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ACADSB Gene

protein-coding GIFtS: 59

GC10P124758

acyl-Coenzyme A dehydrogenase, short/branched chain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
2-MEBCAD ^², ³
ACAD7 ^¹, ²
EC 1.3.99.- ^³
OTTHUMP00000020685 ^²
OTTHUMP00000046795 ^²
SBCAD ^¹, ², ³, ⁵

Descriptions
2-methyl branched chain acyl-CoA dehydrogenase ^², ³
2-methylbutyryl-CoA dehydrogenase ^², ³
2-methylbutyryl-coenzyme A dehydrogenase ^³
acyl-Coenzyme A dehydrogenase, short/branched chain ^²

External Ids
HGNC: 91¹
Entrez Gene: 36²
UniProtKB: P45954³
Ensembl: ENSG00000196177⁷

Search outside databases for aliases for ACADSB gene

Previous GC identifers: GC10P123785 GC10P124018 GC10P124775 GC10P124308

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACADSB:

Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase

family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of

fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic

used to define members of this gene family. The ACADSB gene product has the greatest activity

towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts

significantly with other 2-methyl branched chain substrates and with short straight chain

acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon

mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided

by RefSeq]

UniProtKB/Swiss-Prot: ACDSB_HUMAN, P45954

Function: Has greatest activity toward short branched chain acyl-CoA derivative such as

(s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight

chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may

play a role in controlling the metabolic flux of valproic acid in the development of toxicity of

this agent

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACADSB gene

Entrez Gene cytogenetic band: 10q26.13 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q25-q26

ACADSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P124758: (about GC identifiers)

Start:	124,758,419 bp from pter
End:	124,807,796 bp from pter
Size:	49,378 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACDSB_HUMAN, P45954 (See protein sequence)

Recommended Name: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Size: 432 amino acids; 47485 Da

Cofactor: FAD

Subunit: Homotetramer

Subcellular location: Mitochondrion matrix

PDB structures from and Proteopedia :

2JIF (3D)

Secondary accessions: Q96CX7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001600.1

ENSEMBL proteins:

ENSP00000357873 ENSP00000357862

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ACADSB)
	Human Recombinant Proteins from Abnova (ACADSB)

OriGene Purified Recombinant Human Protein: ACADSB

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	7698750
GO:0005759	mitochondrial matrix	IEA	--

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Antibodies for ACADSB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACADSB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ACADSB), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ACADSB

Assays for ACADSB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P45954

ProtoNet protein and cluster: P45954

1 Blocks protein family: IPB006089 Acyl-CoA dehydrogenase

UniProtKB/Swiss-Prot: ACDSB_HUMAN, P45954

Similarity: Belongs to the acyl-CoA dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACADSB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001609

Applied Biosystems Silencer® siRNAs for ACADSB

Sigma-Aldrich siRNA for ACADSB

Sigma-Aldrich shRNA for ACADSB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001609
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001609
untagged cDNA clone in CMV expression vector: NM_001609

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001609

UniProtKB/Swiss-Prot: ACDSB_HUMAN, P45954

Function: Has greatest activity toward short branched chain acyl-CoA derivative such as

(s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight

chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may

play a role in controlling the metabolic flux of valproic acid in the development of toxicity of

this agent

Catalytic activity: Acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF

Enzyme Number (IUBMB): EC 1.3.99.-

Genatlas biochemistry entry for ACADSB:

acyl-CoA dehydrogenase,short branched chain,mitochondrial,fatty acid beta-oxidation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003995	acyl-CoA dehydrogenase activity	TAS	7698750
GO:0009055	electron carrier activity	IEA	--
GO:0050660	FAD binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ACADSB (Your Favorite Gene powered by Ingenuity)

&beta
Propanoate Metabolism
Valine, Leucine and Isoleucine Degradation
Fatty Acid Metabolism

GeneDecks ACADSB for the pathways selected above

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UniProtKB/Swiss-Prot: ACDSB_HUMAN, P45954

Pathway: Lipid metabolism; mitochondrial fatty acid beta-oxidation

5/9 Interacting proteins for ACADSB (ENSP00000357873³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACAT1	ENSP00000265838³	STRING (score=.953)
ACAA2	ENSP00000285093³	STRING (score=.932)
ACAA1	ENSP00000333664³	STRING (score=.931)
ECHS1	ENSP00000357535³	STRING (score=.92)
ACAT2	ENSP00000356015³	STRING (score=.911)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006631	fatty acid metabolic process	TAS	7698750
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACADSB
4 Novoseek chemical compound relationships for ACADSB gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2-methylbutyryl-coa	98.84	17	15574432 (5), 17393751 (2), 12837870 (2), 17883863 (2) (see all 7)
2-methyl-3-hydroxybutyryl-coa	93.44	2	16602099 (1), 16950638 (1)
acyl-coa	85.86	21	15574432 (2), 7759115 (2), 16602099 (1), 9487154 (1) (see all 10)
isoleucine	73.28	8	17945527 (2), 11013134 (1), 17393751 (1), 12837870 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACADSB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001609

