V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ADRB1 Gene

protein-coding GIFtS: 69

GC10P115793

adrenergic, beta-1-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADRB1R)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADRB1R ^², ³, ⁵
B1AR ^², ³
BETA1AR ^²
OTTHUMP00000020519 ^²
RHR ^², ⁵

Descriptions
Beta-1 adrenoceptor ^³
Beta-1 adrenoreceptor ^³
adrenergic, beta-1-, receptor ^²
beta-1-adrenergic receptor ^²

External Ids
HGNC: 285¹
Entrez Gene: 153²
UniProtKB: P08588³
Ensembl: ENSG00000043591⁷

Search outside databases for aliases for ADRB1 gene

Previous GC identifers: GC10P114711 GC10P115037 GC10P115935 GC10P115468

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADRB1:

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of

guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological

effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms

in this gene have been shown to affect the resting heart rate and can be involved in heart

failure. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate

cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with

approximately equal affinity

Gene Wiki entry for ADRB1 (Beta-1_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRB1 gene

Entrez Gene cytogenetic band: 10q24-q26 Ensembl cytogenetic band: 10q25.3 HGNC cytogenetic band: 10q24-q26

ADRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P115793: (about GC identifiers)

Start:	115,793,796 bp from pter
End:	115,796,657 bp from pter
Size:	2,862 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588 (See protein sequence)

Recommended Name: Beta-1 adrenergic receptor

Size: 477 amino acids; 51323 Da

Subunit: Interacts with GOPC, MAGI3 and DLG4

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma

membrane. Found in the Golgi upon GOPC overexpression

Secondary accessions: B0LPE2 Q5T5Y4 Q9UKG7 Q9UKG8

Post-translational modifications:

Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic

receptor kinase¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000675.1

ENSEMBL proteins:

ENSP00000358301

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADRB1 Protein
	Sigma-Aldrich Proteins for ADRB1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (beta 1 Adrenergic Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005886	plasma membrane	TAS	10212248
GO:0005887	integral to plasma membrane	TAS	10212248

About this table

Antibodies for ADRB1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (beta 1 Adrenergic Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADRB1)
	Novus Biologicals Antibodies for ADRB1

Assays for ADRB1:

	Invitrogen Assays for ADRB1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08588

ProtoNet protein and cluster: P08588

2 Blocks protein families:

IPB000507 Beta-1 adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588

Domain: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4

and plays a role in subcellular location of the receptor

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000684

Applied Biosystems Silencer® siRNAs for ADRB1

Sigma-Aldrich siRNA and siRNA Panels for ADRB1

Sigma-Aldrich shRNA Panels and shRNA for ADRB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of ADRB1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000684
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000684
untagged cDNA clone in CMV expression vector: NM_000684

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000684

UniProtKB/Swiss-Prot: ADRB1_HUMAN, P08588

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate

cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with

approximately equal affinity

Genatlas biochemistry entry for ADRB1:

adrenergic,beta-1-,receptor,G protein coupled receptor superfamily,mostly expressed in

heart,activating adenylate cyclase,lung,placenta,cerebral cortex,and in other organs mediating the

action of catecholamines and sympathetic nervous system,with no apparent association of the C1165G

variant with idiopathic cardiomyopathy

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adrb1):

	adipose tissue	endocrine/exocrine gland	growth/size	homeostasis/metabolism
lethality-prenatal/perinatal	muscle	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004940	beta1-adrenergic receptor activity	TAS	10212248
GO:0005515	protein binding	IPI	16316992

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRB1 (Your Favorite Gene powered by Ingenuity)

TR/RXR Activation
G-Protein Coupled Receptor Signaling
Cardiac Hypertrophy Signaling
cAMP-mediated Signaling
Cardiac &beta

GeneDecks ADRB1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADRB1

5/7 Interacting proteins for ADRB1 (P08588^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 7 )
Interactant Interaction Details
GeneCard External ID(s)
MAGI2 Q86UL8¹^,² EBI-991009, EBI-311035 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361 EBI-991009, EBI-311035 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361
GOPC Q9HD26¹ EBI-991009, EBI-349832
MAGI1 Q96QZ7¹ EBI-991009, EBI-924464
- Q9HBC4¹ EBI-991009, EBI-991068
Dlg1 Dlg1 (xeno) Q62696¹ EBI-991009, EBI-389325
About this table
5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA --
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IEA --
GO:0007165 signal transduction IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADRB1

