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ACHE Gene

protein-coding GIFtS: 71

GC07M100325

acetylcholinesterase (Yt blood group)
(Previous name: acetylcholinesterase (YT blood group) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: YT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AChE ^³
ARACHE ^²
EC 3.1.1.7 ^³
N-ACHE ^²
YT ^², ⁵
acetylcholinesterase ^²

Descriptions
acetylcholinesterase (Yt blood group) ^¹, ²
apoptosis-related acetylcholinesterase ^²

External Ids
HGNC: 108¹
Entrez Gene: 43²
UniProtKB: P22303³
Ensembl: ENSG00000087085⁷

Search outside databases for aliases for ACHE gene

Previous GC identifers: GC07M099022 GC07M100085 GC07M100099 GC07M100132

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACHE:

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and

brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red

blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists

in multiple molecular forms which possess similar catalytic properties, but differ in their

oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single

ACHE gene, and the structural diversity in the gene products arises from alternative mRNA

splicing, and post-translational associations of catalytic and structural subunits. The major form

of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which

forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The

other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the

C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates

with the membranes through the phosphoinositide (PI) moieties added post-translationally.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ACES_HUMAN, P22303

Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the

acetylcholine released into the synaptic cleft. Role in neuronal apoptosis

Gene Wiki entry for ACHE (Acetylcholinesterase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACHE gene

Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22

ACHE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M100325: (about GC identifiers)

Start:	100,325,551 bp from pter
End:	100,331,477 bp from pter
Size:	5,927 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 99,847,220-99,853,146

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACES_HUMAN, P22303 (See protein sequence)

Recommended Name: Acetylcholinesterase precursor

Size: 614 amino acids; 67796 Da

Subunit: Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal

lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored

dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and

dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are

associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In

the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which

triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be

monomeric

Subcellular location: Cell junction, synapse. Secreted (By similarity). Cell membrane; Peripheral

membrane protein (By similarity)

Subcellular location: Isoform T: Nucleus. Note=Only observed in apoptotic nuclei

Subcellular location: Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By

similarity)

Sequence caution: Sequence=AAA68151.1; Type=Frameshift; Positions=604;

PDB structures from and Proteopedia :

1B41 (3D)

1F8U (3D)

1PUV (3D)

1PUW (3D)

1VZJ (3D)

2CLJ (3D)

Secondary accessions: A4D2E2 Q16169 Q29S23 Q2M324 Q504V3 Q86TM9 Q86YX9 Q9BXP7

Alternative splicing: 4 isoforms: P22303-1 P22303-2 P22303-4 P22303-3

REFSEQ proteins (2 alternative transcripts):

NP_000656.1 NP_056646.1

ENSEMBL proteins:

ENSP00000303211 ENSP00000241069 ENSP00000350037

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ACHE
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Acetylcholinesterase)
	Human Recombinant Proteins from Abnova (ACHE)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	11283752
GO:0005605	basal lamina	NAS	16289501
GO:0005634	nucleus	IEA	--
GO:0005794	Golgi apparatus	IDA	15454088
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for ACHE:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ACHE
	Sigma-Aldrich Antibodies for ACHE
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Acetylcholinesterase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACHE)
	Novus Biologicals Antibodies for ACHE

Assays for ACHE:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22303

ProtoNet protein and cluster: P22303

1 Blocks protein family: IPB000997 Cholinesterase signature

UniProtKB/Swiss-Prot: ACES_HUMAN, P22303

Similarity: Belongs to the type-B carboxylesterase/lipase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACHE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACHE)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000665

Applied Biosystems Silencer® siRNAs for ACHE

Sigma-Aldrich siRNA and siRNA Panels for ACHE

Sigma-Aldrich shRNA Panels and shRNA for ACHE

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACHE
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000665
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000665
untagged cDNA clones in CMV expression vector (see all 2): NM_000665

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015831

UniProtKB/Swiss-Prot: ACES_HUMAN, P22303

Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the

acetylcholine released into the synaptic cleft. Role in neuronal apoptosis

Catalytic activity: Acetylcholine + H(2)O = choline + acetate

Enzyme Number (IUBMB): EC 3.1.1.7

Genatlas biochemistry entry for ACHE:

acetylcholinesterase

15/16 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ache) (see all 16 ):

adipose tissue	behavior/neurological	craniofacial	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging
muscle	nervous system	no phenotypic analysis	reproductive system	respiratory system

