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ADORA3 Gene

protein-coding GIFtS: 68

GC01M111827

adenosine A3 receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
A3AR ^²
AD026 ^¹, ²
OTTHUMP00000013476 ^²
OTTHUMP00000013739 ^²
OTTHUMP00000082917 ^²
bA552M11.5 ^²

Descriptions
adenosine A3 receptor ^²

External Ids
HGNC: 268¹
Entrez Gene: 140²
UniProtKB: P33765³
Ensembl: ENSG00000121933⁷

Search outside databases for aliases for ADORA3 gene

Previous GC identifers: GC01M112458 GC01M110913 GC01M111144 GC01M111340 GC01M111326 GC01M111739

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADORA3:

This gene encodes a protein that belongs to the family of adenosine receptors, which are

G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and

physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective

function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in

neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and

neurodegenerative effects, and it may also mediate both cell proliferation and cell death.

Multiple transcript variants encoding different isoforms have been found for this gene. [provided

by RefSeq]

UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which

inhibits adenylyl cyclase. Possible role in reproduction

Gene Wiki entry for ADORA3 (Adenosine_A3_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADORA3 gene

Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p21-p13

ADORA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M111827: (about GC identifiers)

Start:	111,827,493 bp from pter
End:	111,908,120 bp from pter
Size:	80,628 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765 (See protein sequence)

Recommended Name: Adenosine A3 receptor

Size: 318 amino acids; 36185 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structure from and Proteopedia :

1OEA (3D)

1R7N (3D)

Secondary accessions: A2A3P4 Q6UWU0 Q9BYZ1

Alternative splicing: 2 isoforms: P33765-1 P33765-2

Post-translational modifications:

Phosphorylation on Ser-317 may be crucial for rapid desensitization (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000668.1 NP_001075445.1 NP_065734.5

ENSEMBL proteins:

ENSP00000358731 ENSP00000347612 ENSP00000358730 ENSP00000358728 ENSP00000337962 ENSP00000241356

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADORA3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Adenosine A3 Receptor)
	Human Recombinant Proteins from Abnova (ADORA3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8399349

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Antibodies for ADORA3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADORA3
	Sigma-Aldrich Antibodies for ADORA3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Adenosine A3 Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADORA3)
	Novus Biologicals Antibodies for ADORA3

Assays for ADORA3:

	Invitrogen Assays for ADORA3
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P33765

ProtoNet protein and cluster: P33765

2 Blocks protein families:

IPB000466 Adenosine A3 receptor signature

IPB001634 Adenosine receptor signature

UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADORA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADORA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC029831

Applied Biosystems Silencer® siRNAs for ADORA3

Sigma-Aldrich siRNA and siRNA Panels for ADORA3

Sigma-Aldrich shRNA Panels and shRNA for ADORA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADORA3
		Millipore Clones for the Expression of ADORA3

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000677
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000677
untagged cDNA clones in CMV expression vector (see all 4): BC029831

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020683

UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which

inhibits adenylyl cyclase. Possible role in reproduction

Genatlas biochemistry entry for ADORA3:

adenosine receptor A3,widely expressed,most abundant in brain and some endocrine tissues,G protein

coupled receptor superfamily,activating adenylate cyclase

2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adora3):

immune system

no phenotypic analysis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001609	adenosine receptor activity, G-protein coupled	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADORA3 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling

GeneDecks ADORA3 for the pathways selected above

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5/6 Interacting proteins for ADORA3 (ENSP00000358730³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADA	ENSP00000361965³	STRING (score=.852)
ADORA2B	ENSP00000304501³	STRING (score=.846)
ADORA2A	ENSP00000351480³	STRING (score=.845)
ADORA1	ENSP00000356205³	STRING (score=.836)
ADCY2	ENSP00000371971³	STRING (score=.775)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	9164961
GO:0007165	signal transduction	TAS	8399349 9380026
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0007190	activation of adenylate cyclase activity	TAS	9380026
GO:0008016	regulation of heart contraction	TAS	9837869

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ADORA3:

