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ADRA1D Gene

protein-coding GIFtS: 66

GC20M004149

adrenergic, alpha-1D-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADRA1 ^¹, ²
ADRA1A ^¹, ², ³, ⁵
ADRA1R ^¹, ²
ALPHA1 ^²
DAR ^²
OTTHUMP00000030160 ^²
dJ779E11.2 ^²

Descriptions
Alpha 1D-adrenoceptor ^³
Alpha 1D-adrenoreceptor ^³
Alpha-1A adrenergic receptor ^³
Alpha-adrenergic receptor 1a ^³
adrenergic, alpha -1D-, receptor ^²
adrenergic, alpha-1A-, receptor ^²
adrenergic, alpha-1D-, receptor ^²
alpha-1D-adrenergic receptor ^²

External Ids
HGNC: 280¹
Entrez Gene: 146²
UniProtKB: P25100³
Ensembl: ENSG00000171873⁷

Search outside databases for aliases for ADRA1D gene

Previous GC identifers: GC20M004189 GC20M004196

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADRA1D:

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor

superfamily. They activate mitogenic responses and regulate growth and proliferation of many

cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the

Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene

encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene

comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA1D_HUMAN, P25100

Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular

calcium

Gene Wiki entry for ADRA1D (Alpha-1D_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRA1D gene

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

ADRA1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M004149: (about GC identifiers)

Start:	4,149,278 bp from pter
End:	4,177,659 bp from pter
Size:	28,382 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011387.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADA1D_HUMAN, P25100 (See protein sequence)

Recommended Name: Alpha-1D adrenergic receptor

Size: 572 amino acids; 60463 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q9NPY0

REFSEQ proteins: NP_000669.1

ENSEMBL proteins:

ENSP00000368766

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha 1 Adrenergic Receptor, alpha 1d Adrenergic Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	7746284

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Antibodies for ADRA1D:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADRA1D
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (alpha 1 Adrenergic Receptor, alpha 1d Adrenergic Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for ADRA1D

Assays for ADRA1D:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P25100

ProtoNet protein and cluster: P25100

2 Blocks protein families:

IPB000363 Alpha-1A adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA1D_HUMAN, P25100

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA1D)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA1D)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000678

Applied Biosystems Silencer® siRNAs for ADRA1D

Sigma-Aldrich siRNA and siRNA Panels for ADRA1D

Sigma-Aldrich shRNA Panels and shRNA for ADRA1D

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000678
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000678
untagged cDNA clone in CMV expression vector: NM_000678

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000678

UniProtKB/Swiss-Prot: ADA1D_HUMAN, P25100

Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular

calcium

Genatlas biochemistry entry for ADRA1D:

adrenergic,alpha-1D-,receptor,G protein coupled receptor superfamily,stimulating,acting through the

phosphadidylinositol/Ca2+ second messenger system

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adra1d):

behavior/neurological

hearing/vestibular/ear

muscle

nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004935	adrenoceptor activity	IEA	--
GO:0004937	alpha1-adrenergic receptor activity	TAS	10820200

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRA1D (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
Cardiac Hypertrophy Signaling

GeneDecks ADRA1D for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADRA1D

5/11 Interacting proteins for ADRA1D (ENSP00000368766³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRA1A	ENSP00000348729³	STRING (score=.962)
ADRA1B	ENSP00000306662³	STRING (score=.904)
GNAQ	ENSP00000286548³	STRING (score=.902)
GNA11	ENSP00000078429³	STRING (score=.86)
ELANE	ENSP00000263621³	STRING (score=.809)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001986	negative regulation of the force of heart contraction during baroreceptor response to increased systemic arterial blood pressure	IEA	--
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IEA	--
GO:0006259	DNA metabolic process	TAS	10969806
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	1656955

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ADRA1D

Sigma-Aldrich Small Molecules for ADRA1D:

Antagonist Agonist

Compounds for ADRA1D available from Tocris Bioscience

Compound	Action	CAS number
Naftopidil hydrochloride	alpha1 antagonist	[57149-07 2]
Cirazoline hydrochloride	Selective alpha1 agonist	[40600-13-3]
alpha-Conotoxin MII	Potent alpha3beta2 and beta3 subunit selective nicotinic antagonist
HEAT hydrochloride	Highly selective alpha1 antagonist	[30007-39-7]
Prazosin hydrochloride	alpha1 antagonist. MT3 antagonist	[19237-84-4]

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2 PharmGKB drug compound relationships for ADRA1D gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA1D)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA1D)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000678

