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ALB Gene

protein-coding GIFtS: 66

GC04P074509

albumin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp779N1935 ^²
PRO0883 ^²
PRO0903 ^²
PRO1341 ^²
albumin ^²

Descriptions
cell growth inhibiting protein 42 ^²
growth-inhibiting protein 20 ^²
serum albumin ^²

External Ids
HGNC: 399¹
Entrez Gene: 213²
UniProtKB: P02768³
Ensembl: ENSG00000163631⁷

Search outside databases for aliases for ALB gene

Previous GC identifers: GC04P074259 GC04P074670 GC04P074736 GC04P074635

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALB:

Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein.

Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones

and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated

serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin

which has an N-terminal peptide that is removed before the nascent protein is released from the

rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to

produce the secreted albumin. [provided by RefSeq]

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768

Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+),

Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of

the colloidal osmotic pressure of blood

Gene Wiki entry for ALB (Human_serum_albumin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALB gene

Entrez Gene cytogenetic band: 4q11-q13 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3

ALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P074509: (about GC identifiers)

Start:	74,488,870 bp from pter
End:	74,505,996 bp from pter
Size:	17,127 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_006216.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768 (See protein sequence)

Recommended Name: Serum albumin precursor

Size: 609 amino acids; 69367 Da

Subcellular location: Secreted

Miscellaneous: Acetylated on Lys-223 by acetylsalicylic acid

Caution: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and

PubMed:2437111) termed neurotensin-related peptide (NRP) or kinetensin and was thought to

regulates fat digestion, lipid absorption, and blood flow

PDB structures from and Proteopedia :

1AO6 (3D)

1BJ5 (3D)

1BKE (3D)

1BM0 (3D)

1E78 (3D)

1E7A (3D)

1E7B (3D)

1E7C (3D)

1E7E (3D)

1E7F (3D)

1E7G (3D)

1E7H (3D)

1E7I (3D)

1GNI (3D)

1GNJ (3D)

1H9Z (3D)

1HA2 (3D)

1HK1 (3D)

1HK2 (3D)

1HK3 (3D)

1HK4 (3D)

1HK5 (3D)

1N5U (3D)

1O9X (3D)

1TF0 (3D)

1UOR (3D)

1YSX (3D)

2BX8 (3D)

2BXA (3D)

2BXB (3D)

2BXC (3D)

2BXD (3D)

2BXE (3D)

2BXF (3D)

2BXG (3D)

2BXH (3D)

2BXI (3D)

2BXK (3D)

2BXL (3D)

2BXM (3D)

2BXN (3D)

2BXO (3D)

2BXP (3D)

2BXQ (3D)

2ESG (3D)

2I2Z (3D)

2I30 (3D)

2VDB (3D)

2VUE (3D)

2VUF (3D)

3B9L (3D)

3B9M (3D)

3CX9 (3D)

Secondary accessions: O95574 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q9P157 Q9P1I7 Q9UHS3 Q9UJZ0

Alternative splicing: 2 isoforms: P02768-1 P02768-2

Post-translational modifications:

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to

Cys-602 and Cys-601 to Cys-606¹

Glycated in diabetic patients¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000468.1

ENSEMBL proteins:

ENSP00000384695 ENSP00000295897 ENSP00000331666 ENSP00000370290

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Human Serum Albumin)
	Human Recombinant Proteins from Abnova (ALB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IEA	--
GO:0031093	platelet alpha granule lumen	EXP	6457647
GO:0043234	protein complex	IDA	16283771

About this table

Antibodies for ALB:

	Invitrogen Antibodies for ALB
	Millipore Mono- and Polyclonal Antibodies for the study of ALB
	Sigma-Aldrich Antibodies for ALB
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ALB (Albumin)
	Antibodies from Abcam (Human Serum Albumin), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ALB

Assays for ALB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02768

ProtoNet protein and cluster: P02768

1 Blocks protein family: IPB000264 Serum albumin family

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768

Similarity: Belongs to the ALB/AFP/VDB family

Similarity: Contains 3 albumin domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC035969