Sigma-Aldrich siRNA for ACADSB

Sigma-Aldrich shRNA for ACADSB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001609

REFSEQ mRNAs for ACADSB gene:

NM_001609.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001609

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001609
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001609
                                 untagged cDNA clone in CMV expression vector: NM_001609

Additional cDNA sequence:

AK298638.1 AK314241.1 AL831821.2 BC013756.1 BC020931.1 BC032395.1 BC045723.1 CR612602.1

U12778.1

10 DOTS entries:

DT.416941 DT.100024007 DT.100779963 DT.121295563 DT.121295582 DT.95263418 DT.100689618 DT.121295569

DT.121295691 DT.92425400

24/209 AceView cDNA sequences (see all 209 ):

AA917930 AA236877 AI915897 AA505970 BM836131 AW408417 AI911527 AV682059

BU190209 AV645726 AI672498 BC013756 N53122 AA424737 AI492506 AV656592

AA953543 CR612602 AI680749 AI111193 NM_001609 AV658287 BU839630 BE875638

highest scoring ESTs for ACADSB:

AA203252 U12778 AA122129 AA225979 AA225980 AA226440 AA226578 AA235920 AA236877 AA255953

Unigene Cluster for ACADSB:

Acyl-Coenzyme A dehydrogenase, short/branched chain

Hs.81934 [show with all ESTs]

Unigene Representative Sequence: NM_001609

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000358776 ENST00000368869

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACADSB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACADSB

¹ / ² / ³

7 probe-sets matching ACADSB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48447_at²^{, 3}	U95-B	1	1.00	1.00	0.96	0.83	R07477	0.60	1.00	0.82	1
40673_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.04	U12778	1.00	1.00	1.00	1
56518_at²^{, 3}	U95-B	2	1.00	0.97	0.99	1.14	AA203252	1.00	1.00	1.00	1
226030_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE897866	0.80	1.00	0.91	1
205355_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001609	0.60	1.00	0.82	1
226030_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205355_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACADSB for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCAAATGTGA

SOURCE GeneReport for Unigene cluster: Hs.81934
Expression variation in blood from EXPOLDB for ACADSB
UniProtKB/Swiss-Prot: ACDSB_HUMAN, P45954
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACADSB gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACADSB¹	--	acyl-Coenzyme A dehydrogenase, short/branched chain	84.85(n) 82.3(a)	477856 XM_535048.2 XP_535048.2
chimpanzee (Pan troglodytes)	ACADSB¹	--	acyl-Coenzyme A dehydrogenase, short/branched chain	95.9(n) 95.04(a)	745464 XM_001151318.1 XP_001151318.1
cow (Bos taurus)	ACADSB¹	--	acyl-Coenzyme A dehydrogenase, short/branched chain	84.26(n) 82.41(a)	504301 NM_001017933.1 NP_001017933.1
rat (Rattus norvegicus)	Acadsb¹	--	acyl-Coenzyme A dehydrogenase, short/branched chain	83.41(n) 84.11(a)	25618 NM_013084.1 NP_037216.1
mouse (Mus musculus)	Acadsb^{1, 5}	7⁵	acyl-Coenzyme A dehydrogenase, short/branched chain^{1, 5}	82.17(n)¹ 83.18(a)¹	66885¹ NM_025826.2¹ NP_080102.1¹ AI845920⁵ AK004889⁵ (see all 18)

About this table Species with no ortholog for ACADSB

ENSEMBL Gene Tree for ACADSB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACADSB gene

ACAD9² ACADVL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/267 NCBI SNPs in ACADSB are shown (see all 267 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 126)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7732^1,2	A,C,F,H,O	124807697(+)	`TGGTAT/CGTATC`	1	--	ut3¹ ese³		20		MN NS NA EU EA WA	1640
	rs3980942^1,2	A,C,F,H	124807090(+)	`AGAAGG/ATAAAG`	1	--	ut3¹ ese³		7		EU EA WA NA	560
	rs6838^1,2	A,C,F,H	124807738(+)	`ATTCGA/TTGTTA`	1	--	ut3¹		23		MN NS EA NA EU WA	1944
	rs3763738^1,2	A,C,F	124806505(+)	`ATTCAG/CTCTTT`	1	--	ut3¹ ese³		4		EA NA	216
	rs11248371^1,2	C,F,H	124804471(+)	`CCATTA/TAGAAG`	1	--	ut3¹		11		NA EU EA WA	980
--	rs7909871^1,2	A,C	124805446(+)	`cccaaA/Caagtt`	1	--	ut3¹		0	--	--	--	--
--	rs7922412^1,2	F,H	124805384(+)	`caaggG/Aaaaga`	1	--	ut3¹ trp³		4		EU EA WA	414
--	rs7079265^1,2	A,C	124805602(+)	`ccaacC/Gtctgc`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs1140593^1,2	A,C	124803816(+)	`ccaccA/Gtgcct`	1	--	ut3¹ ese³		0	--	--	--	--
	rs12248648^1,2	F,H	124803768(+)	`gatatC/Tgccca`	1	--	ut3¹		4		EU EA WA	416