Sigma-Aldrich Small Molecules for ADRB1:

Antagonist Blocker Agonist

Compounds for ADRB1 available from Tocris Bioscience

Compound	Action	CAS number
(S)-Timolol maleate	beta1 antagonist	[26921-17-5]
Betaxolol hydrochloride	Selective beta1 antagonist	[63659-19-8]
Xamoterol hemifumarate	beta1 selective partial agonist	[73210-73-8]
(�)-Bisoprolol hemifumarate	beta1 antagonist	[104344-23-2]
CGP 20712 dihydrochloride	Highly potent and selective beta1 antagonist	[105737-62-0]

About this table

10/17 Novoseek chemical compound relationships for ADRB1 gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
catecholamine	50.66	5	12034720 (1), 15071399 (1), 19010176 (1), 12439640 (1) (see all 5)
cyclic amp	42.25	16	12391161 (4), 2158543 (1), 11705454 (1), 16316992 (1) (see all 5)
forskolin	40.52	7	11705454 (3), 1311717 (1)
6-sulfatoxymelatonin	37.16	1	9406983 (1)
calcium	20.95	12	1600963 (1), 7848894 (1), 10190137 (1), 11606476 (1) (see all 9)
phosphoserine	17.50	1	14990580 (1)
melatonin	17.30	5	9406983 (2), 1652052 (1), 10335905 (1), 7857585 (1)
nitric oxide	13.33	7	11147805 (1), 15174896 (1), 19121451 (1), 11707696 (1) (see all 6)
guanylate	3.48	3	11526121 (2), 17170109 (1)
lipid	1.98	1	8994185 (1)

About this table

9 PharmGKB drug compound relationships for ADRB1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Beta adrenergic antagonists	PD GN	12523655
acebutolol	PD	12942043
atenolol	PD GN	12709726
beta adrenergic agonists	PD GN	12523655
carvedilol	CO GN	14502278
dobutamine	PD GN	15564877
epinephrine hydrochloride	FA	12525504
metoprolol	PD GN	12844134
xenobiotics	GN	11942593

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000684

Sigma-Aldrich siRNA and siRNA Panels for ADRB1

Sigma-Aldrich shRNA Panels and shRNA for ADRB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000684

REFSEQ mRNAs for ADRB1 gene:

NM_000684.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000684

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000684
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000684
                                 untagged cDNA clone in CMV expression vector: NM_000684

Additional cDNA sequence:

AF272890.1 J03019.1 U29690.1

2 DOTS entries:

DT.92040573 DT.99969854

24/38 AceView cDNA sequences (see all 38 ):

AA702310 AW665324 AI003679 BQ023488 BM681157 AW138985 BM727728 BX279952

AA749352 AF272890 BU665017 AA383612 BU633369 BF055463 BC045633 AI625747

BX097351 BI836679 NM_000684 J03019 BM700625 BF108867 AA011176 C01127

highest scoring ESTs for ADRB1:

J03019 BI836679 BX279952 AI625747 BI544382 NM_000684 AA010748 AA011176 AA383612 AA702310

Unigene Cluster for ADRB1:

Adrenergic, beta-1-, receptor

Hs.99913 [show with all ESTs]

Unigene Representative Sequence: AF272890

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000369295

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADRB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRB1

¹ / ² / ³

8 probe-sets matching ADRB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45148_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI625747	0.60	1.00	0.82	1
31550_at²^{, 3}	U95-A	1	1.00	1.00	0.58	0.33	J03019	1.00	1.00	1.00	1
229309_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI625747	0.60	1.00	0.82	1
208214_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000684	0.60	1.00	0.82	1
229277_at²^{, 3}	U133-B	1	0.82	1.00	--	--	T96352	0.20	1.00	0.72	1
229309_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208214_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229277_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks ADRB1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGCAATAAAT

SOURCE GeneReport for Unigene cluster: Hs.99913
Expression variation in blood from EXPOLDB for ADRB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADRB1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRB1¹	--	adrenergic, beta-1-, receptor	91.86(n) 89.94(a)	493972 NM_001008713.1 NP_001008713.1
chimpanzee (Pan troglodytes)	ADRB1¹	--	adrenergic, beta-1-, receptor	99.16(n) 98.53(a)	466206 XM_521608.2 XP_521608.2
cow (Bos taurus)	ADRB1¹	--	adrenergic, beta-1-, receptor	90.16(n) 87.07(a)	281604 NM_194266.1 NP_919242.1
rat (Rattus norvegicus)	Adrb1¹	--	adrenergic, beta-1-, receptor	90.25(n) 92.9(a)	24925 NM_012701.1 NP_036833.1
mouse (Mus musculus)	Adrb1^{1, 5}	19 (51.00 cM)⁵	adrenergic receptor, beta 1^{1, 5}	90.47(n)¹ 93.12(a)¹	11554¹ NM_007419.1¹ NP_031445.1¹ AK018378⁵ AK039569⁵ (see all 8)

About this table Species with no ortholog for ADRB1

ENSEMBL Gene Tree for ADRB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRB1 gene

ADRB2² ADRB3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

8 NCBI SNPs in ADRB1 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3813720^1,2	A,C,F,H	115797006(+)	`TTTCAT/CGGAAA`	1	--	ng3¹		6		NS EU EA WA	500
	rs3813719^1,2	C,F	115796872(+)	`CTAGAC/TTACTT`	1	--	ng3¹		2		NS	92
	rs17875449^1,2	F	115796988(+)	`TTTAAC/TTCAGC`	1	--	ng3¹		2		NS	82
	rs3813721^1,2	H	115797061(+)	`ATGCAG/ATAAGT`	1	--	ng3¹		4		EU EA WA	366
	rs17875450^1,2	--	115797150(+)	`GCTGTT/CTAGAA`	1	--	ng3¹		2		NS	82
	rs17875478^1,2	--	115796822(+)	`CTGAGA/CGCTAC`	1	--	ng3¹		2		NS	92
	rs35233676^1,2	--	115796772(+)	`ACTCAA/GTAACA`	1	--	ng3¹		0	--	--	--	--
--	rs34916734^1,2	--	115796970(+)	`AAAAA-/AGTGAC`	1	--	ng3¹		0	--	--	--	--

About this table
The following additional 66 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs17875459	rs7919873	rs365722	rs17875434	rs12766366	rs17875425	rs17875441
rs11593575	rs17875451	rs17875477	rs35476499	rs17875468	rs2183378	rs34844626
rs7093444	rs17875453	rs2429511	rs3177559	rs17875430	rs2050394	rs17875435
rs35691923	rs17875474	rs35548411	rs7901971	rs17875440	rs12359003	rs4619105
rs2773469	rs17875475	rs17875431	rs11196600	rs171169	rs1801252	rs17875444
rs7917912	rs17875439	rs17875482	rs1047284	rs17875467	rs10885531	rs238740
rs238743	rs7920400	rs17875483	rs238741	rs17875473	rs1801253	rs238739
rs17875480	rs180897	rs17875447	rs2210096	rs17875479	rs17875454	rs34947712
rs11196616	rs728422	rs10787516	rs17875432	rs238742	rs7921133	rs17875456
rs35705839	rs189429	rs35818742

HapMap Linkage Disequilibrium images for ADRB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109630

10/32 Novoseek disease relationships for ADRB1 gene (see all 32 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure	68.73	45	8522688 (5), 18947427 (4), 19010176 (3), 12034720 (2) (see all 30)
dilated cardiomyopathy	65.08	16	16153393 (3), 1283934 (2), 12791320 (2), 7902783 (1) (see all 11)
neuroepithelioma	48.21	3	11705454 (1), 1671088 (1)
cardiomyopathy	47.05	8	16412044 (2), 17362986 (1), 9832494 (1), 19158054 (1) (see all 5)
resting heart rate	44.45	4	11854867 (3), 16907703 (1)
heart failure congestive	42.41	8	12422153 (2), 1600963 (1), 12463096 (1), 18325466 (1) (see all 7)
heart diseases	34.53	6	16878723 (1), 16816115 (1), 10794544 (1), 17419712 (1)
cardiac hypertrophy	32.89	1	12754996 (1)
ventricular arrhythmia	27.53	3	17023080 (1), 19246813 (1), 19327624 (1)
essential hypertension	26.22	6	18298953 (3), 17635183 (1), 15237695 (1), 16815314 (1)

About this table

7 PharmGKB disease relationships for ADRB1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Acquired Long QT Syndrome (aLQTS)	GN	11942593
Angina Pectoris	PD GN	12709726 11337934
Cardiovascular Diseases	CO PD GN	11854867 12523655
Heart Failure	CO PD GN	14502278 12709726 11337934
Heart Failure, Congestive	CO FA GN	12374873
Hypertension	PD GN	12844134 12709726 11337934 12942043
Ischemia	PD GN	11704005

