred chemical compound relationships for CHIA Gene

Compound -log(P) Hits PubMed IDs
chitin 84.3 10
rantes 29.5 1
lipid 0 1
genes like me logo Genes that share compounds with CHIA: view

Transcripts for CHIA Gene

Unigene Clusters for CHIA Gene

Chitinase, acidic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHIA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3: - -
SP4: -

Relevant External Links for CHIA Gene

GeneLoc Exon Structure for
CHIA
ECgene alternative splicing isoforms for
CHIA

Expression for CHIA Gene

mRNA expression in normal human tissues for CHIA Gene

mRNA differential expression in normal tissues according to GTEx for CHIA Gene

This gene is overexpressed in Stomach (50.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHIA Gene

SOURCE GeneReport for Unigene cluster for CHIA Gene Hs.128814

mRNA Expression by UniProt/SwissProt for CHIA Gene

Q9BZP6-CHIA_HUMAN
Tissue specificity: Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.
genes like me logo Genes that share expressions with CHIA: view

Orthologs for CHIA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHIA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHIA 36
  • 84.39 (n)
  • 80.51 (a)
CHIA 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHIA 36
  • 88.73 (n)
  • 88.45 (a)
CHIA 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC051070 37
  • 59 (a)
OneToMany
Chi3l3 37
  • 68 (a)
OneToMany
Chi3l4 37
  • 66 (a)
OneToMany
Chi3l7 37
  • 61 (a)
OneToMany
Chia 16
Chia 37
  • 82 (a)
OneToMany
Chia1 36
  • 84.18 (n)
  • 81.57 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Chia 36
  • 83.47 (n)
  • 82.84 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 72 (a)
OneToMany
CHIA 36
  • 75.07 (n)
  • 74.16 (a)
CHIA 37
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 78 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chia 36
  • 73.89 (n)
  • 79.58 (a)
Str.8480 36
zebrafish
(Danio rerio)
Actinopterygii zgc:173927 36
  • 60.38 (n)
  • 55.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cht7 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cht-1 37
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTS2 37
  • 21 (a)
OneToMany
CTS2 39
bread mold
(Neurospora crassa)
Ascomycetes NCU03209 36
  • 47.18 (n)
  • 32.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8046 37
  • 27 (a)
OneToMany
Species with no ortholog for CHIA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHIA Gene

ENSEMBL:
Gene Tree for CHIA (if available)
TreeFam:
Gene Tree for CHIA (if available)

Paralogs for CHIA Gene

Paralogs for CHIA Gene

Selected SIMAP similar genes for CHIA Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CHIA Gene

genes like me logo Genes that share paralogs with CHIA: view

Variants for CHIA Gene

Sequence variations from dbSNP and Humsavar for CHIA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1541156 -- 111,316,065(+) CTGGG(G/T)CAGGA intron-variant
rs2256721 -, - 111,320,330(+) TGCTG(G/T)CAGAG missense, reference
rs2275253 - 111,319,219(+) ACAAC(A/G)TCAAG reference, missense
rs2275254 - 111,319,352(+) CAAAT(C/T)TGGAG missense, reference
rs2282290 -- 111,320,829(+) GCTGA(A/G)GTGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CHIA Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV Loss 19166990
dgv87e1 CNV Complex 17122850
esv2665968 CNV Deletion 23128226
nsv441709 CNV CNV 18776908
essv5780 CNV CNV 17122850
esv2716163 CNV Deletion 23290073
dgv41e201 CNV Deletion 23290073
esv2716185 CNV Deletion 23290073
esv1564747 CNV Deletion 17803354
nsv518232 CNV Loss 19592680

Relevant External Links for CHIA Gene

HapMap Linkage Disequilibrium report
CHIA
Human Gene Mutation Database (HGMD)
CHIA

Disorders for CHIA Gene

(1) University of Copenhagen DISEASES for CHIA Gene

(3) Novoseek inferred disease relationships for CHIA Gene

Disease -log(P) Hits PubMed IDs
asthma 58.4 22
gaucher disease 53.8 1
inflammation 24.7 6

Relevant External Links for CHIA

Genetic Association Database (GAD)
CHIA
Human Genome Epidemiology (HuGE) Navigator
CHIA
genes like me logo Genes that share disorders with CHIA: view

No data available for UniProtKB/Swiss-Prot for CHIA Gene

Publications for CHIA Gene

  1. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. (PMID: 11085997) Boot R.G. … Aerts J.M.F.G. (J. Biol. Chem. 2001) 2 3 4 23
  2. Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member. (PMID: 10548734) Saito A. … Tanigami A. (Gene 1999) 3 4 23
  3. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. (PMID: 15192232) Zhu Z. … Elias J.A. (Science 2004) 3 4 23
  4. Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels. (PMID: 18602573) Chatterjee R. … Ghosh B. (J. Allergy Clin. Immunol. 2008) 3 23 49
  5. Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism. (PMID: 19342690) Hartl D. … Elias J.A. (J. Immunol. 2009) 3 4 23

Products for CHIA Gene

Sources for CHIA Gene

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