Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ACOT2 Gene

protein-coding   GIFtS: 61
GCID: GC14P074036

Acyl-CoA Thioesterase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Acyl-CoA Thioesterase 21 2 3     EC 3.1.2.23 8
PTE22 3 5     MTE12 5
Mitochondrial Acyl-CoA Thioesterase 11 2     CTE-IA2
Acyl-Coenzyme A Thioester Hydrolase 2a2 3     CTE1A2
Long-Chain Acyl-CoA Thioesterase 22 3     Acyl-Coenzyme A Thioesterase 2, Mitochondrial2
PTE2A2 3     Peroxisomal Long-Chain Acyl-CoA Thioesterase 22
ZAP1282 3     CTE-Ia3

External Ids:    HGNC: 184311   Entrez Gene: 109652   Ensembl: ENSG000001196737   OMIM: 6099725   UniProtKB: P497533   

Export aliases for ACOT2 gene to outside databases

Previous GC identifers: GC14P073106 GC14P054203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ACOT2 Gene:
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase
genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jan 2012)

GeneCards Summary for ACOT2 Gene:
ACOT2 (acyl-CoA thioesterase 2) is a protein-coding gene. Diseases associated with ACOT2 include labyrinthitis, and alzheimer's disease. GO annotations related to this gene include palmitoyl-CoA hydrolase activity and receptor binding. An important paralog of this gene is ACOT6.

UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs

Gene Wiki entry for ACOT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT2 gene promoter:
         GR   STAT5B   AML1a   Pax-5   FOXD1   Arnt   AREB6   HFH-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT2 promoter sequence
   Search Chromatin IP Primers for ACOT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

ACOT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P074036:  view genomic region     (about GC identifiers)

Start:
74,034,324 bp from pter      End:
74,042,359 bp from pter
Size:
8,036 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 2, mitochondrial precursor  
Size: 483 amino acids; 53218 Da
Caution: Was originally (PubMed:10944470) thought to be peroxisomal but was later shown (PubMed:16940157) to be
mitochondrial
Sequence caution: Sequence=AAC42007.1; Type=Frameshift; Positions=215, 226;
1 PDB 3D structure from and Proteopedia for ACOT2:
3HLK (3D)    
Secondary accessions: Q3I5F8 Q53EK4 Q9NUX4
Alternative splicing: 2 isoforms:  P49753-1   P49753-2   

Explore the universe of human proteins at neXtProt for ACOT2: NX_P49753

Explore proteomics data for ACOT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys348
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACOT2 (P49753) (see all 10)
     DDHNWKS  WKSEFYA  IEPPYFP  PALGGSF 


    See ACOT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006812.3  
    ENSEMBL proteins: 
     ENSP00000440961   ENSP00000238651  

    ACOT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ACOT2
    GenScript Custom Purified and Recombinant Proteins Services for ACOT2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACOT2

    ACOT2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACOT2
    OriGene Custom Antibody Services for ACOT2
    Novus Biologicals ACOT2 Antibodies
    Abcam antibodies for ACOT2
    Cloud-Clone Corp. Antibodies for ACOT2
    ThermoFisher Antibody for ACOT2
    LSBio Antibodies in human, mouse, rat for ACOT2

    ACOT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACOT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACOT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACOT2
    Cloud-Clone Corp. CLIAs for ACOT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ACOT: Acyl CoA thioesterases

    3 InterPro protein domains:
     IPR006862 Thio_Ohase/aa_AcTrfase
     IPR014940 BAAT_C
     IPR016662 Acyl-CoA_thioEstase_long-chain

    Graphical View of Domain Structure for InterPro Entry P49753

    ProtoNet protein and cluster: P49753

    1 Blocks protein domain: IPB006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

    UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753
    Similarity: Belongs to the C/M/P thioester hydrolase family


