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CACNA1I Gene

protein-coding   GIFtS: 62

GC22P038291
calcium channel, voltage-dependent, T type, alpha 1I subunit
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for CACNA1I

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
Ca(v)3.3 3
Cav3.3 1, 2
KIAA1120 2, 3, 5
Descriptions
Voltage-gated calcium channel subunit alpha Cav3.3 3
calcium channel, voltage-dependent, T type, alpha 1I
subunit 2
calcium channel, voltage-dependent, alpha 1I subunit 2
External Ids
HGNC: 13961
Entrez Gene: 89112
UniProtKB: Q9P0X43
Ensembl: ENSG000001003467
Search outside databases for aliases for CACNA1I gene

Previous GC identifers: GC22P036581 GC22P038209

Summaries
for CACNA1I

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for CACNA1I:
Voltage-dependent calcium channels control the rapid entry of Ca(2+) into a variety of cell types
and are therefore involved in both electrical and cellular signaling. T-type channels, such as
CACNA1I, are activated by small membrane depolarizations and can generate burst firing and
pacemaker activity.[supplied by OMIM]

UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into
excitable cells and are also involved in a variety of calcium-dependent processes, including
muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell
division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium
channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and
mibefradil. A particularity of this type of channels is an opening at quite negative potentials,
and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central
neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular
smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is
important for information processing as well as in cell growth processes. Gates in voltage ranges
similar to, but higher than alpha 1G or alpha 1H (By similarity)

Genomic Location
for CACNA1I

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CACNA1I gene  

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

CACNA1I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038291:     (about GC identifiers)

Start:
 38,296,704 bp from pter
End:
 38,415,688 bp from pter
Size:
 118,985 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  

Proteins
for CACNA1I

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4 (See protein sequence)
Recommended Name: Voltage-dependent T-type calcium channel subunit alpha-1I  
Size: 2223 amino acids; 245103 Da
Subunit: Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O95504 Q5JZ88 Q7Z6S9 Q8NFX6 Q9NZC8 Q9UH15 Q9UH30 Q9ULU9 Q9UNE6
Alternative splicing: 4 isoforms:  Q9P0X4-1   Q9P0X4-2   Q9P0X4-3   Q9P0X4-4   

Post-translational modifications:

  • In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II
    (By similarity)1


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001003406.1  NP_066919.2  


    ENSEMBL proteins: 
    ENSP00000337829 ENSP00000384093 ENSP00000385019 ENSP00000385680 ENSP00000383887 ENSP00000334198 
    ENSP00000383028 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (CACNA1I)
    Human Recombinant Proteins from Abnova (CACNA1I)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005891 voltage-gated calcium channel complex NAS--
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for CACNA1I: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of CACNA1I
    Sigma-Aldrich Antibodies for CACNA1I
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (CACNA1I), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CACNA1I)
    Novus Biologicals Antibody for CACNA1I

    Assays for CACNA1I: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for CACNA1I

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR002077 VDCCAlpha1
     IPR005821 Ion_trans
     IPR005445 VDCC_T_a1su


       GeneDecks  CACNA1I for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9P0X4

    ProtoNet protein and cluster: Q9P0X4

    1 Blocks protein family: IPB005445 T-type voltage-dependent calcium channel alpha-1 subunit signature

    UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4
    Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2,
    S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent
    the voltage-sensor and are characterized by a series of positively charged amino acids at every
    third position
    Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family

    Gene Function
    for CACNA1I

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CACNA1I)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CACNA1I)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021096

                  Applied Biosystems Silencer® siRNAs for CACNA1I

                  Sigma-Aldrich siRNA and siRNA Panels for CACNA1I  
                         Sigma-Aldrich shRNA Panels and shRNA for CACNA1I  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001003406
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001003406
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001003406 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021096

    UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4
    Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into
    excitable cells and are also involved in a variety of calcium-dependent processes, including
    muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell
    division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium
    channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and
    mibefradil. A particularity of this type of channels is an opening at quite negative potentials,
    and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central
    neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular
    smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is
    important for information processing as well as in cell growth processes. Gates in voltage ranges
    similar to, but higher than alpha 1G or alpha 1H (By similarity)

    Genatlas biochemistry entry for CACNA1I:
    calcium low activated (LVA) voltage-gated channel,T type alpha 1I subunit,predominantly expressed
    in brain,involved in pacing neuronal firing and producing network oscillations such as those that
    occurs during sleeep and epilepsy (potential drug target),existing as two alternatively spliced
    forms