About this table

Human Gene Mutation Database: ADRB1
Genetic Association Database: ADRB1
Human Genome Epidemiology Navigator: ADRB1 (128 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/355 PubMed articles for ADRB1 gene (see all 355 ):

A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. (PubMed id 11854867)^{1, 3, 4, 6, 7} Ranade K.... Risch N. (2002)
A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. (PubMed id 12709726)^{3, 6, 7} Sofowora G.G....Stein C.M. (2003)
Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. (PubMed id 12844134)^{3, 6, 7} Johnson J.A....Pauly D.F. (2003)
Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics. (PubMed id 12523655)^{1, 6, 7} Johnson J.A. and Terra S.G. (2002)
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. (PubMed id 12374873)^{3, 6, 7} Small K.M....Liggett S.B. (2002)
Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo. (PubMed id 11337934)^{3, 6, 7} Xie H.G....Stein C.M. (2001)
A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure. (PubMed id 11052857)^{3, 4, 6} Borjesson M.... Andersson B. (2000)
Interaction with cystic fibrosis transmembrane conductance regulator- associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. (PubMed id 15358775)^{1, 3, 4} He J.... Hall R.A. (2004)
Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction. (PubMed id 12851615)^{1, 3, 6} Iwai C....Yokoyama M. (2003)
A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. (PubMed id 10212248)^{1, 3, 4} Mason D.A.... Liggett S.B. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 153	HGNC: 285	AceView: ADRB1	Ensembl:ENSG00000043591	euGenes: HUgn153
ECgene: ADRB1	H-InvDB: ADRB1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/adrb1/

Licensable Technologies for ADRB1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRB1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRB1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRB1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for ADRB1
	Lentivirus-delivered shRNAs for ADRB1		Small molecules for ADRB1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (ADRB1)
	Chimera RNAi (ADRB1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (beta 1 Adrenergic Receptor)
	Antibodies (beta 1 Adrenergic Receptor)

Search OriGene for ADRB1

Tocris compounds for ADRB1

	Drugs for ADRB1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADRB1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ADRB1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ADRB1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ADRB1

Summaries
for ADRB1

Genomic Location
for ADRB1

Proteins
for ADRB1

Protein Domains/
Families
for ADRB1

Gene Function
for ADRB1

Pathways & Interactions
for ADRB1

Drugs & Compounds
for ADRB1

Transcripts
for ADRB1

Expression
for ADRB1

Orthologs
for ADRB1

Paralogs
for ADRB1

SNPs/Variants
for ADRB1

Disorders & Mutations
for ADRB1

Medical News
for ADRB1

Publications
for ADRB1

Search for ADRB1

Genome Databases showing ADRB1

Other Databases showing ADRB1

Specialized Databases showing ADRB1

Licensable Technologies
for ADRB1

Services
for ADRB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRB1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ADRB1

Summariesfor ADRB1

Genomic Locationfor ADRB1

Proteinsfor ADRB1

Protein Domains/Familiesfor ADRB1

Gene Functionfor ADRB1

Pathways & Interactionsfor ADRB1

Drugs & Compoundsfor ADRB1

Transcriptsfor ADRB1

Expression for ADRB1

Orthologsfor ADRB1

Paralogsfor ADRB1

SNPs/Variantsfor ADRB1

Disorders & Mutationsfor ADRB1

Medical Newsfor ADRB1

Publicationsfor ADRB1

Search for ADRB1

Genome Databases showing ADRB1

Other Databases showing ADRB1

Specialized Databases showing ADRB1

Licensable Technologiesfor ADRB1

Servicesfor ADRB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRB1

Summaries
for ADRB1

Genomic Location
for ADRB1

Proteins
for ADRB1

Protein Domains/
Families
for ADRB1

Gene Function
for ADRB1

Pathways & Interactions
for ADRB1

Drugs & Compounds
for ADRB1

Transcripts
for ADRB1

Expression
for ADRB1

Orthologs
for ADRB1

Paralogs
for ADRB1

SNPs/Variants
for ADRB1

Disorders & Mutations
for ADRB1

Medical News
for ADRB1

Publications
for ADRB1

Licensable Technologies
for ADRB1

Services
for ADRB1