    ACOT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOT2_HUMAN, P49753
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs
    Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate
    Biophysicochemical properties: Kinetic parameters: KM=40.3 uM for C10-acyl-CoA; KM=8.9 uM for C12-acyl-CoA; KM=1.6
    uM for C14-acyl-CoA; KM=2.0 uM for C16-acyl-CoA; KM=2.8 uM for C18-acyl-CoA; KM=4.8 uM for C20-acyl-CoA; KM=4.5
    uM for C16:1-acyl-CoA; KM=6.1 uM for C18:1-acyl-CoA; KM=4.3 uM for C18:1-trans-acyl-CoA; Vmax=212 nmol/min/mg
    enzyme toward C10-acyl-CoA; Vmax=681 nmol/min/mg enzyme toward C12-acyl-CoA; Vmax=766 nmol/min/mg enzyme toward
    C14-acyl-CoA; Vmax=656 nmol/min/mg enzyme toward C16-acyl-CoA; Vmax=488 nmol/min/mg enzyme toward C18-acyl-CoA;
    Vmax=408 nmol/min/mg enzyme toward C20-acyl-CoA; Vmax=661 nmol/min/mg enzyme toward C16:1-acyl-CoA; Vmax=304
    nmol/min/mg enzyme toward C18:1-acyl-CoA; Vmax=418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA;

         Enzyme Number (IUBMB): EC 3.1.2.21 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0016290palmitoyl-CoA hydrolase activity IEA--
    GO:0016790thiolester hydrolase activity ----
    GO:0047617acyl-CoA hydrolase activity IDA10944470
         
    ACOT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACOT2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACOT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACOT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACOT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACOT2:
    hsa-mir-17-5p (MIRT050818)

    Block miRNA regulation of human, mouse, rat ACOT2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ACOT2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACOT2
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACOT2

    Clone
    Products:
         
    OriGene clones in human, mouse for ACOT2 (see all 6)
    OriGene ORF clones in mouse, rat for ACOT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACOT2 (NM_006821)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACOT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACOT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACOT2_HUMAN, P49753: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome2
    cytosol1
    golgi apparatus1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA16940157

    ACOT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ACOT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    Fatty acid elongation0.38
    2Metabolism
    Metabolic pathways0.38
    3stearate biosynthesis I (animals)
    stearate biosynthesis I (animals)0.35
    4palmitate biosynthesis I (animals)
    palmitate biosynthesis I (animals)
    5Ovarian steroidogenesis
    Ovarian steroidogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ACOT2
        stearate biosynthesis I (animals)
    oleate biosynthesis II (animals)
    palmitate biosynthesis I (animals)


    4 Kegg Pathways  (Kegg details for ACOT2):
        Fatty acid elongation
    Biosynthesis of unsaturated fatty acids
    Metabolic pathways
    Ovarian steroidogenesis


    ACOT2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACOT2
    Interactions:

        Search GeneGlobe Interaction Network for ACOT2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ACOT2 (P497533 ENSP000002386514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF277Q9NRM23, ENSP000003545014I2D: score=2 STRING: ENSP00000354501
    NRBF2Q96F243I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA16940157
    GO:0001676long-chain fatty acid metabolic process IDA16940157
    GO:0006637acyl-CoA metabolic process IDA10944470

    ACOT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT2

    Selected HMDB Compounds for ACOT2 (see all 68)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    11'-Carboxy-alpha-chromanol2,5,7,8-Tetramethyl-2-(4',8'-dimethyl-11'-carboxy-undecyl)-6-chromanol;RRR-11'-carboxy-alpha-chromanol;2-(11-carboxy-4,8-dimethylundecyl)-6-hydroxy-2,5,7,8-tetramethylchroman;11'-carboxy-alpha-tocopherol ----
    11'-Carboxy-alpha-tocotrienolalpha-CDMD(en)(2)HC;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,5,7,8-tetramethylchroman;alpha-CDMD(en)(,2)HC ----
    11'-Carboxy-gama-chromanol2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-chromanol;2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-hydroxychroman;RRR-11'-carboxy-gama-chromanol;11'-Carboxy-gama-tocopherol ----
    11'-carboxy-gama-tocotrienolgama-CDMD(en)(2)HC;carboxydimethyldecadienyl hydroxychroman;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,7,8-trimethylchroman ----
    13'-carboxy-alpha-tocotrienol13AaTE ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ACOT2 gene: 
    NM_006821.5  

