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ABAT Gene

protein-coding GIFtS: 65

GC16P008675

4-aminobutyrate aminotransferase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 2.6.1.19,EC 2.6.1.22 ^³
FLJ17813 ^²
G ^⁵
GABA-AT ^², ³
GABA-T ^³
GABAT ^¹, ², ³
L-AIBAT ^³
NPD009 ^²

Descriptions
(S)-3-amino-2-methylpropionate transaminase ^³
4-aminobutyrate aminotransferase ^²
GABA aminotransferase ^², ³
GABA transaminase ^³
GABA transferase ^²
Gamma-amino-N-butyrate transaminase ^², ³

External Ids
HGNC: 23¹
Entrez Gene: 18²
UniProtKB: P80404³
Ensembl: ENSG00000183044⁷

Search outside databases for aliases for ABAT gene

Previous GC identifers: GC16P008572 GC16P008868 GC16P008735

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABAT:

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid

(GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into

succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to

pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is

estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is

controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44.

The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia,

lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript

variants encoding the same protein isoform have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: GABT_HUMAN, P80404

Function: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate

semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate

and beta-alanine

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABAT gene

Entrez Gene cytogenetic band: 16p13.2 Ensembl cytogenetic band: 16p13.2 HGNC cytogenetic band: 16p13.2

ABAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P008675: (about GC identifiers)

Start:	8,675,928 bp from pter
End:	8,785,933 bp from pter
Size:	110,006 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GABT_HUMAN, P80404 (See protein sequence)

Recommended Name: 4-aminobutyrate aminotransferase, mitochondrial precursor

Size: 500 amino acids; 56439 Da

Cofactor: Pyridoxal phosphate

Subunit: Homodimer (By similarity)

Subcellular location: Mitochondrion matrix

Secondary accessions: A8K386 Q16260 Q8N5W2 Q96BG2 Q99800

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000654.2 NP_001120920.1 NP_065737.2

ENSEMBL proteins:

ENSP00000268251 ENSP00000379845

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABAT)
	Human Recombinant Proteins from Abnova (ABAT)

OriGene Purified Recombinant Human Proteins (see all 2): ABAT

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	ISS	--
GO:0005759	mitochondrial matrix	IEA	--
GO:0032144	4-aminobutyrate transaminase complex	IDA	15528998

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Antibodies for ABAT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABAT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABAT), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABAT)
	Novus Biologicals Antibody for ABAT

Assays for ABAT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P80404

ProtoNet protein and cluster: P80404

1 Blocks protein family: IPB005814 Aminotransferase class-III

UniProtKB/Swiss-Prot: GABT_HUMAN, P80404

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABAT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000663

Applied Biosystems Silencer® siRNAs for ABAT

Sigma-Aldrich siRNA and siRNA Panels for ABAT

Sigma-Aldrich shRNA for ABAT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABAT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000663
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000663
untagged cDNA clones in CMV expression vector (see all 3): NM_000663

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000663

UniProtKB/Swiss-Prot: GABT_HUMAN, P80404

Function: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate

semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate

and beta-alanine

Catalytic activity: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

Catalytic activity: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate +

L-glutamate

Enzyme Number (IUBMB): EC 2.6.1.19,EC

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003867	contributes to 4-aminobutyrate transaminase activity	IDA	15528998
GO:0005515	protein binding	IPI	17474147
GO:0016740	transferase activity	IEA	--
GO:0030170	pyridoxal phosphate binding	IDA	15650327
GO:0032145	succinate-semialdehyde dehydrogenase binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for ABAT (Your Favorite Gene powered by Ingenuity) (see all 7 )

GABA Receptor Signaling
Alanine and Aspartate Metabolism
Propanoate Metabolism
Butanoate Metabolism
Valine, Leucine and Isoleucine Degradation

