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BDKRB2 Gene

protein-coding   GIFtS: 68
GCID: GC14P096671

Bradykinin Receptor B2

  See BDKRB2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bradykinin Receptor B21 2     BK-22
B2R2 3     BK22
BKR22 3     BRB22
BK-2 Receptor2 3     B2 Bradykinin Receptor2

External Ids:    HGNC: 10301   Entrez Gene: 6242   Ensembl: ENSG000001683987   OMIM: 1135035   UniProtKB: P304113   

Export aliases for BDKRB2 gene to outside databases

Previous GC identifers: GC14P094182 GC14P090487 GC14P094661 GC14P095740 GC14P076856


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BDKRB2 Gene:
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including
vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins
that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two
isoforms of the protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for BDKRB2 Gene:
BDKRB2 (bradykinin receptor B2) is a protein-coding gene. Diseases associated with BDKRB2 include acute mountain sickness, and polycystic kidney disease, type 1. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and protein heterodimerization activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411
Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium
second messenger system

summary for BDKRB2 Gene:
Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and
pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their
action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor.
Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation,
smooth muscle contraction and pain.

Gene Wiki entry for BDKRB2 (Bradykinin receptor B2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the BDKRB2 gene promoter:
         CREB   deltaCREB   Nkx2-5   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BDKRB2 promoter sequence
   Search Chromatin IP Primers for BDKRB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BDKRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1-q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.1-q32.2

BDKRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDKRB2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096671:  view genomic region     (about GC identifiers)

Start:
96,671,016 bp from pter      End:
96,710,666 bp from pter
Size:
39,651 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411 (See protein sequence)
Recommended Name: B2 bradykinin receptor  
Size: 391 amino acids; 44461 Da
Subunit: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1
Alternative splicing: 2 isoforms:  P30411-1   P30411-2   

Explore the universe of human proteins at neXtProt for BDKRB2: NX_P30411

Explore proteomics data for BDKRB2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn30, Asn39, Asn207
  • Modification sites at PhosphoSitePlus

  • See BDKRB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000614.1  
    ENSEMBL proteins: 
     ENSP00000439459   ENSP00000450482   ENSP00000438376   ENSP00000307713  
    Reactome Protein details: P30411

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    Browse Sino Biological Cell Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BDKR: GPCR / Class A : Bradykinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: B2 receptor
    Bradykinin receptors

    4 InterPro protein domains:
     IPR001504 Brdyknn_2_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000496 Brdyknn_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30411

    ProtoNet protein and cluster: P30411

    2 Blocks protein domains:
    IPB000496 Bradykinin receptor signature
    IPB001504 B2 bradykinin receptor signature


    UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411
    Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2
    sub-subfamily


    Find genes that share domains with BDKRB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BKRB2_HUMAN, P30411
    Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium
    second messenger system

         Genatlas biochemistry entry for BDKRB2:
    bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor
    superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI17077303
    GO:0004435phosphatidylinositol phospholipase C activity TAS8302267
    GO:0004930G-protein coupled receptor activity ----
    GO:0004947bradykinin receptor activity IDA17077303
    GO:0005515protein binding IPI18672896
         
    Find genes that share ontologies with BDKRB2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for BDKRB2:
     Decreased telomerase activity  G0/1 arrest  Increased G1 DNA content  Increased cell transformation 
     Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bdkrb2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  normal  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with BDKRB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BDKRB2: Bdkrb2tm1Jfh Bdkrb2/Bdkrb1Bdkrb2/tm1Mki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BDKRB2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BDKRB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BDKRB2

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate BDKRB2:
    hsa-miR-885-3p hsa-miR-1827 hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidBDKRB2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: BDKRB2 (NM_000623)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BKRB2_HUMAN, P30411: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA17077303
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7916737
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with BDKRB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BDKRB2 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway0.00
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with BDKRB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BDKRB2
        eNOS Signaling

    5 BioSystems Pathways for BDKRB2
        ACE Inhibitor Pathway
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like
    Direct p53 effectors
    Peptide GPCRs

