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Aliases for AVPR1B Gene

Aliases for AVPR1B Gene

  • Arginine Vasopressin Receptor 1B 2 3
  • AVPR3 3 4 6
  • Vasopressin V3 Receptor 3 4
  • AVPR V1b 3 4
  • AVPR V3 3 4
  • V1bR 3 4
  • Antidiuretic Hormone Receptor 1B 3
  • Pituitary Vasopressin Receptor 3 3
  • Antidiuretic Hormone Receptor 1b 4
  • Arginine Vasopressin Receptor 3 3
  • Vasopressin V1b Receptor 3
  • VPR3 4

External Ids for AVPR1B Gene

Previous HGNC Symbols for AVPR1B Gene

  • AVPR3

Previous GeneCards Identifiers for AVPR1B Gene

  • GC01U990014
  • GC01P202767
  • GC01P204390
  • GC01P206223
  • GC01P177157

Summaries for AVPR1B Gene

Entrez Gene Summary for AVPR1B Gene

  • The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for AVPR1B Gene

AVPR1B (Arginine Vasopressin Receptor 1B) is a Protein Coding gene. Diseases associated with AVPR1B include melancholia and acth-independent macronodular adrenal hyperplasia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein kinase C binding and vasopressin receptor activity. An important paralog of this gene is NPSR1.

UniProtKB/Swiss-Prot for AVPR1B Gene

  • Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system

Tocris Summary for AVPR1B Gene

  • Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for AVPR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AVPR1B Gene

Genomics for AVPR1B Gene

Regulatory Elements for AVPR1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AVPR1B Gene

Start:
206,109,692 bp from pter
End:
206,117,699 bp from pter
Size:
8,008 bases
Orientation:
Minus strand

Genomic View for AVPR1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AVPR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AVPR1B Gene

Proteins for AVPR1B Gene

  • Protein details for AVPR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47901-V1BR_HUMAN
    Recommended name:
    Vasopressin V1b receptor
    Protein Accession:
    P47901
    Secondary Accessions:
    • B0M0J6
    • Q5TZ00

    Protein attributes for AVPR1B Gene

    Size:
    424 amino acids
    Molecular mass:
    46971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AVPR1B Gene

Proteomics data for AVPR1B Gene at MOPED

Post-translational modifications for AVPR1B Gene

  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for AVPR1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AVPR1B Gene

Domains for AVPR1B Gene

Gene Families for AVPR1B Gene

HGNC:
  • AVPR :GPCR / Class A : Vasopressin and oxytocin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for AVPR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47901

UniProtKB/Swiss-Prot:

V1BR_HUMAN :
  • P47901
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with AVPR1B: view

Function for AVPR1B Gene

Molecular function for AVPR1B Gene

GENATLAS Biochemistry: vasopressin pituitary V3-type,receptor,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for AVPR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005000 vasopressin receptor activity IEA --
GO:0005080 protein kinase C binding TAS 10858434
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with AVPR1B: view
genes like me logo Genes that share phenotypes with AVPR1B: view

Animal Models for AVPR1B Gene

MGI Knock Outs for AVPR1B:

Animal Model Products

miRNA for AVPR1B Gene

miRTarBase miRNAs that target AVPR1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AVPR1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AVPR1B Gene

Localization for AVPR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AVPR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AVPR1B Gene COMPARTMENTS Subcellular localization image for AVPR1B gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for AVPR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10858434
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7805841
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with AVPR1B: view

Pathways for AVPR1B Gene

genes like me logo Genes that share pathways with AVPR1B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for AVPR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007202 activation of phospholipase C activity TAS 7805841
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 7929452
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with AVPR1B: view

Compounds for AVPR1B Gene

(5) Tocris Compounds for AVPR1B Gene

Compound Action Cas Number
d[Leu4,Lys8]-VP Selective V1B agonist [42061-33-6]
[Arg8]-Vasopressin Antidiuretic hormone [113-79-1]
Desmopressin Synthetic vasopressin analog; V1B and V2 agonist [16679-58-6]
SR 49059 Selective, orally active vasopressin V1A receptor antagonist [150375-75-0]
Tolvaptan Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active [150683-30-0]