GeneDecks ABAT for the pathways selected above

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5/23 Interacting proteins for ABAT (P80404¹ ENSP00000268251³) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRK	P46108¹	EBI-1753838, EBI-886
ALDH5A1	ENSP00000314649³	STRING (score=.997)
GAD1	ENSP00000350928³	STRING (score=.982)
GAD2	ENSP00000259271³	STRING (score=.982)
CNDP1	ENSP00000351682³	STRING (score=.958)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007610	behavior	NAS	11918424
GO:0009450	gamma-aminobutyric acid catabolic process	NAS	15528998
GO:0042135	neurotransmitter catabolic process	NAS	15528998
GO:0048148	behavioral response to cocaine	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ABAT

Sigma-Aldrich Small Molecules for ABAT:

Inhibitor

Compounds for ABAT available from Tocris Bioscience

Compound	Action	CAS number
Vigabatrin	GABA-T inhibitor	[60643-86-9]
3-Methyl-GABA	Activator of GABA amino-transferase	[71424-95-8]

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10/16 Novoseek chemical compound relationships for ABAT gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
succinic semialdehyde	92.82	34	18846220 (3), 8412016 (2), 14984687 (1), 12891648 (1) (see all 20)
aba-t	92.71	11	15830322 (4), 19294962 (2), 18334916 (1), 15642443 (1) (see all 6)
p-hydroxybenzaldehyde	63.47	7	16290145 (2), 16690313 (1), 19138517 (1)
beta-alanine	52.02	3	16435204 (1), 12238932 (1)
nipecotic acid	50.34	1	8101728 (1)
ornithine	41.01	4	16096275 (1), 7592550 (1), 17504214 (1), 18398873 (1)
2-mercaptoethanol	28.33	2	15528998 (1), 14640537 (1)
carboxylate	10.13	2	10579835 (1)
taurine	5.80	3	14567543 (3)
lysine	0.00	1	1901730 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABAT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000663

Sigma-Aldrich siRNA and siRNA Panels for ABAT

Sigma-Aldrich shRNA for ABAT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000663 NM_001127448 NM_020686

REFSEQ mRNAs for ABAT gene (3 alternative transcripts):

NM_000663.4 NM_001127448.1 NM_020686.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000663 NM_001127448 NM_020686

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000663
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000663
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000663

Additional cDNA sequence:

AF237813.1 AK290501.1 AK293983.1 AK310771.1 AL137454.1 BC008990.1 BC013965.2 BC015628.2

BC031413.1 BC075851.1 BX537362.1 CR593324.1 CR599622.1 L32961.1 S75578.1 U80226.1

13 DOTS entries:

DT.454527 DT.101983594 DT.99933573 DT.100814053 DT.100723837 DT.100777194 DT.99981159 DT.100814054

DT.120686051 DT.452778 DT.91773661 DT.100008010 DT.120686077

24/270 AceView cDNA sequences (see all 270 ):

BG060102 CR599622 CB250491 AV651195 AV727134 AI445779 AW572541 AI284203

AA319794 AW196473 AI248676 BM876183 T33495 AV652821 AI076281 AI580324

AA331613 AW024973 BF196112 NM_000663 BC015628 NM_020686 AI282925 BG056506

highest scoring ESTs for ABAT:

L32961 AA203138 AA233454 AA233527 AA319352 AA319794 AA332265 AA332691 AA334268 AA337336

Unigene Cluster for ABAT:

4-aminobutyrate aminotransferase

Hs.336768 [show with all ESTs]

Unigene Representative Sequence: NM_000663

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ABAT (see all 8 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:					-		-		-		-		-		-		-				-														-
SP2:																					-
SP3:					-		-		-		-		-		-		-
SP4:							-		-
SP5:									-

About this scheme

ECgene alternative splicing isoforms for ABAT

2 Ensembl transcripts including schematic representations:

ENST00000268251 ENST00000396600

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABAT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABAT

¹ / ² / ³

9 probe-sets matching ABAT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36364_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.75	L32961	1.00	0.87	0.94	1
33446_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.05	W26407	0.60	1.00	0.82	1
68707_at²^{, 3}	U95-E	1	0.94	1.00	-0.38	1.28	AA806200	0.60	1.00	0.82	1
206527_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000663	0.60	1.00	0.82	1
209460_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF237813	0.80	1.00	0.91	1
209459_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF237813	0.80	1.00	0.91	1
206527_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209460_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209459_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABAT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.336768
Expression variation in blood from EXPOLDB for ABAT
UniProtKB/Swiss-Prot: GABT_HUMAN, P80404
Tissue specificity: Liver > pancreas > brain > kidney > heart > placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABAT gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABAT¹	--	4-aminobutyrate aminotransferase	90.95(n) 94.77(a)	479856 XM_846331.1 XP_851424.1
chimpanzee (Pan troglodytes)	ABAT¹	--	4-aminobutyrate aminotransferase	99.33(n) 98.8(a)	453903 XM_001137090.1 XP_001137090.1
cow (Bos taurus)	ABAT¹	--	4-aminobutyrate aminotransferase	90.2(n) 94.2(a)	506219 XM_582638.3 XP_582638.2
rat (Rattus norvegicus)	Abat¹	--	4-aminobutyrate aminotransferase	87.53(n) 91.8(a)	81632 NM_031003.1 NP_112265.1
mouse (Mus musculus)	Abat^{1, 5}	16⁵	4-aminobutyrate aminotransferase^{1, 5}	87.2(n)¹ 91.2(a)¹	268860¹ NM_172961.2¹ NP_766549.2¹ AI255750⁵ AI853123⁵ (see all 17)

About this table Species with no ortholog for ABAT

ENSEMBL Gene Tree for ABAT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ABAT gene

OAT²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1078 NCBI SNPs in ABAT are shown (see all 1078 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 334)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs737695^1,2	A,C,F,H	8783046(-)	`CTTCCC/GAAGAT`	3	--	ut3¹		6	NA EA EU WA	575
	rs4985000^1,2	A,C,F,H	8783778(+)	`CACTTC/GTGAGC`	3	--	ut3¹ ese³		8	EA NA EU WA	610
	rs3743801^1,2	A,C,F,H	8783703(+)	`GGCAAC/GTTGAG`	3	--	ut3¹ ese³		8	EA NA EU WA	2064
--	rs2270288^1,2	A,C,F,H	8783030(+)	`CTTGAG/TCCCTG`	3	--	ut3¹ ese³		4	EU EA WA	412
	rs7205816^1,2	A,C,F,H	8783919(+)	`TCAACA/GTGGTT`	3	--	ut3¹ ese³		12	EA NA EU WA	1042
	rs12597124^1,2	A,C,F,H	8785355(+)	`TTTAGG/CTAGAA`	3	--	ut3¹ ese³		8	NA EA EU WA	774
	rs3743798^1,2	A,C,F,H	8783300(+)	`TGCAGG/AAGGGA`	3	--	ut3¹ ese³		7	EA NA EU WA	2088
	rs11648372^1,2	A,C,F,H	8784902(+)	`AAGGCA/GTATCA`	3	--	ut3¹		4	EU EA WA	420
	rs4985036^1,2	A,C,F,H	8784721(+)	`TGCTAC/TGACAG`	3	--	ut3¹ ese³		11	NA EU EA WA	978
	rs1731017^1,2	A,C,F,H	8747455(-)	`TCACCC/TGAGAT`	3	Q/R	mis¹ ese³		17	MN EA EU WA NA	2872

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HapMap Linkage Disequilibrium images for ABAT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 137150

UniProtKB/Swiss-Prot: GABT_HUMAN, P80404

Defects in ABAT are a cause of GABA-AT deficiency [MIM:137150]. The phenotype of this

deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory

seizures, and EEG abnormalities

10/19 Novoseek disease relationships for ABAT gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
homocarnosinosis	87.47	2	15021235 (2)
visual field constriction	79.20	2	16793827 (1), 16675198 (1)
epilepsy	70.63	19	1396437 (1), 14984687 (1), 12358316 (1), 1652757 (1) (see all 19)
complex partial seizures	65.50	2	7750512 (1)
hyperglycinemia nonketotic	58.88	1	17690069 (1)
deficiency diseases	48.89	4	9746906 (3)
cocaine addiction	40.21	2	10503933 (1)
neurological disorders	34.19	5	8979623 (1), 17128990 (1), 16314106 (1), 15650327 (1) (see all 5)
epilepsy generalized	32.00	1	1313057 (1)
autistic	31.15	4	12160695 (3), 11918424 (1)