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001540	beta-amyloid binding	TAS	11283752
GO:0003990	acetylcholinesterase activity	IMP	1517212
GO:0004104	cholinesterase activity	IDA	1517212
GO:0005518	collagen binding	IDA	12524166
GO:0017171	serine hydrolase activity	IDA	3954986

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ACHE (Your Favorite Gene powered by Ingenuity)

Glycerophospholipid Metabolism

GeneDecks ACHE for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ACHE

5/60 Interacting proteins for ACHE (ENSP00000350037³ P22303²) via UniProtKB, MINT, and/or STRING (see all 60 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COLQ	ENSP00000373298³	STRING (score=.995)
NGF	ENSP00000358525³	STRING (score=.953)
APP	ENSP00000284981³	STRING (score=.948)
CHKA	ENSP00000265689³	STRING (score=.929)
CHKB-CPT1B	ENSP00000312189³	STRING (score=.929)

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5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001507	acetylcholine catabolic process in synaptic cleft	NAS	1517212
GO:0002076	osteoblast development	IEP	15454088
GO:0006260	DNA replication	TAS	11283752
GO:0007155	cell adhesion	TAS	11283752
GO:0007416	synaptogenesis	TAS	11283752

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ACHE

Sigma-Aldrich Small Molecules for ACHE:

Agonist Inhibitor

Compounds for ACHE available from Tocris Bioscience

Compound	Action	CAS number
Tacrine hydrochloride	Cholinesterase inhibitor	[1684-40-8]
Physostigmine hemisulfate	Cholinesterase inhibitor	[64-47-1]
Galanthamine hydrobromide	Cholinesterase inhibitor	[1953-04-4]
Ambenonium dichloride	Cholinesterase inhibitor	[52022-31-8]
Acephate	Anticholinesterase insecticide	[30560-19-1]

About this table

10/35 Novoseek chemical compound relationships for ACHE gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acetylthiocholine	92.92	103	10869180 (3), 9427520 (2), 11275256 (2), 18602908 (2) (see all 64)
oxime	88.35	393	15498514 (6), 17900152 (6), 16904809 (5), 18281016 (5) (see all 99)
thiocholine	86.62	26	15987132 (2), 19238297 (2), 15826103 (1), 17499494 (1) (see all 17)
bw 284 c 51	86.28	43	8762162 (3), 8545050 (1), 11169626 (1), 10593614 (1) (see all 26)
carbamate	83.59	80	19269469 (3), 8948071 (2), 9890446 (2), 18631301 (2) (see all 57)
butyrylthiocholine	82.45	9	10340441 (1), 8367669 (1), 11275256 (1), 17300836 (1) (see all 6)
acetylthiocholine chloride	79.52	6	17499494 (1), 17111624 (1), 10679638 (1)
cyclosarin	79.09	33	18045198 (3), 17438836 (3), 17370251 (2), 17960099 (2) (see all 16)
phenserine	78.16	13	9675107 (2), 15795050 (1), 15974893 (1), 10874131 (1) (see all 9)
propidium	77.14	29	9521743 (2), 15267237 (2), 10648652 (2), 18468882 (2) (see all 20)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACHE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACHE)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000665

Sigma-Aldrich siRNA and siRNA Panels for ACHE

Sigma-Aldrich shRNA Panels and shRNA for ACHE

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000665 NM_015831

REFSEQ mRNAs for ACHE gene (2 alternative transcripts):

NM_000665.3 NM_015831.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000665 NM_015831

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000665
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000665
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000665

Additional cDNA sequence:

AF334270.1 AK223443.1 AK291321.1 AY389977.1 BC026315.1 BC036813.1 BC094752.1 BC105060.1

BC105062.1 BC143469.1 M55040.1

11 DOTS entries:

DT.416657 DT.121041597 DT.100751908 DT.101984170 DT.121041603 DT.100751910 DT.75103919 DT.97776847

DT.121041601 DT.101984168 DT.101984171

24/134 AceView cDNA sequences (see all 134 ):

BM023149 CD014076 CK904419 BC036813 BI753192 BE466391 CD014075 AI360141

CD014074 CD014073 BE551703 CD014072 CD014071 BC001541 BM719818 CA394873

H38691 BQ225068 BM718116 AI081892 AA401251 AW182170 BI489087 H19954

highest scoring ESTs for ACHE:

AA446656 AF334270 AI091215 AI207928 BC026315 BC036813 BG395920 BG705869 BG708331 BI915019

Unigene Cluster for ACHE:

Acetylcholinesterase (Yt blood group)

Hs.154495 [show with all ESTs]