Mixed Agonist/Antagonist Antagonist Agonist Inhibitor Ligand

Compounds for ADORA3 available from Tocris Bioscience

Compound	Action	CAS number
MRS 1220	Highly potent, selective hA3 antagonist	[183721-15-5]
2-Cl-IB-MECA	Highly selective A3 agonist	[163042-96-4]
IB-MECA	A3 selective agonist	[152918-18-8]
Staurosporine	Non-selective protein kinase inhibitor	[62996-74-1]

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10/37 Novoseek chemical compound relationships for ADORA3 gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cf 101	92.94	16	17101059 (5), 15720820 (2), 14562031 (2), 18050382 (2) (see all 8)
4'-thioadenosine	92.82	1	18776543 (1)
2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide	89.29	4	18059189 (2)
mrs1191	89.24	1	18059189 (1)
vuf 5574	87.25	1	16088125 (1)
mrs 1220	86.56	1	15147729 (1)
dpcpx	70.68	1	16026998 (1)
ribose	66.80	7	16305531 (3), 15104242 (1), 17067963 (1), 18038898 (1) (see all 5)
thiadiazole	63.97	5	15670924 (2), 15928917 (2), 14738972 (1)
nucleoside	57.88	3	16640329 (1), 16438031 (1), 17555308 (1)

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2 PharmGKB drug compound relationships for ADORA3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
caffeine	FA	12106498
methotrexate	FA	12528125 12106498

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADORA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADORA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC029831

Sigma-Aldrich siRNA and siRNA Panels for ADORA3

Sigma-Aldrich shRNA Panels and shRNA for ADORA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000677 NM_001081976 NM_020683

REFSEQ mRNAs for ADORA3 gene (3 alternative transcripts):

NM_000677.3 NM_001081976.1 NM_020683.6

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000677 NM_001081976 NM_020683

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000677
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000677
                                 untagged cDNA clones in CMV expression vector (see all 4): BC029831

Additional cDNA sequence:

AK313095.1 AY136749.1 AY358644.1 BC029831.1 BC041707.1 BC064411.1 L20463.1 L22607.1

X76981.1

10 DOTS entries:

DT.309636 DT.95167280 DT.410375 DT.95167281 DT.92471263 DT.95167272 DT.91680433 DT.97773741

DT.121382674 DT.121382732

24/87 AceView cDNA sequences (see all 87 ):

BG205723 BQ575272 CF456186 AI129184 AA974687 BI828255 BC041707 AY358644

AI198874 BX093971 CA843261 BF432324 BI822569 BC064411 CD013875 NM_020683

CK903038 CD104512 AI338828 X76981 CF147805 BE044135 BG708949 BV177564

highest scoring ESTs for ADORA3:

AU100171 BC029831 BI763461 BI822569 CA843261 L20463 L22607 X76981 AA313084 AI146579

Unigene Cluster for ADORA3:

Adenosine A3 receptor

Hs.281342 [show with all ESTs]

Unigene Representative Sequence: NM_000677

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ADORA3 (see all 12 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10a	·	10b	·
SP1:					-		-		-		-		-		-		-		-		-		-						-		-		-										-								-
SP2:															-		-		-		-		-						-		-		-										-								-
SP3:					-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-								-								-
SP4:																																	-										-								-
SP5:																													-		-		-		-								-

ExUns:	10c	^	11a	·	11b
SP1:	-
SP2:	-
SP3:	-
SP4:	-
SP5:

About this scheme

ECgene alternative splicing isoforms for ADORA3

6 Ensembl transcripts including schematic representations:

ENST00000369717 ENST00000355437 ENST00000369716 ENST00000369714 ENST00000335940 ENST00000241356

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADORA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADORA3

¹ / ² / ³

6 probe-sets matching ADORA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
61642_at²^{, 3}	U95-C	1	1.00	1.00	0.97	1.14	AI357650	0.60	1.00	0.82	1
36255_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.87	L77730	0.20	1.00	0.72	1
223660_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF226731	0.20	1.00	0.72	1
206171_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000677	0.60	1.00	0.82	1
223660_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206171_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADORA3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCATTGTGGA