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005244 voltage-gated ion channel activity IEA--
    GO:0005509 calcium ion binding IEA--
    GO:0005515 protein binding IPI16740636
    GO:0008332 low voltage-gated calcium channel activity NAS--
    About this table

    Pathways & Interactions
    for CACNA1I

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/9 Invitrogen iPath™ Online BioAtlas - Pathways for CACNA1I (see all 9 ) (Maps provided by GeneGo):
     PKA signaling
     A2BR signaling via G-protein beta/gamma dimer. Activation of PI3K, PLCB and PLA2
     IP3 signaling
     CREB pathway
     Calcium signaling

       GeneDecks  CACNA1I for the pathways selected above  
    About GeneDecksing

    3 Millipore Pathways for CACNA1I
      ion currents
     Transcription CREB pathway
     Calcium channels

       GeneDecks  CACNA1I for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for CACNA1I):
     hsa04010 MAPK signaling pathway
     hsa04020 Calcium signaling pathway

       GeneDecks  CACNA1I for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  CACNA1I 


    5/36 Interacting proteins for CACNA1I (ENSP000003378293 Q9P0X41) via UniProtKB, MINT, and/or STRING (see all 36 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CATSPER1Q8NEC51EBI-1220829, EBI-744545
    CATSPER2Q96P561EBI-1220829, EBI-2215024
    CACNA2D1ENSP000003493203STRING (score=.988)
    CACNB1ENSP000002019433STRING (score=.92)
    CACNG1ENSP000002260213STRING (score=.92)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811 ion transport IEA--
    GO:0006816 calcium ion transport NAS--
    GO:0007165 signal transduction TAS10454147
    About this table

    Drugs & Compounds
    for CACNA1I

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for CACNA1I
    Browse Small Molecules at Sigma-Aldrich

    Compounds for CACNA1I available from Tocris Bioscience
    CompoundAction CAS number
    NNC 55-0396 dihydrochlorideHighly selective Ca2+ channel blocker (T-type)[357400-13-6]
    Mibefradil dihydrochlorideCa2+ channel blocker (T-type)[116644-53-2]
    About this table


    1 Novoseek chemical compound relationship for CACNA1I gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 57.19 10 16740636 (2), 11860462 (1), 17317015 (1), 17082234 (1) (see all 8)
    About this table


    Transcripts
    for CACNA1I

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CACNA1I)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CACNA1I)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021096

                  Sigma-Aldrich siRNA and siRNA Panels for CACNA1I  
                         Sigma-Aldrich shRNA Panels and shRNA for CACNA1I  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001003406  NM_021096  

    REFSEQ mRNAs for CACNA1I gene (2 alternative transcripts): 

    NM_001003406.1   NM_021096.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001003406  NM_021096  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001003406
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001003406
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001003406 

    Additional cDNA sequence: 

    AB032946.1 AF129133.1 AF142567.1 AF211189.1 AF393329.1 BC042972.1 

    3 DOTS entries:

    DT.100743777  DT.40125911  DT.40272792 

    24/32 AceView cDNA sequences (see all 32 ):

    BF879321 AB032946 H55617 BX101763 BQ637689 F13540 N57586 BX951618 
    AF129133 BF940871 BC042972 AF211189 F11119 NM_021096 AF142567 NM_001003406 
    AJ573520 BM695724 N52765 BE164503 AF393329 BI597525 BG707996 BX488084 

    highest scoring ESTs for CACNA1I:

    T65410 AB032946 AJ573520 BC042972 BF940871 BG707996 BI597525 BI666530 BI758428 BM688784 

    Unigene Cluster for CACNA1I:

    Calcium channel, voltage-dependent, T type, alpha 1I subunit
    Hs.125116  [show with all ESTs]
    Unigene Representative Sequence: NM_021096


    GeneLoc Exon Structure

    7 Ensembl transcripts including schematic representations:
    ENST00000336649  ENST00000404898  ENST00000402142  ENST00000407673  ENST00000401624  ENST00000348261  
    ENST00000400164  

    Expression
    for CACNA1I

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CACNA1I expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CACNA1I

    1 / 2 / 3

    7 probe-sets matching CACNA1I gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    65058_at2, 3 U95-C 1 0.94 1.00 1.00 1.00 T65410 1.00 1.00 1.00 1

    		221631_at2, 3 U133-A 1 1.00 1.00 -- -- AB032946 0.80 1.00 0.91 1

    		208299_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021096 0.60 1.00 0.82 1

