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ADORA1 Gene

protein-coding GIFtS: 69

GC01P201326

adenosine A1 receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
OTTHUMP00000039090 ^²
OTTHUMP00000039091 ^²
RDC7 ^¹, ², ⁵

Descriptions
adenosine A1 receptor ^²

External Ids
HGNC: 262¹
Entrez Gene: 134²
UniProtKB: P30542³
Ensembl: ENSG00000163485⁷

Search outside databases for aliases for ADORA1 gene

Previous GC identifers: GC01P200742 GC01P198489 GC01P199526 GC01P200348 GC01P199791

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADORA1:

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled

receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of

ligand binding and tissue distribution, and together they regulate a diverse set of physiologic

functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization

process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol

intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which

inhibit adenylyl cyclase

Gene Wiki entry for ADORA1 (Adenosine_A1_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADORA1 gene

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

ADORA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P201326: (about GC identifiers)

Start:	201,326,405 bp from pter
End:	201,403,156 bp from pter
Size:	76,752 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542 (See protein sequence)

Recommended Name: Adenosine receptor A1

Size: 326 amino acids; 36512 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A6NFY5 A6NGP4 A8K1L3 B3KXQ4 Q6FHK3 Q8TAM8

Alternative splicing: 2 isoforms: P30542-1 P30542-2

REFSEQ proteins (2 alternative transcripts):

NP_000665.1 NP_001041695.1

ENSEMBL proteins:

ENSP00000356205 ENSP00000338435 ENSP00000308549 ENSP00000356204

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADORA1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Adenosine A1 Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1530647

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Antibodies for ADORA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADORA1
	Sigma-Aldrich Antibodies for ADORA1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Adenosine A1 Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADORA1)
	Novus Biologicals Antibodies for ADORA1

Assays for ADORA1:

	Invitrogen Assays for ADORA1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P30542

ProtoNet protein and cluster: P30542

2 Blocks protein families:

IPB001068 Adenosine A1 receptor signature

IPB001634 Adenosine receptor signature

UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADORA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADORA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000674

Applied Biosystems Silencer® siRNAs for ADORA1

Sigma-Aldrich siRNA and siRNA Panels for ADORA1

Sigma-Aldrich shRNA Panels and shRNA for ADORA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of ADORA1

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000674
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000674
untagged cDNA clones in CMV expression vector (see all 2): NM_000674

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001048230

UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which

inhibit adenylyl cyclase

Genatlas biochemistry entry for ADORA1:

adenosine receptor A1,G protein coupled receptor superfamily,with no likely role of promoters

polymorphism in bipolar affective disorders inhibiting adenylate cyclase

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adora1):

	behavior/neurological	homeostasis/metabolism	nervous system	normal
respiratory system	touch/vibrissae

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001609	adenosine receptor activity, G-protein coupled	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADORA1 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling

GeneDecks ADORA1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADORA1

5/14 Interacting proteins for ADORA1 (ENSP00000356205³ P30542²) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADA	ENSP00000361965³	STRING (score=.99)
SLC29A1	ENSP00000360778³	STRING (score=.869)
GNAO1	ENSP00000262493³	STRING (score=.862)
ADORA3	ENSP00000358730³	STRING (score=.836)
IL6	ENSP00000258743³	STRING (score=.832)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006909	phagocytosis	TAS	8360491
GO:0006954	inflammatory response	TAS	8360491
GO:0007165	signal transduction	TAS	1530647
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0007267	cell-cell signaling	TAS	7818494

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ADORA1:

Antagonist Blocker Agonist Inhibitor Ligand

Compounds for ADORA1 available from Tocris Bioscience

Compound	Action	CAS number
2-Chloro-N6-cyclopentyladenosine	Potent, selective A1 agonist	[37739-05-2]
DPCPX	A1 selective antagonist	[102146-07-6]
SLV 320	Potent and selective A1 antagonist	[251945-92-3]
PSB 36	Potent and selective A1 antagonist	[524944-72-7]

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10/35 Novoseek chemical compound relationships for ADORA1 gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dpcpx	93.16	82	15572277 (2), 1331765 (2), 16329119 (2), 2143656 (1) (see all 52)
n6-cyclopentyladenosine	93.14	42	12819231 (2), 10676861 (2), 9692782 (2), 15145705 (2) (see all 23)
8-cyclopentyltheophylline	88.40	22	15145705 (2), 9185835 (1), 7649219 (1), 15992577 (1) (see all 11)
pd81723	87.63	5	8700102 (2), 11163328 (1), 14645687 (1)
n(6)-cyclohexyladenosine	87.45	23	11230994 (2), 8605954 (1), 9769229 (1), 7980632 (1) (see all 12)
tecadenoson	85.70	2	16230891 (1), 15956124 (1)
n(6)-cyclohexyl-2-o-methyladenosine	80.92	2	8822971 (2)
fk 352	80.12	1	16496028 (1)
ccpa	79.59	7	18054348 (2), 8618917 (1), 7980632 (1), 8878427 (1)
n(6)-endonorbornan-2-yl-9-methyladenine	77.40	1	1545393 (1)

