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ANXA1 Gene

protein-coding GIFtS: 68

GC09P074956

annexin A1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ANX1, LPC1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ANX1 ^², ³
Annexin-1 ^³
Chromobindin-9 ^³
LPC1 ^², ³, ⁵
OTTHUMP00000021474 ^²
OTTHUMP00000021475 ^²
p35 ^³

Descriptions
Annexin I ^², ³
Calpactin II ^³
Lipocortin I ^², ³
Phospholipase A2 inhibitory protein ^³
annexin A1 ^²
annexin I (lipocortin I) ^²

External Ids
HGNC: 533¹
Entrez Gene: 301²
UniProtKB: P04083³
Ensembl: ENSG00000135046⁷

Search outside databases for aliases for ANXA1 gene

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ANXA1:

Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a

molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic

face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa,

with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis

of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have

potential anti-inflammatory activity. [provided by RefSeq]

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in

exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four

calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin_A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ANXA1 gene

Entrez Gene cytogenetic band: 9q12-q21.2|9q12-q21.2 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P074956: (about GC identifiers)

Start:	74,956,601 bp from pter
End:	74,975,129 bp from pter
Size:	18,529 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)

Recommended Name: Annexin A1

Size: 346 amino acids; 38714 Da

Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By

similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium

(By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and

basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in

the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity)

PDB structures from and Proteopedia :

1AIN (3D)

1BO9 (3D)

1QLS (3D)

Post-translational modifications:

Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7.

Phosphorylation results in loss of the inhibitory activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000691.1

ENSEMBL proteins:

ENSP00000366109 ENSP00000366110 ENSP00000257497

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for ANXA1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Annexin A1)
	Human Recombinant Proteins from Abnova (ANXA1)

OriGene Purified Recombinant Human Protein: ANXA1

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001533	cornified envelope	IDA	10908733
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	16130169
GO:0005929	cilium	IEA	--
GO:0016323	basolateral plasma membrane	IEA	--

About this table

Antibodies for ANXA1:

	Invitrogen Antibodies for ANXA1
	Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
	Sigma-Aldrich Antibodies for ANXA1
	R&D Systems Antibodies for ANXA1 (Annexin A1/Annexin I)
	Cell Signaling Technology (CST) Antibodies for ANXA1 (Annexin A1)
	Antibodies from Abcam (Annexin A1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ANXA1)
	Novus Biologicals Antibodies for ANXA1

Assays for ANXA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04083

ProtoNet protein and cluster: P04083

2 Blocks protein families:

IPB001464 Annexin

IPB002388 Annexin type I signature

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid

Similarity: Belongs to the annexin family

Similarity: Contains 4 annexin repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANXA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ANXA1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000700

Applied Biosystems Silencer® siRNAs for ANXA1

Sigma-Aldrich siRNA and siRNA Panels for ANXA1

Sigma-Aldrich shRNA for ANXA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ANXA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000700
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000700
untagged cDNA clone in CMV expression vector: NM_000700

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000700

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in

exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four

calcium ions with high affinity

Genatlas biochemistry entry for ANXA1:

annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the

supporting cells of the organ of Corti,located in the DFNB7 interval,involved in the regulation of

early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Anxa1):

immune system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	10882119
GO:0005198	structural molecule activity	IDA	10908733
GO:0005509	calcium ion binding	TAS	2967291
GO:0005544	calcium-dependent phospholipid binding	IEA	--
GO:0019834	phospholipase A2 inhibitor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ANXA1 (Your Favorite Gene powered by Ingenuity)

Glucocorticoid Receptor Signaling

GeneDecks ANXA1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ANXA1

5/32 Interacting proteins for ANXA1 (P04083^{1, 2} ENSP00000366109³) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	P00533², ENSP00000275493³	MINT-51101 MINT-51102 STRING (score=.764)
DLG3	Q92796¹	EBI-354007, EBI-80440
PPM1B	O75688¹	EBI-354007, EBI-1047039
YWHAZ	P63104²	MINT-3297886
S100A11	ENSP00000271638³	STRING (score=.993)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	2936963
GO:0006916	anti-apoptosis	TAS	16130169
GO:0006928	cell motion	TAS	10882119
GO:0006954	inflammatory response	TAS	10882119
GO:0007049	cell cycle	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ANXA1
10/35 Novoseek chemical compound relationships for ANXA1 gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phospholipid	61.14	33	8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
calcium	55.63	123	11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 56)
arachidonic acid	47.83	15	2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 9)
glyceraldehyde 3-phosphate	44.17	6	16220529 (1), 17268060 (1), 15274135 (1), 18665625 (1) (see all 6)
p-opc	32.56	7	16307464 (3), 18237543 (2)
ethylene glycol bis(beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid	25.34	2	1422205 (1), 1670773 (1)
phosphatidylinositol	15.84	3	7627125 (1), 2138016 (1), 10548514 (1)
ionomycin	14.22	2	8645229 (1), 12236584 (1)
prostaglandin	13.40	6	17873281 (2), 1469069 (1), 8730889 (1), 1826422 (1) (see all 5)
12-o-tetradecanoylphorbol 13-acetate	12.86	9	11142771 (4), 1444457 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANXA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ANXA1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000700

