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Aliases for BDKRB2 Gene

Aliases for BDKRB2 Gene

  • Bradykinin Receptor B2 2 3 5
  • BK-2 Receptor 3 4
  • BKR2 3 4
  • B2R 3 4
  • BK-2 3
  • BRB2 3
  • BK2 3

External Ids for BDKRB2 Gene

Previous GeneCards Identifiers for BDKRB2 Gene

  • GC14P094182
  • GC14P090487
  • GC14P094661
  • GC14P095740
  • GC14P096671
  • GC14P076856

Summaries for BDKRB2 Gene

Entrez Gene Summary for BDKRB2 Gene

  • This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for BDKRB2 Gene

BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include Angioedema and Hereditary Angioedema. Among its related pathways are Peptide ligand-binding receptors and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include G-protein coupled receptor activity and protease binding. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for BDKRB2 Gene

  • Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for BDKRB2 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Gene Wiki entry for BDKRB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB2 Gene

Genomics for BDKRB2 Gene

Regulatory Elements for BDKRB2 Gene

Enhancers for BDKRB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BDKRB2 on UCSC Golden Path with GeneCards custom track

Promoters for BDKRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BDKRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BDKRB2 Gene

Chromosome:
14
Start:
96,204,679 bp from pter
End:
96,244,329 bp from pter
Size:
39,651 bases
Orientation:
Plus strand

Genomic View for BDKRB2 Gene

Genes around BDKRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BDKRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BDKRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDKRB2 Gene

Proteins for BDKRB2 Gene

  • Protein details for BDKRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30411-BKRB2_HUMAN
    Recommended name:
    B2 bradykinin receptor
    Protein Accession:
    P30411

    Protein attributes for BDKRB2 Gene

    Size:
    391 amino acids
    Molecular mass:
    44461 Da
    Quaternary structure:
    • Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.

    Alternative splice isoforms for BDKRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BDKRB2 Gene

Proteomics data for BDKRB2 Gene at MOPED

Post-translational modifications for BDKRB2 Gene

  • Glycosylation at Asn 30, Asn 39, and Asn 207
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BDKRB2 Gene

Domains & Families for BDKRB2 Gene

Gene Families for BDKRB2 Gene

Suggested Antigen Peptide Sequences for BDKRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30411

UniProtKB/Swiss-Prot:

BKRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
genes like me logo Genes that share domains with BDKRB2: view

Function for BDKRB2 Gene

Molecular function for BDKRB2 Gene

GENATLAS Biochemistry:
bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD)
UniProtKB/Swiss-Prot Function:
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
genes like me logo Genes that share phenotypes with BDKRB2: view

Animal Models for BDKRB2 Gene

MGI Knock Outs for BDKRB2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BDKRB2 Gene

Localization for BDKRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BDKRB2 Gene COMPARTMENTS Subcellular localization image for BDKRB2 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with BDKRB2: view

Pathways & Interactions for BDKRB2 Gene

genes like me logo Genes that share pathways with BDKRB2: view

Interacting Proteins for BDKRB2 Gene

Selected Interacting proteins: P30411-BKRB2_HUMAN for BDKRB2 Gene via UniProtKB I2D

SIGNOR curated interactions for BDKRB2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002438 acute inflammatory response to antigenic stimulus IEA --
GO:0006939 smooth muscle contraction IC 17077303
GO:0007166 cell surface receptor signaling pathway TAS 7916737
GO:0008285 negative regulation of cell proliferation IEA --
GO:0019229 regulation of vasoconstriction IC 17077303
genes like me logo Genes that share ontologies with BDKRB2: view

Drugs & Compounds for BDKRB2 Gene

(62) Drugs for BDKRB2 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icatibant Approved Pharma Antagonist, antagonist, Target 16
Lisinopril Approved, Investigational Pharma ACE inhibitor 117
Enalapril Approved Pharma 114
Anatibant Investigational Pharma Antagonist, antagonist 0
Bradykinin Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 50

(29) Additional Compounds for BDKRB2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Phe<sup>8</sup>,<i>psi</i>(CH<sub>2</sub>-NH)Arg<sup>9</sup>]BK
Full agonist, Agonist
[Des-Arg9]-Bradykinin
15958-92-6
Bombinakinin M
509151-65-9
Lys-[Des-Arg9]Bradykinin
71800-36-7
Lys-Bradykinin
342-10-9

(5) Tocris Compounds for BDKRB2 Gene

Compound Action Cas Number
[Des-Arg9]-Bradykinin Bradykinin receptor agonist (B1 > B2) 15958-92-6
Bombinakinin M Potent bradykinin receptor agonist 509151-65-9
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) 58-82-2
Lys-[Des-Arg9]Bradykinin Selective B1 agonist 71800-36-7
Lys-Bradykinin Potent bradykinin receptor agonist (B2 > B1) 342-10-9
genes like me logo Genes that share compounds with BDKRB2: view

