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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADH4 Gene

protein-coding   GIFtS: 63
GCID: GC04M100044

alcohol dehydrogenase 4 (class II), pi polypeptide
 Explore 23 diseases affiliated with
ADH4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADH4    

Aliases
for ADH4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide1 2     Alcohol Dehydrogenase 42
ADH-21 2     Aldehyde Reductase2
Alcohol Dehydrogenase Class II Pi Chain2 3     EC 1.1.18
EC 1.1.1.13 8     

External Ids:    HGNC: 2521   Entrez Gene: 1272   Ensembl: ENSG000001980997   OMIM: 1037405   UniProtKB: P083193   

Export aliases for ADH4 gene to outside databases

Previous GC identifers: GC04M100290 GC04M100453 GC04M100458 GC04M100401 GC04M095782


Summaries
for ADH4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADH4:
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family.
Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic
alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of
2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is
less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
(provided by RefSeq, Jul 2008)

Gene Wiki entry for ADH4


Genomic Views
for ADH4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADH4 gene promoter:
         c-Fos   AP-1   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   S8   E2F-1   E2F   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADH4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q22

ADH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100044:  view genomic region     (about GC identifiers)

Start:
 100,044,808 bp from pter      End:
 100,078,949 bp from pter
Size:
 34,142 bases      Orientation:
 minus strand

Proteins
for ADH4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADH4_HUMAN, P08319 (See protein sequence)
Recommended Name: Alcohol dehydrogenase 4  
Size: 380 amino acids; 40222 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Homodimer
Subcellular location: Cytoplasm
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to
class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
1 PDB 3D structure from and Proteopedia for ADH4:
3COS (3D)    
Secondary accessions: A8K470 B4DIE7 C9J4A9 Q8TCD7
Alternative splicing: 2 isoforms:  P08319-1   P08319-2   

Explore the universe of human proteins at neXtProt for ADH4: NX_P08319

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08319

    • 4/17 DME Specific Peptides for ADH4 (P08319) (see all 17)
     TSLCHTD  FSQYTVV  EVAPPKA  WEAGKPL 

    ADH4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000661.2  
    ENSEMBL proteins: 
     ENSP00000424630   ENSP00000265512   ENSP00000424583   ENSP00000425416   ENSP00000426667  
     ENSP00000423571   ENSP00000427525   ENSP00000427261   ENSP00000397939  
    Reactome Protein details: P08319
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADH4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0015630microtubule cytoskeleton IDA--


    ADH4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADH4

    Protein Domains /
    Families
    for ADH4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADH4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR016040 NAD(P)-bd_dom
     IPR002328 ADH_Zn_CS
     IPR013154 ADH_GroES-like

    Graphical View of Domain Structure for InterPro Entry P08319

    ProtoNet protein and cluster: P08319

    2 Blocks protein families:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH4_HUMAN, P08319
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily


    Function
    for ADH4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADH4_HUMAN, P08319
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Genatlas biochemistry entry for ADH4:
    alcohol dehydrogenase (class II),pi polypeptide (see ADH@)

    Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003960NADPH:quinone reductase activity ISS--
    GO:0004022alcohol dehydrogenase (NAD) activity IDA3466164
    GO:0004024alcohol dehydrogenase activity, zinc-dependent IDA10407146
    GO:0004032alditol:NADP+ 1-oxidoreductase activity IEA--


    ADH4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADH4:
     Increased homologous recombina 


    Pathways & Interactions
    for ADH4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ethanol oxidation
    		Ethanol oxidation1.00
    		Cyclophosphamide Pathway, Pharmacodynamics0.42
    		Fatty Acid Omega Oxidation0.47
    2Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Retinol metabolism0.40
    		Metabolism of xenobiotics by cytochrome P4500.73
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4Vitamin A and carotenoid metabolism
    		Vitamin A and carotenoid metabolism1.00
    5Tyrosine metabolism
    		Tyrosine metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for ADH4 
        Vitamin A and carotenoid metabolism
    noradrenaline and adrenaline degradation
    Fatty Acid Omega Oxidation