Sigma-Aldrich siRNA and siRNA Panels for ADRA1D

Sigma-Aldrich shRNA Panels and shRNA for ADRA1D

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000678

REFSEQ mRNAs for ADRA1D gene:

NM_000678.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000678

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000678
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000678
                                 untagged cDNA clone in CMV expression vector: NM_000678

Additional cDNA sequence:

L31772.1 S70782.1 U03864.1

4 DOTS entries:

DT.442233 DT.92416103 DT.95254294 DT.95357194

21 AceView cDNA sequences:

BX280890 AI457674 CA424283 BE439970 U03864 BI828457 NM_000678 CA310090

L31772 AI611270 S70782 AW875208 AW975996 AA809802 M76446 AW875213

BM546478 AA921964 AA909273 BQ067091 AW577200

highest scoring ESTs for ADRA1D:

AA909273 AI457674 L31772 M76446 S70782 U03864 AA921964 AW577200 NM_000678 AA809802

Unigene Cluster for ADRA1D:

Adrenergic, alpha-1D-, receptor

Hs.557 [show with all ESTs]

Unigene Representative Sequence: NM_000678

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000379453

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADRA1D expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRA1D

¹ / ² / ³

7 probe-sets matching ADRA1D gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36729_g_at²^{, 3}	U95-A	1	1.00	1.00	0.68	0.96	M76446	0.80	1.00	0.91	1
36728_at²^{, 3}	U95-A	1	1.00	1.00	0.65	0.78	M76446	0.80	1.00	0.91	1
90822_at²^{, 3}	U95-D	1	0.94	1.00	0.60	1.28	AA921964	0.60	1.00	0.82	1
210961_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M76446	0.80	1.00	0.91	1
210960_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M76446	0.80	1.00	0.91	1
210961_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210960_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADRA1D for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCCCGCTGT

SOURCE GeneReport for Unigene cluster: Hs.557
Expression variation in blood from EXPOLDB for ADRA1D

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADRA1D gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADRA1D¹	--	adrenergic, alpha-1D-, receptor	99.76(n) 99.27(a)	469869 XM_525254.2 XP_525254.2
cow (Bos taurus)	ADRA1D¹	--	adrenergic, alpha-1D-, receptor	83.39(n) 82.74(a)	539543 XM_587980.3 XP_587980.3
rat (Rattus norvegicus)	Adra1d¹	--	adrenergic, alpha-1D-, receptor	83.36(n) 86.99(a)	29413 NM_024483.1 NP_077809.1
mouse (Mus musculus)	Adra1d^{1, 5}	2 (74.90 cM)⁵	adrenergic receptor, alpha 1d^{1, 5}	83.51(n)¹ 86.83(a)¹	11550¹ NM_013460.4¹ NP_038488.4¹ AB030642⁵ AL831731⁵ (see all 8)
chicken (Gallus gallus)	ADRA1D¹	--	adrenergic, alpha-1D-, receptor	68.35(n) 64.65(a)	422933 XM_420871.2 XP_420871.2

About this table Species with no ortholog for ADRA1D

ENSEMBL Gene Tree for ADRA1D

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRA1D gene

ADRA1A² ADRA1B² HRH2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/288 NCBI SNPs in ADRA1D are shown (see all 288 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 71)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2236554^1,2	A,C,F,H	4150041(+)	`GGATGT/ACACAG`	1	--	ut3¹		6		EA EU WA	2088
	rs709024^1,2	A,C,F,H	4149984(+)	`CCCCAT/CTACTT`	1	--	ut3¹		7		EA MN EU WA	2276
	rs709023^1,2	A,C,F,H	4149130(+)	`GACAAT/ATTGTG`	1	--	ng5¹		8		EU EA WA	838
	rs3810568^1,2	C,F,H	4179258(+)	`AGGCCT/CGTTTG`	1	--	ng3¹		4		EU EA WA	418
--	rs3810566^1,2	C	4178503(+)	`GAAGAG/TAGCCC`	1	--	ng3¹		0	--	--	--	--
--	rs7508786^1,2	C	4149913(+)	`AAAGGC/TCCCAC`	1	--	ut3¹		0	--	--	--	--
	rs3803964^1,2	F,H	4177218(+)	`GTGACG/AGTCTG`	1	T/T	syn¹ ese³		5		EA EU WA	1904
	rs1556832^1,2	A,C,F,H,O	4163557(+)	`AGGACC/TGCCAA`	1	--	int¹		12		EA NA EU WA	974
--	rs2326478^1,2	A,C,F,H,O	4156247(+)	`CTTCAC/TGTTAC`	1	--	int¹		7		EU EA NA	510
	rs835879^1,2	A,C,F,H,O	4156227(+)	`CTCGAG/CTTTCT`	1	--	int¹		5		EA NA	292