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3 PharmGKB drug compound relationships for ADORA1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
caffeine	FA	10728760 12106498
methotrexate	FA	10728760 12106498
theophylline	FA	10728760

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADORA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADORA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000674

Sigma-Aldrich siRNA and siRNA Panels for ADORA1

Sigma-Aldrich shRNA Panels and shRNA for ADORA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000674 NM_001048230

REFSEQ mRNAs for ADORA1 gene (2 alternative transcripts):

NM_000674.2 NM_001048230.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000674 NM_001048230

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000674
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000674
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000674

Additional cDNA sequence:

AB004662.1 AK095060.1 AK127752.1 AK289928.1 AK293647.1 AK295584.1 AK308733.1 AK316106.1

AY136746.1 BC026340.1 BT019854.1 CR541749.1 CR612499.1 S45235.1 S56143.1 X68485.1

14 DOTS entries:

DT.92423938 DT.100786201 DT.97813786 DT.442942 DT.101983052 DT.100023710 DT.121394043 DT.121394049

DT.86851151 DT.100668605 DT.100696781 DT.121394028 DT.121394033 DT.100786204

24/92 AceView cDNA sequences (see all 92 ):

CB126404 BQ231015 BI829806 BU193080 BU740906 AK095060 BM673005 BM548386

BE250294 BF724405 BM055365 CD014133 CR612499 AU131780 BQ958975 BI772068

BU173243 T28868 BI820645 BC026340 BG423878 BI604013 BE314976 AU147420

highest scoring ESTs for ADORA1:

AA477718 AI094603 AK127752 AL134499 AU147420 BC026340 BE271489 BE314976 BF526869 BF927171

Unigene Cluster for ADORA1:

Adenosine A1 receptor

Hs.77867 [show with all ESTs]

Unigene Representative Sequence: AK127752

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ADORA1 (see all 11 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:																	-		-		-		-		-		-		-
SP2:																	-		-		-						-		-
SP3:							-		-		-						-		-		-		-		-		-		-
SP4:																	-		-		-		-		-		-
SP5:													-				-		-		-

About this scheme

ECgene alternative splicing isoforms for ADORA1

4 Ensembl transcripts including schematic representations:

ENST00000367236 ENST00000337894 ENST00000309502 ENST00000367235

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADORA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADORA1

¹ / ² / ³

5 probe-sets matching ADORA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40400_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L22214	0.80	1.00	0.91	1
216220_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X68485	0.80	1.00	0.91	1
205481_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000674	0.60	1.00	0.82	1
216220_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205481_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADORA1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGACTAATAA

SOURCE GeneReport for Unigene cluster: Hs.77867
Expression variation in blood from EXPOLDB for ADORA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADORA1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADORA1¹	--	adenosine A1 receptor	91.62(n) 94.17(a)	403961 NM_001003279.1 NP_001003279.1
chimpanzee (Pan troglodytes)	ADORA1¹	--	adenosine A1 receptor	99.59(n) 99.69(a)	457638 XM_001154129.1 XP_001154129.1
cow (Bos taurus)	ADORA1¹	--	adenosine A1 receptor	91.1(n) 94.48(a)	282133 NM_174497.3 NP_776922.2
rat (Rattus norvegicus)	Adora1¹	--	adenosine A1 receptor	88.85(n) 94.48(a)	29290 NM_017155.1 NP_058851.1
mouse (Mus musculus)	Adora1^{1, 5}	1⁵	adenosine A1 receptor^{1, 5}	88.65(n)¹ 94.79(a)¹	11539¹ NM_001039510.1¹ NP_001034599.1¹ AF133099⁵ AI848715⁵ (see all 24)

About this table Species with no ortholog for ADORA1

ENSEMBL Gene Tree for ADORA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADORA1 gene

ADORA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/253 NCBI SNPs in ADORA1 are shown (see all 253 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 212)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs16851030^1,2	C,F,H	201402075(+)	`GCAGCC/TCCAGG`	2	--	ut3¹ ese³		7		NA EU EA WA	536
	rs12744240^1,2	C,F,H	201402297(+)	`TGTACG/TTGGGA`	2	--	ut3¹ ese³		4		EU EA WA	418
	rs16851029^1,2	F,H	201402024(+)	`TGGGCT/GTCTGC`	2	--	ut3¹ ese³		7		NA EU EA WA	526
--	rs6427994^1,2	A,C	201401948(+)	`TCCAGA/CGCTTC`	2	--	ut3¹ ese³		0	--	--	--	--
--	rs33912180^1,2	C	201402465(+)	`AGCCT-/TGGAGT`	2	--	ut3¹		0	--	--	--	--
--	rs11547175^1,2	H	201364719(+)	`GGGATG/TCCACC`	2	A/S	mis¹ ese³		4		EU EA WA	414
--	rs11547176^1,2	H	201364906(+)	`GGACCG/ACTACC`	2	H/R	mis¹		1		WA	114
	rs12135560^1,2	H	201402537(+)	`TCCTAG/AGTGAC`	2	--	ut3¹		4		EU EA WA	414
--	rs2275349^1,2	H	201364737(+)	`TCATCG/CTGTCG`	2	L/V	mis¹ ese³		4		EU EA WA	418
	rs10920568^1,2	A,C,F,H	201364898(+)	`ATTGCT/GGTGGA`	2	A/A	syn¹ ese³		7		EU EA WA NA	554

