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AVPR1B Gene

protein-coding   GIFtS: 67
GCID: GC01P206223

Arginine Vasopressin Receptor 1B


(Previous symbol: AVPR3)
  See AVPR1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginine Vasopressin Receptor 1B1 2     AVPR V32 3
AVPR31 2 3 5     Arginine Vasopressin Receptor 32
Antidiuretic Hormone Receptor 1b2 3     Pituitary Vasopressin Receptor 32
Vasopressin V3 Receptor2 3     Vasopressin V1b Receptor2
V1bR2 3     VPR33
AVPR V1b2 3     

External Ids:    HGNC: 8961   Entrez Gene: 5532   Ensembl: ENSG000001980497   OMIM: 6002645   UniProtKB: P479013   

Export aliases for AVPR1B gene to outside databases

Previous GC identifers: GC01U990014 GC01P202767 GC01P204390 GC01P177157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AVPR1B Gene:
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily
of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G
proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily
located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in
ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A
spliced antisense transcript of this gene has been reported but its function is not known. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AVPR1B Gene:
AVPR1B (arginine vasopressin receptor 1B) is a protein-coding gene. Diseases associated with AVPR1B include melancholia, and acth-independent macronodular adrenal hyperplasia. GO annotations related to this gene include vasopressin receptor activity and protein kinase C binding. An important paralog of this gene is GPR150.

UniProtKB/Swiss-Prot: V1BR_HUMAN, P47901
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which
activate a phosphatidyl-inositol-calcium second messenger system

summary for AVPR1B Gene:
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis
and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to
oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle
cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found
to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in
the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively
on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for AVPR1B (Arginine vasopressin receptor 1B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the AVPR1B gene promoter:
         HFH-3   GR   AML1a   GR-beta   FOXD3   LCR-F1   HEN1   FOXI1   GR-alpha   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAVPR1B promoter sequence
   Search Chromatin IP Primers for AVPR1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AVPR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

AVPR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVPR1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206223:  view genomic region     (about GC identifiers)

Start:
206,223,976 bp from pter      End:
206,231,639 bp from pter
Size:
7,664 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: V1BR_HUMAN, P47901 (See protein sequence)
Recommended Name: Vasopressin V1b receptor  
Size: 424 amino acids; 46971 Da
Secondary accessions: B0M0J6 Q5TZ00

Explore the universe of human proteins at neXtProt for AVPR1B: NX_P47901

Explore proteomics data for AVPR1B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn21

  • See AVPR1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000698.1  
    ENSEMBL proteins: 
     ENSP00000356094  
    Reactome Protein details: P47901

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AVPR: GPCR / Class A : Vasopressin and oxytocin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: V1B receptor
    Vasopressin and oxytocin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000628 Vprs_rcpt_V1B
     IPR000276 GPCR_Rhodpsn
     IPR001817 Vasoprsn_rcpt

    Graphical View of Domain Structure for InterPro Entry P47901

    ProtoNet protein and cluster: P47901

    2 Blocks protein domains:
    IPB000628 Vasopressin VIB receptor signature
    IPB001817 Vasopressin receptor signature


    UniProtKB/Swiss-Prot: V1BR_HUMAN, P47901
    Similarity: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily


    Find genes that share domains with AVPR1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: V1BR_HUMAN, P47901
    Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which
    activate a phosphatidyl-inositol-calcium second messenger system

         Genatlas biochemistry entry for AVPR1B:
    vasopressin pituitary V3-type,receptor,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0005000vasopressin receptor activity IEA--
    GO:0005080protein kinase C binding TAS10858434
         
    Find genes that share ontologies with AVPR1B           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for AVPR1B:
     Decreased Hepatitis C virus re  Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased substrate adherent c 
     Decreased telomerase activity  Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Avpr1b):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with AVPR1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AVPR1B: Avpr1btm1Wsy Avpr1btm1Gzt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AVPR1B
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    miRNA
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    miRTarBase miRNAs that target AVPR1B:
    hsa-mir-335-5p (MIRT019153)

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    2 qRT-PCR Assays for microRNAs that regulate AVPR1B:
    hsa-miR-3176 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidAVPR1B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    V1BR_HUMAN, P47901: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS10858434
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7805841
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with AVPR1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AVPR1B About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Vasopressin-like receptors0.00
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Oxytocin signaling pathway
    Vascular smooth muscle contraction0.32


    Find genes that share SuperPaths with AVPR1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for AVPR1B
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for AVPR1B
        G alpha (q) signalling events
    Vasopressin-like receptors


