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ADRA2A Gene

protein-coding GIFtS: 66

GC10P112826

adrenergic, alpha-2A-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ADRA2, ADRA2R)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADRA2 ^²
ADRA2R ^², ³, ⁵
ADRAR ^¹, ², ³
ALPHA2AAR ^²
Alpha-2AAR ^³
OTTHUMP00000058849 ^²
ZNF32 ^²

Descriptions
Alpha-2 adrenergic receptor subtype C10 ^³
Alpha-2A adrenoceptor ^², ³
Alpha-2A adrenoreceptor ^³
adrenergic, alpha-2A-, receptor ^²
alpha-2-adrenergic receptor, platelet type ^²
alpha-2A-adrenergic receptor ^²
alpha-2AAR subtype C10 ^²

External Ids
HGNC: 281¹
Entrez Gene: 150²
UniProtKB: P08913³
Ensembl: ENSG00000150594⁷

Search outside databases for aliases for ADRA2A gene

Previous GC identifers: GC10P111730 GC10P112070 GC10P112968 GC10P112501

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADRA2A:

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They

include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a

critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic

neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C

subtypes were required for normal presynaptic control of transmitter release from sympathetic

nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited

transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated

neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it

contains no introns in either its coding or untranslated sequences. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate

cyclase through the action of G proteins. The rank order of potency for agonists of this receptor

is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine >

p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine

> phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol =

pindolol

Gene Wiki entry for ADRA2A (Alpha-2A_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRA2A gene

Entrez Gene cytogenetic band: 10q24-q26 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q24-q26

ADRA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P112826: (about GC identifiers)

Start:	112,826,911 bp from pter
End:	112,830,560 bp from pter
Size:	3,650 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913 (See protein sequence)

Recommended Name: Alpha-2A adrenergic receptor

Size: 450 amino acids; 48957 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1HLL (3D)

1HO9 (3D)

1HOD (3D)

1HOF (3D)

Secondary accessions: B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000672.3

ENSEMBL proteins:

ENSP00000280155

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADRA2A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha 2a Adrenergic Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	2823383 6259160
GO:0005887	integral to plasma membrane	TAS	1354394

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Antibodies for ADRA2A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADRA2A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (alpha 2a Adrenergic Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADRA2A)
	Novus Biologicals Antibody for ADRA2A

Assays for ADRA2A:

	Invitrogen Assays for ADRA2A
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08913

ProtoNet protein and cluster: P08913

2 Blocks protein families:

IPB001946 Alpha-2A adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000681

Applied Biosystems Silencer® siRNAs for ADRA2A

Sigma-Aldrich siRNA and siRNA Panels for ADRA2A

Sigma-Aldrich shRNA Panels and shRNA for ADRA2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADRA2A
		Millipore Clones for the Expression of ADRA2A

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000681
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000681
untagged cDNA clone in CMV expression vector: NM_000681

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000681

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate

cyclase through the action of G proteins. The rank order of potency for agonists of this receptor

is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine >

p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine

> phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol =

pindolol

Genatlas biochemistry entry for ADRA2A:

adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP

opening K+ channels,inhibiting Ca2+ channels

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adra2a):

embryogenesis

homeostasis/metabolism

lethality-prenatal/perinatal

nervous system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004935	adrenoceptor activity	IEA	--
GO:0004938	alpha2-adrenergic receptor activity	TAS	10896916
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRA2A (Your Favorite Gene powered by Ingenuity)

cAMP-mediated Signaling
&alpha
G-Protein Coupled Receptor Signaling
Cardiac Hypertrophy Signaling

GeneDecks ADRA2A for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADRA2A

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	10896916
GO:0006928	cell motion	TAS	9624180
GO:0007165	signal transduction	TAS	2823383 10896916
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	1354394
GO:0007194	negative regulation of adenylate cyclase activity	TAS	10896916

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADRA2A

Sigma-Aldrich Small Molecules for ADRA2A:

Mixed Agonist/Antagonist Antagonist Blocker Agonist

Compounds for ADRA2A available from Tocris Bioscience

Compound	Action	CAS number
BRL 44408 maleate	Selective alpha2A antagonist	[118343-19-4]
Medetomidine hydrochloride	Potent, highly selective alpha2 agonist	[106807-72-1]

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10/13 Novoseek chemical compound relationships for ADRA2A gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mspi	74.64	11	11886485 (1), 16917924 (1), 9112004 (1), 16806103 (1) (see all 9)
dids	27.05	3	8393664 (3)
thromboxane a2	21.57	1	9174358 (1)
asparagine	11.47	2	7961941 (1)
catecholamine	9.15	1	17075692 (1)
tyrosine	7.45	4	7568118 (1), 7782310 (1), 9020193 (1)
cyclic amp	6.64	1	10845764 (1)
glucose	4.46	3	11886485 (3)
adp	2.64	1	16634757 (1)
phospholipid	0.00	1	7517495 (1)

