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ADRB2 Gene

protein-coding GIFtS: 71

GC05P148186

adrenergic, beta-2-, receptor, surface
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADRB2R)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADRB2R ^², ³
ADRBR ^¹, ²
B2AR ^¹, ², ³
BAR ^¹, ²
BETA2AR ^²

Descriptions
Beta-2 adrenoceptor ^², ³
Beta-2 adrenoreceptor ^³
adrenergic, beta-2-, receptor, surface ^²
beta-2 adrenergic receptor ^²
catecholamine receptor ^²

External Ids
HGNC: 286¹
Entrez Gene: 154²
UniProtKB: P07550³
Ensembl: ENSG00000169252⁷

Search outside databases for aliases for ADRB2 gene

Previous GC identifers: GC05P148250 GC05M148800 GC05P148187 GC05P148235 GC05P148236

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADRB2:

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor

superfamily. This receptor is directly associated with one of its ultimate effectors, the class C

L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an

adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly

of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G

protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations,

and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2

diabetes. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate

cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an

approximately 30-fold greater affinity than it does norepinephrine

Gene Wiki entry for ADRB2 (Beta-2_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRB2 gene

Entrez Gene cytogenetic band: 5q31-q32 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q31-q32

ADRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P148186: (about GC identifiers)

Start:	148,186,349 bp from pter
End:	148,188,381 bp from pter
Size:	2,033 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550 (See protein sequence)

Recommended Name: Beta-2 adrenergic receptor

Size: 413 amino acids; 46427 Da

Subunit: Binds SLC9A3R1 and GPRASP1

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2R4R (3D)

2R4S (3D)

2RH1 (3D)

3D4S (3D)

Secondary accessions: B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9

Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Post-translational modifications:

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma

membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346

phosphorylation¹

Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization

of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.

Phosphorylated upon DNA damage, probably by ATM or ATR¹

Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000015.1

ENSEMBL proteins:

ENSP00000305372

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (beta 2 Adrenergic Receptor)
	Human Recombinant Proteins from Abnova (ADRB2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/12 Gene Ontology (GO) cellular component terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005764	lysosome	TAS	9507004
GO:0005768	endosome	TAS	10734107
GO:0005887	integral to plasma membrane	TAS	9228019

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Antibodies for ADRB2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADRB2
	Sigma-Aldrich Antibodies for ADRB2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (beta 2 Adrenergic Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADRB2)
	Novus Biologicals Antibodies for ADRB2

Assays for ADRB2:

	Invitrogen Assays for ADRB2
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: P07550

2 Blocks protein families:

IPB000332 Beta-2 adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRB2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000024

Applied Biosystems Silencer® siRNAs for ADRB2

Sigma-Aldrich siRNA and siRNA Panels for ADRB2

Sigma-Aldrich shRNA Panels and shRNA for ADRB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADRB2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000024
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000024
untagged cDNA clone in CMV expression vector: NM_000024

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000024

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate

cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an

approximately 30-fold greater affinity than it does norepinephrine

Genatlas biochemistry entry for ADRB2:

adrenergic,beta-2-,receptor,G protein coupled receptor superfamily,activating adenylate

cyclase,major lipolytic receptor in human fat cell altered in obesity,also associated to

susceptibility to hypertension (polymorphism,R16G)

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adrb2):

	adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	muscle
skeleton

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004941	beta2-adrenergic receptor activity	IDA	15123695
GO:0008144	drug binding	IEA	--
GO:0008179	adenylate cyclase binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRB2 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling
Glucocorticoid Receptor Signaling
Cardiac Hypertrophy Signaling

GeneDecks ADRB2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADRB2

5/78 Interacting proteins for ADRB2 (ENSP00000305372³ P07550^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 78 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R1	O14745²	STRING (score=.999) MINT-1796489 MINT-2842955 MINT-1796525 MINT-2843018 MINT-2842994 MINT-1796656 MINT-2842879 MINT-2842917
SRC	P12931²	STRING (score=.934) MINT-4051805 MINT-4051815 MINT-4051585
HTR4	Q13639²	STRING (score=.926) MINT-60083
EIF2B1	Q14232¹	EBI-491169, EBI-491065
ADRBK1	ENSP00000312262³	STRING (score=.999)

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5/29 Gene Ontology (GO) biological process terms (links to tree view) (see all 29 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	9924018
GO:0002024	diet induced thermogenesis	IEA	--
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	IEA	--
GO:0002028	regulation of sodium ion transport	IEA	--
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	IDA	15123695

