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ADRA1B Gene

protein-coding GIFtS: 72

GC05P159276

adrenergic, alpha-1B-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADRA1 ^²
ALPHA1BAR ^²

Descriptions
Alpha 1B-adrenoceptor ^³
Alpha 1B-adrenoreceptor ^³
adrenergic, alpha-1B-, receptor ^²
alpha-1B-adrenergic receptor ^²

External Ids
HGNC: 278¹
Entrez Gene: 147²
UniProtKB: P35368³
Ensembl: ENSG00000170214⁷

Search outside databases for aliases for ADRA1B gene

Previous GC identifers: GC05P159198 GC05P159853 GC05P159324

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADRA1B:

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor

superfamily. They activate mitogenic responses and regulate growth and proliferation of many

cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the

Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene

encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected

into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a

protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that

interrupts the coding region. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368

Function: This alpha-adrenergic receptor mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system

Gene Wiki entry for ADRA1B (Alpha-1B_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRA1B gene

Entrez Gene cytogenetic band: 5q23-q32 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q23-q32

ADRA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P159276: (about GC identifiers)

Start:	159,276,318 bp from pter
End:	159,332,595 bp from pter
Size:	56,278 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368 (See protein sequence)

Recommended Name: Alpha-1B adrenergic receptor

Size: 520 amino acids; 56836 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000670.1

ENSEMBL proteins:

ENSP00000306662

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADRA1B Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha 1b Adrenergic Receptor, alpha 1 Adrenergic Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000299	integral to membrane of membrane fraction	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1328250

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Antibodies for ADRA1B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADRA1B
	R&D Systems Antibodies for ADRA1B
	Antibodies from Abcam (alpha 1b Adrenergic Receptor, alpha 1 Adrenergic Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ADRA1B

Assays for ADRA1B:

	Invitrogen Assays for ADRA1B
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35368

ProtoNet protein and cluster: P35368

2 Blocks protein families:

IPB001115 Alpha-1B adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000679

Applied Biosystems Silencer® siRNAs for ADRA1B

Sigma-Aldrich siRNA and siRNA Panels for ADRA1B

Sigma-Aldrich shRNA Panels and shRNA for ADRA1B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of ADRA1B

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000679
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000679
untagged cDNA clone in CMV expression vector: NM_000679

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000679

UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368

Function: This alpha-adrenergic receptor mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for ADRA1B:

adrenergic,alpha-1B-,receptor,G protein coupled receptor superfamily,stimulating,acting through the

phosphatidylinositol/Ca2+ second messenger system,involved in the control of vascular tone

11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adra1b):

	adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	life span-post-weaning/aging	muscle	nervous system
renal/urinary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004935	adrenoceptor activity	IEA	--
GO:0004937	alpha1-adrenergic receptor activity	TAS	1328250

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRA1B (Your Favorite Gene powered by Ingenuity)

Cardiac Hypertrophy Signaling
G-Protein Coupled Receptor Signaling

GeneDecks ADRA1B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADRA1B

5/35 Interacting proteins for ADRA1B (P35368² ENSP00000306662³) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1R9B	Q96SB3², ENSP00000320510³	MINT-4953469 STRING (score=.7)
ADRBK1	ENSP00000312262³	STRING (score=.97)
ADRA1A	ENSP00000348729³	STRING (score=.963)
GNAQ	ENSP00000286548³	STRING (score=.951)
TGM2	ENSP00000355330³	STRING (score=.943)

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5/22 Gene Ontology (GO) biological process terms (links to tree view) (see all 22 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001974	blood vessel remodeling	IEA	--
GO:0001975	response to amphetamine	IEA	--
GO:0001987	vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure	IEA	--
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IEA	--
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADRA1B

Sigma-Aldrich Small Molecules for ADRA1B:

Antagonist Agonist

Compounds for ADRA1B available from Tocris Bioscience

Compound	Action	CAS number
Rec 15/2615 dihydrochloride	Selective alpha1B antagonist	[173059-17-1]
AH 11110 hydrochloride	Subtype-selective alpha1B ligand	[179388-65-9]
Cirazoline hydrochloride	Selective alpha1 agonist	[40600-13-3]
HEAT hydrochloride	Highly selective alpha1 antagonist	[30007-39-7]
Prazosin hydrochloride	alpha1 antagonist. MT3 antagonist	[19237-84-4]