    Unigene Cluster for ACOT2:

    Acyl-CoA thioesterase 2
    Hs.446685  [show with all ESTs]
    Unigene Representative Sequence: NM_006821
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538782(uc001xom.3) ENST00000238651(uc001xon.4) ENST00000557857

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACOT2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ACOT2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACOT2
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT2
    Clone
    Products:
         
    OriGene clones in human, mouse for ACOT2 (see all 6)
    OriGene ORF clones in mouse, rat for ACOT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACOT2 (NM_006821)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACOT2
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ACOT2
      QuantiTect SYBR Green Assays in human, mouse, rat ACOT2
      QuantiFast Probe-based Assays in human, mouse, rat ACOT2

    Additional mRNA sequence: 

    AK001939.1 AK093131.1 AK223635.1 AY005822.1 BC004436.1 BC006335.2 BC006500.2 BC144425.1 
    DQ082755.1 L40401.1 NR_046028.1 

    8 DOTS entries:

    DT.445656  DT.95157623  DT.100824506  DT.100824503  DT.100824504  DT.99970598  DT.100824510  DT.100824511 

    Selected AceView cDNA sequences (see all 403):

    BI821071 BQ424599 BI819848 BQ221601 CB961857 CR624943 CR618088 CR599629 
    BX161396 CA392013 F25969 CR610624 BE409053 BM853353 CR617797 CB998061 
    BM763353 BP340920 AA953357 BM982293 BQ021741 CR599069 BG741665 BU517172 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ACOT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCTCTCT
    ACOT2 Expression
    About this image


    ACOT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Lens
     
     Adipose (Muscoskeletal System)
     
     Liver (Hepatobiliary System)
    ACOT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446685

    UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753
    Tissue specificity: Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas

        Custom PCR Arrays for ACOT2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACOT2
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ACOT2
    QuantiTect SYBR Green Assays in human, mouse, rat ACOT2
    QuantiFast Probe-based Assays in human, mouse, rat ACOT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ACOT2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot21 , 5 acyl-CoA thioesterase 21, 5 79.81(n)1
    75.72(a)1
      12 (38.99 cM)5
    1712101  NM_134188.31  NP_598949.31 
     839878615 
    chicken
    (Gallus gallus)
    Aves LOC7717531 acyl-coenzyme A thioesterase 2, mitochondrial-like 67.32(n)
    64.77(a)
      771753  XM_003641392.2  XP_003641440.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    1 → many
    1(39211695-39218982)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.122472 Transcribed sequence with weak similarity to protein more 69.66(n)    BX708583.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:776516
    zgc:77651
    33(a)
    many ↔ many
    4(24765246-24778640) ENSDARG00000088524
    worm
    (Caenorhabditis elegans)
    Secernentea K05B2.46
    W03D8.86
    (see all 4)
    Protein W03D8.8 (W03D8.8) mRNA, complete cds
    (see all 4)
    28(a)
    27(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(4919020-4920988) WBGene00019404
    I(2791689-2794895) WBGene00020989


    ENSEMBL Gene Tree for ACOT2 (if available)
    TreeFam Gene Tree for ACOT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ACOT2 gene
    ACOT62  ACOT42  ACOT12  BAAT2  
    4 SIMAP similar genes for ACOT2 using alignment to 2 protein entries:     ACOT2_HUMAN (see all proteins):
    ACOT1    ACOT4    ACOT6    BAAT