    3 Kegg Pathways  (Kegg details for AVPR1B):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Vascular smooth muscle contraction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AVPR1B: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AVPR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AVPR1B (P479013 ENSP000003560944) via UniProtKB, MINT, STRING, and/or I2D (see all 131)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AVPP011853, ENSP000003696474I2D: score=1 STRING: ENSP00000369647
    GRK5P349473, ENSP000003766094I2D: score=2 STRING: ENSP00000376609
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    ADRA1DENSP000003687664STRING: ENSP00000368766
    AGTR1ENSP000002734304STRING: ENSP00000273430
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001992regulation of systemic arterial blood pressure by vasopressin IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS10858434
    GO:0007202activation of phospholipase C activity TAS7805841
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS7929452

    Find genes that share ontologies with AVPR1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for AVPR1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    d[Leu4,Lys8]-VP Selective V1B agonist[42061-33-6]
    [Arg8]-VasopressinAntidiuretic hormone[113-79-1]
    SR 49059 Selective, orally active vasopressin V1A receptor antagonist [150375-75-0]
    DesmopressinSynthetic vasopressin analog; V1B and V2 agonist[16679-58-6]
    (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Selective vasopressin V1A antagonist[73168-24-8]

    2 HMDB Compounds for AVPR1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Vasopressin3-(Phenylalanine)-8-lysine oxytocin (see all 8)11000-17-2--

    3 DrugBank Compounds for AVPR1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TerlipressinN-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin (see all 4)14636-12-5target--17027167 17284170 16720725 16114100 15993108
    Vasopressin3-Isoleucyl vasopressin (see all 8)11000-17-2target--17284170 16720725 16114100 17027167 15993108
    Desmopressin1-Desamino-8-D-arginine vasopressin (see all 4)16679-58-6target--18655906 15613460 14971638

    Selected IUPHAR Ligands for AVPR1B (V1B receptor) (see all 37)    About this table
    LigandTypeActionAffinityPubmed IDs
    d[Cha4]AVP
    AgonistFull agonist9 - 9.712446593 16158071
    [3H]AVP
    AgonistFull agonist8.6 - 9.611429400 9884074 9264324 10866830 8106369 9334232 10780976 9459574 9864265 9792651 11337500 7774575 9322919
    vasopressin
    AgonistFull agonist9 - 9.59884074 12446593 16158071 9264324 9322919 10519430 10780976 9459574 15084136 9864265
    dAVP
    AgonistFull agonist8.2 - 9.49884074 12446593 15084136
    SSR149415
    AntagonistAntagonist8.4 - 9.311861823 16158071 11959912
    d[Leu4]AVP
    AgonistFull agonist9.315084136
    d[D-Phe2]AVP
    AgonistFull agonist9.312446593
    [Val4]AVP
    AgonistFull agonist912446593
    dVDAVP
    AgonistFull agonist7.6 - 99322919 12446593
    [3H]d[Cha4]AVP
    AgonistFull agonist8.912446593

    4 Novoseek inferred chemical compound relationships for AVPR1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 74.5 11 15642780 (2), 15512850 (1), 7626108 (1), 12213135 (1) (see all 10)
    desmopressin 69.7 7 18426818 (2), 9264324 (1), 11380491 (1)
    arginine 59.5 10 15094789 (1), 17909131 (1), 7626108 (1), 18384079 (1) (see all 8)
    corticosterone 15.5 1 12213135 (1)



    Find genes that share compounds with AVPR1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AVPR1B gene: 
    NM_000707.3  

    Unigene Cluster for AVPR1B:

    Arginine vasopressin receptor 1B
    Hs.1372  [show with all ESTs]
    Unigene Representative Sequence: L37112
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367126(uc001hds.2)
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      QuantiFast Probe-based Assays in human, mouse, rat AVPR1B

    Additional mRNA sequence: 

    AF030512.1 AF101726.1 D31833.1 EU432111.1 L37112.1 

    2 DOTS entries:

    DT.206498  DT.100725325 

    5 AceView cDNA sequences:

    AF101726 AF030512 NM_000707 L37112 D31833 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AVPR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCCCAGA
    AVPR1B Expression
    About this image

    AVPR1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AVPR1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1372
        Pathway & Disease-focused RT2 Profiler PCR Arrays including AVPR1B: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVPR1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AVPR1B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Avpr1b1 , 5 arginine vasopressin receptor 1B1, 5 83.17(n)1
    81.67(a)1
      1 (57.09 cM)5
    263611  NM_011924.21  NP_036054.11 
     1315992395 
    chicken
    (Gallus gallus)
    Aves AVPR1B1 arginine vasopressin receptor 1B 71.42(n)
    66.58(a)
      428263  NM_001031498.1  NP_001026669.1 
    zebrafish
    (Danio rerio)
    Actinopterygii avpr2l6
    arginine vasopressin receptor 2, like
    48(a)
    many ↔ many
    4(16904282-16906363) ENSDARG00000076690