Unigene Representative Sequence: NM_015831

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ACHE (see all 11 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b
SP1:			-		-																						-
SP2:					-										-		-		-								-
SP3:					-																						-
SP4:															-		-										-
SP5:																											-

About this scheme

ECgene alternative splicing isoforms for ACHE

3 Ensembl transcripts including schematic representations:

ENST00000302913 ENST00000241069 ENST00000357451

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACHE expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACHE

¹ / ² / ³

6 probe-sets matching ACHE gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40249_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.11	M55040	0.80	1.00	0.91	1
35387_r_at²^{, 3}	U95-A	1	0.38	1.00	0.28	0.91	S71129	0.20	1.00	0.72	1
205377_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI190022	0.60	1.00	0.82	1
205378_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015831	0.60	1.00	0.82	1
205377_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205378_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACHE for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.154495
Expression variation in blood from EXPOLDB for ACHE
UniProtKB/Swiss-Prot: ACES_HUMAN, P22303
Tissue specificity: Isoform H is highly expressed in erythrocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACHE gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACHE¹	--	acetylcholinesterase (Yt blood group)	89.63(n) 93.13(a)	489828 XM_546946.2 XP_546946.2
cow (Bos taurus)	ACHE¹	--	acetylcholinesterase (Yt blood group)	89.67(n) 93.15(a)	540446 NM_001076220.1 NP_001069688.1
mouse (Mus musculus)	Ache^{1, 5}	5 (77.00 cM)⁵	acetylcholinesterase^{1, 5}	84.91(n)¹ 88.44(a)¹	11423¹ NM_009599.3¹ NP_033729.1¹ AF148849⁵ AF312033⁵ (see all 27)
zebrafish (Danio rerio)	ache²	--	acetylcholinesterase	73.74(n)	114549 NM_131846.1
fruit fly (Drosophila melanogaster)	&agr;-Est8³	3 84D9	carboxylesterase	36(a) (best of 26)	--

About this table Species with no ortholog for ACHE

ENSEMBL Gene Tree for ACHE

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACHE gene

TG² BCHE²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ACES_HUMAN, P22303

Polymorphism: ACHE is responsible for the Yt blood group system. The molecular basis of the

Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353

corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b)

10/50 NCBI SNPs in ACHE are shown (see all 50 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs17881088^1,2	C,F	100332896(-)	`ACACCA/AA /C/CCCAACC`	2	--	ng3¹		4	NS	160
	rs17880400^1,2	C,F	100333466(-)	`ACCTGC/TGTGGC`	2	--	ng3¹		8	NS	754
	rs3757869^1,2	C,F	100331934(+)	`CAGAGG/TACCGT`	2	--	ng3¹		12	NS NA EA	1112
--	rs17884589^1,2	C,F	100331647(-)	`CACTGC/TGCTCT`	2	--	ng3¹		2	NS	94
--	rs17883319^1,2	F	100332860(-)	`TGGCTGC/-TTTTT`	2	--	ng3¹		2	NS	82
	rs17883557^1,2	F	100332885(-)	`CCAGCC/ACAGTC`	2	--	ng3¹		2	NS	80
	rs17879155^1,2	F	100332648(-)	`CGTGCC/GCGAGG`	2	--	ng3¹		2	NS	94
	rs10953305^1,2	A,C,F	100330504(+)	`GCCGTG/ACACGC`	2	--	int¹		2	NS	94
	rs2571600^1,2	C,F	100330429(+)	`CCAGCC/GCAGCC`	2	--	int¹		2	NS	94
--	rs3808356^1,2	C,F	100330258(+)	`AGACCC/TGGGGC`	2	--	int¹		2	NS	90

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HapMap Linkage Disequilibrium images for ACHE (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 100740 disorders: 112100

UniProtKB/Swiss-Prot: ACES_HUMAN, P22303

Behaves as an amyloid-promoting factor to promote the formation of amyloid plaques in

Alzheimer disease

10/93 Novoseek disease relationships for ACHE gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	88.80	753	1469405 (5), 17553629 (4), 9269216 (4), 1671469 (4) (see all 99)
acetylcholinesterase expression	83.90	30	17000130 (5), 17320203 (4), 12707285 (2), 1692114 (1) (see all 20)
endplate acetylcholinesterase deficiency	82.82	14	12609505 (3), 16009904 (1), 18647752 (1), 18374322 (1) (see all 9)
myasthenic syndromes congenital	78.91	21	12609505 (2), 9758617 (2), 15248101 (1), 16009904 (1) (see all 12)
hirschsprung disease	78.10	94	11528605 (4), 14680278 (3), 8747488 (3), 11719866 (3) (see all 44)
poisoning	76.13	159	15065394 (4), 10477195 (3), 16601804 (2), 18281016 (2) (see all 82)
dementia	74.97	162	1469405 (4), 9351648 (4), 8951800 (3), 14676050 (3) (see all 95)
senile plaques	70.48	93	1703383 (3), 9282941 (3), 9062656 (3), 1717194 (2) (see all 46)
dementia vascular	64.85	17	17215726 (2), 15224429 (1), 18174021 (1), 2403232 (1) (see all 14)
intoxication	62.78	64	16601804 (2), 18045198 (2), 17194020 (2), 1757241 (1) (see all 42)

