ABCC3 Gene
protein-coding GIFtS: 66
GCID: GC17P048712
|
|
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
| |
Aliases
for ABCC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 31 2 | | CMOAT23 5 | | MLP21 2 3 5 | | ABC312 | | MRP31 2 3 5 | | Canalicular Multispecific Organic Anion Transporter 22 | | MOAT-D1 2 3 | | Canicular Multispecific Organic Anion Transporter2 | | EST907571 2 | | Multidrug Resistance Associated Protein2 | | CMOAT23 5 | | EC 3.6.38 | | Multi-Specific Organic Anion Transporter D2 3 | | EC 3.6.3.448 | | Multidrug Resistance-Associated Protein 32 3 | | EC 6.3.2.48 | | ATP-Binding Cassette Sub-Family C Member 32 3 | | |
Export aliases for ABCC3 gene to outside databasesPrevious GC identifers: GC17P048425 GC17P051193 GC17P049054 GC17P049186 GC17P046067 GC17P044080 |
Summaries
for ABCC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ABCC3:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into sevendistinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamilywhich is involved in multi-drug resistance. The specific function of this protein has not yet been determined;however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions.Alternatively spliced variants which encode different protein isoforms have been described; however, not all variantshave been fully characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as analternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)
Gene Wiki entry for ABCC3
|
Genomic Views
for ABCC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABCC3 gene promoter:
COUP-TF1 GR Sp1 p53 GR-beta COUP HNF-4alpha2 HNF-4alpha1 COUP-TF GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABCC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21ABCC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P048712: view genomic region
(about GC identifiers)
Start:
|
48,712,138 bp from pter |
End:
|
48,769,613 bp from pter |
Size:
|
57,476 bases |
Orientation:
|
plus strand |
|
Proteins
for ABCC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438 (See
protein sequence)Recommended Name: Canalicular multispecific organic anion transporter 2 Size: 1527 amino acids; 169343 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Sequence=AAD01430.1; Type=Frameshift;Positions=355, 359, 361; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B2RPA9 D3DTX9 O60265 O60922 O75621 O95078 O95289 O95290 Q86X85 Q9UN52Alternative splicing: 5 isoforms: O15438-1 O15438-2 O15438-3 O15438-4 O15438-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ABCC3: NX_O15438
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15438
4 DME Specific Peptides for ABCC3 (O15438)
ABCC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001137542.1 NP_003777.2
ENSEMBL proteins: ENSP00000422786 ENSP00000425697 ENSP00000395160 ENSP00000285238 ENSP00000427073 ENSP00000427521 ENSP00000424981 ENSP00000422058 ENSP00000421755 Reactome Protein details: O15438
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ABCC3 for ontologies About GeneDecksing
ABCC3 Antibody Products:
Assay Products for ABCC3: |
Protein
Domains /
Families
for ABCC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABCC3 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O15438ProtoNet protein and cluster: O15438 UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity: Contains 2 ABC transmembrane type-1 domainsSimilarity: Contains 2 ABC transporter domains |
Function
for ABCC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as analternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity) Genatlas biochemistry entry for ABCC3:ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine andprostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions
Enzyme Numbers (IUBMB): EC 6.3.2.42 EC 3.6.3.442 EC 3.6.32
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0008514 | organic anion transmembrane transporter activity |
TAS | 9738950 | | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
IEA | -- |
ABCC3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ABCC3:
Animal Models:
Mouse knock-outs for ABCC3: Abcc3tm1Kruh Abcc3tm1Bor
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Abcc3):
ABCC3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ABCC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Codeine and morphine metabolism | | | 3 | Fluoropyrimidine Activity | | | 4 | ABC-family proteins mediated transport | | | 5 | Synthesis of bile acids and bile salts | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for ABCC3
5/6 
Reactome Pathways for ABCC3 (see all 6)
5/7  PharmGKB Pathways for ABCC3 (see all 7)
2 
Kegg Pathways (Kegg details for ABCC3):
ABCC3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for ABCC3 (O154383 ENSP000002852384) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
ABCC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ABCC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ABCC3 for compounds About GeneDecksing
 Browse Tocris compounds for ABCC3
