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Aliases for ADH4 Gene

Aliases for ADH4 Gene

  • Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide 2 3
  • Alcohol Dehydrogenase Class II Pi Chain 3 4
  • EC 1.1.1.1 4 64
  • Epididymis Secretory Protein Li 4 3
  • Alcohol Dehydrogenase 4 3
  • Aldehyde Reductase 3
  • EC 1.1.1 64
  • HEL-S-4 3
  • ADH-2 3

External Ids for ADH4 Gene

Summaries for ADH4 Gene

Entrez Gene Summary for ADH4 Gene

  • This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH4 Gene

ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide) is a Protein Coding gene. Diseases associated with ADH4 include alcoholic liver cirrhosis and alcohol dependence. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NAD binding and retinol binding. An important paralog of this gene is ADH6.

Gene Wiki entry for ADH4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH4 Gene

Genomics for ADH4 Gene

Genomic Location for ADH4 Gene

Start:
99,123,657 bp from pter
End:
99,157,792 bp from pter
Size:
34,136 bases
Orientation:
Minus strand

Genomic View for ADH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH4 Gene

Regulatory Elements for ADH4 Gene

Proteins for ADH4 Gene

  • Protein details for ADH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08319-ADH4_HUMAN
    Recommended name:
    Alcohol dehydrogenase 4
    Protein Accession:
    P08319
    Secondary Accessions:
    • A8K470
    • B4DIE7
    • C9J4A9
    • Q8TCD7

    Protein attributes for ADH4 Gene

    Size:
    380 amino acids
    Molecular mass:
    40222 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

    Three dimensional structures from OCA and Proteopedia for ADH4 Gene

    Alternative splice isoforms for ADH4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH4 Gene

Proteomics data for ADH4 Gene at MOPED

Post-translational modifications for ADH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH4 Gene

Domains for ADH4 Gene

Gene Families for ADH4 Gene

HGNC:
  • ADH :Alcohol dehydrogenases

UniProtKB/Swiss-Prot:

ADH4_HUMAN
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.:
    • P08319
genes like me logo Genes that share domains with ADH4: view

Function for ADH4 Gene

Molecular function for ADH4 Gene

GENATLAS Biochemistry: alcohol dehydrogenase (class II),pi polypeptide (see ADH@)
UniProtKB/Swiss-Prot CatalyticActivity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Numbers (IUBMB) for ADH4 Gene

Gene Ontology (GO) - Molecular Function for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003960 NADPH:quinone reductase activity ISS --
GO:0004022 alcohol dehydrogenase (NAD) activity IDA 16787387
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IDA 10407146
GO:0004032 alditol:NADP+ 1-oxidoreductase activity IEA --
GO:0004745 retinol dehydrogenase activity IDA 15369820
genes like me logo Genes that share ontologies with ADH4: view

Phenotypes for ADH4 Gene

GenomeRNAi human phenotypes for ADH4:
genes like me logo Genes that share phenotypes with ADH4: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADH4 Gene

Localization for ADH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH4 Gene COMPARTMENTS Subcellular localization image for ADH4 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
chloroplast 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADH4: view

Pathways for ADH4 Gene

genes like me logo Genes that share pathways with ADH4: view

Gene Ontology (GO) - Biological Process for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IDA 15369820
GO:0006066 alcohol metabolic process IDA 3466164
GO:0006067 ethanol metabolic process --
GO:0006069 ethanol oxidation TAS --
GO:0006081 cellular aldehyde metabolic process IDA 3466164
genes like me logo Genes that share ontologies with ADH4: view

Compounds for ADH4 Gene

(9) HMDB Compounds for ADH4 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
Ethanol
  • 1-Hydroxyethane
64-17-5
Isobutanol
  • 1-Hydroxymethylpropane
78-83-1

(4) Drugbank Compounds for ADH4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cyclohexylformamide
target
NADH
  • beta-DPNH
606-68-8 target
NADH
  • beta-DPNH
606-68-8 enzyme substrate
Nicotinamide-Adenine-Dinucleotide
53-84-9 target