    3 Reactome Pathways for BDKRB2
        Peptide ligand-binding receptors
    G alpha (q) signalling events
    G alpha (i) signalling events

    2 PharmGKB Pathways for BDKRB2
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for BDKRB2) (see all 7):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Complement and coagulation cascades
    Inflammatory mediator regulation of TRP channels
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BDKRB2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BDKRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BDKRB2 (P304111, 3 ENSP000003077134) via UniProtKB, MINT, STRING, and/or I2D (see all 261)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    AGTR1P305563, ENSP000002734304I2D: score=2 STRING: ENSP00000273430
    GRK6P432503, ENSP000003772044I2D: score=2 STRING: ENSP00000377204
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006939smooth muscle contraction IC17077303
    GO:0006954inflammatory response IC17077303
    GO:0007166cell surface receptor signaling pathway TAS7916737
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS10653985
    GO:0007186G-protein coupled receptor signaling pathway TAS1314587

    Find genes that share ontologies with BDKRB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for BDKRB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HOE 140Potent and selective B2 antagonist[138614-30-9]
    WIN 64338 hydrochlorideBradykinin B2 antagonist[151039-63-3]
    R 715Potent and selective B1 antagonist[185052-09-9]
    Lys-[Des-Arg9]BradykininSelective B1 agonist[71800-36-7]
    BradykininEndogenous agonist at bradykinin receptors (B2 > B1)[6846-03-3]

    2 HMDB Compounds for BDKRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for BDKRB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Icatibant-- 130308-48-4targetantagonist14514033 11752352

    Selected IUPHAR Ligands for BDKRB2 (B2 receptor) (see all 25)    About this table
    LigandTypeActionAffinityPubmed IDs
    B-9430
    AntagonistAntagonist8.6 - 9.68856115 9276157
    [3H]NPC17731
    AntagonistAntagonist9.1 - 9.411379050 9651119
    icatibant
    AntagonistAntagonist8 - 9.49203620 8302267
    kallidin
    AgonistFull agonist9.38302267
    bradykinin
    AgonistFull agonist7 - 9.39203620 8302267
    FR191413
    AgonistFull agonist9.215139763
    JMV1116
    AgonistFull agonist9.1 - 9.210514288
    Met-Lys-bradykinin
    AgonistFull agonist8.78302267
    JMV1431
    AntagonistAntagonist8.410882364
    anatibant
    AntagonistAntagonist8.210596852

    Selected Novoseek inferred chemical compound relationships for BDKRB2 gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    icatibant 91.5 26 8813637 (2), 10219847 (2), 11104833 (2), 9786500 (1) (see all 23)
    fr190997 89.8 6 9647466 (1), 15140628 (1), 9224807 (1), 10615010 (1) (see all 6)
    des-arg(10)-kallidin 86.9 2 18187413 (1), 11379050 (1)
    fr173657 86.1 5 11104833 (2), 9051299 (1), 10204994 (1), 9203620 (1)
    kallidin 85.3 6 10419551 (2), 18187413 (1), 8856153 (1), 11379050 (1)
    cereport 82.2 8 19439100 (3), 11286321 (2), 10362103 (1), 11550318 (1)
    anatibant 78.8 4 19958523 (2), 19958522 (2), 16379582 (1), 19958521 (1)
    kininogen 65.2 6 19725054 (1), 18187413 (1), 16272198 (1), 15375773 (1) (see all 5)
    enalaprilat 54.5 2 7853175 (1), 8953504 (1)
    captopril 53.3 8 9383175 (1), 12424228 (1), 8953933 (1), 8389325 (1) (see all 7)

    1 PharmGKB related drug/compound annotation for BDKRB2 gene    About this table
    Drug/compound PharmGKB Annotation
    Ace Inhibitors, PlainCA  



    Find genes that share compounds with BDKRB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BDKRB2 gene: 
    NM_000623.3  

    Unigene Cluster for BDKRB2:

    Bradykinin receptor B2
    Hs.654542  [show with all ESTs]
    Unigene Representative Sequence: CR749338
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542454(uc010avl.2 uc010twu.1) ENST00000554311 ENST00000539359
    ENST00000306005(uc010avm.1 uc001yfg.2)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate BDKRB2:
    hsa-miR-885-3p hsa-miR-1827 hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidBDKRB2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: BDKRB2 (NM_000623)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BDKRB2
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      QuantiTect SYBR Green Assays in human, mouse, rat BDKRB2
      QuantiFast Probe-based Assays in human, mouse, rat BDKRB2

    Additional mRNA sequence: 

    AK299316.1 AK311049.1 AY275465.1 BC074894.2 BC074895.2 CR749338.1 M88714.1 U35875.1 
    X69680.1 X86163.1 X86164.1 X86165.1 

    8 DOTS entries:

    DT.95369242  DT.110466  DT.95235331  DT.91849441  DT.92431959  DT.95369243  DT.92431960  DT.120783283 

    Selected AceView cDNA sequences (see all 87):

    CA430240 AI095360 BC074895 X86165 AJ238044 AI742135 AI803477 AY275465 
    BQ024471 CD216772 BQ917469 NM_000710 BM823930 CA432819 BU540691 AW239080 
    BC074894 BQ014905 AU142100 AI242364 CA413343 CB121289 BP340852 CB130642 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BDKRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTTTTCT
    BDKRB2 Expression
    About this image


    BDKRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    BDKRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BDKRB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654542

    UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411
    Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BDKRB2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BDKRB2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bdkrb21 , 5 bradykinin receptor, beta 21, 5 83.25(n)1
    80.83(a)1
      12 (55.76 cM)5
    120621  NM_009747.21  NP_033877.31 
     1055631725 
    chicken
    (Gallus gallus)
    Aves BDKRB21 bradykinin receptor B2 62.55(n)
    56.63(a)
      428906  NM_001031553.1  NP_001026724.1 
    lizard
    (Anolis carolinensis)
    Reptilia BDKRB26
    bradykinin receptor B2
    51(a)
    1 ↔ 1
    1(7747242-7748551)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bdkrb21 bradykinin receptor B2 59.88(n)
    54.87(a)
      100127763  XM_004917087.1  XP_004917144.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003309601 B2 bradykinin receptor-like 55.42(n)
    47.29(a)
      100330960  XM_002665091.2  XP_002665137.1 


    ENSEMBL Gene Tree for BDKRB2 (if available)
    TreeFam Gene Tree for BDKRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BDKRB2 gene
    RXFP32  BDKRB12  AGTR22  GPR252  AGTR12  APLNR2  ACKR32  GPR152  
    RXFP42  GPR1822  
    Selected SIMAP similar genes for BDKRB2 using alignment to 2 protein entries:     BKRB2_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O088    CCR8    CCR1    BDKRB1    CX3CR1    CCR2
    CCR4    CXCR1    AGTR2    CXCR2    IL8RB    AGTR1
    CCR3    CCR5    ACKR4    APLNR    CCR9    CXCR3

    Find genes that share paralogs with BDKRB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BDKRB2 (see all 1353)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1135629421,2
    C,F--96669157(+) CAGACG/AGATGG 1 -- us2k13Minor allele frequency- A:0.06CSA WA NA 240
    rs286057431,2
    C,F--96669180(+) ATGGAC/TGGACA 1 -- us2k13Minor allele frequency- T:0.18NA WA 122
    rs1921889161,2
    --96669207(+) GATGGA/TTGGAT 1 -- us2k10--------
    rs1840286771,2
    --96669240(+) ACAGGC/TGAATA 1 -- us2k10--------
    rs1388754971,2
    --96669241(+) CAGGCA/GAATAA 1 -- us2k10--------
    rs1899326521,2
    C--96669285(+) TGGGCA/GGATGT 1 -- us2k10--------
    rs1428008241,2
    C--96669344(+) TAAGAC/TTAAAA 1 -- us2k10--------
    rs41441311,2
    C,F,A,H--96669401(-) gttctA/Gccttt 1 -- us2k123Minor allele frequency- G:0.33NS EA NA CSA WA 2763
    rs1927617441,2
    --96669403(+) AGGTAA/GAACTT 1 -- us2k10--------
    rs1158066771,2
    F--96669466(+) TGCAAC/GTGGGG 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for BDKRB2 (96671016 - 96710666 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BDKRB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1416CNV Insertion18451855
    esv1004672CNV Insertion20482838
    dgv262n27CNV Loss19166990
    nsv515629CNV Loss19592680