    ACOT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ACOT2 (see all 317)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71427981,2
    C,H--74032326(+) ggttcG/Atggtc 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1159455101,2
    F--74032355(+) AGCTGC/TGGACC 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1381909521,2
    C--74032389(+) TAAGGC/TGGCGT 1 -- us2k10--------
    rs1162388311,2
    F--74032408(+) TTGTTC/TGTTTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1437593991,2
    --74032435(+) GTCTCA/GCTGGC 1 -- us2k10--------
    rs1153039611,2
    F--74032477(+) AGTGTT/CAGAGC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1471918981,2
    --74032499(+) GTGTGA/GACGCA 1 -- us2k10--------
    rs1395743441,2
    --74032576(+) GGACCC/GCAGCG 1 -- us2k10--------
    rs1497862311,2
    C--74032649(+) GCTGAC/TTGGTA 1 -- us2k10--------
    rs1447453191,2
    C--74032730(+) CTCCAC/TGTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACOT2 (74034324 - 74042359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ACOT2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821106CNV Deletion20802225
    esv2672436CNV Deletion23128226
    esv2748867CNV Deletion23290073
    nsv436178CNV Deletion17901297
    esv1006342CNV Deletion20482838
    nsv826985CNV Loss20364138
    esv29945CNV Loss18421352
    nsv510643CNV Loss20534489
    nsv1350CNV Loss18451855
    nsv826987CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACOT2
    DNA2.0 Custom Variant and Variant Library Synthesis for ACOT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609972    OMIM disorders: --

    3 diseases for ACOT2:    
    About MalaCards
    labyrinthitis    alzheimer's disease    cerebritis


    ACOT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACOT2
    Human Genome Epidemiology (HuGE) Navigator: ACOT2 (2 documents)

    Export disorders for ACOT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ACOT2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ACOT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)1, 2, 3 Hunt M.C.... Alexson S.E.H. (FASEB J. 2006)
    2. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PubMed id 10944470)1, 2, 9 Jones J.M. and Gould S.J. (Biochem. Biophys. Res. Commun. 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2 Sherrington R....St George-Hyslop P.H. (Nature 1995)
    9. Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). (PubMed id 19497300)1, 9 Mandel C.R....Tong L. (Biochem. Biophys. Res. Commun. 2009)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10965 HGNC: 18431 AceView: ZAP128 Ensembl:ENSG00000119673 euGenes: HUgn10965
    ECgene: ACOT2 Kegg: 10965 H-InvDB: ACOT2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ACOT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ACOT2 gene:
    Search GeneIP for patents involving ACOT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACOT2   OriGene RNAi products in human, mouse, rat for ACOT2  
     OriGene qPCR primer pairs and template standards for ACOT2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ACOT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACOT2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ACOT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACOT2   OriGene Custom Protein Services for ACOT2  

     
     
     Block miRNA regulation of human, mouse, rat ACOT2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACOT2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT2 Predesigned siRNA for gene silencing in human, mouse, rat ACOT2
     QuantiFast Probe-based Assays in human, mouse, rat ACOT2 QuantiTect SYBR Green Assays in human, mouse, rat ACOT2
     Custom PCR Arrays for ACOT2 Search Chromatin IP Primers for ACOT2
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ACOT2 Search GeneGlobe Interaction Network for ACOT2
     Regulatory tfbs in ACOT2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ACOT2 GenScript cDNA clones with any tag delivered in your preferred vector for ACOT2
     GenScript Custom Assay Services for ACOT2 GenScript Custom overexpressing Cell Line Services for ACOT2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ACOT2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ACOT2 antibodies
     Antibodies for ACOT2
     See all of Abcam's Antibodies, Kits and Proteins for ACOT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ACOT2
     Antibodies for ACOT2
     ELISAs for ACOT2
     CLIAs for ACOT2



     Browse ESI BIO Cell Lines and PureStem Progenitors for ACOT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ACOT2
     SwitchGear Promoter luciferase reporter plasmids for ACOT2
     ThermoFisher Antibody for ACOT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACOT2
     LSBio Antibodies in human, mouse, rat for ACOT2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes       gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4