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3 PharmGKB drug compound relationships for ADRA2A gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Beta adrenergic antagonists	FA	9174358
sibutramine	PD	12781566
yohimbine	PD	9663918

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000681

Sigma-Aldrich siRNA and siRNA Panels for ADRA2A

Sigma-Aldrich shRNA Panels and shRNA for ADRA2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000681

REFSEQ mRNAs for ADRA2A gene:

NM_000681.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000681

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000681
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000681
                                 untagged cDNA clone in CMV expression vector: NM_000681

Additional cDNA sequence:

AF284095.1 BC035047.1 BC050414.1

2 DOTS entries:

DT.101972051 DT.453118

24/70 AceView cDNA sequences (see all 70 ):

BF725008 AW196450 F09185 AW075300 AI147682 T16471 AI597708 T34699

Z40854 BC035047 F03845 AI656344 AW241599 CB045497 T08946 AW513366

BM695296 BF725007 BM723451 H89355 AI572103 AI828415 T34698 AW235147

highest scoring ESTs for ADRA2A:

AI651732 AA328564 AA513474 AA885436 AF284095 AI131333 AI147682 AI572103 AI597708 AI656344

Unigene Cluster for ADRA2A:

Adrenergic, alpha-2A-, receptor

Hs.249159 [show with all ESTs]

Unigene Representative Sequence: NM_000681

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000280155

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADRA2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRA2A

¹ / ² / ³

4 probe-sets matching ADRA2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
64888_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AI651732	1.00	1.00	1.00	1
264_at²^{, 3}	U95-A	1	0.94	1.00	-0.16	0.43	M23533	0.20	1.00	0.72	1
209869_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF284095	0.80	1.00	0.91	1
209869_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADRA2A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.249159
Expression variation in blood from EXPOLDB for ADRA2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADRA2A gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRA2A¹	--	adrenergic, alpha-2A-, receptor	93.24(n) 93.14(a)	486888 XM_544018.2 XP_544018.2
chimpanzee (Pan troglodytes)	ADRA2A¹	--	adrenergic, alpha-2A-, receptor	98.99(n) 98.23(a)	466201 XM_521603.2 XP_521603.2
cow (Bos taurus)	ADRA2A¹	--	adrenergic, alpha-2A-, receptor	90.35(n) 91.76(a)	282135 NM_174499.1 NP_776924.1
mouse (Mus musculus)	Adra2a^{1, 5}	19 (50.00 cM)⁵	adrenergic receptor, alpha 2a^{1, 5}	87.7(n)¹ 92.22(a)¹	11551¹ NM_007417.2¹ NP_031443.2¹ AK046802⁵ AK138518⁵ (see all 14)
zebrafish (Danio rerio)	adra2a¹	--	adrenergic, alpha-2A-, receptor	66.23(n) 69.82(a)	266750 NM_207637.2 NP_997520.2

About this table Species with no ortholog for ADRA2A

ENSEMBL Gene Tree for ADRA2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRA2A gene

ADRA2B² HTR5A² ADRA2C² HTR7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/41 NCBI SNPs in ADRA2A are shown (see all 41 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs553668^1,2	A,C,F,H	112829569(-)	`TTCTTC/TAAAAA`	1	--	ut3¹ ese³		9	EA MN NS EU WA	2081
	rs521674^1,2	A,C,F,H	112825580(+)	`CCTTAT/ATGAAG`	1	--	ng5¹ tfbs³		8	EA NA EU WA	572
	rs11195419^1,2	A,C,F,H	112829358(+)	`TTTGGC/ACACTC`	1	--	ut3¹ ese³		12	MN EU EA WA NS	1021
	rs1800545^1,2	A,C,F	112827528(+)	`AAGGCG/ACCCAC`	1	--	ut5¹ ese³		4	MN NS	227
	rs12246561^1,2	C,F,H	112825099(+)	`TTTTGA/CGACTA`	1	--	ng5¹		10	EA NA EU WA NS	724
	rs1800544^1,2	A,C,F	112826493(+)	`GGCCCC/GGAGCT`	1	--	ng5¹		2	NS	92
	rs11195418^1,2	C,F,H	112825149(+)	`GGGCTA/GTAGAC`	1	--	ng5¹		6	EU EA WA NS	504
	rs3750625^1,2	C,F,H	112829591(+)	`GCAGCC/ACTGCC`	1	--	ut3¹ ese³		9	EA MN EU WA NS	2099
--	rs7089069^1,2	C,F	112826254(+)	`GGGTTC/TCATCC`	1	--	ng5¹		2	NS	92
	rs1800035^1,2	C,F	112828542(+)	`CCCAAC/GGGTCT`	1	N/K	mis¹		2	NS	92

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HapMap Linkage Disequilibrium images for ADRA2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 104210