    ENSEMBL Gene Tree for AVPR1B (if available)
    TreeFam Gene Tree for AVPR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AVPR1B gene
    GPR1502  AVPR1A2  AVPR22  OXTR2  GNRHR2  NPSR12  
    4 SIMAP similar genes for AVPR1B using alignment to 1 protein entry:     V1BR_HUMAN:
    AVPR1    AVPR1A    OXTR    AVPR2

    Find genes that share paralogs with AVPR1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AVPR1B (see all 295)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840743481,2
    --206222354(+) CCCAGA/CTACTT 1 -- us2k10--------
    rs1890499321,2
    --206222425(+) TTGTGC/TCACTG 1 -- us2k10--------
    rs284476451,2
    C,F--206222490(+) AAAAAG/AGCAAG 1 -- us2k1 trp32Minor allele frequency- A:0.50NA WA 4
    rs580756211,2
    C--206222490(+) AAAAA-/A/GGCAAG 1 -- us2k10--------
    rs2019123841,2
    C--206222503(-) GAAGTC/GCTTTT 1 -- us2k10--------
    rs1917110621,2
    --206222540(+) TGAGAG/TTCTGG 1 -- us2k10--------
    rs2015223051,2
    C--206222571(+) TAAAT-/TTT   
       GTTTG
    TTTGT
    1 -- us2k10--------
    rs353946841,2
    C,F--206222677(+) CAAGCC/TCTGCC 1 -- us2k14Minor allele frequency- T:0.38NS WA CSA 85
    rs346455951,2
    C,F--206222705(+) TCTCCT/CGCCTC 1 -- us2k12Minor allele frequency- C:0.01NS 84
    rs347869641,2
    C,F--206222742(-) GTGGCG/AGGCGC 1 -- us2k14Minor allele frequency- A:0.21NS NA 90

    HapMap Linkage Disequilibrium report for AVPR1B (206223976 - 206231639 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AVPR1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873118CNV Loss21882294
    dgv519n71CNV Loss21882294
    nsv832414CNV Gain17160897
    dgv520n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): AVPR1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AVPR1B
    DNA2.0 Custom Variant and Variant Library Synthesis for AVPR1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600264    OMIM disorders: --

    6 diseases for AVPR1B:    
    About MalaCards
    melancholia    acth-independent macronodular adrenal hyperplasia    acth-secreting pituitary adenoma    cushing's syndrome
    asperger syndrome    mood disorder


    Find genes that share disorders with AVPR1B           About GenesLikeMe

    5 Novoseek inferred disease relationships for AVPR1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cushing syndrome 66.5 1 9838245 (1)
    carcinoid 51.1 1 9425403 (1)
    major depression 30 2 15094789 (2)
    adenoma 28.6 1 9425403 (1)
    tumors 0 4 9167961 (1), 18426818 (1), 11932296 (1)

    Genetic Association Database (GAD): AVPR1B
    Human Genome Epidemiology (HuGE) Navigator: AVPR1B (13 documents)

    Export disorders for AVPR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AVPR1B gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with AVPR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. (PubMed id 17909131)1, 2, 4, 9 Dempster E.L.... Barr C.L. (Arch. Gen. Psychiatry 2007)
    2. Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor. (PubMed id 7929452)1, 2, 3, 9 Sugimoto T....Kawashima H. (J. Biol. Chem. 1994)
    3. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PubMed id 18384079)1, 4, 9 Keck M.E....Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    4. A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. (PubMed id 15094789)1, 4, 9 van West D....Claes S. (Mol. Psychiatry 2004)
    5. Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population. (PubMed id 20472303)1, 4 van West D....Claes S. (Psychiatry Res 2010)
    6. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
    7. Arginine vasopressin receptor gene-based single-nucleotide polymorphism analysis in attention deficit hyperactivity disorder. (PubMed id 19668115)1, 4 van West D....Claes S. (Psychiatr. Genet. 2009)
    8. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene. (PubMed id 10607899)1, 2 Rene P.... de Keyzer Y. (Gene 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 553 HGNC: 896 AceView: AVPR1B Ensembl:ENSG00000198049 euGenes: HUgn553
    ECgene: AVPR1B Kegg: 553 H-InvDB: AVPR1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AVPR1B Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/avpr1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AVPR1B gene:
    Search GeneIP for patents involving AVPR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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