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Aliases for ACOT2 Gene

Aliases for ACOT2 Gene

  • Acyl-CoA Thioesterase 2 2 3 4
  • PTE2 3 4 6
  • Acyl-Coenzyme A Thioester Hydrolase 2a 3 4
  • Mitochondrial Acyl-CoA Thioesterase 1 2 3
  • Long-Chain Acyl-CoA Thioesterase 2 3 4
  • EC 3.1.2.2 4 63
  • CTE-IA 3 4
  • ZAP128 3 4
  • PTE2A 3 4
  • MTE1 3 6
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase 2 3
  • Acyl-Coenzyme A Thioesterase 2, Mitochondrial 3
  • CTE1A 3

External Ids for ACOT2 Gene

Previous GeneCards Identifiers for ACOT2 Gene

  • GC14P073106
  • GC14P074036
  • GC14P054203

Summaries for ACOT2 Gene

Entrez Gene Summary for ACOT2 Gene

  • This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for ACOT2 Gene

ACOT2 (Acyl-CoA Thioesterase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Ovarian steroidogenesis. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT4.

UniProtKB/Swiss-Prot for ACOT2 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.

Gene Wiki entry for ACOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT2 Gene

Genomics for ACOT2 Gene

Regulatory Elements for ACOT2 Gene

Genomic Location for ACOT2 Gene

Start:
73,567,620 bp from pter
End:
73,575,658 bp from pter
Size:
8,039 bases
Orientation:
Plus strand

Genomic View for ACOT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT2 Gene

Proteins for ACOT2 Gene

  • Protein details for ACOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49753-ACOT2_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 2, mitochondrial
    Protein Accession:
    P49753
    Secondary Accessions:
    • Q3I5F8
    • Q53EK4
    • Q9NUX4

    Protein attributes for ACOT2 Gene

    Size:
    483 amino acids
    Molecular mass:
    53218 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC42007.1; Type=Frameshift; Positions=215, 226; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACOT2 Gene

    Alternative splice isoforms for ACOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT2 Gene

Proteomics data for ACOT2 Gene at MOPED

Post-translational modifications for ACOT2 Gene

  • Ubiquitination at Lys348
  • Modification sites at PhosphoSitePlus

Other Protein References for ACOT2 Gene

Domains for ACOT2 Gene

Gene Families for ACOT2 Gene

HGNC:
  • ACOT :Acyl CoA thioesterases

Suggested Antigen Peptide Sequences for ACOT2 Gene

Graphical View of Domain Structure for InterPro Entry

P49753

UniProtKB/Swiss-Prot:

ACOT2_HUMAN :
  • P49753
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT2: view

Function for ACOT2 Gene

Molecular function for ACOT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=40.3 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=8.9 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=1.6 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.0 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.8 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.5 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=6.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.3 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=212 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=681 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=766 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=656 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=488 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=408 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=661 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=304 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + H(2)O = CoA + palmitate
UniProtKB/Swiss-Prot Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.

Enzyme Numbers (IUBMB) for ACOT2 Gene

Gene Ontology (GO) - Molecular Function for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity --
GO:0047617 acyl-CoA hydrolase activity IDA 10944470
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT2: view

Phenotypes for ACOT2 Gene

GenomeRNAi human phenotypes for ACOT2:
genes like me logo Genes that share phenotypes with ACOT2: view

miRNA for ACOT2 Gene

miRTarBase miRNAs that target ACOT2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACOT2 Gene

Localization for ACOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT2 Gene COMPARTMENTS Subcellular localization image for ACOT2 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 16940157
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ACOT2: view

Pathways for ACOT2 Gene

genes like me logo Genes that share pathways with ACOT2: view

Interacting Proteins for ACOT2 Gene

Gene Ontology (GO) - Biological Process for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IDA 10944470
genes like me logo Genes that share ontologies with ACOT2: view

Compounds for ACOT2 Gene

(68) HMDB Compounds for ACOT2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT2: view

Transcripts for ACOT2 Gene

Unigene Clusters for ACOT2 Gene

Acyl-CoA thioesterase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT2 Gene

No ASD Table

Relevant External Links for ACOT2 Gene

GeneLoc Exon Structure for
ACOT2
ECgene alternative splicing isoforms for
ACOT2

Expression for ACOT2 Gene

mRNA expression in normal human tissues for ACOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT2 Gene