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Blood Group Antigen Gene Mutation Database (BGMUT) Yt blood group system

Human Gene Mutation Database: ACHE
Genetic Association Database: ACHE
Human Genome Epidemiology Navigator: ACHE (23 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1308 PubMed articles for ACHE gene (see all 1308 ):

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. (PubMed id 1517212)^{1, 3, 4} Shafferman A.... Barak D. (1992)
Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. (PubMed id 8299725)^{1, 3, 4} Karpel R.... Soreq H. (1994)
Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. (PubMed id 15715671)^{1, 3, 6} Bryk B....Soreq H. (2005)
Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. (PubMed id 15690550)^{1, 3, 6} Cook L.J....Rubinsztein D.C. (2005)
Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. (PubMed id 15974920)^{1, 3, 6} Hasin Y....Sussman J.L. (2005)
Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. (PubMed id 15060281)^{3, 6} Sklan E.H....Soreq H. (2004)
A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. (PubMed id 15459952)^{3, 6} Hasin Y....Sussman J.L. (2004)
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. (PubMed id 15526038)^{3, 4} Dvir H.... Silman I. (2004)
Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1. (PubMed id 12928915)^{3, 6} Clarimon J....Comas D. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 43	HGNC: 108	AceView: ACHE	Ensembl:ENSG00000087085	euGenes: HUgn43
ECgene: ACHE	H-InvDB: ACHE

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=yt
Wikipedia	http://en.wikipedia.org/wiki/Acetylcholinesterase
SeattleSNPs	http://pga.gs.washington.edu/data/ache/

Licensable Technologies for ACHE
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACHE:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACHE-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACHE		Antibodies for ACHE
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	Lentivirus-delivered shRNAs for ACHE		Small molecules for ACHE
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (ACHE)
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	Custom Service for Mouse Mab
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Tocris compounds for ACHE

	Drugs for ACHE
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACHE

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ACHE Gene at Home site.
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ACHE Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for ACHE

Summaries
for ACHE

Genomic Location
for ACHE

Proteins
for ACHE

Protein Domains/
Families
for ACHE

Gene Function
for ACHE

Pathways & Interactions
for ACHE

Drugs & Compounds
for ACHE

Transcripts
for ACHE

Expression
for ACHE

Orthologs
for ACHE

Paralogs
for ACHE

SNPs/Variants
for ACHE

Disorders & Mutations
for ACHE

Medical News
for ACHE

Publications
for ACHE

Search for ACHE

Genome Databases showing ACHE

Other Databases showing ACHE

Specialized Databases showing ACHE

Licensable Technologies
for ACHE

Services
for ACHE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACHE Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor ACHE

Summariesfor ACHE

Genomic Locationfor ACHE

Proteinsfor ACHE

Protein Domains/Familiesfor ACHE

Gene Functionfor ACHE

Pathways & Interactionsfor ACHE

Drugs & Compoundsfor ACHE

Transcriptsfor ACHE

Expression for ACHE

Orthologsfor ACHE

Paralogsfor ACHE

SNPs/Variantsfor ACHE

Disorders & Mutationsfor ACHE

Medical Newsfor ACHE

Publicationsfor ACHE

Search for ACHE

Genome Databases showing ACHE

Other Databases showing ACHE

Specialized Databases showing ACHE

Licensable Technologiesfor ACHE

Servicesfor ACHE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACHE

Summaries
for ACHE

Genomic Location
for ACHE

Proteins
for ACHE

Protein Domains/
Families
for ACHE

Gene Function
for ACHE

Pathways & Interactions
for ACHE

Drugs & Compounds
for ACHE

Transcripts
for ACHE

Expression
for ACHE

Orthologs
for ACHE

Paralogs
for ACHE

SNPs/Variants
for ACHE

Disorders & Mutations
for ACHE

Medical News
for ACHE

Publications
for ACHE

Licensable Technologies
for ACHE

Services
for ACHE