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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BDKRB2 Gene

protein-coding   GIFtS: 68
GCID: GC14P096671

Bradykinin Receptor B2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bradykinin Receptor B21 2     BK-22
B2R2 3     BK22
BKR22 3     BRB22
BK-2 Receptor2 3     B2 Bradykinin Receptor2

External Ids:    HGNC: 10301   Entrez Gene: 6242   Ensembl: ENSG000001683987   OMIM: 1135035   UniProtKB: P304113   

Export aliases for BDKRB2 gene to outside databases

Previous GC identifers: GC14P094182 GC14P090487 GC14P094661 GC14P095740 GC14P076856


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BDKRB2 Gene:
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including
vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins
that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two
isoforms of the protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for BDKRB2 Gene: 
BDKRB2 (bradykinin receptor B2) is a protein-coding gene. Diseases associated with BDKRB2 include placenta accreta, and acute mountain sickness, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and ACE Inhibitor Pathway. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and protein heterodimerization activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411
Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium
second messenger system

summary for BDKRB2 Gene:
Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and
pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their
action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor.
Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation,
smooth muscle contraction and pain.

Gene Wiki entry for BDKRB2 (Bradykinin receptor B2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BDKRB2 gene promoter:
         CREB   deltaCREB   Nkx2-5   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BDKRB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BDKRB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BDKRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1-q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.1-q32.2

BDKRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDKRB2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096671:  view genomic region     (about GC identifiers)

Start:
96,671,016 bp from pter      End:
96,710,666 bp from pter
Size:
39,651 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411 (See protein sequence)
Recommended Name: B2 bradykinin receptor  
Size: 391 amino acids; 44461 Da
Subunit: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1
Subcellular location: Cell membrane; Multi-pass membrane protein
Alternative splicing: 2 isoforms:  P30411-1   P30411-2   

Explore the universe of human proteins at neXtProt for BDKRB2: NX_P30411

Explore proteomics data for BDKRB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30411

  • BDKRB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BDKRB2 Protein Expression
    REFSEQ proteins: NP_000614.1  
    ENSEMBL proteins: 
     ENSP00000439459   ENSP00000450482   ENSP00000438376   ENSP00000307713  
    Reactome Protein details: P30411
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    Cloud-Clone Corp. Proteins for BDKRB2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA17077303
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7916737
    GO:0016021integral to membrane ----

    BDKRB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BDKR: GPCR / Class A : Bradykinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: B2 receptor 
    Bradykinin receptors

    4 InterPro protein domains:
     IPR001504 Brdyknn_2_rcpt
     IPR000496 Brdyknn_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30411

    ProtoNet protein and cluster: P30411

    2 Blocks protein domains:
    IPB000496 Bradykinin receptor signature
    IPB001504 B2 bradykinin receptor signature


    UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411
    Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2
    sub-subfamily


    BDKRB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BKRB2_HUMAN, P30411
    Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium
    second messenger system

         Genatlas biochemistry entry for BDKRB2:
    bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor
    superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI17077303
    GO:0004435phosphatidylinositol phospholipase C activity TAS8302267
    GO:0004930G-protein coupled receptor activity ----
    GO:0004947bradykinin receptor activity IDA17077303
    GO:0005515protein binding IPI18672896
         
    BDKRB2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for BDKRB2:
     Decreased telomerase activity  G0/1 arrest  Increased G1 DNA content  Increased cell transformation 
     Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bdkrb2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  normal  renal/urinary system  reproductive system  skeleton 

    BDKRB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BDKRB2: Bdkrb2tm1Jfh Bdkrb2/Bdkrb1Bdkrb2/tm1Mki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BDKRB2 
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    SwitchGear 3'UTR luciferase reporter plasmidBDKRB2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BDKRB2 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.37
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    ACE Inhibitor Pathway0.85
    ACE Inhibitor Pathway, Pharmacodynamics0.85
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.85
    3Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for BDKRB2
        Selected targets of CREB1
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Selected targets of p53