    		211830_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF211189 0.60 0.75 0.68 1

    		221631_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		208299_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		211830_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  CACNA1I for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACAGCAGTCA

    SOURCE GeneReport for Unigene cluster: Hs.125116

    UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4
    Tissue specificity: Brain specific

    Orthologs
    for CACNA1I

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for CACNA1I gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 CACNA1I1   -- calcium channel, voltage-dependent, T type, alpha 1I more 91.33(n)
    94.62(a)    		 481243  XM_538364.2  XP_538364.2 
    chimpanzee
    (Pan troglodytes)    		 CACNA1I1   -- calcium channel, voltage-dependent, T type, alpha 1I more 97.52(n)
    97.35(a)    		 458848  XM_515143.2  XP_515143.2 
    cow
    (Bos taurus)    		 CACNA1I1   -- calcium channel, voltage-dependent, T type, alpha 1I more 89.81(n)
    92.63(a)    		 282413  XM_616599.3  XP_616599.3 
    rat
    (Rattus norvegicus)    		 Cacna1i1   -- calcium channel, voltage-dependent, T type, alpha 1I more 88.15(n)
    94.75(a)    		 56827  NM_020084.2  NP_064469.2 
    mouse
    (Mus musculus)    		 Cacna1i1, 5 155
    		 calcium channel, voltage-dependent, alpha 1I subunit1, 5 87.7(n)1
    93.25(a)1    		 2395561  NM_001044308.11  NP_001037773.11 
     AK1475855  AY0263845  (see all 6)
    About this table        Species with no ortholog for CACNA1I

    ENSEMBL Gene Tree for CACNA1I

    Paralogs
    for CACNA1I

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CACNA1I gene
    CACNA1H2  CACNA1G2  SCN7A2  

    SNPs/Variants
    for CACNA1I

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/851 NCBI SNPs in CACNA1I are shown (see all 851 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 216)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs81412621,2
    		C,F,H38396904(+) GCCCAC/TGGTGA 2 T/M mis1 ese37Minor allele frequency- T:0.09EU EA WA NA 562
    rs1368531,2
    		C,F,H38388132(+) ACCACG/ATTCAT 2 V/I mis15Minor allele frequency- A:0.27MN EU EA WA 598
    rs170014261,2
    		C,F,H38415959(+) GAATAA/CTCTGT 2 -- ng3111Minor allele frequency- C:0.11NA EU EA WA 980
    rs37471791,2
    		C,F,H38413676(+) AGACTT/GGGGTG 2 -- ut3112Minor allele frequency- G:0.15EA NA EU WA 2600
    rs170014231,2
    		F,H38413740(+) TTGAAC/GCCGTG 2 -- ut31 ese37Minor allele frequency- G:0.13NA EU EA WA 554
    --
    rs22943691,2
    		C,F38405346(+) GCGGCG/AGGGGC 2 R/G mis11Minor allele frequency- A:0.04EA 1496
    rs72884551,2
    		A,C38296493(+) GAAGCA/GGATTC 2 -- ng510--------
    rs48219111,2
    		C38415789(+) CAGGCA/GTGGGG 2 -- ng310--------
    rs96111991,2
    		H38296712(+) GCTGAG/TAGCGC 2 E/D mis1 ese34Minor allele frequency- T:0.00EU EA WA 418
    rs57577611,2
    		A,C,F,H38384894(+) GAGATC/TGTGGG 2 I/I syn14Minor allele frequency- T:0.21EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for CACNA1I (up to first 250kb)

    Disorders & Mutations
    for CACNA1I

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 608230

    Human Genome Epidemiology Navigator: CACNA1I (1 document)

    Medical News
    for CACNA1I

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for CACNA1I

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/28 PubMed articles for CACNA1I gene (see all 28 ):

    Search for CACNA1I

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CACNA1I

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 8911 HGNC: 1396 AceView: CACNA1I Ensembl:ENSG00000100346 euGenes: HUgn8911
    ECgene: CACNA1I H-InvDB: CACNA1I

    Other Databases showing CACNA1I

    (According to HUGE)
    About This Section
    HUGE: KIAA1120

    Specialized Databases showing CACNA1I

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for CACNA1I

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for CACNA1I

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CACNA1I:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CACNA1I-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for CACNA1I Antibodies for CACNA1I
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CACNA1I Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Cell Culture Products   ELISAs  
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