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HapMap Linkage Disequilibrium images for ACADSB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600301 disorders: 610006

UniProtKB/Swiss-Prot: ACDSB_HUMAN, P45954

Defects in ACADSB are the cause of short/branched-chain acyl-CoA dehydrogenase deficiency

(SBCADD) [MIM:610006]; also called 2-methylbutyryl-CoA dehydrogenase deficiency or 2-methylbutyryl

glycinuria. SBCADD is an autosomal recessive disorder and consists of a defect in catabolism of

L-isoleucine which is characterized by an increase of 2-methylbutyrylglycine and

2-methylbutyrylcarnitine in blood and urine. Affected individuals have seizures and psychomotor

delay as the main clinical features

1 Novoseek disease relationship for ACADSB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
isovaleric acidemia	87.01	2	17393751 (1), 11427446 (1)

About this table

Human Gene Mutation Database: ACADSB
Human Genome Epidemiology Navigator: ACADSB (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/26 PubMed articles for ACADSB gene (see all 26 ):

Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family. (PubMed id 7698750)^{2, 3, 4} Rozen R.... Fournier B. (1994)
Localization of short/branched chain acyl-CoA dehydrogenase (ACADSB) to human chromosome 10. (PubMed id 7759115)^{1, 2, 3} Arden K.C....Rozen R. (1995)
Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism. (PubMed id 11013134)^{1, 3, 4} Andresen B.S.... Skovby F. (2000)
Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping. (PubMed id 16317551)^{3, 4} Madsen P.P.... Andresen B.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
2-methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism. (PubMed id 10832746)^{3, 4} Gibson K.M.... Vockley J. (2000)
A novel approach to the characterization of substrate specificity in short/branched chain Acyl-CoA dehydrogenase. (PubMed id 12855692)^{1, 3} He M....Vockley J. (2003)
Association of genetic polymorphisms of ACADSB and COMT with human hypertension. (PubMed id 17143180)³ Kamide K....Miyata T. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 36	HGNC: 91	AceView: ACADSB	Ensembl:ENSG00000196177	euGenes: HUgn36
ECgene: ACADSB	H-InvDB: ACADSB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ACADSB

Licensable Technologies for ACADSB
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ACADSB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACADSB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACADSB		Antibodies for ACADSB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACADSB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ACADSB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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ACADSB Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ACADSB

Summaries
for ACADSB

Genomic Location
for ACADSB

Proteins
for ACADSB

Protein Domains/
Families
for ACADSB

Gene Function
for ACADSB

Pathways & Interactions
for ACADSB

Drugs & Compounds
for ACADSB

Transcripts
for ACADSB

Expression
for ACADSB

Orthologs
for ACADSB

Paralogs
for ACADSB

SNPs/Variants
for ACADSB

Disorders & Mutations
for ACADSB

Medical News
for ACADSB

Publications
for ACADSB

Search for ACADSB

Genome Databases showing ACADSB

Other Databases showing ACADSB

Specialized Databases showing ACADSB

Licensable Technologies
for ACADSB

Services
for ACADSB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACADSB Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ACADSB

Summariesfor ACADSB

Genomic Locationfor ACADSB

Proteinsfor ACADSB

Protein Domains/Familiesfor ACADSB

Gene Functionfor ACADSB

Pathways & Interactionsfor ACADSB

Drugs & Compoundsfor ACADSB

Transcriptsfor ACADSB

Expression for ACADSB

Orthologsfor ACADSB

Paralogsfor ACADSB

SNPs/Variantsfor ACADSB

Disorders & Mutationsfor ACADSB

Medical Newsfor ACADSB

Publicationsfor ACADSB

Search for ACADSB

Genome Databases showing ACADSB

Other Databases showing ACADSB

Specialized Databases showing ACADSB

Licensable Technologiesfor ACADSB

Servicesfor ACADSB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACADSB

Summaries
for ACADSB

Genomic Location
for ACADSB

Proteins
for ACADSB

Protein Domains/
Families
for ACADSB

Gene Function
for ACADSB

Pathways & Interactions
for ACADSB

Drugs & Compounds
for ACADSB

Transcripts
for ACADSB

Expression
for ACADSB

Orthologs
for ACADSB

Paralogs
for ACADSB

SNPs/Variants
for ACADSB

Disorders & Mutations
for ACADSB

Medical News
for ACADSB

Publications
for ACADSB

Licensable Technologies
for ACADSB

Services
for ACADSB