10/85 HMDB Compounds for ABCC3 (see all 85) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid | Chenodeoxycholic acid 3-glucuronide (see all 3) | 58814-71-4 | -- | | 1,3,12-Trihydroxycholan-24-oic acid | 1,3,12-Trihydroxycholan-24-oate (see all 6) | 63266-91-1 | -- | | 1,3,7,12-Tetrahydroxycholan-24-oic acid | 1,3,7,12-Tetrahydroxycholan-24-oate (see all 10) | 63266-89-7 | -- | | 12-Ketodeoxycholic acid | 12-Dehydrodeoxycholate (see all 20) | 5130-29-0 | -- | | 12a-Hydroxy-3-oxocholadienic acid | 12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8) | 13535-96-1 | -- | | 12b-Hydroxy-5b-cholanoic acid | 12b-Hydroxy-5b-cholanic acid (see all 9) | 15173-23-6 | -- | | 1b,3a,12a-Trihydroxy-5b-cholanoic acid | 1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6) | 80434-32-8 | -- | | 1b,3a,7a-Trihydroxy-5b-cholanoic acid | 1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18) | 99598-04-6 | -- | | 1b-Hydroxycholic acid | 1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5) | 80875-94-1 | -- | | 2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid | 2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7) | 60696-60-8 | -- |
10/23 DrugBank Compounds for ABCC3 (see all 23) About this table
10/45 Novoseek chemical compound relationships for ABCC3 gene (see all 45) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| estradiol-17beta-glucuronide |
89.7 |
6 |
10644759 (1), 14667926 (1), 12388190 (1), 12924948 (1) |
| etoposide glucuronide |
87.6 |
10 |
20028753 (3), 11581266 (2), 12220224 (1) |
| taurocholate |
71.7 |
8 |
12220224 (3), 16637898 (1), 12388190 (1), 12763363 (1) (see all 5) |
| 5-carboxyfluorescein |
68.1 |
3 |
14603501 (1), 14570758 (1) |
| androstane |
68 |
2 |
14705863 (1) |
| glycocholate |
65.3 |
7 |
12220224 (3), 10987286 (1), 12388190 (1) |
| glucuronide |
62.5 |
3 |
14667926 (1), 14643890 (1) |
| tbhq |
60.3 |
1 |
11841785 (1) |
| bile acid |
59.7 |
4 |
12220224 (1), 15814571 (1) |
| mk 571 |
59.2 |
1 |
14667926 (1) |
1 PharmGKB related drug/compound annotation for ABCC3 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about ABCC3 / MRP3
|
Transcripts
for ABCC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABCC3 gene (4 alternative transcripts): NM_001144070.1 NM_003786.3 NM_020037.1 NM_020038.1 Unigene Cluster for ABCC3: ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Hs.463421 [show with all ESTs]Unigene Representative Sequence: AF08569218 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515707 ENST00000513511 ENST00000427699(uc002isk.4) ENST00000285238(uc002isl.3)
ENST00000502426 ENST00000505699 ENST00000515585 ENST00000513589 ENST00000571855(uc002ism.3)
ENST00000515070 ENST00000503304 ENST00000510633 ENST00000506464 ENST00000513745
ENST00000510891 ENST00000503337(uc002isn.3) ENST00000508929 ENST00000504586
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC3 |
Additional cDNA sequence: AB010887.1 AB208954.1 AF009670.1 AF083552.1 AF085690.1 AF085692.1 AF104943.1 BC046126.1 BC050370.1 BC058907.1 BC104952.1 BC137347.1 BC137348.1 U66674.1 U83659.1 Y17151.2 23 DOTS entries: DT.215229 DT.100789082 DT.100789080 DT.92436625 DT.40118229 DT.95148897 DT.91972802 DT.92436630 DT.70105371 DT.444291 DT.95082800 DT.99950674 DT.121001282 DT.121001284 DT.86844736 DT.92436622 DT.95082810 DT.100705669 DT.40303139 DT.91940419 DT.91940550 DT.95082805 DT.95230357 24/233 AceView cDNA sequences (see all 233): BU552498 BM795857 AI887269 BQ955138 AI281129 AI916490 BQ227366 BU631704 AF083552 NM_020037 AV656424 AW848421 AF085690 AL709936 BM852191 NM_020038 BG328614 CA445870 AF085691 BM828847 BU543427 AA843535 AI282631 CB055248
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | · | 23d | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ | 33a | · | 33b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 34 | ^ | 35a | · | 35b | · | 35c | ^ | 36 | ^ | 37a | · | 37b | · | 37c | · | 37d |
|---|
|
| SP1: | | | - | | - | | | | - | | | | | | | | | | |
| SP2: | | | - | | - | | | | - | | | | | | | | | | |
| SP3: | | | - | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ABCC3
|
Expression
for ABCC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABCC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCAACAGTA
About this image
See ABCC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABCC3
SOURCE GeneReport for Unigene cluster: Hs.463421
UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brainand at a lower level in the kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC3 |
Orthologs
for ABCC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ABCC3 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ABCC31 |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
67.6(n)
69.65(a) |
|
422099 XM_420102.3 XP_420102.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
71(a) |
1 ↔ 1 |
2(117276883-117323370) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX732495.12 |
-- |
71.32(n) |
|
BX732495.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CT030207.16 |
-- |
62(a) |
1 ↔ 1 |
12(922361-983336) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG62143
MRP1 |
xenobiotic-transporting ATPase3
Multidrug-Resistance like Protein 11 |
47(a)
(best of 2)3
56.85(n)1
51.24(a)1 |
|
33F43
346861 NM_205973.11 NP_995695.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
mrp-23
mrp-41 |
ATP-binding transport family3
Protein MRP-41 |
45(a)
(best of 4)3
50.51(n)1
44.33(a)1 |
|
X(599137-607953)3
1812021 NM_077257.31 NP_509658.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MRP101 |
ABC transporter C family member 14 |
45.61(n)
35.8(a) |
|
825444 NM_116135.2 NP_191829.1 |
rice
