Aliases for BDKRB2 Gene
External Ids for BDKRB2 Gene
Previous GeneCards Identifiers for BDKRB2 Gene
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for BDKRB2 Gene
BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include Brain Edema and Hereditary Angioedema. Among its related pathways are Toll-like receptor signaling pathway and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and protease binding. An important paralog of this gene is BDKRB1.
UniProtKB/Swiss-Prot for BDKRB2 Gene
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.