    Human Gene Mutation Database (HGMD): BDKRB2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 113503    OMIM disorders: --

    6 diseases for BDKRB2:    
    About MalaCards
    acute mountain sickness    polycystic kidney disease, type 1    placenta accreta    brain edema
    angioedema    essential hypertension


    Find genes that share disorders with BDKRB2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BDKRB2 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    angioedema, hereditary 62 3 19758369 (2), 17073887 (1)
    inflammation 37 13 9228537 (1), 16740128 (1), 20036002 (1), 9786513 (1) (see all 11)
    angioedema 36.8 1 20461661 (1)
    brain edema 34.5 2 14534854 (1), 14753436 (1)
    glioma 19.1 7 12500695 (3), 8906560 (1), 9009737 (1), 16455538 (1)
    reactive hyperemia 16.2 1 9054837 (1)
    essential hypertension 14.5 3 15643125 (1), 15894833 (1), 18803964 (1)
    diabetic nephropathies 14.3 5 15934924 (2), 16555685 (2), 15326315 (1)
    airways disease 12.7 1 16455073 (1)
    brain tumors 11.5 6 19439100 (2), 9525816 (1), 12500695 (1), 17359538 (1) (see all 5)

    Genetic Association Database (GAD): BDKRB2
    Human Genome Epidemiology (HuGE) Navigator: BDKRB2 (60 documents)

    Export disorders for BDKRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BDKRB2 gene, integrated from 10 sources (see all 410):
    (articles sorted by number of sources associating them with BDKRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PubMed id 7916737)1, 2, 3, 9 Powell S.J.... Graham A. (Genomics 1993)
    2. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. (PubMed id 15894833)1, 4, 9 Fu Y....Ogihara T. (Hypertens. Res. 2004)
    3. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. (PubMed id 12522467)1, 4, 9 Mukae S....Katagiri T. (J Hum Hypertens 2002)
    4. Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. (PubMed id 7835885)1, 2, 9 Ma J.-X.... Chao L. (Genomics 1994)
    5. The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons. (PubMed id 16461337)1, 4, 9 Saunders C.J....Collins M. (Hum. Mol. Genet. 2006)
    6. Association of the human bradykinin B2 receptor gene with chronic renal failure. (PubMed id 15771553)1, 4, 9 Jozwiak L....Buraczynska M. (Mol. Diagn. 2004)
    7. Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. (PubMed id 1314587)1, 2, 9 Hess J.F.R.... Ransom R.W. (Biochem. Biophys. Res. Commun. 1992)
    8. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PubMed id 15643125)1, 4, 9 Cui J....Gavras H. (J. Hypertens. 2005)
    9. Rapid and reliable genotyping of the C181T polymorphism in the bradykinin B2 receptor gene. (PubMed id 12705334)1, 4, 9 Weiss J....Haefeli W.E. (Clin. Chem. Lab. Med. 2003)
    10. Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. (PubMed id 14499231)1, 4, 9 Dhamrait S.S....Montgomery H.E. (Eur. Heart J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 624 HGNC: 1030 AceView: BDKRB2 Ensembl:ENSG00000168398 euGenes: HUgn624
    ECgene: BDKRB2 Kegg: 624 H-InvDB: BDKRB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BDKRB2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Bradykinin_receptor
    SeattleSNPshttp://pga.gs.washington.edu/data/bdkrb2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BDKRB2 gene:
    Search GeneIP for patents involving BDKRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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