Aliases for BDKRB2 Gene
External Ids for BDKRB2 Gene
Previous GeneCards Identifiers for BDKRB2 Gene
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for BDKRB2 Gene
BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include angioedema and hereditary angioedema. Among its related pathways are Signaling by GPCR and Complement and coagulation cascades. GO annotations related to this gene include G-protein coupled receptor activity and protease binding. An important paralog of this gene is ACKR3.
UniProtKB/Swiss-Prot for BDKRB2 Gene
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.