Applied Biosystems Silencer® siRNAs for ALB

Sigma-Aldrich siRNA and siRNA Panels for ALB

Sigma-Aldrich shRNA for ALB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000477
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000477
untagged cDNA clones in CMV expression vector (see all 2): BC035969

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000477

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768

Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+),

Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of

the colloidal osmotic pressure of blood

Genatlas biochemistry entry for ALB:

albumin,putative down-regulated c-Myc target gene,

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alb):

digestive/alimentary

homeostasis/metabolism

normal

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	16405401
GO:0005504	fatty acid binding	NAS	9731778
GO:0005507	copper ion binding	NAS	14726550
GO:0005515	protein binding	IPI	16099937
GO:0008144	drug binding	NAS	10940303

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ALB (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling
Caveolar-mediated Endocytosis

GeneDecks ALB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ALB

5/152 Interacting proteins for ALB (ENSP00000370290³ P02768²) via UniProtKB, MINT, and/or STRING (see all 152 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACADVL	P49748²	MINT-6549314
CDC2	P06493²	MINT-6549314
DENR	O43583²	MINT-6549314
EEF2K	O00418²	MINT-6549314
EIF4A3	P38919²	MINT-6549314

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	12617161
GO:0009267	cellular response to starvation	IDA	16245148
GO:0019836	hemolysis by symbiont of host erythrocytes	IDA	16394536
GO:0043066	negative regulation of apoptosis	IDA	16153637
GO:0051659	maintenance of mitochondrion location	IDA	16153637

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ALB:

Antagonist

Browse Tocris compounds for ALB
10/40 Novoseek chemical compound relationships for ALB gene (see all 40 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	83.64	1462	16703327 (7), 9610611 (7), 11422756 (7), 12969171 (7) (see all 99)
cholesterol	79.17	1789	15082432 (7), 8524502 (6), 18563300 (6), 17279492 (5) (see all 99)
rhsa	78.96	70	9167443 (2), 10502345 (2), 18199895 (2), 9688461 (2) (see all 37)
dansylsarcosine	78.50	30	1382424 (6), 9430764 (3), 8720306 (2), 1706921 (2) (see all 16)
urea	77.51	616	8366899 (5), 8573919 (4), 7606993 (4), 10666933 (4) (see all 99)
uric acid	75.65	447	10910618 (5), 10898045 (4), 18442624 (4), 16554340 (3) (see all 99)
glucose	72.96	1442	9103700 (6), 8575721 (6), 16920285 (5), 7986543 (5) (see all 99)
fructosamine	71.30	205	10326628 (7), 1597333 (5), 8893144 (5), 8502341 (5) (see all 91)
hepaplastin	69.13	36	10430305 (2), 7874270 (1), 10390961 (1), 10982623 (1) (see all 32)
sodium	66.07	501	9574640 (6), 8686978 (5), 8023982 (5), 15367175 (5) (see all 99)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC035969

Sigma-Aldrich siRNA and siRNA Panels for ALB

Sigma-Aldrich shRNA for ALB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000477

REFSEQ mRNAs for ALB gene:

NM_000477.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000477

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000477
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000477
                                 untagged cDNA clones in CMV expression vector (see all 2): BC035969

Additional cDNA sequence:

AF190168.1 AF542069.1 AK292755.1 AK298437.1 AK298461.1 AK308044.1 AK314794.1 AY358313.1

AY544124.1 AY550967.1 AY728024.1 AY960291.1 BC014308.1 BC034023.1 BC034026.1 BC035969.1

BC036003.1 BC039235.1 BC041789.1 CR590441.1 CR590559.1 CR590565.1 CR590662.1 CR590860.1

CR590946.1 CR591135.1 CR591316.1 CR592047.1 CR592175.1 CR592642.1 CR592816.1 CR593238.1

CR593239.1 CR593838.1 CR593839.1 CR593996.1 CR594121.1 CR594216.1 CR594507.1 CR594508.1

CR594567.1 CR595087.1 CR595460.1 CR596141.1 CR596272.1 CR596480.1 CR596833.1 CR596880.1

CR596914.1 CR597043.1 CR597211.1 CR597943.1 CR598093.1 CR598383.1 CR598385.1 CR598603.1

CR599168.1 CR599458.1 CR599721.1 CR600034.1 CR600037.1 CR600791.1 CR601390.1 CR601415.1

CR601553.1 CR602440.1 CR602816.1 CR603329.1 CR603331.1 CR603379.1 CR603655.1 CR603842.1

CR604028.1 CR604468.1 CR604471.1 CR605000.1 CR605103.1 CR605340.1 CR605517.1 CR605670.1

CR606186.1 CR606327.1 CR606332.1 CR606409.1 CR606433.1 CR606436.1 CR606456.1 CR606725.1

CR607762.1 CR607982.1 CR608360.1 CR608361.1 CR608483.1 CR609761.1 CR610097.1 CR610411.1

CR610438.1 CR611727.1 CR611846.1 CR612534.1 CR612673.1 CR612742.1 CR612869.1 CR613164.1

CR613537.1 CR613656.1 CR614762.1 CR615003.1 CR615080.1 CR615140.1 CR615141.1 CR615515.1

CR615566.1 CR616077.1 CR616559.1 CR617076.1 CR617086.1 CR617173.1 CR617306.1 CR617317.1

CR617604.1 CR617605.1 CR617809.1 CR617825.1 CR617917.1 CR618745.1 CR618825.1 CR618884.1

CR618985.1 CR619204.1 CR619209.1 CR619440.1 CR619916.1 CR620317.1 CR620357.1 CR620627.1

CR621036.1 CR621037.1 CR621584.1 CR621629.1 CR622690.1 CR622692.1 CR623499.1 CR623708.1

CR624078.1 CR624084.1 CR624085.1 CR624270.1 CR624330.1 CR624773.1 CR624987.1 CR625370.1

CR625426.1 CR625546.1 CR626041.1 CR626274.1 CR626607.1 CR626733.1 CR626747.1 CR749331.1

DQ986150.1 V00494.1 V00495.1

24/205 DOTS entries (see all 205 ):

DT.100864734 DT.98132054 DT.95377482 DT.100746389 DT.87011119 DT.100861910 DT.100746447 DT.91816166

DT.95377906 DT.100746541 DT.95376678 DT.100746432 DT.95376610 DT.95376706 DT.100844172 DT.100861974

DT.100746557 DT.100746613 DT.95376631 DT.91998425 DT.92056056 DT.98132061 DT.100746529 DT.95376639

24/3197 AceView cDNA sequences (see all 3197 ):

AA334865 BX448871 CB153849 H72186 CB153375 AA343603 CB154310 AA344188

AI187111 CB116624 AI114559 BG617320 CB153817 BG568328 CR625426 BX400104

CR592642 BG569573 CR607762 CR607982 AV682630 BX464248 BX423811 CB154718

highest scoring ESTs for ALB:

AA063526 AA312610 AA312816 AA312971 AA313106 AA341950 AA342078 AA342121 AA342129 AA342131

Unigene Cluster for ALB:

Albumin

Hs.418167 [show with all ESTs]

Unigene Representative Sequence: NM_000477

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ALB (see all 10 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	^	13	^	14a	·
SP1:																					-										-								-
SP2:																	-		-		-		-		-		-		-		-		-		-				-
SP3:							-		-		-		-		-		-		-		-		-		-						-								-
SP4:									-		-		-		-		-		-		-		-		-		-				-								-
SP5:													-		-		-		-		-		-								-

ExUns:	14b	^	15	^	16a	·	16b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ALB

4 Ensembl transcripts including schematic representations:

ENST00000401494 ENST00000295897 ENST00000329326 ENST00000380904

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALB

¹ / ² / ³

11 probe-sets matching ALB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33991_g_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.17	U22961	0.20	1.00	0.72	1
33992_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.00	M12523	0.20	1.00	0.72	1
33990_at²^{, 3}	U95-A	1	1.00	1.00	0.85	0.81	U22961	0.20	1.00	0.72	1
64635_at*²^{, 3}	U95-C	1	--	--	0.95	1.15	H65265	0.20	1.00	0.72	1
211298_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF116645	0.60	1.00	0.82	1
214837_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	M12523	0.20	1.00	0.72	1
214842_s_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	M12523	0.20	1.00	0.72	1
1565228_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211298_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214837_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--
214842_s_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks ALB for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAATAAGAG

SOURCE GeneReport for Unigene cluster: Hs.418167
Expression variation in blood from EXPOLDB for ALB
UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
Tissue specificity: Plasma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALB gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALB¹	--	albumin	82.37(n) 80.07(a)	403550 XM_850464.1 XP_855557.1
chimpanzee (Pan troglodytes)	ALB¹	--	albumin	99.33(n) 98.83(a)	461260 XM_517233.2 XP_517233.2
cow (Bos taurus)	ALB¹	--	albumin	82.34(n) 76.57(a)	280717 NM_180992.2 NP_851335.1
rat (Rattus norvegicus)	Alb¹	--	albumin	76.22(n) 73.48(a)	24186 NM_134326.1 NP_599153.1
mouse (Mus musculus)	Alb^{1, 5}	5 (50.00 cM)⁵	albumin^{1, 5}	77.05(n)¹ 72.32(a)¹	11657¹ NM_009654.2¹ NP_033784.1¹ AA103180⁵ AI047510⁵ (see all 20)

About this table Species with no ortholog for ALB

ENSEMBL Gene Tree for ALB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALB gene

AFM² GC² AFP²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768

Polymorphism: The sequence shown is that of variant albumin A

10/176 NCBI SNPs in ALB are shown (see all 176 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3756066^1,2	A,C,F,H	74488552(-)	`CTTGGA/TGTTTG`	1	--	ng5¹		20		EA NA EU WA NS	3120
	rs7688274^1,2	A,C,F,H	74487522(+)	`AAGAAA/GAAATA`	1	--	ng5¹ tfbs³ trp³		9		EU EA WA NA NS	634
--	rs3204504^1,2	C,F,H	74494921(+)	`GAAGGC/TTTCGT`	1	A/V	mis¹		9		MN EU EA WA	1024
	rs3756067^1,2	C,F	74488509(-)	`CCAAAC/TTAAAT`	1	--	ng5¹		4		MN EA NS	450
--	rs11538228^1,2	C,H	74494930(+)	`GTCTGC/GCAAAC`	1	A/G	mis¹ ese³		8		EU EA WA	812
--	rs11538227^1,2	H	74502861(+)	`CACTTT/CCTGAG`	1	P/S	mis¹		4		EU EA WA	406
--	rs11538209^1,2	H	74488937(+)	`CCTTCT/CTTTTC`	1	P/L	mis¹ trp³		4		EU EA WA	406
--	rs4429703^1,2	A	74506267(+)	`TGGAAC/TAGAAC`	1	--	ng3¹		0	--	--	--	--
--	rs11538223^1,2	H	74498181(+)	`GCAAAA/GACTAT`	1	N/D	mis¹		4		EU EA WA	406
	rs1063469^1,2	F	74502708(+)	`ATGAGA/GAAACG`	1	K/E	mis¹		1		MN	184

About this table

HapMap Linkage Disequilibrium images for ALB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 103600

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768

Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH)

[MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of

ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian

population

A variant structure of albumin could lead to increased binding of zinc resulting in an

asymptomatic augmentation of zinc concentration in the blood [MIM:194470]

10/96 Novoseek disease relationships for ALB gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
microalbuminuria	94.73	993	7634745 (5), 9759691 (5), 15717883 (5), 12788992 (4) (see all 99)
albuminuria	92.00	332	16703327 (5), 17405790 (5), 10489399 (4), 9179466 (4) (see all 99)
hypoalbuminemia	90.10	249	1569418 (4), 9397418 (4), 10428270 (3), 8363760 (3) (see all 99)
diabetic nephropathies	88.89	339	1881577 (4), 8264568 (3), 11131103 (3), 1493158 (3) (see all 99)
renal disease	86.31	582	8163055 (4), 8593760 (4), 17928473 (3), 18941353 (3) (see all 99)
proteinuria	86.12	586	12521234 (5), 9915226 (5), 16425574 (5), 1831839 (5) (see all 99)
malnutrition	85.66	381	17957127 (4), 19218044 (4), 11592443 (3), 17321950 (3) (see all 99)
renal failure chronic	80.09	95	2082760 (2), 1951474 (2), 9101098 (2), 1282889 (1) (see all 90)
nephrotic syndrome	79.49	182	2082057 (6), 8502517 (5), 1379421 (3), 15481604 (3) (see all 99)
protein-energy malnutrition	76.79	29	10219494 (2), 15695952 (2), 9106105 (1), 10433138 (1) (see all 23)