Transcripts for BDKRB2 Gene

mRNA/cDNA for BDKRB2 Gene

Unigene Clusters for BDKRB2 Gene

Bradykinin receptor B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB2 Gene

No ASD Table

Relevant External Links for BDKRB2 Gene

GeneLoc Exon Structure for
BDKRB2
ECgene alternative splicing isoforms for
BDKRB2

Expression for BDKRB2 Gene

mRNA expression in normal human tissues for BDKRB2 Gene

Protein differential expression in normal tissues from HIPED for BDKRB2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BDKRB2 Gene



SOURCE GeneReport for Unigene cluster for BDKRB2 Gene Hs.654542

mRNA Expression by UniProt/SwissProt for BDKRB2 Gene

P30411-BKRB2_HUMAN
Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
genes like me logo Genes that share expression patterns with BDKRB2: view

Protein tissue co-expression partners for BDKRB2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for BDKRB2 Gene

Orthologs for BDKRB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BDKRB2 35
  • 85.68 (n)
  • 81.51 (a)
BDKRB2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BDKRB2 35
  • 87.09 (n)
  • 81.03 (a)
BDKRB2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bdkrb2 35
  • 83.25 (n)
  • 80.83 (a)
Bdkrb2 16
Bdkrb2 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BDKRB2 35
  • 99.32 (n)
  • 99.49 (a)
BDKRB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bdkrb2 35
  • 81.97 (n)
  • 78.97 (a)
oppossum
(Monodelphis domestica)
Mammalia BDKRB2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BDKRB2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves BDKRB2 35
  • 62.55 (n)
  • 56.63 (a)
BDKRB2 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BDKRB2 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bdkrb2 35
  • 59.88 (n)
  • 54.87 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330960 35
  • 55.42 (n)
  • 47.29 (a)
BDKRB2 (1 of 2) 36
  • 38 (a)
OneToMany
CABZ01058422.1 36
  • 44 (a)
OneToMany
Species with no ortholog for BDKRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB2 Gene

ENSEMBL:
Gene Tree for BDKRB2 (if available)
TreeFam:
Gene Tree for BDKRB2 (if available)

Paralogs for BDKRB2 Gene

Paralogs for BDKRB2 Gene

(20) SIMAP similar genes for BDKRB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BDKRB2: view

Variants for BDKRB2 Gene

Sequence variations from dbSNP and Humsavar for BDKRB2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1046248 - 96,237,147(+) CTGTT(C/T)GTGAG reference, missense
rs2227279 - 96,241,389(+) GAAAG(A/G)GGGCT reference, missense
rs2887499 -- 96,216,041(+) ACAGG(A/G)GCCAA intron-variant
rs8005195 -- 96,217,468(+) AGGCA(C/T)ATTGT intron-variant
rs8005240 -- 96,233,192(+) CACGC(C/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BDKRB2 Gene

Variant ID Type Subtype PubMed ID
nsv1416 CNV Insertion 18451855
nsv515629 CNV Loss 19592680
dgv262n27 CNV Loss 19166990
esv1004672 CNV Insertion 20482838

Variation tolerance for BDKRB2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BDKRB2 Gene

Human Gene Mutation Database (HGMD)
BDKRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDKRB2 Gene

Disorders for BDKRB2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for BDKRB2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
angioedema
  • angioneurotic edema
hereditary angioedema
  • c1 inhibitor deficiency
brain edema
  • intracranial swelling
placenta accreta
acute mountain sickness
  • altitude anoxia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BDKRB2

Genetic Association Database (GAD)
BDKRB2
Human Genome Epidemiology (HuGE) Navigator
BDKRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BDKRB2
genes like me logo Genes that share disorders with BDKRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BDKRB2 Gene

Publications for BDKRB2 Gene

  1. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PMID: 7916737) Powell S.J. … Graham A. (Genomics 1993) 2 3 4 23 67
  2. Distribution and expression of B2-kinin receptor on human leukocyte subsets in young adults and elderly using flow cytometry. (PMID: 20045189) Bourdet B. … Tack I. (Neuropeptides 2010) 3 23
  3. Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer? (PMID: 19017652) Hansen J.L. … Sheikh S.P. (J. Biol. Chem. 2009) 3 23
  4. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. (PMID: 19038786) Bertram C.M. … Bhoola K.D. (J. Leukoc. Biol. 2009) 3 23
  5. Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells. (PMID: 19725054) Lim S.K. … Park S.H. (J. Cell. Physiol. 2009) 3 23

Products for BDKRB2 Gene

Sources for BDKRB2 Gene

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