(2) HMDB Compounds for AVPR1B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Vasopressin
  • 3-(Phenylalanine)-8-lysine oxytocin
11000-17-2

(3) Drugbank Compounds for AVPR1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Desmopressin
  • 1-Desamino-8-D-arginine vasopressin
16679-58-6 target
Terlipressin
  • N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
14636-12-5 target
Vasopressin
  • 3-Isoleucyl vasopressin
11000-17-2 target

(37) IUPHAR Ligand for AVPR1B Gene

Ligand Type Action Affinity Pubmed IDs
d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT Antagonist Antagonist 10
oxytocin Agonist Full agonist 9.6
[3H]OT (human, mouse, rat) Agonist Full agonist 9.5
AVT Agonist Full agonist 9.4
vasopressin Agonist Partial agonist 9.3
SR 121463A Antagonist Antagonist 9.3
dVDAVP Agonist Full agonist 9.1
d(CH2)5[Tyr(Me)2,Thr4,Phe(3I,4N3)-NH29]OVT Antagonist Antagonist 9
[3H]AVP Agonist Partial agonist 8.9
[3H]d[Cha4]AVP Agonist Full agonist 8.9
YM 471 Antagonist Antagonist 8.9
SSR149415 Antagonist Antagonist 8.8
LVP Agonist Full agonist 8.5
[Val4]AVP Agonist Full agonist 8.4
dAVP Agonist Full agonist 8.3
d(CH2)5[Tyr(Me)2]AVP Antagonist Antagonist 8.3
d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP Antagonist Antagonist 8.3
d[Cha4]AVP Agonist Full agonist 7.7
d(CH2)5[D-Ile2,Ile4,Ala-NH29]AVP Antagonist Antagonist 7.7
desmopressin Agonist Full agonist 7.6
atosiban Antagonist Antagonist 7.6
OPC-31260 Antagonist Inverse antagonist 7.6
[tBaa1,D-Tyr(Et)2,Val4,Lys6,Arg-NH28,des-Gly9]AVP Antagonist Antagonist 7.3
d(CH2)5[D-Ile2,Ile4,Ala-NH2]AVP Antagonist Antagonist 7.1
SR 49059 Antagonist Antagonist 7
d[Leu4]AVP Agonist Full agonist 6.7
d[Pen1,Tyr(Me)2]AVP Antagonist Antagonist 6.7
d[D-Phe2]AVP Agonist Full agonist 6.6
[Phaa1,D-Tyr2,Val4,Arg6,Arg-NH29]AVP Antagonist Antagonist 6.6
[Phaa1,D-Tyr(Et)2,Lys6,des-Gly9]AVP Antagonist Antagonist 6.6
[Phaa1,D-Tyr(Me)2,Arg6,Tyr-NH29]AVP Antagonist Antagonist 6.5
OH-LVA Antagonist Antagonist 6.4
YM 218 Antagonist Antagonist 6.4
[Phaa1,D-Tyr(Et)2,Val4,Lys6,Tyr-NH28,des-Gly9]AVP Antagonist Antagonist 5.7
d[D-Pal2]AVP Antagonist Antagonist 5.2
d(CH2)5[Tyr(Me)2,Thr4]OVT Antagonist Antagonist 5.2
[3H]SSR149415 Antagonist Antagonist

(4) Novoseek inferred chemical compound relationships for AVPR1B Gene

Compound -log(P) Hits PubMed IDs
acth 74.5 11
desmopressin 69.7 4
arginine 59.5 8
corticosterone 15.5 1
genes like me logo Genes that share compounds with AVPR1B: view

Transcripts for AVPR1B Gene

mRNA/cDNA for AVPR1B Gene

(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AVPR1B Gene

Arginine vasopressin receptor 1B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AVPR1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AVPR1B Gene

No ASD Table

Relevant External Links for AVPR1B Gene

GeneLoc Exon Structure for
AVPR1B
ECgene alternative splicing isoforms for
AVPR1B

Expression for AVPR1B Gene

mRNA expression in normal human tissues for AVPR1B Gene

mRNA differential expression in normal tissues according to GTEx for AVPR1B Gene

This gene is overexpressed in Pituitary (39.3).

