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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACSS1 Gene

protein-coding GIFtS: 59
GCID: GC20M024986

acyl-CoA synthetase short-chain family member 1

(Previous name: acetyl-Coenzyme A synthetase 2 (AMP forming)-like )
(Previous symbol: ACAS2L)

Explore 7 diseases affiliated with
ACSS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Short-Chain Family Member 1¹ ² ³		DJ568C11.3¹
ACAS2L¹ ² ³		ACECS1²
AceCS2L¹ ²		Acetyl-Coenzyme A Synthetase 2-Like, Mitochondrial²
Acetate--CoA Ligase 2² ³		AceCS2³
EC 6.2.1.1³ ⁸		KIAA1846³
MGC33843¹		Acetyl-CoA Synthetase 2³
Acetyl-Coenzyme A Synthetase 2 (AMP Forming)-Like¹		EC 6.2.1⁸

External Ids:	HGNC: 16091¹	Entrez Gene: 84532²	Ensembl: ENSG00000154930⁷	OMIM: 614355⁵	UniProtKB: Q9NUB1³

Export aliases for ACSS1 gene to outside databases

Previous GC identifer: GC20M024935

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSS1:

This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in

the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript

variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: ACS2L_HUMAN, Q9NUB1

Function: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for

energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used

for oxidation through the tricarboxylic cycle to produce ATP and CO(2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACSS1 gene promoter:
C/EBPbeta AML1a SREBP-1c p300 STAT5A SREBP-1b C/EBPalpha AREB6 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACSS1 promoter sequence

Search SABiosciences Chromatin IP Primers for ACSS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23-p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.23-p11.21

ACSS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSS1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M024986: view genomic region (about GC identifiers)

Start:	24,986,868 bp from pter	End:	25,039,616 bp from pter
Size:	52,749 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACS2L_HUMAN, Q9NUB1 (See protein sequence)

Recommended Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

Size: 689 amino acids; 74857 Da

Subunit: Interacts with SIRT3

Subcellular location: Mitochondrion matrix

Sequence caution: Sequence=BAB55390.1; Type=Erroneous initiation; Sequence=BAC03853.1; Type=Frameshift; Positions=250;

Sequence=BAC03853.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;

3 PDB 3D structures from and Proteopedia for ACSS1:

3GLR (3D)

3GLT (3D)

3GLU (3D)

Secondary accessions: B3KXL2 B4DJZ3 D3DW48 F5H6F4 F8W7Y1 Q5TF42 Q8IV99 Q8N234 Q96JI1 Q96JX6 Q9NU28

Alternative splicing: 4 isoforms: Q9NUB1-1 Q9NUB1-2 Q9NUB1-3 Q9NUB1-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACSS1: NX_Q9NUB1

Post-translational modifications:

Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by

deacetylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NUB1

4/11 DME Specific Peptides for ACSS1 (Q9NUB1) (see all 11)

YFTGDGA

AMLACAR

WQTETGG

YVVYGPL

ACSS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001239604.1 NP_001239605.1 NP_001239606.1 NP_115890.2

ENSEMBL proteins:

ENSP00000316924 ENSP00000365916 ENSP00000388793 ENSP00000437657 ENSP00000439304

Reactome Protein details: Q9NUB1
Human Recombinant Protein Products for ACSS1:

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	Uscn Proteins for ACSS1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005759	mitochondrial matrix	TAS	--

ACSS1 for ontologies About GeneDecksing

ACSS1 Antibody Products:

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Assay Products for ACSS1:

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	Uscn ELISAs and CLIAs for ACSS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACSS1 for domains About GeneDecksing

5 InterPro domains/families:

IPR011904 Ac_CoA_lig

IPR000873 AMP-dep_Synth/Lig

IPR024597 Acyl-CoA_synth_DUF3448

IPR020845 AMP-binding_CS

IPR025110 DUF4009

Graphical View of Domain Structure for InterPro Entry Q9NUB1

ProtoNet protein and cluster: Q9NUB1

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: ACS2L_HUMAN, Q9NUB1

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ACS2L_HUMAN, Q9NUB1

Function: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for

energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used

for oxidation through the tricarboxylic cycle to produce ATP and CO(2)

Catalytic activity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

Enzyme regulation: Inhibited by acetylation at Lys-642 and activated by deacetylation

Enzyme Numbers (IUBMB): EC 6.2.1.1¹ ² EC 6.2.1²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003987	acetate-CoA ligase activity	IDA	16788062
GO:0005515	protein binding	IPI	16788062
GO:0005524	ATP binding	IEA	--
GO:0016208	AMP binding	IEA	--

ACSS1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ACSS1:

Decreased POU5F1-GFP protein e

Decreased homologous recombina

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Acss1):

behavior/neurological

cellular

growth/size

homeostasis/metabolism

mortality/aging

ACSS1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Acss1^tm1Jsak for ACSS1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACSS1