    4        Reactome Pathways for ADH4
        Ethanol oxidation
    Metabolism
    Biological oxidations
    Phase 1 - Functionalization of compounds

    1 PharmGKB Pathway for ADH4
        Cyclophosphamide Pathway, Pharmacodynamics

    5/7         Kegg Pathways  (Kegg details for ADH4) (see all 7):
        Glycolysis / Gluconeogenesis
    Fatty acid metabolism
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450


    ADH4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for ADH4 (P083193 ENSP000002655124) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583I2D: score=1 
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH2ENSP000002617334STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process IDA15369820
    GO:0006066alcohol metabolic process IDA3466164
    GO:0006067ethanol metabolic process ----
    GO:0006069ethanol oxidation TAS--
    GO:0006081cellular aldehyde metabolic process IDA3466164


    ADH4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADH4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADH4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADH4

    9 HMDB Compounds for ADH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--

    3 DrugBank Compounds for ADH4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 1938903 3593480 17016423 11306066
    enzymesubstrate17139284 1938903 3593480 17016423 11306066 19583966
    Cyclohexylformamide-- --target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235

    4 Novoseek chemical compound relationships for ADH4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 57.6 5 12604207 (2), 11916005 (1), 19011747 (1)
    retinoid 54.8 1 11306066 (1)
    retinoic acid 43.9 2 12604207 (1), 19011747 (1)
    ethanol 30.4 7 12604207 (3), 11916005 (1), 11306066 (1), 7598661 (1)

    Search CenterWatch for drugs/clinical trials and news about ADH4 

    Transcripts
    for ADH4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADH4 gene: 
    NM_000670.3  

    Unigene Cluster for ADH4:

    Alcohol dehydrogenase 4 (class II), pi polypeptide
    Hs.1219  [show with all ESTs]
    Unigene Representative Sequence: AK295556
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508393(uc011ced.2) ENST00000265512(uc003hun.3) ENST00000509471
    ENST00000505590 ENST00000506705 ENST00000512499 ENST00000503416 ENST00000504125
    ENST00000503944 ENST00000504894 ENST00000504581 ENST00000423445

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK290835.1 AK295556.1 AK313649.1 BC022319.1 M15943.1 

    14 DOTS entries:

    DT.313803  DT.95160319  DT.121224116  DT.102830037  DT.92446277  DT.92446282  DT.92446275  DT.101981924 
    DT.92446278  DT.92446279  DT.121224157  DT.92446273  DT.100024083  DT.100893417 

    24/75 AceView cDNA sequences (see all 75):

    CB161911 BV201803 CB161793 T29660 CB164064 CB134869 AA333940 CB163762 
    CB156842 CB137736 CB162220 CB164477 CB157024 AA007395 AA693785 CB154322 
    M15943 BC022319 CB146687 BG567667 CB157048 N58528 BG569045 AV682236 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADH4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                                     
    SP2:              -     -     -                                                         
    SP3:              -           -                                                         
    SP4:                    -     -                                                         
    SP5:                                                                    -               


    ECgene alternative splicing isoforms for ADH4

    Expression
    for ADH4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCCTGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ADH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADH4

    SOURCE GeneReport for Unigene cluster: Hs.1219
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADH4: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
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    Orthologs
    for ADH4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ADH4 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:779386
    zgc:635686
    (see all 4)    		 zgc:63568
    (see all 4)    		 57(a)
    56(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 14(37121611-37132341)
    14(37113161-37120779)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Fdh6
    		 Formaldehyde dehydrogenase
    		 54(a)
    		 1 → many
    		 3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)    		 Secernentea H24K24.36
    Y50D4C.26
    		 Protein Y50D4C.2
    		 49(a)
    32(a)
    		 many ↔ many
    many ↔ many
    		 V(911775-916461)
    V(936399-939368)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATGSNOR16
    ADH16
    (see all 9)    		 alcohol dehydrogenase class-P
    (see all 9)    		 51(a)
    49(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 5(17684156-17686534)
    1(28975394-28977417)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 dehydrogenase, putative, expressed
    (see all 9)    		 52(a)
    50(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 2(34924401-34928315)
    11(5751396-5755778)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria frmA6
    yphC6
    		 alcohol dehydrogenase class III/glutathione-depend...
    predicted oxidoreductase, Zn-dependent and NAD(P)-...
    		 48(a)
    26(a)
    		 1 ↔ many
    possible ortholog
    		 Chromosome(377686-378795)
    Chromosome(2672722-2673783)