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BDKRB2
        eNOS Signaling

    5 BioSystems Pathways for BDKRB2
        ACE Inhibitor Pathway
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like
    Direct p53 effectors
    Peptide GPCRs

    5/9        Reactome Pathways for BDKRB2 (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding

    2 PharmGKB Pathways for BDKRB2
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    5/6         Kegg Pathways  (Kegg details for BDKRB2) (see all 6):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Complement and coagulation cascades
    Regulation of actin cytoskeleton
    Endocrine and other factor-regulated calcium reabsorption


    BDKRB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BDKRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/261 Interacting proteins for BDKRB2 (P304113 ENSP000003077134) via UniProtKB, MINT, STRING, and/or I2D (see all 261)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    AGTR1P305563, ENSP000002734304I2D: score=2 STRING: ENSP00000273430
    GRK6P432503, ENSP000003772044I2D: score=2 STRING: ENSP00000377204
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006939smooth muscle contraction IC17077303
    GO:0006954inflammatory response IC17077303
    GO:0007166cell surface receptor signaling pathway TAS7916737
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS10653985
    GO:0007186G-protein coupled receptor signaling pathway TAS1314587

    BDKRB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BDKRB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for BDKRB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HOE 140Potent and selective B2 antagonist[138614-30-9]
    WIN 64338 hydrochlorideBradykinin B2 antagonist[151039-63-3]
    R 715Potent and selective B1 antagonist[185052-09-9]
    Lys-[Des-Arg9]BradykininSelective B1 agonist[71800-36-7]
    BradykininEndogenous agonist at bradykinin receptors (B2 > B1)[6846-03-3]

    2 HMDB Compounds for BDKRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for BDKRB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Icatibant-- 130308-48-4targetantagonist14514033 11752352

    10/25 IUPHAR Ligands for BDKRB2 (B2 receptor) (see all 25)    About this table 
    LigandTypeActionAffinityPubmed IDs
    B-9430
    AntagonistAntagonist8.6 - 9.68856115 9276157
    [3H]NPC17731
    AntagonistAntagonist9.1 - 9.411379050 9651119
    icatibant
    AntagonistAntagonist8 - 9.49203620 8302267
    kallidin
    AgonistFull agonist9.38302267
    bradykinin
    AgonistFull agonist7 - 9.39203620 8302267
    FR191413
    AgonistFull agonist9.215139763
    JMV1116
    AgonistFull agonist9.1 - 9.210514288
    Met-Lys-bradykinin
    AgonistFull agonist8.78302267
    JMV1431
    AntagonistAntagonist8.410882364
    anatibant
    AntagonistAntagonist8.210596852

    10/63 Novoseek inferred chemical compound relationships for BDKRB2 gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    icatibant 91.5 26 8813637 (2), 10219847 (2), 11104833 (2), 9786500 (1) (see all 23)
    fr190997 89.8 6 9647466 (1), 15140628 (1), 9224807 (1), 10615010 (1) (see all 6)
    des-arg(10)-kallidin 86.9 2 18187413 (1), 11379050 (1)
    fr173657 86.1 5 11104833 (2), 9051299 (1), 10204994 (1), 9203620 (1)
    kallidin 85.3 6 10419551 (2), 18187413 (1), 8856153 (1), 11379050 (1)
    cereport 82.2 8 19439100 (3), 11286321 (2), 10362103 (1), 11550318 (1)
    anatibant 78.8 4 19958523 (2), 19958522 (2), 16379582 (1), 19958521 (1)
    kininogen 65.2 6 19725054 (1), 18187413 (1), 16272198 (1), 15375773 (1) (see all 5)
    enalaprilat 54.5 2 7853175 (1), 8953504 (1)
    captopril 53.3 8 9383175 (1), 12424228 (1), 8953933 (1), 8389325 (1) (see all 7)