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		hsa-miR-3163 hsa-miR-3149 hsa-miR-513c hsa-miR-548l hsa-miR-3667-3p hsa-miR-670 hsa-miR-9* hsa-miR-514b-5p

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSS1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Ethanol oxidation

Ethanol oxidation

1.00

Signaling events mediated by HDAC Class III

Signaling events mediated by HDAC Class III

1.00

Pyruvate metabolism

Pyruvate metabolism

1.00

Biological oxidations

Biological oxidations

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for ACSS1

	SREBP signalling
	Statin Pathway
	Signaling events mediated by HDAC Class III

4 Reactome Pathways for ACSS1

	Ethanol oxidation
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

4 Kegg Pathways (Kegg details for ACSS1):

	Glycolysis / Gluconeogenesis
	Pyruvate metabolism
	Propanoate metabolism
	Metabolic pathways

ACSS1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ACSS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/186 Interacting proteins for ACSS1 (Q9NUB1³ ENSP00000316924⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 186)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM1	P62158³	I2D: score=1
CALM2	P62158³	I2D: score=1
CALM3	P62158³	I2D: score=1
ACACB	O00763³, ENSP00000367079⁴	I2D: score=2 STRING: ENSP00000367079
ACAA1	P09110³, ENSP00000333664⁴	I2D: score=1 STRING: ENSP00000333664

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006069	ethanol oxidation	TAS	--
GO:0006085	acetyl-CoA biosynthetic process	IDA	16788062
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0019413	acetate biosynthetic process	IEA	--
GO:0019427	acetyl-CoA biosynthetic process from acetate	IEA	--

ACSS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACSS1

10/12 HMDB Compounds for ACSS1 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetic acid	Acetate (see all 12)	64-19-7	--
Acetyl adenylate	5'-O-[acetoxy(hydroxy)phosphoryl]adenosine (see all 5)	13015-87-7	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine tetraphosphate	Adenosine 5'-tetraphosphate (see all 6)	58337-43-2	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Propinol adenylate	Propionyladenylate	--	--
Propionic acid	Adofeed (see all 23)	79-09-4	--

2 DrugBank Compounds for ACSS1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Adenosine monophosphate	5'-Adenosine monophosphate (see all 15)	61-19-8	target	product of	17139284 17016423
Adenosine triphosphate	5'-ATP (see all 8)	56-65-5	target	--	17139284 17016423

Search CenterWatch for drugs/clinical trials and news about ACSS1 / ACS2L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACSS1 gene (4 alternative transcripts):

NM_001252675.1 NM_001252676.1 NM_001252677.1 NM_032501.3

Unigene Cluster for ACSS1:

Acyl-CoA synthetase short-chain family member 1

Hs.529353 [show with all ESTs]

Unigene Representative Sequence: AK125923

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484396 ENST00000323482(uc002wud.1 uc002wub.3 uc002wuc.3 uc021wbm.1 uc010gdc.3)

ENST00000376726 ENST00000432802 ENST00000542618 ENST00000537502(uc002wua.3 uc021wbl.1)

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		hsa-miR-3163 hsa-miR-3149 hsa-miR-513c hsa-miR-548l hsa-miR-3667-3p hsa-miR-670 hsa-miR-9* hsa-miR-514b-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ACSS1 3' UTR sequence

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Additional cDNA sequence:

AB058749.1 AK027817.1 AK090851.1 AK092295.1 AK125923.1 AK127566.1 AK296306.1 AK314440.1

AL832939.1 AL833041.1 BC032076.1 BC039261.1 BC044588.1 BC055008.1 BC114612.1

20 DOTS entries:

DT.441489 DT.100036403 DT.100710053 DT.101977443 DT.100789155 DT.100789153 DT.91941783 DT.120832524

DT.91919704 DT.120832547 DT.120832552 DT.120832558 DT.120832561 DT.120832563 DT.120832593 DT.120832607

DT.120832621 DT.320002 DT.92439525 DT.80100506

24/209 AceView cDNA sequences (see all 209):

AK027817 BF930930 AK127566 AI086481 CK299554 AX746647 BQ366261 BF514433

CR593620 BU740271 BU740860 BX641221 BE293600 CR624354 BX360085 BE855412

BX358720 AI356425 AK090851 BE041281 BM855125 AI832144 F09996 BM727197

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for ACSS1 (see all 18) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·
SP1:									-				-		-		-								-										-						-						-		-
SP2:									-				-		-		-								-										-						-						-		-
SP3:																									-										-						-						-		-
SP4:									-				-		-		-								-										-						-						-		-
SP5:																																			-						-

ExUns:	14b	·	14c	·	14d	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19a	·	19b	·	19c	^	20a	·	20b	·	20c	·	20d	·	20e	^	21	^	22
SP1:							-				-		-		-				-		-		-
SP2:							-				-		-		-				-		-		-
SP3:							-				-		-		-				-		-		-
SP4:					-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for ACSS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACSS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCCGGGCA

About this image

ACSS1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Yolk Sac

Definitive Yolk Sac

Erythroid Progenitor Cells

Blood

Adipose

Thoracic Perivascular Adipose

Adipose

Bone

Mandibular Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ACSS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACSS1

SOURCE GeneReport for Unigene cluster: Hs.529353

SABiosciences Custom PCR Arrays for ACSS1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ACSS1 gene from 5/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACSS1¹	acyl-CoA synthetase short-chain family member 1	74.84(n) 79.39(a)		416714 XM_415011.3 XP_415011.3
lizard (Anolis carolinensis)	Reptilia	ACSS1⁶ --	--	73(a) 66(a)	1 ↔ 1 possible ortholog	1(254564583-254615126) 1(23535964-23557522)
zebrafish (Danio rerio)	Actinopterygii	sbcb395²	sbcb395	74.23(n)		321238 CA452364.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ACS2(YLR153C)⁴ ACS1¹	Acetyl-coA synthetase isoform which, along with Acs1p, more⁴ Acs1p¹	52.47(n)¹ 48.62(a)¹		12(447575-445524)⁴ 851245¹ NP_009347.1¹ 850846⁴ NP_013254.1⁴
E. coli (Escherichia coli)	Gamma proteobacteria	acs⁶ prpE⁶	propionate--CoA ligase	46(a) 34(a)	1 ↔ many possible ortholog	Chromosome(4283436-4285394) Chromosome(351930-353816)

ENSEMBL Gene Tree for ACSS1 (if available)
TreeFam Gene Tree for ACSS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ACSS1 gene

C10orf129² ACSM5² ACSM3² ACSS2² ACSM2A² ACSM1² ACSM4² ACSS3²

ACSM2B² ACSF2²

5 SIMAP similar genes for ACSS1 using alignment to 5 protein entries: ACS2L_HUMAN (see all proteins):

ACSS2 ACSS3 DKFZp762G026 A-923A4.2 DKFZp666G0810

ACSS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137980069^1,2	C	other	25004239(+)	`ACCCCG/AGAGTC`	8	/R /W	mis¹		1		NA	4552
rs112170666^1,2		--	24986457(+)	`CCTAGT/CGGAGG`	4	--	ds500¹		1		CSA	1
rs8184324^1,2	C,H	--	24986471(+)	`GACCCA/GGGGAC`	4	--	ds500¹		6		NS EA NA	422
rs181688568^1,2		--	24986474(+)	`CCAGGA/GACCAG`	4	--	ds500¹		0	--	--	--	--
rs147433211^1,2		--	24986655(+)	`TTTCTA/GTTCTG`	4	--	ds500¹		0	--	--	--	--
rs200905627^1,2		--	24986820(+)	`TCAGG-/AAAAAA`	4	--	ds500¹		0	--	--	--	--
rs185365937^1,2		--	24986927(+)	`ATGCCC/TGGGAC`	4	--	ut3¹		0	--	--	--	--
rs2294980^1,2	C,F	--	24986965(+)	`GAAAGC/TTAAGC`	4	--	ut3¹		1		EA	1500
rs149995450^1,2		--	24987173(+)	`ACCCCC/GCGAAC`	4	--	ut3¹		0	--	--	--	--
rs189849393^1,2		--	24987242(+)	`CCTCCC/TCTAAG`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ACSS1 (24986868 - 25039616 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACSS1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACSS1

DNA2.0 Custom Variant and Variant Library Synthesis for ACSS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ACSS1 for disorders           About GeneDecksing

OMIM gene information: 614355    OMIM disorders: --

7 diseases for ACSS1:    About MalaCards

kidney disease hepatocellular carcinoma tuberculosis carcinoma

hepatitis malaria mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: ACSS1 (5 documents)

Export disorders for ACSS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACSS1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with ACSS1)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structures of human SIRT3 displaying substrate-induced conformational changes. (PubMed id 19535340)^{1, 2, 9} Jin L.... Perni R.B. (2009)
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PubMed id 16788062)^{1, 2, 9} Schwer B.... Verdin E. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
The importance of acetyl coenzyme A synthetase for 11 C-acetate uptake and cell survival in hepatocellular carcinoma. (PubMed id 19617323)^{1, 9} Yun M....Lee J.D. (2009)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)¹ Oguri M....Yamada Y. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84532	HGNC: 16091	AceView: ACAS2L	Ensembl:ENSG00000154930	euGenes: HUgn84532
ECgene: ACSS1	Kegg: 84532	H-InvDB: ACSS1

(According to HUGE)
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HUGE: KIAA1846

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ACSS1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACSS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACSS1 gene:
Search GeneIP for patents involving ACSS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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acyl-CoA synthetase short-chain family member 1

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ACSS1 Gene

acyl-CoA synthetase short-chain family member 1

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