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADRB2

Sigma-Aldrich Small Molecules for ADRB2:

Antagonist Blocker Agonist

Compounds for ADRB2 available from Tocris Bioscience

Compound	Action	CAS number
ICI 118,551 hydrochloride	Very selective beta2 antagonist	[72795-01-8]
Salmeterol	Potent beta2 agonist; long acting	[89365-50-4]
Salbutamol hemisulfate	beta agonist (beta2 > beta1)	[51022-70-9]
Formoterol hemifumarate	Potent and selective beta2 agonist	[183814-30-4]

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10/35 Novoseek chemical compound relationships for ADRB2 gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
catecholamine	73.44	99	7608992 (3), 11591153 (3), 8756182 (2), 8685890 (2) (see all 69)
ianbd	67.46	4	9585127 (2), 7499324 (1)
zilpaterol	64.39	4	16335946 (2), 16332507 (1), 16579610 (1)
forskolin	60.71	6	10822171 (1), 8903846 (1), 16332507 (1), 10473590 (1) (see all 6)
cyclic amp	57.40	35	12399592 (2), 16763224 (2), 1325962 (2), 10614711 (2) (see all 20)
ici118551	55.61	2	1353486 (1), 18469068 (1)
arg-arg	53.08	2	16339181 (1)
nppa	53.05	2	17036337 (1), 15699455 (1)
gtp	36.28	9	9729456 (2), 9716378 (2), 10102993 (1), 16571971 (1) (see all 6)
tyrosine	30.92	35	17224079 (2), 7507928 (2), 11278940 (2), 9880482 (2) (see all 29)

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10/12 PharmGKB drug compound relationships for ADRB2 gene (see all 12 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Beta adrenergic antagonists	PD FA GN	12523655 9174358 8489482 11900882 12574160 11807178 12540746 12464928 14499340 9560162
albuterol	CO PD PK FA GN	10340917 10903223 10984540 11306963 11371409 9399966 11516429
albuterol sulfate	CO PD GN	15500895
beta adrenergic agonists	PD GN	12523655
carvedilol	PD GN	12835612
formoterol	FA GN	11516429
isoproterenol	PD FA GN	12142724 20447473 12527744 11586955 15284533 14990578 7915137 9363896 11516429 7901205 2545714 12399592 10711498
metaproterenol	FA GN	11516429
salbutamol	PD GN	10515402 99301892 10950895
salmeterol	CO PD FA GN	11934710 12642431 11516429 10950895

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRB2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000024

Sigma-Aldrich siRNA and siRNA Panels for ADRB2

Sigma-Aldrich shRNA Panels and shRNA for ADRB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000024

REFSEQ mRNAs for ADRB2 gene:

NM_000024.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000024

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000024
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000024
                                 untagged cDNA clone in CMV expression vector: NM_000024

Additional cDNA sequence:

AK223025.1 AK313151.1 AY136741.1 BC012481.2 BC063486.1 BC073856.1 CR595085.1 M15169.1

X04827.1

2 DOTS entries:

DT.313911 DT.95267150

24/50 AceView cDNA sequences (see all 50 ):

BQ447101 CR595085 BC073856 BM544409 BP347785 AV647785 NM_000024 BQ017003

X04827 CA440083 CN837362 AY136741 BC012481 BC063486 BG256156 AA948091

BX092021 BP366282 M15169 BI915042 AL553611 BM702832 AU155755 H90431

highest scoring ESTs for ADRB2:

M15169 AA522578 AA886615 AA948091 AI453828 AL576640 AV647785 AY136741 BC012481 BC063486

Unigene Cluster for ADRB2:

Adrenergic, beta-2-, receptor, surface

Hs.591251 [show with all ESTs]

Unigene Representative Sequence: M15169

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000305988

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADRB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRB2

¹ / ² / ³

3 probe-sets matching ADRB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
610_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M15169	1.00	1.00	1.00	1
206170_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000024	0.60	1.00	0.82	1
206170_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADRB2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACTCTTCCC

SOURCE GeneReport for Unigene cluster: Hs.591251
Expression variation in blood from EXPOLDB for ADRB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADRB2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRB2¹	--	adrenergic, beta-2-, receptor, surface	90(n) 90.24(a)	403910 NM_001003234.1 NP_001003234.1
chimpanzee (Pan troglodytes)	ADRB2¹	--	adrenergic, beta-2-, receptor, surface	99.6(n) 99.03(a)	471690 XM_527068.2 XP_527068.2
cow (Bos taurus)	ADRB2¹	--	adrenergic, beta-2-, receptor, surface	89.99(n) 89.1(a)	281605 NM_174231.1 NP_776656.1
rat (Rattus norvegicus)	Adrb2¹	--	adrenergic, beta-2-, receptor, surface	87.2(n) 88.75(a)	24176 NM_012492.2 NP_036624.2
mouse (Mus musculus)	Adrb2^{1, 5}	18 (34.00 cM)⁵	adrenergic receptor, beta 2^{1, 5}	85.71(n)¹ 87.65(a)¹	11555¹ NM_007420.2¹ NP_031446.2¹ AK080241⁵ AK080276⁵ (see all 11)

About this table Species with no ortholog for ADRB2

ENSEMBL Gene Tree for ADRB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRB2 gene

ADRB3² ADRB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/89 NCBI SNPs in ADRB2 are shown (see all 89 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 91)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1801704^1,2	A,C,F,H	148186568(+)	`GCGCTT/CACCTG`	1	--	ut5¹ ese³		19	MN EA WA NA NS CSAM	3005
	rs12654778^1,2	A,C,F,H	148185934(+)	`AGTCTG/AAGCAT`	1	--	ng5¹		21	NA MN EA EU WA NS	5621
	rs2400707^1,2	A,C,F,H	148185245(+)	`atggcG/Acaacc`	1	--	ng5¹ ese³		7	EU EA WA NS	1494
	rs1042713^1,2	A,C,F,H	148186633(+)	`CCAATG/AGAAGC`	1	G/R	mis¹		66	MN EU EA WA CA NA NS CSAM	18619
	rs1042714^1,2	A,C,F,H	148186666(+)	`CGCAGC/GAAAGG`	1	Q/E	mis¹ ese³ trp³		63	EU EA WA CA NA NS MN CSAM	18602
	rs2053044^1,2	A,C,F,H	148185565(+)	`AAATCG/AGCAGC`	1	--	ng5¹ ese³		11	EA WA NS MN	4615
	rs1042711^1,2	A,C,F,H	148186541(+)	`CCGCCT/CGCTGA`	1	--	ut5¹		58	EA WA CA NA NS MN CSAM	11100
	rs3729943^1,2	C,F,H	148187246(+)	`CTACTC/GCAGGG`	1	S/C	mis¹ ese³		7	EU EA WA NS	3254
--	rs11959427^1,2	A,C,F	148186221(+)	`CAGCCT/CCAGGA`	1	--	ng5¹		9	NS MN	4885
	rs11168070^1,2	C,F,H	148186120(+)	`GTAAGC/GACACC`	1	--	ng5¹		13	EA WA NS MN NA	7749

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HapMap Linkage Disequilibrium images for ADRB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 109690

UniProtKB/Swiss-Prot: ADRB2_HUMAN, P07550

Polymorphic forms of ADRB2 could impart some form of nocturnal asthma

10/93 Novoseek disease relationships for ADRB2 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	68.12	226	18156033 (5), 16357573 (5), 10374285 (5), 16207148 (5) (see all 99)
heart failure	39.42	21	17117186 (2), 11208703 (1), 14573333 (1), 18353108 (1) (see all 20)
essential hypertension	39.41	27	17963627 (2), 12361188 (2), 10981553 (2), 19102885 (2) (see all 13)
status asthmaticus	38.49	4	16395068 (3), 12628991 (1)
obesity	38.07	56	11288039 (5), 17907319 (3), 11016907 (3), 17221209 (3) (see all 27)
cholera	35.44	4	10822171 (2), 10473590 (1), 17008315 (1)
atopy	28.50	1	11941312 (1)
pulmonary disease chronic obstructive	25.64	11	16463710 (1), 16861834 (1), 18667995 (1), 16980556 (1) (see all 9)
heart failure congestive	22.84	10	17361123 (3), 9788966 (1), 17336757 (1), 11392464 (1) (see all 7)
lung diseases obstructive	21.90	1	18024720 (1)

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9 PharmGKB disease relationships for ADRB2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Acquired Long QT Syndrome (aLQTS)	GN	11942593
Angina Pectoris	PD GN	11586955
Asthma	CO PD FA GN	11934710 10903223 10515402 11306963 11371409 12925702 9399966 12642431 15500895 14610472 11516429 9731005 10950895
Cardiovascular Diseases	PD GN	12523655
Cystic Fibrosis	PD	12142724
Heart Failure, Congestive	FA	14499340
Hypertension	PD FA GN	11586955 14499340
Obesity	GN	12888635
essential hypertension	PD GN	99301892