10 Novoseek disease relationships for ADRA2A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
attention-deficit hyperactivity disorder	66.32	16	19150055 (1), 16172611 (1), 16389583 (1), 10334470 (1) (see all 12)
tourette syndrome	49.91	4	10334470 (1), 18794646 (1), 18075481 (1), 12707939 (1)
colon carcinoma	19.00	2	9152409 (1), 8863348 (1)
schizophrenia	3.62	7	17034020 (2), 19439247 (1), 15115947 (1), 18558152 (1)
tumors	0.61	2	9344667 (1)
mood disorders	0.00	2	16526032 (1), 9631415 (1)
obesity	0.00	1	11886485 (1)
disability	0.00	2	10334470 (1), 16178932 (1)
adenocarcinoma	0.00	2	1677644 (1), 8863348 (1)
cholera	0.00	1	1848855 (1)

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2 PharmGKB disease relationships for ADRA2A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Hypertension	PD	9663918
Obesity	PD	12781566

About this table

Human Gene Mutation Database: ADRA2A
Genetic Association Database: ADRA2A
Human Genome Epidemiology Navigator: ADRA2A (67 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/204 PubMed articles for ADRA2A gene (see all 204 ):

Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder. (PubMed id 16389583)^{1, 3, 6} Wang B....Faraone S.V. (2006)
Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder? (PubMed id 12815749)^{1, 3, 6} Roman T....Hutz M.H. (2003)
Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. (PubMed id 16178932)^{1, 3, 6} Stevenson J....Thapar A. (2005)
A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. (PubMed id 11886485)^{1, 3, 6} Rosmond R....Bjorntorp P. (2002)
Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression. (PubMed id 16567612)^{1, 3, 4} Small K.M.... Liggett S.B. (2006)
An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. (PubMed id 10948191)^{1, 3, 4} Small K.M.... Liggett S.B. (2000)
A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene. (PubMed id 12627476)^{1, 3, 6} Comings D.E....MacMurray J. (2003)
A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status. (PubMed id 11039642)^{1, 3, 6} Wolfarth B....Bouchard C. (2000)
NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. (PubMed id 11888275)^{1, 3, 4} Chung D.A....Neubig R.R. (2002)
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)^{1, 3, 6} Matayoshi T....Kawano Y. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 150	HGNC: 281	AceView: ADRA2A	Ensembl:ENSG00000150594	euGenes: HUgn150
ECgene: ADRA2A	H-InvDB: ADRA2A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/adra2a/

Licensable Technologies for ADRA2A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRA2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRA2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRA2A		Antibodies for ADRA2A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADRA2A		Small molecules for ADRA2A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADRA2A Gene at Home site.
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ADRA2A Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ADRA2A

Summaries
for ADRA2A

Genomic Location
for ADRA2A

Proteins
for ADRA2A

Protein Domains/
Families
for ADRA2A

Gene Function
for ADRA2A

Pathways & Interactions
for ADRA2A

Drugs & Compounds
for ADRA2A

Transcripts
for ADRA2A

Expression
for ADRA2A

Orthologs
for ADRA2A

Paralogs
for ADRA2A

SNPs/Variants
for ADRA2A

Disorders & Mutations
for ADRA2A

Medical News
for ADRA2A

Publications
for ADRA2A

Search for ADRA2A

Genome Databases showing ADRA2A

Other Databases showing ADRA2A

Specialized Databases showing ADRA2A

Licensable Technologies
for ADRA2A

Services
for ADRA2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRA2A Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ADRA2A

Summariesfor ADRA2A

Genomic Locationfor ADRA2A

Proteinsfor ADRA2A

Protein Domains/Familiesfor ADRA2A

Gene Functionfor ADRA2A

Pathways & Interactionsfor ADRA2A

Drugs & Compoundsfor ADRA2A

Transcriptsfor ADRA2A

Expression for ADRA2A

Orthologsfor ADRA2A

Paralogsfor ADRA2A

SNPs/Variantsfor ADRA2A

Disorders & Mutationsfor ADRA2A

Medical Newsfor ADRA2A

Publicationsfor ADRA2A

Search for ADRA2A

Genome Databases showing ADRA2A

Other Databases showing ADRA2A

Specialized Databases showing ADRA2A

Licensable Technologiesfor ADRA2A

Servicesfor ADRA2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRA2A

Summaries
for ADRA2A

Genomic Location
for ADRA2A

Proteins
for ADRA2A

Protein Domains/
Families
for ADRA2A

Gene Function
for ADRA2A

Pathways & Interactions
for ADRA2A

Drugs & Compounds
for ADRA2A

Transcripts
for ADRA2A

Expression
for ADRA2A

Orthologs
for ADRA2A

Paralogs
for ADRA2A

SNPs/Variants
for ADRA2A

Disorders & Mutations
for ADRA2A

Medical News
for ADRA2A

Publications
for ADRA2A

Licensable Technologies
for ADRA2A

Services
for ADRA2A