SOURCE GeneReport for Unigene cluster: Hs.281342
Expression variation in blood from EXPOLDB for ADORA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADORA3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADORA3¹	--	adenosine A3 receptor	87.69(n) 88.22(a)	403805 NM_001003178.1 NP_001003178.1
chimpanzee (Pan troglodytes)	ADORA3¹	--	adenosine A3 receptor	99.79(n) 100(a)	457108 XM_001158919.1 XP_001158919.1
rat (Rattus norvegicus)	Adora3¹	--	adenosine A3 receptor	78.69(n) 72.15(a)	25370 NM_012896.1 NP_037028.1
mouse (Mus musculus)	Adora3^{1, 5}	3 (55.70 cM)⁵	adenosine A3 receptor^{1, 5}	78.9(n)¹ 74.05(a)¹	11542¹ NM_009631.3¹ NP_033761.2¹ AF069778⁵ AK013534⁵ (see all 9)
chicken (Gallus gallus)	ADORA3¹	--	adenosine A3 receptor	64.97(n) 60.34(a)	373956 NM_204151.1 NP_989482.1

About this table Species with no ortholog for ADORA3

ENSEMBL Gene Tree for ADORA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADORA3 gene

ADORA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/619 NCBI SNPs in ADORA3 are shown (see all 619 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 97)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1415792^1,2	A,C,F,H,O	111843718(+)	`AATGGC/TATGGA`	3	--	ut3¹ int¹ ese³		14	NS MN NA EU EA WA	952
	rs1415793^1,2	A,C,F,H,O	111843759(+)	`CAACTA/GGAGCC`	3	--	int¹ ut3¹ ese³		18	NA EA MN NS EU WA	1442
	rs10857887^1,2	A,C,F,H	111848868(+)	`ACTTCG/AGAGTG`	3	--	ng3¹ int¹		3	EA WA	258
--	rs10776733^1,2	A,C,F,H	111909192(+)	`atttaG/Ataaga`	1	--	ng3¹		4	EU EA WA	416
	rs923^1,2	A,C,F,H	111843906(+)	`GACAAA/GGGAAA`	3	--	int¹ ut3¹ trp³		18	NS MN NA EA EU WA	1316
	rs1544223^1,2	A,C,F,H	111848080(-)	`GCATAA/GTCAGT`	3	--	ut5¹ int¹ ese³		14	NA EA MN EU WA	1508
	rs10776728^1,2	A,C,F,H	111848643(+)	`GCCATT/AGTTAT`	3	--	int¹ ng3¹		13	MN EA EU WA NA	1474
--	rs4839145^1,2	A,C,F,H	111909358(+)	`caaagG/Cggggg`	1	--	ng3¹ tfbs³ trp³		2	EU WA	240
--	rs3394^1,2	A,C,F,H	111843654(+)	`TATTTC/TTTCTG`	3	--	int¹ ut3¹		9	MN NA EU EA WA	922
	rs2800889^1,2	A,C,F,H	111844255(+)	`TGCCCA/TTGTAC`	3	M/K	mis¹ int¹ ese³		8	EU EA WA	840

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HapMap Linkage Disequilibrium images for ADORA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600445

10/22 Novoseek disease relationships for ADORA3 gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pseudoexfoliation syndrome	49.01	1	15914619 (1)
cerebral ischemia	43.13	3	10078988 (1), 10668416 (1), 7821362 (1)
ischemia	42.22	5	9988118 (1), 12970092 (1), 10355598 (1), 15922260 (1) (see all 5)
brain ischemia	27.45	1	11462807 (1)
aqueous humor	23.26	3	15914619 (1), 15830199 (1)
glaucoma	18.17	3	15203160 (1), 15914619 (1), 15830199 (1)
effects cardiovascular	17.01	2	9380026 (1)
rheumatoid arthritis	11.83	10	17216675 (2), 18050382 (2), 16305531 (1), 17922624 (1) (see all 7)
astrocytoma	11.39	3	11462805 (1), 9425266 (1), 12435805 (1)
colon carcinoma	11.18	4	15720820 (2), 14562031 (1)