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Human Gene Mutation Database: ABAT
Genetic Association Database: ABAT
Human Genome Epidemiology Navigator: ABAT (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/145 PubMed articles for ABAT gene (see all 145 ):

Screening and sequence determination of a cDNA encoding the human brain 4-aminobutyrate aminotransferase. (PubMed id 7721088)^{2, 3, 4} Osei Y.D. and Churchich J.E. (1995)
4-aminobutyrate aminotransferase (GABA-transaminase) deficiency. (PubMed id 10407778)^{1, 3, 4} Medina-Kauwe L.K.... Gibson K.M. (1999)
Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase. (PubMed id 7851425)^{1, 3, 4} de Biase D.... Bossa F. (1995)
An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia. (PubMed id 15642443)^{1, 3, 6} Zhang B....Shen Y. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking. (PubMed id 15528998)^{1, 3} Yoon C.S....Choi S.Y. (2004)
Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. (PubMed id 12694932)^{1, 3} Rainesalo S....Keranen T. (2003)
Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. (PubMed id 15830322)^{1, 3} Barnby G....Monaco A.P. (2005)
Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site. (PubMed id 15650327)^{1, 3} Kim D.W....Choi S.Y. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 18	HGNC: 23	AceView: ABAT	Ensembl:ENSG00000183044	euGenes: HUgn18
ECgene: ABAT	H-InvDB: ABAT

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ABAT
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ABAT+%40+GABAT

Licensable Technologies for ABAT
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABAT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABAT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABAT		Antibodies for ABAT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABAT		Small molecules for ABAT
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABAT)
	Antibodies (ABAT)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ABAT)
	Antibodies (ABAT)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for ABAT

	Drugs for ABAT
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABAT

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABAT Gene at Home site.
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ABAT Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ABAT

Summaries
for ABAT

Genomic Location
for ABAT

Proteins
for ABAT

Protein Domains/
Families
for ABAT

Gene Function
for ABAT

Pathways & Interactions
for ABAT

Drugs & Compounds
for ABAT

Transcripts
for ABAT

Expression
for ABAT

Orthologs
for ABAT

Paralogs
for ABAT

SNPs/Variants
for ABAT

Disorders & Mutations
for ABAT

Medical News
for ABAT

Publications
for ABAT

Search for ABAT

Genome Databases showing ABAT

Other Databases showing ABAT

Specialized Databases showing ABAT

Licensable Technologies
for ABAT

Services
for ABAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABAT Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ABAT

Summariesfor ABAT

Genomic Locationfor ABAT

Proteinsfor ABAT

Protein Domains/Familiesfor ABAT

Gene Functionfor ABAT

Pathways & Interactionsfor ABAT

Drugs & Compoundsfor ABAT

Transcriptsfor ABAT

Expression for ABAT

Orthologsfor ABAT

Paralogsfor ABAT

SNPs/Variantsfor ABAT

Disorders & Mutationsfor ABAT

Medical Newsfor ABAT

Publicationsfor ABAT

Search for ABAT

Genome Databases showing ABAT

Other Databases showing ABAT

Specialized Databases showing ABAT

Licensable Technologiesfor ABAT

Servicesfor ABAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABAT

Summaries
for ABAT

Genomic Location
for ABAT

Proteins
for ABAT

Protein Domains/
Families
for ABAT

Gene Function
for ABAT

Pathways & Interactions
for ABAT

Drugs & Compounds
for ABAT

Transcripts
for ABAT

Expression
for ABAT

Orthologs
for ABAT

Paralogs
for ABAT

SNPs/Variants
for ABAT

Disorders & Mutations
for ABAT

Medical News
for ABAT

Publications
for ABAT

Licensable Technologies
for ABAT

Services
for ABAT