    ENSEMBL Gene Tree for ADH4 (if available)
    TreeFam Gene Tree for ADH4 (if available) 

    Paralogs
    for ADH4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADH4 gene
    ADH62  ADH1A2  ADH1B2  ADH52  ADH72  
    6 SIMAP similar genes for ADH4 using alignment to 5 protein entries:     ADH4_HUMAN (see all proteins):
    ADH5    ADH1C    ADH1B    ADH1A    ADH7    ADH6

    ADH4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADH4
    PGOHUM00000250725


    Genomic Variants
    for ADH4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): ADH4
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADH4
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH4

    Disorders / Diseases
    for ADH4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADH4 for disorders           About GeneDecksing

    OMIM gene information: 103740    OMIM disorders: --

    20/23 diseases for ADH4 (see all 23):    About MalaCards
    alcoholism    cluster headache    substance abuse    alcoholic liver cirrhosis
    substance dependence    drug dependence    liver cirrhosis    headache
    alcohol dependence    hearing loss    adhd    parkinson's disease
    hepatocellular carcinoma    esophageal cancer    esophagitis    pneumonia
    cerebritis    retinitis    tuberculosis    adenocarcinoma

    4 diseases from the University of Copenhagen DISEASES database for ADH4:
    Alcohol dependence     Substance abuse     Esophageal cancer     Liver disease

    1 Novoseek disease relationship for ADH4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 52 3 15863808 (1), 16571603 (1), 8583138 (1)

    Genetic Association Database (GAD): ADH4
    Human Genome Epidemiology (HuGE) Navigator: ADH4 (26 documents)

    Export disorders for ADH4 gene to outside databases

    Publications
    for ADH4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADH4 gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with ADH4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (PubMed id 15863808)1, 4, 9 Guindalini C....Zatz M. (2005)
    2. Alcohol dehydrogenase alleles in Parkinson's disease. (PubMed id 11009184)1, 4, 9 Buervenich S....Olson L. (2000)
    3. Cloning and characterization of the human ADH4 gene. (PubMed id 1889753)1, 2, 9 von Bahr-Lindstroem H.... Hoeoeg J.-O. (1991)
    4. ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies. (PubMed id 16237392)1, 4 Luo X....Gelernter J. (2006)
    5. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. (PubMed id 16220108)1, 4 Luo X....Gelernter J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Alcohol dehydrogenase ADH2-1 and ADH2-2 allelic isoforms in the Russian population correlate with type of alcoholic disease. (PubMed id 11900616)1, 4 Ogurtsov P.P....Moiseev V.S. (2001)
    8. Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit. (PubMed id 3036213)1, 2 Hoeoeg J.-O.... Joernvall H. (1987)
    9. Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes. (PubMed id 1362387)1, 9 Edman K. and Maret W. (1992)
    10. Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). (PubMed id 20363298)1, 9 Pochareddy S. and Edenberg H.J. (2010)

    External Searches for ADH4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADH4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 127 HGNC: 252 AceView: ADH4 Ensembl:ENSG00000198099 euGenes: HUgn127
    ECgene: ADH4 Kegg: 127 H-InvDB: ADH4

    Other Databases showing ADH4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADH4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADH4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh4/

    Intellectual Property
    for ADH4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADH4 gene:
    Search GeneIP for patents involving ADH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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