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Human Gene Mutation Database: ADORA3
Human Genome Epidemiology Navigator: ADORA3 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/174 PubMed articles for ADORA3 gene (see all 174 ):

Molecular cloning and characterization of the human A3 adenosine receptor. (PubMed id 8234299)^{1, 3, 4} Salvatore C.A.... Johnson R.G. (1993)
cDNA cloning and sequence analysis of the human A3 adenosine receptor. (PubMed id 8399349)^{1, 3, 4} Sajjadi F.G. and Firestein G.S. (1993)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Molecular phylogenetics and the origins of placental mammals. (PubMed id 11214319)^{3, 4} Murphy W.J....O'Brien S.J. (2001)
Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. (PubMed id 7607699)^{2, 3} Monitto C.L....Holroyd K.J. (1995)
Overexpression of A3 adenosine receptor in peripheral blood mononuclear cells in rheumatoid arthritis: involvement of nuclear factor-kappaB in mediating receptor level. (PubMed id 17216675)^{1, 3} Madi L....Fishman P. (2007)
Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor. (PubMed id 9380026)^{1, 3} Palmer T.M....Stiles G.L. (1997)
Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor (ADORA3) gene. (PubMed id 9293494)^{1, 3} Atkinson M.R....Schofield P.R. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 140	HGNC: 268	AceView: ADORA3	Ensembl:ENSG00000121933	euGenes: HUgn140
ECgene: ADORA3	H-InvDB: ADORA3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADORA3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADORA3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADORA3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADORA3		Antibodies for ADORA3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADORA3		Small molecules for ADORA3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADORA3)
	Antibodies (ADORA3)
	Chimera RNAi (ADORA3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Adenosine A3 Receptor)
	Antibodies (Adenosine A3 Receptor)

Search OriGene for ADORA3

Tocris compounds for ADORA3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADORA3

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADORA3 Gene at Home site.
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ADORA3 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ADORA3

Summaries
for ADORA3

Genomic Location
for ADORA3

Proteins
for ADORA3

Protein Domains/
Families
for ADORA3

Gene Function
for ADORA3

Pathways & Interactions
for ADORA3

Drugs & Compounds
for ADORA3

Transcripts
for ADORA3

Expression
for ADORA3

Orthologs
for ADORA3

Paralogs
for ADORA3

SNPs/Variants
for ADORA3

Disorders & Mutations
for ADORA3

Medical News
for ADORA3

Publications
for ADORA3

Search for ADORA3

Genome Databases showing ADORA3

Other Databases showing ADORA3

Specialized Databases showing ADORA3

Licensable Technologies
for ADORA3

Services
for ADORA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADORA3 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ADORA3

Summariesfor ADORA3

Genomic Locationfor ADORA3

Proteinsfor ADORA3

Protein Domains/Familiesfor ADORA3

Gene Functionfor ADORA3

Pathways & Interactionsfor ADORA3

Drugs & Compoundsfor ADORA3

Transcriptsfor ADORA3

Expression for ADORA3

Orthologsfor ADORA3

Paralogsfor ADORA3

SNPs/Variantsfor ADORA3

Disorders & Mutationsfor ADORA3

Medical Newsfor ADORA3

Publicationsfor ADORA3

Search for ADORA3

Genome Databases showing ADORA3

Other Databases showing ADORA3

Specialized Databases showing ADORA3

Licensable Technologiesfor ADORA3

Servicesfor ADORA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADORA3

Summaries
for ADORA3

Genomic Location
for ADORA3

Proteins
for ADORA3

Protein Domains/
Families
for ADORA3

Gene Function
for ADORA3

Pathways & Interactions
for ADORA3

Drugs & Compounds
for ADORA3

Transcripts
for ADORA3

Expression
for ADORA3

Orthologs
for ADORA3

Paralogs
for ADORA3

SNPs/Variants
for ADORA3

Disorders & Mutations
for ADORA3

Medical News
for ADORA3

Publications
for ADORA3

Licensable Technologies
for ADORA3

Services
for ADORA3