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7 Novoseek chemical compound relationships for ADRA1B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphoinositide	42.46	1	12880866 (1)
phorbol	28.17	3	9353340 (3)
bapta	26.97	1	11441921 (1)
catecholamine	23.84	3	10347189 (2), 8980109 (1)
calcium	17.91	4	8190093 (1), 8393524 (1), 11441921 (1), 15306222 (1)
tyrosine	3.78	5	15659118 (1), 12147231 (1), 11441921 (1), 11700022 (1) (see all 5)
hydroxyapatite	0.00	2	15659118 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000679

Sigma-Aldrich siRNA and siRNA Panels for ADRA1B

Sigma-Aldrich shRNA Panels and shRNA for ADRA1B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000679

REFSEQ mRNAs for ADRA1B gene:

NM_000679.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000679

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000679
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000679
                                 untagged cDNA clone in CMV expression vector: NM_000679

Additional cDNA sequence:

AK309989.1 BC136568.1 BC136569.1 L31773.1 U03865.1

1 DOTS entry:

DT.304573

11 AceView cDNA sequences:

CB044689 AI566163 U03865 AW138726 BQ576306 CB044690 L31773 NM_000679

AW732369 AW733134 AW236065

highest scoring ESTs for ADRA1B:

U03865 AI566163 AW138726 AW236065 AW732369 AW733134 BQ576306 CB044689 L31773 CB044690

Unigene Cluster for ADRA1B:

Adrenergic, alpha-1B-, receptor

Hs.368632 [show with all ESTs]

Unigene Representative Sequence: NM_000679

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000306675

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADRA1B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRA1B

¹ / ² / ³

3 probe-sets matching ADRA1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32983_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U03865	1.00	1.00	1.00	1
207589_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_000679	0.60	1.00	0.82	1
207589_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGAGAGCCT

SOURCE GeneReport for Unigene cluster: Hs.368632
Expression variation in blood from EXPOLDB for ADRA1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADRA1B gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRA1B¹	--	adrenergic, alpha-1B-, receptor	93.56(n) 97.56(a)	403962 XM_536449.2 XP_536449.2
cow (Bos taurus)	ADRA1B¹	--	adrenergic, alpha-1B-, receptor	94.05(n) 97.86(a)	407140 XM_001250068.1 XP_001250069.1
rat (Rattus norvegicus)	Adra1b¹	--	adrenergic, alpha-1B-, receptor	90.74(n) 95.73(a)	24173 NM_016991.2 NP_058687.2
mouse (Mus musculus)	Adra1b^{1, 5}	11 (19.00 cM)⁵	adrenergic receptor, alpha 1b^{1, 5}	90.55(n)¹ 96.31(a)¹	11548¹ NM_007416.3¹ NP_031442.2¹ AK004891⁵ AK043877⁵ (see all 13)
chicken (Gallus gallus)	ADRA1B¹	--	adrenergic, alpha-1B-, receptor	68.82(n) 75.99(a)	373890 XM_414483.2 XP_414483.2

About this table Species with no ortholog for ADRA1B

ENSEMBL Gene Tree for ADRA1B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRA1B gene

ADRA1A² ADRA1D² HRH2²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/295 NCBI SNPs in ADRA1B are shown (see all 295 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 109)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10214211^1,2	A,C,F,H	159333089(+)	`TGCATT/CCCCAG`	1	--	ng3¹		4		EU EA WA	412
	rs13155515^1,2	C	159332699(+)	`TCGCTC/TTCCAT`	1	--	ng3¹		0	--	--	--	--
	rs3729604^1,2	C,F,H	159277039(+)	`CTTGGG/ATGGAA`	1	G/G	syn¹		6		EA EU WA NA	1948
	rs3730284^1,2	C,F,H	159277024(+)	`TCCATT/CGGGCC`	1	I/I	syn¹ ese³		4		EU EA WA	420
	rs2229181^1,2	C,F	159276661(+)	`ATCCTC/TTTTGC`	1	L/L	syn¹		2		MN NA	88
	rs2030373^1,2	A,C,F,H,O	159280059(-)	`AGGTGG/TCAAGA`	1	--	int¹		16		EU EA WA NA	1412
	rs952037^1,2	A,C,F,H,O	159323455(+)	`TTTGAC/TCCTTG`	1	--	int¹		18		NS MN EU EA WA	1664
	rs6884105^1,2	A,C,F,H	159281021(+)	`TGAAGA/GCTAAC`	1	--	int¹		12		EA NA EU WA	1048
	rs12653825^1,2	A,C,F,H	159315849(+)	`aaTGTC/TCATTG`	1	--	int¹		4		EU EA WA	420
	rs11741223^1,2	A,C,F,H	159301018(+)	`ggcaaT/Cgtaga`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for ADRA1B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 104220