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HapMap Linkage Disequilibrium images for ADRA1D (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 104219

3 Novoseek disease relationships for ADRA1D gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
benign prostatic hyperplasia	44.93	1	17254786 (1)
essential hypertension	33.24	3	16685204 (2)
obstruction	1.31	1	15112040 (1)

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1 PharmGKB disease relationship for ADRA1D gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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Genetic Association Database: ADRA1D
Human Genome Epidemiology Navigator: ADRA1D (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/61 PubMed articles for ADRA1D gene (see all 61 ):

Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (PubMed id 12442007)^{1, 3, 6} Sugaya K....Ogawa Y. (2002)
Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. (PubMed id 7746284)^{1, 3, 4} Esbenshade T.A.... Murphy T.J. (1995)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. (PubMed id 7815325)^{3, 4} Schwinn D.A.... Bailey D.S. (1995)
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (PubMed id 8183249)^{3, 4} Forray C.... Gluchowski C. (1994)
Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. (PubMed id 8024574)^{3, 4} Weinberg D.H.... Bayne M. (1994)
Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5. (PubMed id 8039425)^{2, 3} Loftus S.K....Wasmuth J.J. (1994)
Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. (PubMed id 1656955)^{3, 4} Bruno J.F.... Berelowitz M. (1991)
Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. (PubMed id 16533813)^{1, 3} Chen Z....Minneman K.P. (2006)
Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. (PubMed id 18187928)^{1, 3} Nagaoka Y....Nagatomo T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 146	HGNC: 280	AceView: ADRA1D	Ensembl:ENSG00000171873	euGenes: HUgn146
ECgene: ADRA1D	H-InvDB: ADRA1D

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADRA1D
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRA1D:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRA1D-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADRA1D		Antibodies for ADRA1D
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADRA1D		Small molecules for ADRA1D
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Recombinant Proteins (alpha 1 Adrenergic Receptor, alpha 1d Adrenergic Receptor)
	Antibodies (alpha 1 Adrenergic Receptor, alpha 1d Adrenergic Receptor)

Search OriGene for ADRA1D

Tocris compounds for ADRA1D

	Drugs for ADRA1D
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADRA1D

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ADRA1D Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ADRA1D

Summaries
for ADRA1D

Genomic Location
for ADRA1D

Proteins
for ADRA1D

Protein Domains/
Families
for ADRA1D

Gene Function
for ADRA1D

Pathways & Interactions
for ADRA1D

Drugs & Compounds
for ADRA1D

Transcripts
for ADRA1D

Expression
for ADRA1D

Orthologs
for ADRA1D

Paralogs
for ADRA1D

SNPs/Variants
for ADRA1D

Disorders & Mutations
for ADRA1D

Medical News
for ADRA1D

Publications
for ADRA1D

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Genome Databases showing ADRA1D

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Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRA1D Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ADRA1D

Summariesfor ADRA1D

Genomic Locationfor ADRA1D

Proteinsfor ADRA1D

Protein Domains/Familiesfor ADRA1D

Gene Functionfor ADRA1D

Pathways & Interactionsfor ADRA1D

Drugs & Compoundsfor ADRA1D

Transcriptsfor ADRA1D

Expression for ADRA1D

Orthologsfor ADRA1D

Paralogsfor ADRA1D

SNPs/Variantsfor ADRA1D

Disorders & Mutationsfor ADRA1D

Medical Newsfor ADRA1D

Publicationsfor ADRA1D

Search for ADRA1D

Genome Databases showing ADRA1D

Other Databases showing ADRA1D

Specialized Databases showing ADRA1D

Licensable Technologiesfor ADRA1D

Servicesfor ADRA1D

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRA1D

Summaries
for ADRA1D

Genomic Location
for ADRA1D

Proteins
for ADRA1D

Protein Domains/
Families
for ADRA1D

Gene Function
for ADRA1D

Pathways & Interactions
for ADRA1D

Drugs & Compounds
for ADRA1D

Transcripts
for ADRA1D

Expression
for ADRA1D

Orthologs
for ADRA1D

Paralogs
for ADRA1D

SNPs/Variants
for ADRA1D

Disorders & Mutations
for ADRA1D

Medical News
for ADRA1D

Publications
for ADRA1D

Licensable Technologies
for ADRA1D

Services
for ADRA1D