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Human Gene Mutation Database: ADRB2
Genetic Association Database: ADRB2
Human Genome Epidemiology Navigator: ADRB2 (374 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

ISC: Single Nucleotide Polymorphisms May Be Implicated in Pediatric Stroke

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1106 PubMed articles for ADRB2 gene (see all 1106 ):

Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. (PubMed id 14610472)^{1, 3, 6, 7} Silverman E.K....Weiss S.T. (2003)
Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking. (PubMed id 11371409)^{1, 3, 6, 7} Wang Z....Xu X. (2001)
Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (PubMed id 7706471)^{1, 3, 4, 6} Turki J.... Liggett S.B. (1995)
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. (PubMed id 8383511)^{1, 3, 4, 6} Reihsaus E.... Liggett S.B. (1993)
Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism. (PubMed id 12888635)^{3, 6, 7} Martinez J.A....Martinez-Gonzalez M.A. (2003)
beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. (PubMed id 12142724)^{1, 3, 7} Buscher R....Ratjen F. (2002)
Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics. (PubMed id 12523655)^{1, 6, 7} Johnson J.A. and Terra S.G. (2002)
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. (PubMed id 10903223)^{1, 6, 7} Israel E....Yandava C.N. (2000)
Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics. (PubMed id 10340917)^{1, 6, 7} Lima J.J....Johnson J.A. (1999)
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. (PubMed id 9560162)^{1, 3, 7} Hall R.A....Lefkowitz R.J. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 154	HGNC: 286	AceView: ADRB2	Ensembl:ENSG00000169252	euGenes: HUgn154
ECgene: ADRB2	H-InvDB: ADRB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ADRB2
SeattleSNPs	http://pga.gs.washington.edu/data/adrb2/

Licensable Technologies for ADRB2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRB2		Antibodies for ADRB2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADRB2		Small molecules for ADRB2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADRB2)
	Antibodies (ADRB2)
	Chimera RNAi (ADRB2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (beta 2 Adrenergic Receptor)
	Antibodies (beta 2 Adrenergic Receptor)

Search OriGene for ADRB2

Tocris compounds for ADRB2

	Drugs for ADRB2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADRB2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ADRB2 Gene at Home site.
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ADRB2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for ADRB2

Summaries
for ADRB2

Genomic Location
for ADRB2

Proteins
for ADRB2

Protein Domains/
Families
for ADRB2

Gene Function
for ADRB2

Pathways & Interactions
for ADRB2

Drugs & Compounds
for ADRB2

Transcripts
for ADRB2

Expression
for ADRB2

Orthologs
for ADRB2

Paralogs
for ADRB2

SNPs/Variants
for ADRB2

Disorders & Mutations
for ADRB2

Medical News
for ADRB2

Publications
for ADRB2

Search for ADRB2

Genome Databases showing ADRB2

Other Databases showing ADRB2

Specialized Databases showing ADRB2

Licensable Technologies
for ADRB2

Services
for ADRB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRB2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor ADRB2

Summariesfor ADRB2

Genomic Locationfor ADRB2

Proteinsfor ADRB2

Protein Domains/Familiesfor ADRB2

Gene Functionfor ADRB2

Pathways & Interactionsfor ADRB2

Drugs & Compoundsfor ADRB2

Transcriptsfor ADRB2

Expression for ADRB2

Orthologsfor ADRB2

Paralogsfor ADRB2

SNPs/Variantsfor ADRB2

Disorders & Mutationsfor ADRB2

Medical Newsfor ADRB2

Publicationsfor ADRB2

Search for ADRB2

Genome Databases showing ADRB2

Other Databases showing ADRB2

Specialized Databases showing ADRB2

Licensable Technologiesfor ADRB2

Servicesfor ADRB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRB2

Summaries
for ADRB2

Genomic Location
for ADRB2

Proteins
for ADRB2

Protein Domains/
Families
for ADRB2

Gene Function
for ADRB2

Pathways & Interactions
for ADRB2

Drugs & Compounds
for ADRB2

Transcripts
for ADRB2

Expression
for ADRB2

Orthologs
for ADRB2

Paralogs
for ADRB2

SNPs/Variants
for ADRB2

Disorders & Mutations
for ADRB2

Medical News
for ADRB2

Publications
for ADRB2

Licensable Technologies
for ADRB2

Services
for ADRB2