Aliases for ACOT2 Gene
External Ids for ACOT2 Gene
Previous GeneCards Identifiers for ACOT2 Gene
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for ACOT2 Gene
ACOT2 (Acyl-CoA Thioesterase 2) is a Protein Coding gene. Diseases associated with ACOT2 include Early-Onset Familial Alzheimer Disease. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Fatty acid elongation. Gene Ontology (GO) annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT1.
UniProtKB/Swiss-Prot for ACOT2 Gene
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.