About this table

Human Gene Mutation Database: ALB
Genetic Association Database: ALB
Human Genome Epidemiology Navigator: ALB (13 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/6363 PubMed articles for ALB gene (see all 6363 ):

Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (PubMed id 7852505)^{1, 3, 4} Rushbrook J.I.... Divino C.M. (1995)
Crystal structure of human serum albumin at 2.5-A resolution. (PubMed id 10388840)^{1, 3, 4} Sugio S.... Kobayashi K. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)^{3, 6} Watanabe I....Koga T. (2003)
Towards defining the urinary proteome using liquid chromatography- tandem mass spectrometry I. Profiling an unfractionated tryptic digest. (PubMed id 11680902)^{3, 4} Spahr C.S.... Patterson S.D. (2001)
A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. (PubMed id 11168369)^{3, 4} Minchiotti L....Galliano M. (2001)
Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. (PubMed id 11743713)^{3, 4} Petitpas I.... Curry S. (2001)
Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)^{3, 4} Yu Y....He F. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 213	HGNC: 399	AceView: ALB	Ensembl:ENSG00000163631	euGenes: HUgn213
ECgene: ALB	H-InvDB: ALB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Mammary Transgene Database entry for ALB	More genetic and clinical information
Albumin Website	http://www.albumin.org
Wikipedia	http://en.wikipedia.org/wiki/Serum_albumin
GeneReviews	http://www.genetests.org/query?gene=ALB
SeattleSNPs	http://pga.gs.washington.edu/data/alb/

Licensable Technologies for ALB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALB		Antibodies for ALB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALB		Small molecules for ALB
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALB)
	Search for Antibodies
	Chimera RNAi (ALB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ALB (Albumin)

	Recombinant Proteins (Human Serum Albumin)
	Antibodies (Human Serum Albumin)

Search OriGene for ALB

Search Tocris compounds for ALB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALB

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ALB Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ALB

Summaries
for ALB

Genomic Location
for ALB

Proteins
for ALB

Protein Domains/
Families
for ALB

Gene Function
for ALB

Pathways & Interactions
for ALB

Drugs & Compounds
for ALB

Transcripts
for ALB

Expression
for ALB

Orthologs
for ALB

Paralogs
for ALB

SNPs/Variants
for ALB

Disorders & Mutations
for ALB

Medical News
for ALB

Publications
for ALB

Search for ALB

Genome Databases showing ALB

Other Databases showing ALB

Specialized Databases showing ALB

Licensable Technologies
for ALB

Services
for ALB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALB Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ALB

Summariesfor ALB

Genomic Locationfor ALB

Proteinsfor ALB

Protein Domains/Familiesfor ALB

Gene Functionfor ALB

Pathways & Interactionsfor ALB

Drugs & Compoundsfor ALB

Transcriptsfor ALB

Expression for ALB

Orthologsfor ALB

Paralogsfor ALB

SNPs/Variantsfor ALB

Disorders & Mutationsfor ALB

Medical Newsfor ALB

Publicationsfor ALB

Search for ALB

Genome Databases showing ALB

Other Databases showing ALB

Specialized Databases showing ALB

Licensable Technologiesfor ALB

Servicesfor ALB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALB

Summaries
for ALB

Genomic Location
for ALB

Proteins
for ALB

Protein Domains/
Families
for ALB

Gene Function
for ALB

Pathways & Interactions
for ALB

Drugs & Compounds
for ALB

Transcripts
for ALB

Expression
for ALB

Orthologs
for ALB

Paralogs
for ALB

SNPs/Variants
for ALB

Disorders & Mutations
for ALB

Medical News
for ALB

Publications
for ALB

Licensable Technologies
for ALB

Services
for ALB