SOURCE GeneReport for Unigene cluster for AVPR1B Gene Hs.1372

genes like me logo Genes that share expressions with AVPR1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for AVPR1B Gene

Orthologs for AVPR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for AVPR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AVPR1B 35
  • 99.21 (n)
  • 99.06 (a)
AVPR1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AVPR1B 35
  • 85.39 (n)
  • 81.04 (a)
AVPR1B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AVPR1B 35
  • 85.87 (n)
  • 82.62 (a)
AVPR1B 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Avpr1b 35
  • 83.17 (n)
  • 81.67 (a)
Avpr1b 16
Avpr1b 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AVPR1B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AVPR1B 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909648 35
  • 83.21 (n)
  • 81.95 (a)
chicken
(Gallus gallus)
Aves AVPR1B 35
  • 71.42 (n)
  • 66.58 (a)
AVT2R 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii avpr2l 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6111 37
  • 32 (a)
Species with no ortholog for AVPR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AVPR1B Gene

ENSEMBL:
Gene Tree for AVPR1B (if available)
TreeFam:
Gene Tree for AVPR1B (if available)

Paralogs for AVPR1B Gene

Paralogs for AVPR1B Gene

Selected SIMAP similar genes for AVPR1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AVPR1B: view

Variants for AVPR1B Gene

Sequence variations from dbSNP and Humsavar for AVPR1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3883899 -- 206,114,223(-) CACCA(C/G)TGGTC intron-variant
rs3888709 -- 206,113,361(+) GGGGC(A/C)AACAG intron-variant
rs3891058 - 206,116,219(-) TGCCA(A/C/T)GAGAT missense, synonymous-codon, reference
rs3891059 -- 206,115,768(-) CGATG(A/C)CATGT intron-variant
rs3891060 -- 206,115,710(-) ACAAT(A/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AVPR1B Gene

Variant ID Type Subtype PubMed ID
nsv832414 CNV Gain 17160897
nsv873118 CNV Loss 21882294
dgv519n71 CNV Loss 21882294
dgv520n71 CNV Gain 21882294

Relevant External Links for AVPR1B Gene

HapMap Linkage Disequilibrium report
AVPR1B
Human Gene Mutation Database (HGMD)
AVPR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AVPR1B Gene

Disorders for AVPR1B Gene

(5) Novoseek inferred disease relationships for AVPR1B Gene

Disease -log(P) Hits PubMed IDs
cushing syndrome 66.5 1
carcinoid 51.1 1
major depression 30 2
adenoma 28.6 1
tumors 0 3

Relevant External Links for AVPR1B

Genetic Association Database (GAD)
AVPR1B
Human Genome Epidemiology (HuGE) Navigator
AVPR1B
genes like me logo Genes that share disorders with AVPR1B: view

No data available for UniProtKB/Swiss-Prot for AVPR1B Gene

Publications for AVPR1B Gene

  1. Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor. (PMID: 7929452) Sugimoto T. … Kawashima H. (J. Biol. Chem. 1994) 2 3 4 23
  2. Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. (PMID: 17909131) Dempster E.L. … Barr C.L. (Arch. Gen. Psychiatry 2007) 3 4 23 48
  3. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck M.E. … Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 48
  4. A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. (PMID: 15094789) van West D. … Claes S. (Mol. Psychiatry 2004) 3 23 48
  5. Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors. (PMID: 17318384) Young S.F. … Aguilera G. (Cell. Mol. Neurobiol. 2007) 3 23

Products for AVPR1B Gene

Sources for AVPR1B Gene

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