    1 PharmGKB related drug/compound annotation for BDKRB2 gene    About this table
    Drug/compound PharmGKB Annotation
    Ace Inhibitors, PlainCA  

    Search CenterWatch for drugs/clinical trials and news about BDKRB2 / BKRB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for BDKRB2 gene: 
    NM_000623.3  

    Unigene Clusters for BDKRB2:

    Bradykinin receptor B2
    Hs.654542  [show with all ESTs], Hs.726620  [show with all ESTs]
    Unigene Representative Sequences: CR749338, NM_000623
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542454(uc010avl.2 uc010twu.1) ENST00000554311 ENST00000539359
    ENST00000306005(uc010avm.1 uc001yfg.2)

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BDKRB2

    8 DOTS entries:

    DT.95369242  DT.110466  DT.95235331  DT.91849441  DT.92431959  DT.95369243  DT.92431960  DT.120783283 

    24/87 AceView cDNA sequences (see all 87):

    NM_000710 CA432819 AY275465 BQ024471 CD216772 BU540691 AU142100 X86165 
    BQ917469 AI803477 BQ014905 BC074895 BC074894 CA430240 BM823930 AW239080 
    AI742135 AI095360 AJ238044 AI242364 U30271 CB126972 BI059256 CR749338 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BDKRB2 expression in normal human tissues (normalized intensities)      BDKRB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTTTTCT
    BDKRB2 Expression
    About this image


    BDKRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells

    See BDKRB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BDKRB2

    SOURCE GeneReport for Unigene clusters: Hs.654542 Hs.726620

    UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411
    Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BDKRB2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bdkrb21 , 5 bradykinin receptor, beta 21, 5 83.25(n)1
    80.83(a)1
      12 (55.76 cM)5
    120621  NM_009747.21  NP_033877.31 
     1055631725 
    chicken
    (Gallus gallus)
    Aves BDKRB21 bradykinin receptor B2 63.02(n)
    56.84(a)
      428906  NM_001031553.1  NP_001026724.1 
    lizard
    (Anolis carolinensis)
    Reptilia BDKRB26
    Uncharacterized protein
    51(a)
    1 ↔ 1
    1(7747242-7748551)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003309601 b2 bradykinin receptor-like 55.25(n)
    46.67(a)
      100330960  XM_002665091.1  XP_002665137.1 


    ENSEMBL Gene Tree for BDKRB2 (if available)
    TreeFam Gene Tree for BDKRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BDKRB2 gene
    RXFP32  BDKRB12  AGTR22  GPR252  AGTR12  APLNR2  ACKR32  GPR152  
    RXFP42  GPR1822  
    18/20 SIMAP similar genes for BDKRB2 using alignment to 2 protein entries:     BKRB2_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O088    CCR8    CCR1    BDKRB1    CX3CR1    CCR2
    CCR4    CXCR1    AGTR2    CXCR2    IL8RB    AGTR1
    CCR3    CCR5    APLNR    CCR9    CCRL1    CXCR3

    BDKRB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1353 SNPs in BDKRB2 are shown (see all 1353)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1135629421,2
    C,F--96669157(+) CAGACG/AGATGG 1 -- us2k13Minor allele frequency- A:0.06CSA WA NA 240
    rs286057431,2
    C,F--96669180(+) ATGGAC/TGGACA 1 -- us2k13Minor allele frequency- T:0.18NA WA 122
    rs1921889161,2
    --96669207(+) GATGGA/TTGGAT 1 -- us2k10--------
    rs1840286771,2
    --96669240(+) ACAGGC/TGAATA 1 -- us2k10--------
    rs1388754971,2
    --96669241(+) CAGGCA/GAATAA 1 -- us2k10--------
    rs1899326521,2
    C--96669285(+) TGGGCA/GGATGT 1 -- us2k10--------
    rs1428008241,2
    C--96669344(+) TAAGAC/TTAAAA 1 -- us2k10--------
    rs41441311,2
    C,F,A,H--96669401(-) gttctA/Gccttt 1 -- us2k123Minor allele frequency- G:0.33NS EA NA CSA WA 2763
    rs1927617441,2
    --96669403(+) AGGTAA/GAACTT 1 -- us2k10--------
    rs1158066771,2
    F--96669466(+) TGCAAC/GTGGGG 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for BDKRB2 (96671016 - 96710666 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BDKRB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1416CNV Insertion18451855
    esv1004672CNV Insertion20482838
    dgv262n27CNV Loss19166990
    nsv515629CNV Loss19592680