3 Novoseek disease relationships for ADRA1B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperfunction	41.15	2	9004925 (1), 9754358 (1)
cardiomyopathy	0.00	1	15674439 (1)
heart failure	0.00	1	15674439 (1)

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Genetic Association Database: ADRA1B
Human Genome Epidemiology Navigator: ADRA1B (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/133 PubMed articles for ADRA1B gene (see all 133 ):

Genomic organization and expression of the human alpha 1B-adrenergic receptor. (PubMed id 1328250)^{1, 3, 4} Ramarao C.S....Graham R.M. (1992)
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)^{3, 6} Matayoshi T....Kawano Y. (2004)
Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. (PubMed id 12023679)^{3, 6} McCaffery J.M....Manuck S.B. (2002)
Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. (PubMed id 7815325)^{3, 4} Schwinn D.A.... Bailey D.S. (1995)
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (PubMed id 8183249)^{3, 4} Forray C.... Gluchowski C. (1994)
Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor. (PubMed id 8617782)^{1, 3} Diviani D....Cotecchia S. (1996)
Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. (PubMed id 18523139)^{1, 3} Stanasila L....Cotecchia S. (2008)
Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor. (PubMed id 9353340)^{1, 3} Diviani D....Cotecchia S. (1997)
Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling. (PubMed id 16352594)^{1, 3} Stanasila L....Cotecchia S. (2006)
Dominance of the alpha1B-adrenergic receptor and its subcellular localization in human and TRAMP prostate cancer cell lines. (PubMed id 17365508)^{1, 3} Shi T....Perez D.M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 147	HGNC: 278	AceView: ADRA1B	Ensembl:ENSG00000170214	euGenes: HUgn147
ECgene: ADRA1B	H-InvDB: ADRA1B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ADRA1B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ADRA1B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADRA1B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRA1B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for ADRA1B		Antibodies for ADRA1B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADRA1B		Small molecules for ADRA1B
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Antibodies (alpha 1b Adrenergic Receptor, alpha 1 Adrenergic Receptor)

Search OriGene for ADRA1B

Tocris compounds for ADRA1B

	Drugs for ADRA1B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADRA1B

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ADRA1B Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for ADRA1B

Summaries
for ADRA1B

Genomic Location
for ADRA1B

Proteins
for ADRA1B

Protein Domains/
Families
for ADRA1B

Gene Function
for ADRA1B

Pathways & Interactions
for ADRA1B

Drugs & Compounds
for ADRA1B

Transcripts
for ADRA1B

Expression
for ADRA1B

Orthologs
for ADRA1B

Paralogs
for ADRA1B

SNPs/Variants
for ADRA1B

Disorders & Mutations
for ADRA1B

Medical News
for ADRA1B

Publications
for ADRA1B

Search for ADRA1B

Genome Databases showing ADRA1B

Other Databases showing ADRA1B

Specialized Databases showing ADRA1B

Licensable Technologies
for ADRA1B

Services
for ADRA1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRA1B Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor ADRA1B

Summariesfor ADRA1B

Genomic Locationfor ADRA1B

Proteinsfor ADRA1B

Protein Domains/Familiesfor ADRA1B

Gene Functionfor ADRA1B

Pathways & Interactionsfor ADRA1B

Drugs & Compoundsfor ADRA1B

Transcriptsfor ADRA1B

Expression for ADRA1B

Orthologsfor ADRA1B

Paralogsfor ADRA1B

SNPs/Variantsfor ADRA1B

Disorders & Mutationsfor ADRA1B

Medical Newsfor ADRA1B

Publicationsfor ADRA1B

Search for ADRA1B

Genome Databases showing ADRA1B

Other Databases showing ADRA1B

Specialized Databases showing ADRA1B

Licensable Technologiesfor ADRA1B

Servicesfor ADRA1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRA1B

Summaries
for ADRA1B

Genomic Location
for ADRA1B

Proteins
for ADRA1B

Protein Domains/
Families
for ADRA1B

Gene Function
for ADRA1B

Pathways & Interactions
for ADRA1B

Drugs & Compounds
for ADRA1B

Transcripts
for ADRA1B

Expression
for ADRA1B

Orthologs
for ADRA1B

Paralogs
for ADRA1B

SNPs/Variants
for ADRA1B

Disorders & Mutations
for ADRA1B

Medical News
for ADRA1B

Publications
for ADRA1B

Licensable Technologies
for ADRA1B

Services
for ADRA1B