(4) Novoseek inferred chemical compound relationships for ADH4 Gene

Compound -log(P) Hits PubMed IDs
vitamin a 57.6 4
retinoid 54.8 1
retinoic acid 43.9 2
ethanol 30.4 6
genes like me logo Genes that share compounds with ADH4: view

Transcripts for ADH4 Gene

Unigene Clusters for ADH4 Gene

Alcohol dehydrogenase 4 (class II), pi polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for ADH4 Gene

GeneLoc Exon Structure for
ADH4
ECgene alternative splicing isoforms for
ADH4

Expression for ADH4 Gene

mRNA expression in normal human tissues for ADH4 Gene

mRNA differential expression in normal tissues according to GTEx for ADH4 Gene

This gene is overexpressed in Liver (50.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADH4 Gene

SOURCE GeneReport for Unigene cluster for ADH4 Gene Hs.1219

genes like me logo Genes that share expressions with ADH4: view

Orthologs for ADH4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH4 36
  • 99.39 (n)
  • 99.47 (a)
ADH4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADH4 36
  • 84.56 (n)
  • 76.84 (a)
ADH4 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADH4 36
  • 86.72 (n)
  • 81 (a)
ADH4 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adh4 36
  • 78.43 (n)
  • 72.41 (a)
Adh4 16
Adh4 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adh4 36
  • 80.19 (n)
  • 73.21 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adh4 36
  • 68.68 (n)
  • 68.95 (a)
zebrafish
(Danio rerio)
Actinopterygii adh5 37
  • 64 (a)
ManyToMany
adh8a 37
  • 54 (a)
ManyToMany
adh8b 37
  • 53 (a)
ManyToMany
zgc:63568 37
  • 56 (a)
ManyToMany
zgc:77938 37
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 37
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 37
  • 51 (a)
ManyToMany
Y50D4C.2 37
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 37
  • 46 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ADH1 36
  • 54.04 (n)
  • 50.13 (a)
rice
(Oryza sativa)
Liliopsida Os11g0210500 36
  • 52.42 (n)
  • 49.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 37
  • 56 (a)
OneToMany
Species with no ortholog for ADH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH4 Gene

ENSEMBL:
Gene Tree for ADH4 (if available)
TreeFam:
Gene Tree for ADH4 (if available)

Paralogs for ADH4 Gene

Paralogs for ADH4 Gene

Selected SIMAP similar genes for ADH4 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ADH4 Gene

genes like me logo Genes that share paralogs with ADH4: view

Variants for ADH4 Gene

Sequence variations from dbSNP and Humsavar for ADH4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_023461 -
VAR_023462 -
VAR_023463 -

Structural Variations from Database of Genomic Variants (DGV) for ADH4 Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294

Relevant External Links for ADH4 Gene

HapMap Linkage Disequilibrium report
ADH4
Human Gene Mutation Database (HGMD)
ADH4

Disorders for ADH4 Gene

(4) University of Copenhagen DISEASES for ADH4 Gene

(1) Novoseek inferred disease relationships for ADH4 Gene

Disease -log(P) Hits PubMed IDs
alcoholism 52 3

Relevant External Links for ADH4

Genetic Association Database (GAD)
ADH4
Human Genome Epidemiology (HuGE) Navigator
ADH4
genes like me logo Genes that share disorders with ADH4: view

No data available for UniProtKB/Swiss-Prot for ADH4 Gene

Publications for ADH4 Gene

  1. Cloning and characterization of the human ADH4 gene. (PMID: 1889753) von Bahr-Lindstroem H. … Hoeoeg J.-O. (Gene 1991) 3 4 23
  2. Alcohol dehydrogenase alleles in Parkinson's disease. (PMID: 11009184) Buervenich S. … Olson L. (Mov. Disord. 2000) 3 23 49
  3. Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (PMID: 15863808) Guindalini C. … Zatz M. (Am J Psychiatry 2005) 3 23 49
  4. Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. (PMID: 19925625) Rainero I. … Pinessi L. (Headache 2010) 3 23 49
  5. Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). (PMID: 20363298) Pochareddy S. … Edenberg H.J. (Gene 2010) 3 23

Products for ADH4 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADH4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADH4
    • Block miRNA regulation of ADH4 using miScript Target Protectors
    • Addgene plasmids for ADH4

    Sources for ADH4 Gene

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