    Human Gene Mutation Database (HGMD): BDKRB2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 113503    OMIM disorders: --

    20/51 diseases for BDKRB2 (see all 51):    About MalaCards
    placenta accreta    acute mountain sickness    polycystic kidney disease, type 1    brain edema
    angioedema    hereditary angioedema    portal hypertension    brain injury
    traumatic brain injury    gastric ulcer    essential hypertension    trypanosomiasis
    chagas disease    eosinophilia    polycystic kidney disease    hypertension
    ischemia    kidney disease    myocardial infarction    migraine


    BDKRB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/33 Novoseek inferred disease relationships for BDKRB2 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    angioedema, hereditary 62 3 19758369 (2), 17073887 (1)
    inflammation 37 13 9228537 (1), 16740128 (1), 20036002 (1), 9786513 (1) (see all 11)
    angioedema 36.8 1 20461661 (1)
    brain edema 34.5 2 14534854 (1), 14753436 (1)
    glioma 19.1 7 12500695 (3), 8906560 (1), 9009737 (1), 16455538 (1)
    reactive hyperemia 16.2 1 9054837 (1)
    essential hypertension 14.5 3 15643125 (1), 15894833 (1), 18803964 (1)
    diabetic nephropathies 14.3 5 15934924 (2), 16555685 (2), 15326315 (1)
    airways disease 12.7 1 16455073 (1)
    brain tumors 11.5 6 19439100 (2), 9525816 (1), 12500695 (1), 17359538 (1) (see all 5)

    Genetic Association Database (GAD): BDKRB2
    Human Genome Epidemiology (HuGE) Navigator: BDKRB2 (60 documents)

    Export disorders for BDKRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BDKRB2 gene, integrated from 9 sources (see all 404):
    (articles sorted by number of sources associating them with BDKRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PubMed id 7916737)1, 2, 3, 9 Powell S.J.... Graham A. (1993)
    2. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. (PubMed id 15894833)1, 4, 9 Fu Y....Ogihara T. (2004)
    3. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. (PubMed id 12522467)1, 4, 9 Mukae S....Katagiri T. (2002)
    4. Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. (PubMed id 7835885)1, 2, 9 Ma J.-X.... Chao L. (1994)
    5. The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons. (PubMed id 16461337)1, 4, 9 Saunders C.J....Collins M. (2006)
    6. Association of the human bradykinin B2 receptor gene with chronic renal failure. (PubMed id 15771553)1, 4, 9 Jozwiak L....Buraczynska M. (2004)
    7. Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. (PubMed id 1314587)1, 2, 9 Hess J.F.R.... Ransom R.W. (1992)
    8. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PubMed id 15643125)1, 4, 9 Cui J....Gavras H. (2005)
    9. Rapid and reliable genotyping of the C181T polymorphism in the bradykinin B2 receptor gene. (PubMed id 12705334)1, 4, 9 Weiss J....Haefeli W.E. (2003)
    10. Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. (PubMed id 14499231)1, 4, 9 Dhamrait S.S....Montgomery H.E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 624 HGNC: 1030 AceView: BDKRB2 Ensembl:ENSG00000168398 euGenes: HUgn624
    ECgene: BDKRB2 Kegg: 624 H-InvDB: BDKRB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BDKRB2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Bradykinin_receptor
    SeattleSNPshttp://pga.gs.washington.edu/data/bdkrb2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BDKRB2 gene:
    Search GeneIP for patents involving BDKRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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