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HapMap Linkage Disequilibrium images for ADORA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 102775

10/42 Novoseek disease relationships for ADORA1 gene (see all 42 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ischemia	45.27	18	7884404 (1), 10396621 (1), 11744026 (1), 18535281 (1) (see all 14)
brain ischemia	41.86	4	9988118 (1), 10355598 (1), 11320597 (1), 8790990 (1)
cerebral ischemia	37.95	7	8050467 (2), 11320597 (1), 17650627 (1), 8790990 (1) (see all 6)
carotid occlusion	25.47	1	2364291 (1)
bradycardia	17.99	3	9763631 (1), 9203590 (1), 8276062 (1)
transient cerebral ischemia	17.95	3	1666408 (2), 1529167 (1)
effects cardiovascular	17.40	2	9988118 (1), 10355598 (1)
brain diseases	11.93	3	9369972 (1), 9988118 (1), 10355598 (1)
syndrome x	11.10	2	9199943 (1), 9191496 (1)
myocardial ischemia	9.08	1	9191496 (1)

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2 PharmGKB disease relationships for ADORA1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Arthritis, Experimental	FA	10728760
Asthma	FA	15630442

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Human Gene Mutation Database: ADORA1
Genetic Association Database: ADORA1
Human Genome Epidemiology Navigator: ADORA1 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/370 PubMed articles for ADORA1 gene (see all 370 ):

The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)^{1, 3, 6} Wright K....Griffiths L.R. (2004)
Cloning and functional characterization of a human A1 adenosine receptor. (PubMed id 1530647)^{1, 3, 4} Libert F.... Mendla K.D. (1992)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. (PubMed id 12825092)^{3, 6} Alsene K....de Wit H. (2003)
Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. (PubMed id 8300646)^{3, 4} Ren H. and Stiles G.L. (1994)
Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. (PubMed id 1339301)^{3, 4} Townsend-Nicholson A. and Shine J. (1992)
Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. (PubMed id 1662665)^{2, 3} Libert F....Mattei M.G. (1991)
Selective amplification and cloning of four new members of the G protein-coupled receptor family. (PubMed id 2541503)^{2, 3} Libert F....Vassart G. (1989)
Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. (PubMed id 8450977)^{1, 3} Ul/as J....Cotman C.W. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 134	HGNC: 262	AceView: ADORA1	Ensembl:ENSG00000163485	euGenes: HUgn134
ECgene: ADORA1	H-InvDB: ADORA1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADORA1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADORA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADORA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADORA1		Antibodies for ADORA1
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Antibodies for ADORA1

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ADORA1 Gene at Home site.
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ADORA1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ADORA1

Summaries
for ADORA1

Genomic Location
for ADORA1

Proteins
for ADORA1

Protein Domains/
Families
for ADORA1

Gene Function
for ADORA1

Pathways & Interactions
for ADORA1

Drugs & Compounds
for ADORA1

Transcripts
for ADORA1

Expression
for ADORA1

Orthologs
for ADORA1

Paralogs
for ADORA1

SNPs/Variants
for ADORA1

Disorders & Mutations
for ADORA1

Medical News
for ADORA1

Publications
for ADORA1

Search for ADORA1

Genome Databases showing ADORA1

Other Databases showing ADORA1

Specialized Databases showing ADORA1

Licensable Technologies
for ADORA1

Services
for ADORA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADORA1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ADORA1

Summariesfor ADORA1

Genomic Locationfor ADORA1

Proteinsfor ADORA1

Protein Domains/Familiesfor ADORA1

Gene Functionfor ADORA1

Pathways & Interactionsfor ADORA1

Drugs & Compoundsfor ADORA1

Transcriptsfor ADORA1

Expression for ADORA1

Orthologsfor ADORA1

Paralogsfor ADORA1

SNPs/Variantsfor ADORA1

Disorders & Mutationsfor ADORA1

Medical Newsfor ADORA1

Publicationsfor ADORA1

Search for ADORA1

Genome Databases showing ADORA1

Other Databases showing ADORA1

Specialized Databases showing ADORA1

Licensable Technologiesfor ADORA1

Servicesfor ADORA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADORA1

Summaries
for ADORA1

Genomic Location
for ADORA1

Proteins
for ADORA1

Protein Domains/
Families
for ADORA1

Gene Function
for ADORA1

Pathways & Interactions
for ADORA1

Drugs & Compounds
for ADORA1

Transcripts
for ADORA1

Expression
for ADORA1

Orthologs
for ADORA1

Paralogs
for ADORA1

SNPs/Variants
for ADORA1

Disorders & Mutations
for ADORA1

Medical News
for ADORA1

Publications
for ADORA1

Licensable Technologies
for ADORA1

Services
for ADORA1