Sigma-Aldrich siRNA and siRNA Panels for ANXA1

Sigma-Aldrich shRNA for ANXA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000700

REFSEQ mRNAs for ANXA1 gene:

NM_000700.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000700

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000700
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000700
                                 untagged cDNA clone in CMV expression vector: NM_000700

Additional cDNA sequence:

AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1

BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 CR592907.1 CR598206.1

CR599722.1 CR600988.1 CR602892.1 CR607819.1 CR608313.1 CR608352.1 CR610492.1 CR618229.1

CR622273.1 CR626421.1 X05908.1

24/52 DOTS entries (see all 52 ):

DT.95080391 DT.100890399 DT.95202652 DT.100765659 DT.100890413 DT.100890422 DT.100890394 DT.100890395

DT.121161786 DT.100890415 DT.95340497 DT.95223581 DT.100890410 DT.92045136 DT.92466092 DT.100040129

DT.100890409 DT.91949347 DT.91793108 DT.91703452 DT.121161854 DT.100890404 DT.92466082 DT.92466099

24/1569 AceView cDNA sequences (see all 1569 ):

CB131626 BU187916 NM_000700 CB123295 BP368115 CB135706 CB134061 BU628406

AI358733 CB139184 BX438944 BM850145 BM970156 CA449230 CB108952 CB120549

BM972091 BU615234 CB132841 BG748968 CB113028 BM476344 CB132807 BE882507

highest scoring ESTs for ANXA1:

AA010674 AA026981 AA031662 AA039737 AA039810 AA040524 AA046308 AA046396 AA099365 AA101915

Unigene Cluster for ANXA1:

Annexin A1

Hs.494173 [show with all ESTs]

Unigene Representative Sequence: AK074480

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:					-		-		-		-		-						-				-						-										-						-
SP2:																			-				-						-										-						-
SP3:					-				-		-		-						-				-						-										-
SP4:																													-										-
SP5:							-		-		-		-						-				-						-

About this scheme

ECgene alternative splicing isoforms for ANXA1

3 Ensembl transcripts including schematic representations:

ENST00000376911 ENST00000376912 ENST00000257497

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ANXA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ANXA1

¹ / ² / ³

3 probe-sets matching ANXA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37403_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X05908	0.60	1.00	0.82	1
201012_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000700	0.60	1.00	0.82	1
201012_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ANXA1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAAAGATGT

SOURCE GeneReport for Unigene cluster: Hs.494173
Expression variation in blood from EXPOLDB for ANXA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ANXA1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ANXA1¹	--	annexin A1	89.53(n) 91.86(a)	476322 XM_533524.2 XP_533524.2
chimpanzee (Pan troglodytes)	ANXA1¹	--	annexin A1	99.42(n) 100(a)	472953 XM_001143668.1 XP_001143668.1
cow (Bos taurus)	ANXA1¹	--	annexin A1	88.57(n) 90.99(a)	327662 NM_175784.3 NP_786978.2
rat (Rattus norvegicus)	Anxa1¹	--	annexin A1	86.13(n) 89.02(a)	25380 NM_012904.1 NP_037036.1
mouse (Mus musculus)	Anxa1^{1, 5}	19 (18.00 cM)⁵	annexin A1^{1, 5}	86.61(n)¹ 87.57(a)¹	16952¹ NM_010730.2¹ NP_034860.2¹ AK002681⁵ AK037064⁵ (see all 37)

About this table Species with no ortholog for ANXA1

ENSEMBL Gene Tree for ANXA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ANXA1 gene

ANXA3² ANXA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/113 NCBI SNPs in ANXA1 are shown (see all 113 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 107)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2795108^1,2	A,C,F,H,O	74955298(+)	`TTTTAT/CGTGAA`	1	--	ng5¹		7		EU EA WA NA	556
	rs2310312^1,2	A,C,F,H,O	74954818(+)	`CAAAGC/AAAAAT`	1	--	ng5¹		11		NA EU EA WA	970
	rs3739956^1,2	C,F,H	74956658(+)	`AGATAA/GAGGTA`	1	--	ut5¹		8		EA NA EU WA	1832
	rs10121585^1,2	F,H	74955329(+)	`AAAAAG/TAACAA`	1	--	ng5¹ trp³		4		EU EA WA	418
--	rs2795110^1,2	A,C	74956232(+)	`TTGTTG/TGTTTG`	1	--	ng5¹		0	--	--	--	--
	rs9561^1,2	A,H	74974925(+)	`AGTTTC/TTTCAA`	1	--	ut3¹ ese³		5		MN EU EA WA	600
	rs3758355^1,2	H	74954920(+)	`TTCCAA/GTAGTT`	1	--	ng5¹		5		EA EU WA	1898
--	rs11557052^1,2	H	74963491(+)	`CCTTCA/GATCCA`	1	N/D	mis¹ ese³		4		EU EA WA	406
	rs1050305^1,2	C,F,H	74965055(+)	`GTTTTA/GGCTCT`	1	L/L	syn¹		4		EU EA WA	418
	rs2795113^1,2	A,C,F,H,O	74959952(+)	`TGGCCA/TATTTC`	1	--	int¹		16		EU EA WA NA	1472