SOURCE GeneReport for Unigene cluster for ACOT2 Gene Hs.446685

mRNA Expression by UniProt/SwissProt for ACOT2 Gene

P49753-ACOT2_HUMAN
Tissue specificity: Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.
genes like me logo Genes that share expressions with ACOT2: view

No data available for mRNA differential expression in normal tissues for ACOT2 Gene

Orthologs for ACOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT2 35
  • 98.62 (n)
  • 98.55 (a)
cow
(Bos Taurus)
Mammalia ACOT2 35
  • 85.67 (n)
  • 81.24 (a)
ACOT2 36
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
ACOT2 35
  • 84.76 (n)
  • 81.08 (a)
mouse
(Mus musculus)
Mammalia Acot1 36
  • 77 (a)
ManyToMany
Acot2 35
  • 79.81 (n)
  • 75.72 (a)
Acot2 16
Acot2 36
  • 75 (a)
ManyToMany
Acot3 36
  • 75 (a)
ManyToMany
Acot5 36
  • 74 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Acot2 35
  • 79.48 (n)
  • 75.11 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 62 (a)
OneToMany
LOC771753 35
  • 67.32 (n)
  • 64.77 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia acot2 35
  • 60.69 (n)
  • 59.33 (a)
Str.12247 35
zebrafish
(Danio rerio)
Actinopterygii zgc:77651 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C31H5.6 36
  • 25 (a)
ManyToMany
K05B2.4 36
  • 28 (a)
ManyToMany
T05E7.1 36
  • 22 (a)
ManyToMany
W03D8.8 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ACOT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOT2 Gene

ENSEMBL:
Gene Tree for ACOT2 (if available)
TreeFam:
Gene Tree for ACOT2 (if available)

Paralogs for ACOT2 Gene

Paralogs for ACOT2 Gene

Selected SIMAP similar genes for ACOT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOT2: view

Variants for ACOT2 Gene

Sequence variations from dbSNP and Humsavar for ACOT2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7494 - 73,575,485(+) TGGCC(A/G)CGAGG reference, missense, nc-transcript-variant
rs14290 -- 73,575,613(+) AATAA(C/T)TAAAG utr-variant-3-prime, nc-transcript-variant
rs1049653 -- 73,575,606(+) TGTTT(A/T)TAATA utr-variant-3-prime, nc-transcript-variant
rs1049658 -- 73,575,612(+) TAATA(A/C)CTAAA utr-variant-3-prime, nc-transcript-variant
rs3178333 -- 73,568,000(-) gccgc(A/G)gaccc upstream-variant-2KB, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT2 Gene

Variant ID Type Subtype PubMed ID
dgv1958n71 CNV Gain 21882294
nsv510643 CNV Loss 20534489
dgv641e1 CNV Complex 17122850
nsv428295 CNV Gain 18775914
nsv832828 CNV Gain+Loss 17160897
nsv1350 CNV Loss 18451855
nsv9153 CNV Gain+Loss 18304495
nsv821106 CNV Deletion 20802225
nsv826976 CNV Loss 20364138
esv29080 CNV Gain+Loss 19812545
esv1006342 CNV Deletion 20482838
esv2748867 CNV Deletion 23290073
nsv902088 CNV Gain 21882294
esv29945 CNV Loss 18421352
esv33155 CNV Gain+Loss 17666407
nsv436178 CNV Deletion 17901297
esv2672436 CNV Deletion 23128226
nsv826985 CNV Loss 20364138
esv30006 CNV Gain 17803354
nsv826987 CNV Loss 20364138
nsv819954 CNV Gain 19587683
nsv826988 CNV Loss 20364138
nsv442346 CNV CNV 18776908
nsv514751 CNV Complex 21397061

Relevant External Links for ACOT2 Gene

HapMap Linkage Disequilibrium report
ACOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT2 Gene

Disorders for ACOT2 Gene

Relevant External Links for ACOT2

Genetic Association Database (GAD)
ACOT2
Human Genome Epidemiology (HuGE) Navigator
ACOT2
genes like me logo Genes that share disorders with ACOT2: view

No data available for UniProtKB/Swiss-Prot for ACOT2 Gene

Publications for ACOT2 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4
  2. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PMID: 10944470) Jones J.M. … Gould S.J. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  3. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PMID: 7596406) Sherrington R. … St George-Hyslop P.H. (Nature 1995) 3 4
  4. Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). (PMID: 19497300) Mandel C.R. … Tong L. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3

Products for ACOT2 Gene

Sources for ACOT2 Gene

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