(Oryza sativa) |
Liliopsida |
Os04g02092001 |
hypothetical protein |
48.04(n)
37.6(a) |
|
4335176 NM_001058786.1 NP_001052251.1 |
ENSEMBL Gene Tree for ABCC3 (if available)
TreeFam Gene Tree for ABCC3 (if available) |
Paralogs
for ABCC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ABCC3 gene
- ABCC42 ABCC122 ABCC12 ABCC102 CFTR2 ABCC82 ABCC52 ABCC62
- ABCC22 ABCC112 ABCC92
18/21 SIMAP similar genes for ABCC3 using alignment to 9 protein entries: MRP3_HUMAN (see all proteins)
(see all similar genes):MRP3 DKFZp781G125 DKFZp434I2115 ABCB4 ABCC1 CTFR
CFTR TAP1 MRP NG-TRA ABCC2 ABCC6
ABCC4 ABCC13 URG7 ABCC10 ABCC9 ABCC11
ABCC3 for paralogs About GeneDecksing
|
Genomic Variants
for ABCC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABCC3 (48712138 - 48769613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ABCC3
1 CNV: 5017
Human Gene Mutation Database (HGMD): ABCC3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC3 |
|
Disorders
/ Diseases
for ABCC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABCC3 for disorders About GeneDecksing
OMIM gene information: 604323
OMIM disorders: --
20/53  diseases for ABCC3 (see all 53): About MalaCardsdubin-johnson syndrome non-small cell lung carcinoma extrahepatic cholestasis soft tissue sarcoma
primary biliary cirrhosis cholangiolocellular carcinoma barrett's esophagus cholestasis
malignant glioma obstructive jaundice lymphoblastic leukemia systemic lupus erythematosus
lupus erythematosus jaundice acute lymphoblastic leukemia malignant mesothelioma
acute myeloid leukemia intrahepatic cholangiocarcinoma myeloid leukemia colon adenocarcinoma
4 diseases from the University of Copenhagen DISEASES database for ABCC3:Cholestasis Bilirubin metabolic disorder Lung cancer Leukemia 10/28 Novoseek disease relationships for ABCC3 gene (see all 28) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dubin-johnson syndrome |
71.4 |
1 |
10094960 (1) |
| cholestasis |
68.3 |
10 |
12837754 (1), 11850532 (1), 12538803 (1), 10728790 (1) (see all 7) |
| cholestasis extrahepatic |
57.3 |
4 |
11076395 (1), 12428063 (1), 19185005 (1) |
| breast cancer |
41.7 |
22 |
12731885 (2), 18393293 (2), 10739113 (1), 14979731 (1) (see all 18) |
| hepatocellular carcinoma |
38 |
8 |
18250047 (3), 18619700 (2), 19956884 (1), 11745434 (1) (see all 5) |
| cancer |
35.8 |
13 |
9270026 (1), 10359813 (1), 12676459 (1), 10100721 (1) (see all 13) |
| biliary cirrhosis primary |
35 |
2 |
14568249 (1) |
| glioma |
32.5 |
11 |
11223551 (5), 16193381 (4) |
| colon adenocarcinoma |
28.4 |
1 |
17430634 (1) |
| colon cancer |
28 |
5 |
19593667 (3), 11820781 (1) |
Human Genome Epidemiology (HuGE) Navigator: ABCC3 (13 documents)
Export disorders for ABCC3 gene to outside databases
|
Publications
for ABCC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABCC3 gene, integrated from 9 sources (see all 268):
(articles sorted by number of sources associating them with ABCC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PubMed id 9827529)1, 2, 3, 9 Belinsky M.G.... Kruh G.D. (1998)
- cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). (PubMed id 9738950)1, 2, 7, 9 Kiuchi Y.... Sugiyama Y. (1998)
- Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PubMed id 12220224)1, 7, 9 Zelcer N....Borst P. (2003)
- Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. (PubMed id 10094960)1, 2, 9 Koenig J.... Keppler D. (1999)
- Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PubMed id 19334674)1, 7, 9 Zehnpfennig B....Galla H.J. (2009)
- Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)1, 2, 9 Kool M.... Borst P. (1997)
- Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. (PubMed id 16460798)1, 7, 9 Gedeon C....Piquette-Miller M. (2006)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
- Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants. (PubMed id 9889399)1, 2 Fromm M.F.... Kim R.B. (1999)
- Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport. (PubMed id 9813153)1, 2 Uchiumi T.... Kuwano M. (1998)
|
External Searches for ABCC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ABCC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABCC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ABCC3 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for ABCC3 | Genetics and Cytogenetics in Oncology and Haematology | | ABCMdb | http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15438 |
|
| | |
About This Section
| Patent Information for ABCC3 gene:
Search GeneIP for patents involving ABCC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABCC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ABCC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCC3 | | | OriGene Protein Over-expression Lysate for ABCC3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ABCC3 | | OriGene 3'-UTR Clone for ABCC3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ABCC3 | | OriGene Custom Protein Services for ABCC3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC3 |
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 |  |  |  | |
| | | | Search Tocris compounds for ABCC3 |
| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC3 |
|  |  |  | | | | ThermoFisher Antibody for ABCC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC3 |
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