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HapMap Linkage Disequilibrium images for ANXA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 151690

10/52 Novoseek disease relationships for ANXA1 gene (see all 52 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	39.28	24	15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 16)
adenocarcinoma lung	33.12	5	17351649 (2), 17974280 (1)
inflammation	30.78	27	9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 17)
prostatic intraepithelial neoplasia	25.94	4	16324197 (2), 11801547 (1)
tumors	21.74	47	16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 24)
premalignant	18.55	2	10448305 (1), 14695321 (1)
lymphoma b-cell	17.88	4	15070421 (2)
colon adenocarcinoma	16.88	6	15526283 (3), 18541673 (2)
metastasis	12.15	18	18535914 (3), 18776816 (3), 18223218 (2), 17974280 (1) (see all 9)
rheumatoid arthritis	11.91	6	1445462 (1), 9831319 (1), 11083278 (1), 17334042 (1) (see all 6)

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Genetic Association Database: ANXA1
Human Genome Epidemiology Navigator: ANXA1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/401 PubMed articles for ANXA1 gene (see all 401 ):

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)^{2, 3, 4} Wallner B.P.... Pepinsky R.B. (1986)
Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)^{1, 3, 4} Weng X.... Huber R. (1993)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)^{3, 4} Dorovkov M.V. and Ryazanov A.G. (2004)
[Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese] (PubMed id 15476183)^{3, 6} Dong Y....Luo M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)^{3, 6} Lindgren C.M....Groop L.C. (2001)
NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)^{3, 4} Gao J.... Yan H. (1999)
Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)^{3, 4} Arcone R.... Ciliberto G. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 301	HGNC: 533	AceView: ANXA1	Ensembl:ENSG00000135046	euGenes: HUgn301
ECgene: ANXA1	H-InvDB: ANXA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ANXA1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ANXA1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ANXA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ANXA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ANXA1		Antibodies for ANXA1
	Explore super-pooled esiRNAs		Proteins for ANXA1
	Lentivirus-delivered shRNAs for ANXA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ANXA1)
	Antibodies (ANXA1)
	Chimera RNAi (ANXA1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ANXA1 (Annexin A1)

	Recombinant Proteins (Annexin A1)
	Antibodies (Annexin A1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ANXA1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ANXA1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ANXA1 Gene at Home site.
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ANXA1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ANXA1

Summaries
for ANXA1

Genomic Location
for ANXA1

Proteins
for ANXA1

Protein Domains/
Families
for ANXA1

Gene Function
for ANXA1

Pathways & Interactions
for ANXA1

Drugs & Compounds
for ANXA1

Transcripts
for ANXA1

Expression
for ANXA1

Orthologs
for ANXA1

Paralogs
for ANXA1

SNPs/Variants
for ANXA1

Disorders & Mutations
for ANXA1

Medical News
for ANXA1

Publications
for ANXA1

Search for ANXA1

Genome Databases showing ANXA1

Other Databases showing ANXA1

Specialized Databases showing ANXA1

Licensable Technologies
for ANXA1

Services
for ANXA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ANXA1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ANXA1

Summariesfor ANXA1

Genomic Locationfor ANXA1

Proteinsfor ANXA1

Protein Domains/Familiesfor ANXA1

Gene Functionfor ANXA1

Pathways & Interactionsfor ANXA1

Drugs & Compoundsfor ANXA1

Transcriptsfor ANXA1

Expression for ANXA1

Orthologsfor ANXA1

Paralogsfor ANXA1

SNPs/Variantsfor ANXA1

Disorders & Mutationsfor ANXA1

Medical Newsfor ANXA1

Publicationsfor ANXA1

Search for ANXA1

Genome Databases showing ANXA1

Other Databases showing ANXA1

Specialized Databases showing ANXA1

Licensable Technologiesfor ANXA1

Servicesfor ANXA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ANXA1

Summaries
for ANXA1

Genomic Location
for ANXA1

Proteins
for ANXA1

Protein Domains/
Families
for ANXA1

Gene Function
for ANXA1

Pathways & Interactions
for ANXA1

Drugs & Compounds
for ANXA1

Transcripts
for ANXA1

Expression
for ANXA1

Orthologs
for ANXA1

Paralogs
for ANXA1

SNPs/Variants
for ANXA1

Disorders & Mutations
for ANXA1

Medical News
for ANXA1

Publications
for ANXA1

Licensable Technologies
for ANXA1

Services
for ANXA1